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- Creators: Arizona State University
Description
Nicotine is thought to underlie the reinforcing and dependence-producing effects of tobacco-containing products. Nicotine supports self-administration in rodents, although measures of its reinforcing effects are often confounded by procedures that are used to facilitate acquisition, such as food restriction, prior reinforcement training, or response-contingent co-delivery of a naturally reinforcing light. This study examined whether rats acquire nicotine self-administration in the absence of these facilitators. A new mathematical modeling procedure was used to define the criterion for acquisition and to determine dose-dependent differences in rate and asymptote levels of intake. Rats were trained across 20 daily 2-h sessions occurring 6 days/week in chambers equipped with active and inactive levers. Each active lever press resulted in nicotine reinforcement (0, 0.015, 0.03, 0.06 mg/kg, IV) and retraction of both levers for a 20-s time out, whereas inactive lever presses had no consequences. Acquisition was defined by the best fit of a logistic function (i.e., S-shaped) versus a constant function (i.e., flat line) for reinforcers obtained across sessions using a corrected Akaike information criterion (AICc) as a model selection tool. The results showed an inverted-U shaped function for dose in relation to the percentage of animals that acquired nicotine self-administration, with 46% acquiring at 0.015 mg/kg, 73% at 0.03 mg/kg, and 58% at 0.06 mg/kg. All saline rats failed to acquire as expected. For rats that acquired nicotine self-administration, multiple model comparisons demonstrated that the asymptote (highest number of reinforcers/session) and half learning point (h; session during which half the assymptote had been achieved) were justified as free parameters of the reinforcers/session function, indicating that these parameters vary with nicotine dose. Asymptote exhibited an inverted U-shaped function across doses and half learning point exhibited a negative relationship to dose (i.e., the higher the dose the fewer sessions to reach h). These findings suggest that some rats acquire nicotine self-administration without using procedures that confound measures of acquisition rate. Furthermore, the modeling approach provides a new way of defining acquisition of drug self-administration that takes advantage of using all data generated from individual subjects and is less arbitrary than some criteria that are currently used.
ContributorsCole, Natalie (Author) / Neisewander, Janet L (Thesis advisor) / Sanabria, Federico (Thesis advisor) / Bimonte-Nelson, Heather A. (Committee member) / Olive, Michael F (Committee member) / Arizona State University (Publisher)
Created2011
Description
Adaptive processing and classification of electrocardiogram (ECG) signals are important in eliminating the strenuous process of manually annotating ECG recordings for clinical use. Such algorithms require robust models whose parameters can adequately describe the ECG signals. Although different dynamic statistical models describing ECG signals currently exist, they depend considerably on a priori information and user-specified model parameters. Also, ECG beat morphologies, which vary greatly across patients and disease states, cannot be uniquely characterized by a single model. In this work, sequential Bayesian based methods are used to appropriately model and adaptively select the corresponding model parameters of ECG signals. An adaptive framework based on a sequential Bayesian tracking method is proposed to adaptively select the cardiac parameters that minimize the estimation error, thus precluding the need for pre-processing. Simulations using real ECG data from the online Physionet database demonstrate the improvement in performance of the proposed algorithm in accurately estimating critical heart disease parameters. In addition, two new approaches to ECG modeling are presented using the interacting multiple model and the sequential Markov chain Monte Carlo technique with adaptive model selection. Both these methods can adaptively choose between different models for various ECG beat morphologies without requiring prior ECG information, as demonstrated by using real ECG signals. A supervised Bayesian maximum-likelihood (ML) based classifier uses the estimated model parameters to classify different types of cardiac arrhythmias. However, the non-availability of sufficient amounts of representative training data and the large inter-patient variability pose a challenge to the existing supervised learning algorithms, resulting in a poor classification performance. In addition, recently developed unsupervised learning methods require a priori knowledge on the number of diseases to cluster the ECG data, which often evolves over time. In order to address these issues, an adaptive learning ECG classification method that uses Dirichlet process Gaussian mixture models is proposed. This approach does not place any restriction on the number of disease classes, nor does it require any training data. This algorithm is adapted to be patient-specific by labeling or identifying the generated mixtures using the Bayesian ML method, assuming the availability of labeled training data.
ContributorsEdla, Shwetha Reddy (Author) / Papandreou-Suppappola, Antonia (Thesis advisor) / Chakrabarti, Chaitali (Committee member) / Kovvali, Narayan (Committee member) / Tepedelenlioğlu, Cihan (Committee member) / Arizona State University (Publisher)
Created2012
Description
The Southwestern Willow Flycatcher (Empidonax traillii extimus) has been studied for over two decades and listed as endangered for most of that time. Though the flycatcher has been granted protected status since 1995, critical habitat designation for the flycatcher has not shared the same history. Critical habitat designation is essential for achieving the long-term goals defined in the flycatcher recovery plan where emphasis is on both the protection of this species and "the habitats supporting these flycatchers [that] must be protected from threats and loss" (U.S. Fish and Wildlife Service 2002). I used a long-term data set of habitat characteristics collected at three study areas along the Lower Colorado River to develop a method for quantifying habitat quality for flycatcher. The data set contained flycatcher nest observations (use) and habitat availability (random location) from 2003-2010 that I statistically analyzed for flycatcher selection preferences. Using both Pearson's Chi-square test and SPSS Principal Component Analysis (PCA) I determined that flycatchers were selecting 30 habitat traits significantly different among an initial list of 127 habitat characteristics. Using PCA, I calculated a weighted value of influence for each significant trait per study area and used those values to develop a habitat classification system to build predictive models for flycatcher habitat quality. I used ArcGIS® Model Builder to develop three habitat suitability models for each of the habitat types occurring in western riparian systems, native, mixed exotic and exotic dominated that are frequented by breeding flycatchers. I designed a fourth model, Topock Marsh, to test model accuracy on habitat quality for flycatchers using reserved accuracy assessment points of previous nest locations. The results of the fourth model accurately predicted a decline in habitat at Topock Marsh that was confirmed by SWCA survey reports released in 2011 and 2012 documenting a significant decline in flycatcher productivity in the Topock Marsh study area.
ContributorsChenevert-Steffler, Ann (Author) / Miller, William (Thesis advisor) / Bateman, Heather (Committee member) / Alford, Eddie (Committee member) / Arizona State University (Publisher)
Created2013
Description
Traditional approaches to modeling microgrids include the behavior of each inverter operating in a particular network configuration and at a particular operating point. Such models quickly become computationally intensive for large systems. Similarly, traditional approaches to control do not use advanced methodologies and suffer from poor performance and limited operating range. In this document a linear model is derived for an inverter connected to the Thevenin equivalent of a microgrid. This model is then compared to a nonlinear simulation model and analyzed using the open and closed loop systems in both the time and frequency domains. The modeling error is quantified with emphasis on its use for controller design purposes. Control design examples are given using a Glover McFarlane controller, gain sched- uled Glover McFarlane controller, and bumpless transfer controller which are compared to the standard droop control approach. These examples serve as a guide to illustrate the use of multi-variable modeling techniques in the context of robust controller design and show that gain scheduled MIMO control techniques can extend the operating range of a microgrid. A hardware implementation is used to compare constant gain droop controllers with Glover McFarlane controllers and shows a clear advantage of the Glover McFarlane approach.
ContributorsSteenis, Joel (Author) / Ayyanar, Raja (Thesis advisor) / Mittelmann, Hans (Committee member) / Tsakalis, Konstantinos (Committee member) / Tylavsky, Daniel (Committee member) / Arizona State University (Publisher)
Created2013
Description
This study was designed to influence consumer habits, specifically those relating to purchases of fruits, vegetables, and junk food. Previous studies have clearly shown the ineffectiveness of simply describing the health benefits of eating more fruits and vegetables (F/V). In contrast, this study aimed to change the result by changing the message: providing participants with insight into the hidden agendas of food companies and grocery stores, provide useful tips on how to include children when selecting F/V, and emphasizing the importance of parental modeling in regard to food purchases. Participants of this study were separated into two groups, the tour group and the education group. The tour group was guided through a grocery store where they learned about sales tactics and manipulations used by grocery stores and food companies to influence purchases. Education group participants were provided with an education session focusing on USDA and FDA handouts displaying current educational suggestions for increasing F/V consumption. Grocery store receipts were collected and analyzed to track the progress of both groups. The goal of the study was to identify a method of informing consumers that will produce a significant change in behavior. Increasing F/V consumption, even in relatively small amounts, would be an important step forward in improving the diet and overall health of Americans. This study was the first of its kind to measure purchasing patterns objectively (through analysis of purchase receipts, rather than personal opinion/evaluation surveys) and in a wide-scope retail environment that includes all grocery store purchases by participants. Significant increases or decreases in the amount of money spent on F/V, or the amount (pounds) of F/V purchased were not seen, however a small correlation (r = 0.133) exists when comparing the weight of F/V purchased pre/post intervention. Data from Food Frequency Questionnaires shows participants consuming significantly higher amounts of F/V post intervention (p=0.043). The tour group and education group experienced an average increase of 0.7 servings per day. Future interventions might benefit by extending their scope to include cooking demonstrations, in-home interventions, and education on healthy eating outside of the home.
ContributorsKinsfather, Diana (Author) / Johnston, Carol (Thesis advisor) / Hekler, Eric (Committee member) / Tetreault, Colin (Committee member) / Arizona State University (Publisher)
Created2013
Description
Many species e.g. sea urchin form amorphous calcium carbonate (ACC) precursor phases that subsequently transform into crystalline CaCO3. It is certainly possible that the biogenic ACC might have more than 10 wt% Mg and ∼ 3 wt% of water. The structure of ACC and the mechanisms by which it transforms to crystalline phase are still poorly understood. In this dissertation our goal is to determine an atomic structure model that is consistent with diffraction and IR measurements of ACC. For this purpose a calcite supercell with 24 formula units, containing 120 atoms, was constructed. Various configurations with substitution of Ca by 6 Mg ions (6 wt.%) and insertion of 3-5 H2O molecules (2.25-3.75 wt.%) in the interstitial positions of the supercell, were relaxed using a robust density function code VASP. The most noticeable effects were the tilts of CO3 groups and the distortion of Ca sub-lattice, especially in the hydrated case. The distributions of Ca-Ca nearest neighbor distance and CO3 tilts were extracted from various configurations. The same methods were also applied to aragonite. Sampling from the calculated distortion distributions, we built models for amorphous calcite/aragonite of size ∼ 1700 nm3 based on a multi-scale modeling scheme. We used these models to generate diffraction patterns and profiles with our diffraction code. We found that the induced distortions were not enough to generate a diffraction profile typical of an amorphous material. We then studied the diffraction profiles from several nano-crystallites as recent studies suggest that ACC might be a random array of nanocryatallites. It was found that the generated diffraction profile from a nano-crystallite of size ∼ 2 nm3 is similar to that from the ACC.
ContributorsSinha, Sourabh (Author) / Rez, Peter (Thesis advisor) / Bearat, Hamdallah A. (Committee member) / Bennett, Peter A. (Committee member) / McCartney, Martha R. (Committee member) / Peng, Xihong (Committee member) / Arizona State University (Publisher)
Created2012
Description
A sequence of models is developed to describe urban population growth in the context of the embedded physical, social and economic environments and an urban disease are developed. This set of models is focused on urban growth and the relationship between the desire to move and the utility derived from city life. This utility is measured in terms of the economic opportunities in the city, the level of human constructed amenity, and the level of amenity caused by the natural environment. The set of urban disease models is focused on examining prospects of eliminating a disease for which a vaccine does not exist. It is inspired by an outbreak of the vector-borne disease dengue fever in Peru, during 2000-2001.
ContributorsMurillo, D (Author) / Castillo-Chavez, Carlos (Thesis advisor) / Anderies, John M (Thesis advisor) / Boone, Christopher (Committee member) / Arizona State University (Publisher)
Created2012
Description
Threshold logic has long been studied as a means of achieving higher performance and lower power dissipation, providing improvements by condensing simple logic gates into more complex primitives, effectively reducing gate count, pipeline depth, and number of interconnects. This work proposes a new physical implementation of threshold logic, the threshold logic latch (TLL), which overcomes the difficulties observed in previous work, particularly with respect to gate reliability in the presence of noise and process variations. Simple but effective models were created to assess the delay, power, and noise margin of TLL gates for the purpose of determining the physical parameters and assignment of input signals that achieves the lowest delay subject to constraints on power and reliability. From these models, an optimized library of standard TLL cells was developed to supplement a commercial library of static CMOS gates. The new cells were then demonstrated on a number of automatically synthesized, placed, and routed designs. A two-stage 2's complement integer multiplier designed with CMOS and TLL gates utilized 19.5% less area, 28.0% less active power, and 61.5% less leakage power than an equivalent design with the same performance using only static CMOS gates. Additionally, a two-stage 32-instruction 4-way issue queue designed with CMOS and TLL gates utilized 30.6% less area, 31.0% less active power, and 58.9% less leakage power than an equivalent design with the same performance using only static CMOS gates.
ContributorsLeshner, Samuel (Author) / Vrudhula, Sarma (Thesis advisor) / Chatha, Karamvir (Committee member) / Clark, Lawrence (Committee member) / Shrivastava, Aviral (Committee member) / Arizona State University (Publisher)
Created2010
Description
Optical Instrument Transformers (OIT) have been developed as an alternative to traditional instrument transformers (IT). The question "Can optical instrument transformers substitute for the traditional transformers?" is the main motivation of this study. Finding the answer for this question and developing complete models are the contributions of this work. Dedicated test facilities are developed so that the steady state and transient performances of analog outputs of a magnetic current transformer (CT) and a magnetic voltage transformer (VT) are compared with that of an optical current transformer (OCT) and an optical voltage transformer (OVT) respectively. Frequency response characteristics of OIT outputs are obtained. Comparison results show that OITs have a specified accuracy of 0.3% in all cases. They are linear, and DC offset does not saturate the systems. The OIT output signal has a 40~60 μs time delay, but this is typically less than the equivalent phase difference permitted by the IEEE and IEC standards for protection applications. Analog outputs have significantly higher bandwidths (adjustable to 20 to 40 kHz) than the IT. The digital output signal bandwidth (2.4 kHz) of an OCT is significantly lower than the analog signal bandwidth (20 kHz) due to the sampling rates involved. The OIT analog outputs may have significant white noise of 6%, but the white noise does not affect accuracy or protection performance. Temperatures up to 50oC do not adversely affect the performance of the OITs. Three types of models are developed for analog outputs: analog, digital, and complete models. Well-known mathematical methods, such as network synthesis and Jones calculus methods are applied. The developed models are compared with experiment results and are verified with simulation programs. Results show less than 1.5% for OCT and 2% for OVT difference and that the developed models can be used for power system simulations and the method used for the development can be used to develop models for all other brands of optical systems. The communication and data transfer between the all-digital protection systems is investigated by developing a test facility for all digital protection systems. Test results show that different manufacturers' relays and transformers based on the IEC standard can serve the power system successfully.
ContributorsKucuksari, Sadik (Author) / Karady, George G. (Thesis advisor) / Heydt, Gerald T (Committee member) / Holbert, Keith E. (Committee member) / Ayyanar, Raja (Committee member) / Farmer, Richard (Committee member) / Arizona State University (Publisher)
Created2010
Description
Cyber Physical Systems (CPSs) are systems comprising of computational systems that interact with the physical world to perform sensing, communication, computation and actuation. Common examples of these systems include Body Area Networks (BANs), Autonomous Vehicles (AVs), Power Distribution Systems etc. The close coupling between cyber and physical worlds in a CPS manifests in two types of interactions between computing systems and the physical world: intentional and unintentional. Unintentional interactions result from the physical characteristics of the computing systems and often cause harm to the physical world, if the computing nodes are close to each other, these interactions may overlap thereby increasing the chances of causing a Safety hazard. Similarly, due to mobile nature of computing nodes in a CPS planned and unplanned interactions with the physical world occur. These interactions represent the behavior of a computing node while it is following a planned path and during faulty operations. Both of these interactions change over time due to the dynamics (motion) of the computing node and may overlap thereby causing harm to the physical world. Lack of proper modeling and analysis frameworks for these systems causes system designers to use ad-hoc techniques thereby further increasing their design and development time. The thesis addresses these problems by taking a holistic approach to model Computational, Physical and Cyber Physical Interactions (CPIs) aspects of a CPS and proposes modeling constructs for them. These constructs are analyzed using a safety analysis algorithm developed as part of the thesis. The algorithm computes the intersection of CPIs for both mobile as well as static computing nodes and determines the safety of the physical system. A framework is developed by extending AADL to support these modeling constructs; the safety analysis algorithm is implemented as OSATE plug-in. The applicability of the proposed approach is demonstrated by considering the safety of human tissue during the operations of BAN, and the safety of passengers traveling in an Autonomous Vehicle.
ContributorsKandula, Sailesh Umamaheswara (Author) / Gupta, Sandeep (Thesis advisor) / Lee, Yann Hang (Committee member) / Fainekos, Georgios (Committee member) / Arizona State University (Publisher)
Created2010