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Throughout history, music has evolved. Composition and songwriting have changed in order to create fresh and original sounds. However, production has been emphasized more than ever in the modern music industry. Due to the fact that music generated with an instrument can only be organized using a specific range, diversity

Throughout history, music has evolved. Composition and songwriting have changed in order to create fresh and original sounds. However, production has been emphasized more than ever in the modern music industry. Due to the fact that music generated with an instrument can only be organized using a specific range, diversity can be limited. Musical production and audio editing introduced an innovative solution. After the creation of the Digital Audio Workstation (DAW), recording transitioned from “being primarily a technical to an artistic matter” (Moorefield). Technology that established reverb, pitch shift, loop, pan, and countless other effects broadened melodic horizons and changed the way that musicians practiced their craft. Notably, once the recording process had been polished by the 1960s, the music industry entered an experimental phase. The term “producer” gained traction along with engineers. To this day, artists prioritize the individuals they choose to produce their album because this factor will drive the overall sound of a song or project. Moreover, an artist may choose to produce their own music as they grow more comfortable with creating music and working with editing software. There is an abundance of music being released into the world on an annual basis. Without production, the community would come to a monotonous halt, making music production the driving force behind musical evolution.

ContributorsKallos, Meghan (Author) / Jaquette, Dan (Thesis director) / Scott Lynch, Jacquelyn (Committee member) / Barrett, The Honors College (Contributor) / School of Music, Dance and Theatre (Contributor) / School of Life Sciences (Contributor)
Created2023-05
Description

Discussions of the nature of time can be enriched using insight from the field of biology. In the evolution of our species, biological timekeeping mechanisms have been honed to a fine point and can accurately adhere to a 24-hour cycle. When considering that these timekeeping mechanisms would only have evolved

Discussions of the nature of time can be enriched using insight from the field of biology. In the evolution of our species, biological timekeeping mechanisms have been honed to a fine point and can accurately adhere to a 24-hour cycle. When considering that these timekeeping mechanisms would only have evolved if they were reasonably accurate, it must be the case that our timekeeping systems are measuring a genuine feature of reality. This thesis explores this idea by discussing the veridicality of the circadian clock and contrasting it with the physiological origin of feelings of duration. As it turns out, duration can not be accounted for by the circadian clock, implying that the felt ‘flow’ of time is a cognitive illusion rather than a feature of objective reality. Given this, our knowledge of biology reconciles best with the Static View (B-theory) of time.

ContributorsDrewsen, Jack (Author) / Kung, Peter (Thesis director) / Sturgess, Jessica (Committee member) / Barrett, The Honors College (Contributor) / Historical, Philosophical & Religious Studies, Sch (Contributor) / School of Life Sciences (Contributor)
Created2023-05
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The study of macaque monkeys harbors advancements in the field of biomedical research. It is imperative to understand the genetic composition of different species of macaques to assess their accuracy as non-human primate (NHP) models for disease detection and treatment assessments. We sought to characterize the hybridization and admixture of

The study of macaque monkeys harbors advancements in the field of biomedical research. It is imperative to understand the genetic composition of different species of macaques to assess their accuracy as non-human primate (NHP) models for disease detection and treatment assessments. We sought to characterize the hybridization and admixture of the Southeast Asian macaques using single nucleotide polymorphism markers and analyzing the populations on the mainland and the island. Using AMOVA tests and STRUCTURE analysis, we determined that there are three distinct populations: Macaca mulatta, M. fascicularis fascicularis, and M. f. aurea. Furthermore, the island species holds an isolated population of M. f. aurea that demonstrate high inbreeding and genetic uniqueness compared to the mainland species. Findings from this study confirm that NHP models may need to be modified or updated according to changing allelic frequencies and genetic drift.

ContributorsFalak, Asiya (Author) / Kanthaswamy, Sreetharan (Thesis director) / Oldt, Robert (Committee member) / Barrett, The Honors College (Contributor) / Computer Science and Engineering Program (Contributor) / School of Life Sciences (Contributor)
Created2022-05
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The relationship between science and religion in the modern day is complex to the point that the lines between them are often blurred. We have a need to distinguish the two from each-other for a variety of practical reasons. Various philosophies, theories, and tests have been suggested on the interaction

The relationship between science and religion in the modern day is complex to the point that the lines between them are often blurred. We have a need to distinguish the two from each-other for a variety of practical reasons. Various philosophies, theories, and tests have been suggested on the interaction between the two and how they are subdivided. One of the sets of criteria which has been shown to work was originally introduced in the opinion of Judge Overton in the case of McLean v Arkansas. McLean v Arkansas is a pivotal case in that it gave us a useful definition of what science is and isn’t in the context of the law. It used the already established Lemon test to show what counts as the establishment of religion. Given the distinction by Judge Overton, there are questions as to whether or not there is even overlap or tension between science and religion, such as in the theory of Stephen Jay Gould’s Nonoverlapping Magisteria (NOMA). What we find in this thesis is that the NOMA principle is doubtful at best. Through the discussion of McLean v. Arkansas, NOMA, and the commentaries of Professors Larry Laudan and Michael Ruse, this thesis develops a contextualization principle that can be used as a guide to develop further theories, particularly regarding the divisions between science and religion.

ContributorsAmmanamanchi, Amrit (Author) / Creath, Richard (Thesis director) / Minteer, Ben (Committee member) / Barrett, The Honors College (Contributor) / School of Politics and Global Studies (Contributor) / School of Life Sciences (Contributor)
Created2022-05
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Mutation rate is the rate of appearance for mutations to occur in a living organism. Studying and quantifying mutation rates and their evolution is important because mutations are the ultimate source of genetic variation and one of the reasons why evolution occurs. Much of the current research has investigated the

Mutation rate is the rate of appearance for mutations to occur in a living organism. Studying and quantifying mutation rates and their evolution is important because mutations are the ultimate source of genetic variation and one of the reasons why evolution occurs. Much of the current research has investigated the mutational rate increase. The evolution of reduced mutation rate, which can be favored by natural selection because the accumulation of too many mutations can be deleterious and result in death, is less studied. Therefore, this study will be focused on antimutators, which are mutations that result in a lowering of the mutation rate. Using Escherichia coli K-12 str. MG1655 as a model system, the effects and reasons for how MMR- background E. coli evolves lower mutation rates were studied. Here we show that the candidate antimutator in dnaE lowers the mutation rate in an experimentally evolved population of E. coli with MMR- background by using a mutation rate assay to demonstrate the difference between populations with and without the antimutator candidate. The results also suggest the importance of an antimutator for populational survival.
ContributorsGraham, Logan (Author) / Ho, Wei-Chin (Thesis director) / Lynch, Michael (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)
Created2022-05
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Cells have mechanisms in place to maintain the specific lipid composition of distinct organelles including vesicular transport by the endomembrane system and non-vesicular lipid transport by lipid transport proteins. Oxysterol Binding Proteins (OSBPs) are a family of lipid transport proteins that transfer lipids at various membrane contact sites (MCSs). OSBPs

Cells have mechanisms in place to maintain the specific lipid composition of distinct organelles including vesicular transport by the endomembrane system and non-vesicular lipid transport by lipid transport proteins. Oxysterol Binding Proteins (OSBPs) are a family of lipid transport proteins that transfer lipids at various membrane contact sites (MCSs). OSBPs have been extensively investigated in human and yeast cells where twelve have been identified in Homo sapiens and seven in Saccharomyces cerevisiae. The evolutionary relationship between these well-characterized OSBPs is still unclear. Reconstructed OSBP phylogenies revealed that the ancestral Saccharomycotinan had four OSBPs, the ancestral Holomycotan had five OSBPs, the ancestral Holozoan had six OSBPs, the ancestral Opisthokont had three OSBPs, and the ancestral Eukaroyte had three OSBPs. Our analysis identified three clades of ancient OSBPs not present in animals or fungi.

ContributorsSingh, Rohan (Author) / Wideman, Jeremy (Thesis director) / Gile, Gillian (Committee member) / Barrett, The Honors College (Contributor) / School of Human Evolution & Social Change (Contributor) / School of Life Sciences (Contributor)
Created2022-05
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Cancers of the reproductive tissues make up a significant portion of the cancer burden and mortality experienced by humans. Humans experience several proximal causative carcinogens that explain a portion of cancer risk, but an evolutionary viewpoint can provide a unique lens into the ultimate causes of reproductive cancer vulnerabilities. A

Cancers of the reproductive tissues make up a significant portion of the cancer burden and mortality experienced by humans. Humans experience several proximal causative carcinogens that explain a portion of cancer risk, but an evolutionary viewpoint can provide a unique lens into the ultimate causes of reproductive cancer vulnerabilities. A life history framework allows us to make predictions on cancer prevalence based on a species’ tempo of reproduction. Moreover, certain variations in the susceptibility and prevalence of cancer may emerge due to evolutionary trade-offs between reproduction and somatic maintenance. For example, such trade-offs could involve the demand for rapid proliferation of cells in reproductive tissues that arises with reproductive events. In this study, I compiled reproductive cancer prevalence for 158 mammalian species and modeled the predictive power of 13 life history traits on the patterns of cancer prevalence we observed, such as Peto’s Paradox or slow-fast life history strategies. We predicted that fast-life history strategists will exhibit higher neoplasia prevalence risk due to reproductive trade-offs. Furthering this analytical framework can aid in predicting cancer rates and stratifying cancer risk across the tree of life.

ContributorsDarapu, Harshini (Author) / Maley, Carlo (Thesis director) / Boddy, Amy (Committee member) / Compton, Zachary (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)
Created2022-05
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Theories about the human origin in evolution and religion are fundamentally countering beliefs that are still debated to this day. This study continues to explore this relationship in the college population at a public university with the intention of targeting a diverse religious population. This research hopes to answer the

Theories about the human origin in evolution and religion are fundamentally countering beliefs that are still debated to this day. This study continues to explore this relationship in the college population at a public university with the intention of targeting a diverse religious population. This research hopes to answer the question: does having greater literacy in evolution lead to a noninterventionist perspective on evolution? The prediction is that evidence of increased evolution comprehension will influence students to have a more agnostic, or noninterventionist, view on evolution. An evolution class was given a survey that had two parts broken into demographic and evolution sections with one question that asks about compatibility between evolution and religion. This was given twice in a single semester to track the growth of evolution knowledge and any other differences. There were 265 students in the initial survey, but only 223 responses in the post-survey. The compatibility question had 8 statements that range from creationist to atheistic perspectives and was divided into two sides: interventionist (divine involvement) and noninterventionist (deity may be present but does not intervene). More than 70% of the class had a noninterventionist perspective on evolution despite the Christian categories being the second largest group students identified with after agnostic. The agnostic statement was the top choice followed by the atheistic answer on the noninterventionist side. Lastly, there was some growth of evolution knowledge for each religious category in the evolution section but is not significant for interpretation. Based on the collected data, it is not sufficient to answer the question and requires more data collection via a longitudinal study.

ContributorsLam, Monica (Author) / Kappes, Janelle (Thesis director) / Sterner, Beckett (Committee member) / Barrett, The Honors College (Contributor) / Watts College of Public Service & Community Solut (Contributor) / School of Life Sciences (Contributor)
Created2022-05
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The morphological characteristics of organisms are intricately linked to their ecological features. As a result, species with similar ecological niches may exhibit shared morphological traits due to convergent evolution. Some genomic features could be relevant to influencing the occurrence of convergence evolution. Anoles, with over 400 species, are an excellent

The morphological characteristics of organisms are intricately linked to their ecological features. As a result, species with similar ecological niches may exhibit shared morphological traits due to convergent evolution. Some genomic features could be relevant to influencing the occurrence of convergence evolution. Anoles, with over 400 species, are an excellent model for studying this process. Within Anolis, groups of species that have evolved similar morphological traits and ecological adaptations in response to specific environmental niches are described as ecomorphs. One ecomorph, the crown-giant anoles, has independently evolved large body sizes and adapted to arboreal habitats, predominantly occupying the upper canopy layer of forests. The objective of this study was to explore the convergent evolution of morphological traits in crown giant anoles, by comparing the osteological traits of two crown giants, Anolis frenatus, and A. equestris, to four non-crown giant species from different ecomorphs, A. auratus, A. carolinensis, A. biporcatus, and A. sagrei. The analysis indicated an absence of convergence in most morphological traits except for body size (SVL). Additionally, this study explored the potential role of transposable elements (TEs) as a genomic feature shaping the morphological diversity of crown giant anoles. The genes located within TE-rich regions on the genome were identified across selected Anolis species. An enrichment of genes associated with regulation and developmental processes was detected in regions with high TE abundance for all analyzed species, but not exclusive to crown giants. The results suggest that crown giants seem to only converge in their substantial body size and that the variability in other morphological characteristics could be attributed to some other ecological features or the phylogenetic relationships of each species. Moreover, TEs may play a role in facilitating morphological evolution and adaptability in all Anolis species, as they could influence gene expression and regulatory pathways. This highlights the need for further investigation into the genomic mechanisms determining convergent evolution.
ContributorsJohnson, Jaime (Author) / Kusumi, Kenro (Thesis director) / Araya-Donoso, Raúl (Committee member) / Dolby, Greer (Committee member) / Fisher, Rebecca (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)
Created2024-05
Description
Adaptive therapy is a novel up-and-coming cancer treatment strategy to minimize chemoresistance in cells to improve patient prognosis. The standard of care cancer treatment has a fixed linear approach known as Maximum Tolerated Dose (MTD) which promotes an exponential growth of resistant cancer cell populations in the tumor. Through this

Adaptive therapy is a novel up-and-coming cancer treatment strategy to minimize chemoresistance in cells to improve patient prognosis. The standard of care cancer treatment has a fixed linear approach known as Maximum Tolerated Dose (MTD) which promotes an exponential growth of resistant cancer cell populations in the tumor. Through this treatment procedure, a population of chemoresistant cells resurges, decreasing the survival in patients, and narrowing potential treatment options (Gatenby). An assortment of chemotherapeutic drugs and dosing schedules were tested on ER+ endocrine-resistant MCF7 breast cancer cells in an immunodeficient mouse model. After the cessation of treatment, some mouse models’ tumors remained stable or began to shrink. Several immunodeficient mouse models have indicated unexpectedly high levels of neutrophils stemming from an unknown origin. We aim to understand if neutrophils' innate immunity may affect tumor size post-chemotherapy treatment and if it has therapeutic implications along with adaptive therapy. MCF7 breast cancer tumors were extracted from the mice, embedded in wax, and sliced, and immunofluorescence was performed to detect neutrophils and nuclear components. Currently, the protocol is in its third round of optimization.
ContributorsMestas, Lauren (Author) / Maley, Carlo (Thesis director) / Richker, Harley (Committee member) / Marquez Alcaraz, Gissel (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)
Created2024-05