Matching Items (12)
Filtering by
- All Subjects: Science Communication
- Creators: School of Mathematical and Natural Sciences
- Member of: Theses and Dissertations
Description
Bexarotene is a commercially produced drug commonly known as Targetin presecribed to treat cutaneous T-cell lymphoma (CTCL). Bex mimics the actions of natural 9-cis retinoic acid in the body, which are derived from Vitamin A in the diet and boost the immune system. Bex has been shown to be effective in the treatment of multiple types of cancer, including lung cancer. However, the disadvantages of using Bex include increased instances of hypothyroidism and excessive concentrations of blood triglycerides. If an analog of Bex can be developed which retains high affinity RXR binding similar to the 9-cis retinoic acid while exhibiting less interference for heterodimerization pathways, it would be of great clinical significance in improving the quality of life for patients with CTCL. This thesis will detail the biological profiling of additional novel (Generation Two) analogs, which are currently in submission for publication, as well as that of Generation Three analogs. The results from these studies reveal that specific alterations in the core structure of the Bex "parent" compound structure can have dramatic effects in modifying the biological activity of RXR agonists.
ContributorsYang, Joanna (Author) / Jurutka, Peter (Thesis director) / Wagner, Carl (Committee member) / Hibler, Elizabeth (Committee member) / Barrett, The Honors College (Contributor)
Created2012-05
Description
Bexarotene (Targretin®) is an FDA approved drug used to treat cutaneous T-cell lymphoma (CTCL), as well as off-label treatments for various cancers and neurodegenerative diseases. Previous research has indicated that bexarotene has a specific affinity for retinoid X receptors (RXR), which allows bexarotene to act as a ligand-activated-transcription factor and in return control cell differentiation and proliferation. Bexarotene targets RXR homodimerization to drive transcription of tumor suppressing genes; however, adverse reactions occur simultaneously when bound to other nuclear receptors. In this study, we used novel bexarotene analogs throughout 5 iterations synthesized in the laboratory of Dr. Wagner to test for their potency and ability to bind RXR. The aim of our study is to quantitatively measure RXR homodimerization driven by bexarotene analogs using a yeast two-hybrid system. Our results suggests there to be several compounds with higher protein activity than bexarotene, particularly in generations 3.0 and 5.0. This higher affinity for RXR homodimers may help scientists identify a compound that will minimize adverse effects and toxicity of bexarotene and serve as a better cancer treatment alternative.
ContributorsSeto, David Hua (Author) / Marshall, Pamela (Thesis director) / Wagner, Carl (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Natural Sciences (Contributor) / School of Social and Behavioral Sciences (Contributor)
Created2015-05
Description
The ever-increasing importance of cancer and neurodegenerative diseases continues to grow as populations across the world are affected by death and aging. The vitamin A (RXR) and vitamin D (VDR) receptor pathways offer promising potential to aid in treatment of cancer and Alzheimer’s disease. This thesis discusses the potential application of novel analogs of Bexarotene (RXR agonist), MeTC7 (a new potent VDR antagonist), and vitamin D as possible therapeutics for cancer and Alzheimer’s disease.
ContributorsHong, Jennifer (Author) / Jurutka, Peter (Thesis director) / Wagner, Carl (Committee member) / Marshall, Pamela (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Natural Sciences (Contributor)
Created2023-05
Description
Forensic science is the application of science to matters of law, especially criminal investigation and procedure. ForenSICK Science, on the other hand, is an educational YouTube channel. It was created in early 2019 after listening to two people on a podcast confidently preach surprisingly inaccurate information about forensic science. My goal in the creation of the channel was to give people the proper information regarding the practice. This goal grew to encompass several different fields including continued education practices, informal and nonformal learning, and combating “science speak.” Using YouTube as a tool in this journey was the first step in combating forensic inaccuracies.
ContributorsByrne, Mckenna Noel (Author) / Kobojek, Kimberly (Thesis director) / Wentzel, Bonnie (Committee member) / College of Health Solutions (Contributor) / School of Film, Dance and Theatre (Contributor) / School of Mathematical and Natural Sciences (Contributor) / Watts College of Public Service & Community Solut (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
The process of communicating science between the general public and scientific community has been marked by several challenges in the modern setting. Namely, scientists’ trepidation toward misinterpretation, jeopardization of professional reputability, and perception of two distinct arenas of communication has led to the perpetuation of the deficit model of communication. This model is exceptionally limiting as it effectively removes the scientists from the public sphere and can have devastating societal repercussions. The dialogue model of communication is a much more effective communicative model for the modern setting but has been met with resistance in its adoption. As communication as a whole is grounded in multiple foundational disciplines of psychology, philosophy, linguistics, and other fields, it would be apparent that the adoption of the principles of polymathy would serve to better prepare scientists to engage in mass communication with the public. As polymathy is a lifelong pursuit, the implementation of narrative training into collegiate undergraduate science curriculum would serve as a particularly potent beginning. That is, narrative's ability to reach near-universal audiences, enhance the recall and comprehension of complex subject matter, and forge an empathetic connection essential to effective communication is uniquely suited in ensuring a more effective communicative dynamic between the scientific community and the general public. As such, this thesis serves to advocate the adoption of narrative-based communicative training into undergraduate science curriculum not as separate courses, but rather as direct incorporation. This would serve to both revitalize polymathy in the modern age and prepare the next generation of scientists to be better equipped for the public dialogue.
ContributorsCoker, Keaton M (Author) / Ramsey, Ramsey E. (Thesis director) / Wentzel, Bonnie (Committee member) / School of Social and Behavioral Sciences (Contributor) / School of Mathematical and Natural Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
My Honors Thesis/ Creative Project was an collection of art pieces that were based on a research done at West Campus in Dr. Weidner's forensic entomology laboratory. In this research, two swine carcasses were place outdoors for 21 days during the four seasons. The goal was to collect insects that approached and colonized the carcasses. The collected data can be used to determine the TOC (time of colonization) of some insects; thus, it can help to calculate the PMI (postmortem interval). Different collection were used like larvae rearing, pitfalls, netting, and hand collection. The larvae were reared into adulthood and then identified into a species. The rest of the insects were identified into orders. To present this information, the data collected from the two carcasses was combined to make the presentation easier to understand. I created four circular canvases to present the collection of flies in each check. It shows both flies were reared and which were seen or collected. The other series of work that I sculpted were 120 ceramics flowers to represent the insects orders that were observed in each season and check. During my thesis defense, I presented the research project, and how my project can help people understand this research.
ContributorsMunoz Zavala, Jaira (Author) / Weidner, Lauren (Thesis director) / Meeds, Andrew (Committee member) / Neubauer, Mary (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Natural Sciences (Contributor) / School of Art (Contributor)
Created2023-12
ContributorsMunoz Zavala, Jaira (Author) / Weidner, Lauren (Thesis director) / Meeds, Andrew (Committee member) / Neubauer, Mary (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Natural Sciences (Contributor) / School of Art (Contributor)
Created2023-12
ContributorsMunoz Zavala, Jaira (Author) / Weidner, Lauren (Thesis director) / Meeds, Andrew (Committee member) / Neubauer, Mary (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Natural Sciences (Contributor) / School of Art (Contributor)
Created2023-12
ContributorsMunoz Zavala, Jaira (Author) / Weidner, Lauren (Thesis director) / Meeds, Andrew (Committee member) / Neubauer, Mary (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Natural Sciences (Contributor) / School of Art (Contributor)
Created2023-12
ContributorsMunoz Zavala, Jaira (Author) / Weidner, Lauren (Thesis director) / Meeds, Andrew (Committee member) / Neubauer, Mary (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Natural Sciences (Contributor) / School of Art (Contributor)
Created2023-12