Matching Items (47)
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- All Subjects: Political Science
- Creators: School of Politics and Global Studies
- Creators: School of Life Sciences
- Member of: Barrett, The Honors College Thesis/Creative Project Collection
- Resource Type: Text
Description
Memory CD8+ T-cells can persist in the absence of antigen, primed for immediate activation and proliferation if later exposed to the same antigen. These cytotoxic lymphocytes provide long-term immunity following an acute infection. Studies have observed that intermediate levels of general T cell transfer prior to infection may cause an inappropriate response resulting in increased pathology rather than prevention. Therefore, our study focused on a memory CD8 T-cell therapy using lymphocytic choriomeningitis virus (LCMV) specific splenocytes, which activate and proliferate at an accelerated pace compared to that of naive T-cells. LCMV is a natural murine pathogen which also poses a zoonotic infection threat to humans, and the effect of immune cell vaccination therapies for LCMV is not fully understood. We observed the effect of multiple memory CD8 T cell dosage levels on overall disease and memory CD8 T-cell response to the virus. Infection by exposure to a carrier was shown to have a reduced impact on mice receiving higher doses of memory T cells prior to infection compared to mice receiving less or no memory cells. Higher presence of activated memory cells were shown to correlate with less disease-related weight loss and accelerated recovery times. Survival rate after exposure to carriers was not shown to be affected by dosage level, warranting further research regarding the prevalence of the immunopathology observed in other studies in natural murine transmission models.
ContributorsMiller, Charles (Author) / Blattman, Joseph (Thesis director) / Holechek, Susan (Committee member) / Carmen, Joshua (Committee member) / W. P. Carey School of Business (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
This thesis paper examines the rise of nationalist parties in the Netherlands from the 1960s to 2015. It examines two major explanations for this growth: increasing numbers of predominantly Islamic immigrants and the increasing powers of the European Union. Concerns with these events have brought neo-nationalist parties to the forefront of the political process. This analysis begins in the 1960s during the depillarization of Dutch society and concludes with Geert Wilders and the Partij voor de Vrijheid.
ContributorsVan Gijlswijk, Christiaan Cornelis (Author) / Bustikova-Siroky, Lenka (Thesis director) / Hechter, Michael (Committee member) / Barrett, The Honors College (Contributor) / School of Politics and Global Studies (Contributor) / School of Human Evolution and Social Change (Contributor)
Created2015-05
Description
The purpose of this research is to identify the factors contributing the resiliency of Syria's President Assad amongst a backdrop of falling authoritarians during the Arab Spring. After determining the Assad's regime's strategies of authoritarian rule both before and after the 2011 uprisings, this paper theorizes what Assad's persistence is most dependent on today by analyzing his discourse throughout the conflict. Assad's framing of the war to the media has significantly legitimized his rule.
ContributorsKassab, Seema (Author) / Parmentier, Mary Jane (Thesis director) / Simon, Sheldon (Committee member) / Barrett, The Honors College (Contributor) / Department of Economics (Contributor) / W. P. Carey School of Business (Contributor) / School of Politics and Global Studies (Contributor) / Sandra Day O'Connor College of Law (Contributor)
Created2015-05
Description
This paper examines the development of United States drone policy outside of traditional battle zones. It poses the question of why do states use drones as a projection of force? In particular, the paper examines the expansion of the drone program within a system of democratic checks and balances. It looks at the effect that political and legal influences have had on the expansion of the drone program and hypothesizes that the presence of these constraints should increase drone use outside of traditional battle zones. In order to investigate this hypothesis, the paper looks at data on drone strikes from Yemen and Somalia. The data partially supports the hypothesis as there has not been a clear linear increase in the number of drone strikes in each of these countries. Nevertheless, an examination of the surrounding literature regarding political and legal influences within these countries seems to favorably point to the increase of drone operations. Future research, however, needs to be cognizant of the limitations in gathering specific statistics on drone operations as these operations are covert. It's also important to understand how the covert nature of the drone operations impacts issues regarding political oversight and legality. Lastly, it's important to constantly examine the broader implications drone policy has for US policy.
ContributorsRajan, Rohit Subramaniam (Author) / Wright, Thorin (Thesis director) / Rothenberg, Daniel (Committee member) / Barrett, The Honors College (Contributor) / Department of Chemistry and Biochemistry (Contributor) / School of Politics and Global Studies (Contributor)
Created2015-05
Description
This thesis comparatively examines the percentage of women who have been appointed to federal level Cabinet positions in the United States and Canada between 1980 and 2010. The thesis will first explain the differences in the nation's democratic systems -- presidential and parliamentarian -- to contextualize how each nation elects federal representatives coupled with their process of appointing individuals to Cabinet positions per administration. Then the thesis will briefly explain the basis of the political parties that have been active in each country alongside their prominent ideals, in an effort to understand the impact it has had on the number of women elected to federal positions. Finally, the research will focus on the number of women appointed to Cabinet to demonstrate how an increase in the amount of political parties, creates more competition between political parties, in turn allowing for a higher number of women to be elected as well as appointed to federal positions. In conclusion, the research suggests that liberal party's push forth more women to federal level positions in both countries. Coupled with the fact that the increase in the amount of office holding parties increases competition between parties and increases the number of women appointed to Cabinet.
ContributorsOkula, Victoria (Author) / Shair-Rosenfield, Sarah (Thesis director) / Kittilson, Miki (Committee member) / Department of English (Contributor) / School of Politics and Global Studies (Contributor) / Barrett, The Honors College (Contributor)
Created2018-12
Description
Over the last 30 years, the public has become somewhat less willing to accept the “feminist” label. However, most Americans indicate support for general feminist ideals. In fact, many of these ideals have become so prevalent in American culture that they are not considered feminist anymore. This thesis will examine the reason behind this disparity and analyze where public opinion began to shift. The disparity between the definition of feminism and the definition perceived by the public will be explored along with the idea that the American people still want and need a “feminist movement,” but that its current state is not resonating with the majority of the public.
ContributorsKasle, Lauren Jessica (Author) / Lennon, Tara (Thesis director) / Woodall, Gina (Committee member) / School of Public Affairs (Contributor) / School of Life Sciences (Contributor) / School of Politics and Global Studies (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
Political scientists have long recognized the importance of representation as being critical to the American form of government. This paper begins by establishing the theoretical basis for representational studies in political science. It then turns to the empirical question of measuring the degree to which legislators represent their constituents. While there have been comprehensive studies of representation among members of Congress, several practical difficulties have prevented similar studies at the state legislature level. Underlying measures of representation are the preferences of constituents and the representational behavior of legislators. This paper proposes two metrics, a modified Partisan Voting Index and the American Conservative Union State Legislative Ratings, to compare the district-level preferences with roll call voting behavior (a form of substantive representation) of the corresponding legislators. This methodology is then tested against data collected from the Arizona legislature, specifically incorporating election returns from 2012, 2014, and 2016, and votes taken during the 2017 and 2018 sessions of the legislature. The findings suggest a strong relationship between the partisan and ideological leaning of a state legislative district and how conservative or liberal a legislator’s voting record is, even when controlling for political party. Two special cases are also examined in the context of this data. First, the three legislative districts with a split delegation are analyzed and determined to have a moderating effect on representative behavior. Second, five mid-term vacancies are examined along with the process for filling a vacancy. The paper concludes with a discussion of how this line of research can better inform legislators and help constituents hold their elected officials to account.
ContributorsFairbanks, Austin Kyle (Author) / Herrera, Richard (Thesis director) / Thomson, Henry (Committee member) / School of Politics and Global Studies (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
News outlets frequently portray people with disabilities as either helpless victims or objects of motivation. Portrayal of people with disabilities has improved over the years, but there is still room to grow. News outlets tend to make disability the center of the story. A story about a disabled person is primarily about their disability, with their other accomplishments framed by it.
As one example of the victimhood narrative, ABC News used to run a special called My Extreme Affliction as part of 20/20 until 2012. As the name implies, the specials covered people with disabilities, specifically extreme versions. One 2008 episode on Tourette’s syndrome described Tourette’s like it was some sort of demonic possession. The narrator talked about children who were “prisoners in their own bodies” and a family that was at risk of being “torn apart by Tourette’s.” I have Tourette’s syndrome myself, which made ABC’s special especially uncomfortable to watch. When not wringing their metaphorical hands over the “victims” of disability, many news outlets fall into the “supercrip” narrative. They refer to people as “heroes” who “overcome” their disabilities to achieve something that ranges from impressive to utterly mundane. The main emphasis is on the disability rather than the person who has it. These articles then exploit that disability to make readers feel good. As a person with a disability, I am aware that it impacts my life, but it is not the center of my life. The tics from my Tourette’s syndrome made it difficult to speak to people when I was younger, but even then they did not rule me.
Disability coverage, however, is still incredibly important for promoting acceptance and giving people with disabilities a voice. A little over a fifth of adults in the United States have a disability (CDC: 53 million adults in the US live with a disability), so poor coverage means marginalizing or even excluding a large amount of people. Journalists should try to reach their entire audience. The news helps shape public opinion with the stories it features. Therefore, it should provide visibility for people with disabilities in order to increase acceptance. This is a matter of civil rights. People with disabilities deserve fair and accurate representation.
My personal experience with ABC’s Tourette’s special leads me to believe that the media, especially the news, needs to be more responsible in their reporting. Even the name “My Extreme Affliction” paints a poor picture of what to expect. A show that focuses on sensationalist portrayals in pursuit of views further ostracizes people with disabilities. The emphasis should be on a person and not their condition. The National Center for Disability Journalism tells reporters to “Focus on the person you are interviewing, not the disability” (Tips for interviewing people with disabilities). This people-first approach is the way to improve disability coverage: Treat people with disabilities with the same respect as any other minority group.
As one example of the victimhood narrative, ABC News used to run a special called My Extreme Affliction as part of 20/20 until 2012. As the name implies, the specials covered people with disabilities, specifically extreme versions. One 2008 episode on Tourette’s syndrome described Tourette’s like it was some sort of demonic possession. The narrator talked about children who were “prisoners in their own bodies” and a family that was at risk of being “torn apart by Tourette’s.” I have Tourette’s syndrome myself, which made ABC’s special especially uncomfortable to watch. When not wringing their metaphorical hands over the “victims” of disability, many news outlets fall into the “supercrip” narrative. They refer to people as “heroes” who “overcome” their disabilities to achieve something that ranges from impressive to utterly mundane. The main emphasis is on the disability rather than the person who has it. These articles then exploit that disability to make readers feel good. As a person with a disability, I am aware that it impacts my life, but it is not the center of my life. The tics from my Tourette’s syndrome made it difficult to speak to people when I was younger, but even then they did not rule me.
Disability coverage, however, is still incredibly important for promoting acceptance and giving people with disabilities a voice. A little over a fifth of adults in the United States have a disability (CDC: 53 million adults in the US live with a disability), so poor coverage means marginalizing or even excluding a large amount of people. Journalists should try to reach their entire audience. The news helps shape public opinion with the stories it features. Therefore, it should provide visibility for people with disabilities in order to increase acceptance. This is a matter of civil rights. People with disabilities deserve fair and accurate representation.
My personal experience with ABC’s Tourette’s special leads me to believe that the media, especially the news, needs to be more responsible in their reporting. Even the name “My Extreme Affliction” paints a poor picture of what to expect. A show that focuses on sensationalist portrayals in pursuit of views further ostracizes people with disabilities. The emphasis should be on a person and not their condition. The National Center for Disability Journalism tells reporters to “Focus on the person you are interviewing, not the disability” (Tips for interviewing people with disabilities). This people-first approach is the way to improve disability coverage: Treat people with disabilities with the same respect as any other minority group.
ContributorsMackrell, Marguerite (Author) / Gilger, Kristin (Thesis director) / Doig, Steve (Committee member) / Walter Cronkite School of Journalism & Mass Comm (Contributor) / School of Politics and Global Studies (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
Influenza is a deadly disease for which effective vaccines are sorely lacking. This is largely due to the phenomena of antigenic shift and drift in the influenza virus's surface proteins, hemagglutinin (HA) and neuraminidase (NA). The ectodomain of the matrix 2 protein (M2e) of influenza A, however, has demonstrated high levels of conservation. On its own it is poorly immunogenic and offers little protection against influenza infections, but by combining it with a potent adjuvant, this limitation may be overcome. Recombinant immune complexes, or antigens fused to antibodies that have been engineered to form incredibly immunogenic complexes with one another, were previously shown to be useful, immunogenic platforms for the presentation of various antigens and could provide the boost in immunogenicity that M2e needs to become a powerful universal influenza A vaccine. In this thesis, genetic constructs containing geminiviral replication proteins and coding for a consensus sequence of dimeric M2e fused to antibodies featuring complimentary epitopes and epitope tags were generated and used to transform Agrobacterium tumefaciens. The transformed bacteria was then used to cause Nicotiana benthamiana to transiently express M2e-RICs at very high levels, with enough RICs being gathered to evaluate their potency in future mouse trials. Future directions and areas for further research are discussed.
ContributorsFavre, Brandon Chetan (Author) / Mason, Hugh (Thesis director) / Mor, Tsafrir (Committee member) / Diamos, Andrew (Committee member) / Department of Psychology (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
In 2016, the Western world was shocked by the victory of the "Leave" campaign in the referendum on European Union membership in Great Britain and by the victory of Donald Trump in the United States' presidential election. These two electoral successes have been called "populist" campaigns in their respective countries. In this paper, I ask whether the widespread populist sentiment in the United States and Great Britain qualifies as "populist" and should be regarded as part of the same movement. I then explore whether Trump and Leave voters are motivated by a common issue or set of issues. Initially, I frame my argument by defining populism and showing how both campaigns meet the definition. Next, I compare the Leave campaign with the Trump campaign and explore the similarities and differences in the demographics and opinions of their supporters. I determine that while the Trump and Leave campaigns certainly have differences, they should ultimately be treated as two branches of the same movement. Finally, I conclude that both campaigns are more motivated by versions of cultural resentment than economic anxiety.
ContributorsDunning, Alexander Chase (Author) / Lennon, Tara (Thesis director) / Simhony, Avital (Committee member) / Department of Finance (Contributor) / School of Politics and Global Studies (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05