Matching Items (22)
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- All Subjects: Forensic Science
- Creators: School of Mathematical and Natural Sciences
- Member of: Barrett, The Honors College Thesis/Creative Project Collection
Description
Bexarotene (Targretin®) is an FDA approved drug used to treat cutaneous T-cell lymphoma (CTCL), as well as off-label treatments for various cancers and neurodegenerative diseases. Previous research has indicated that bexarotene has a specific affinity for retinoid X receptors (RXR), which allows bexarotene to act as a ligand-activated-transcription factor and in return control cell differentiation and proliferation. Bexarotene targets RXR homodimerization to drive transcription of tumor suppressing genes; however, adverse reactions occur simultaneously when bound to other nuclear receptors. In this study, we used novel bexarotene analogs throughout 5 iterations synthesized in the laboratory of Dr. Wagner to test for their potency and ability to bind RXR. The aim of our study is to quantitatively measure RXR homodimerization driven by bexarotene analogs using a yeast two-hybrid system. Our results suggests there to be several compounds with higher protein activity than bexarotene, particularly in generations 3.0 and 5.0. This higher affinity for RXR homodimers may help scientists identify a compound that will minimize adverse effects and toxicity of bexarotene and serve as a better cancer treatment alternative.
ContributorsSeto, David Hua (Author) / Marshall, Pamela (Thesis director) / Wagner, Carl (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Natural Sciences (Contributor) / School of Social and Behavioral Sciences (Contributor)
Created2015-05
Description
Bexarotene is a commercially produced drug commonly known as Targetin presecribed to treat cutaneous T-cell lymphoma (CTCL). Bex mimics the actions of natural 9-cis retinoic acid in the body, which are derived from Vitamin A in the diet and boost the immune system. Bex has been shown to be effective in the treatment of multiple types of cancer, including lung cancer. However, the disadvantages of using Bex include increased instances of hypothyroidism and excessive concentrations of blood triglycerides. If an analog of Bex can be developed which retains high affinity RXR binding similar to the 9-cis retinoic acid while exhibiting less interference for heterodimerization pathways, it would be of great clinical significance in improving the quality of life for patients with CTCL. This thesis will detail the biological profiling of additional novel (Generation Two) analogs, which are currently in submission for publication, as well as that of Generation Three analogs. The results from these studies reveal that specific alterations in the core structure of the Bex "parent" compound structure can have dramatic effects in modifying the biological activity of RXR agonists.
ContributorsYang, Joanna (Author) / Jurutka, Peter (Thesis director) / Wagner, Carl (Committee member) / Hibler, Elizabeth (Committee member) / Barrett, The Honors College (Contributor)
Created2012-05
Description
In this experiment, the viability of gunshot residue (GSR) was examined. This was done through the very rarely researched intersection of forensic firearms analysis and forensic entomology. The question being resolved is if GSR can reliably be detected from secondary evidence transfer of GSR laden carrion onto flies and their larvae. While it is know that secondary and tertiary GSR evidence can be transferred by way of handshakes, no such research has been conducted on flies or their pupae. Findings indicated varying levels of detection of GSR on evidence. GSR could reliably be detected on fly bodies and their legs, but not on their pupae. This research is significant as it provides previously unknown information on this line of research and provides the groundwork for further research on this topic in the future.
ContributorsGill, Brendan J (Author) / Parrott, Jonathan (Thesis director) / Weidner, Lauren (Committee member) / School of Mathematical and Natural Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description
Criminal Justice is a complex subject matter, and not everyone agrees on the way a criminal justice system ought to function. But one feature that is common to virtually all forms of proposed justice systems is that a true justice system treats people ethically. The question, then, is how a justice system can achieve this. This investigation analyzed two ethical theories, Kantianism and Utilitarianism, to determine which one would be better suited for guiding a criminal justice system on how to treat the people involved ethically. This investigation focused on applying the two theories to the U.S. Criminal Justice System in particular.
Kantianism is a duty-based moral theory in which actions have an intrinsic moral worth. This means certain actions are morally right and other are morally wrong, regardless of the intended or realized consequences. The theory relies on the categorical imperative to judge the morality of certain actions. It states that an action is moral if its maxim can be willed universal law and if it avoids treating people as merely a means. In contrast, Utilitarianism is a consequentialist theory which focuses on the consequences of an action in judging moral worth. In Utilitarianism, the morally correct action is the one which will maximize utility; that is to say, the morally right action is the one which will produce the greatest amount of happiness and minimize the amount of pain for the greatest number of people.
After applying these two theories to moral dilemmas facing the U.S. Criminal Justice System, including the appropriate collection of DNA evidence, the use of police deception, and the use of criminal punishments such as solitary confinement or the death penalty, it was clear that Kantianism was the ethical theory best suited for guiding the system in treating people ethically. This is because Kantianism’s focus on the intrinsic moral worth of an action rather than its consequences leaves less room for ambiguity than does Utilitarianism.
Kantianism is a duty-based moral theory in which actions have an intrinsic moral worth. This means certain actions are morally right and other are morally wrong, regardless of the intended or realized consequences. The theory relies on the categorical imperative to judge the morality of certain actions. It states that an action is moral if its maxim can be willed universal law and if it avoids treating people as merely a means. In contrast, Utilitarianism is a consequentialist theory which focuses on the consequences of an action in judging moral worth. In Utilitarianism, the morally correct action is the one which will maximize utility; that is to say, the morally right action is the one which will produce the greatest amount of happiness and minimize the amount of pain for the greatest number of people.
After applying these two theories to moral dilemmas facing the U.S. Criminal Justice System, including the appropriate collection of DNA evidence, the use of police deception, and the use of criminal punishments such as solitary confinement or the death penalty, it was clear that Kantianism was the ethical theory best suited for guiding the system in treating people ethically. This is because Kantianism’s focus on the intrinsic moral worth of an action rather than its consequences leaves less room for ambiguity than does Utilitarianism.
ContributorsMorett, Xavier Laakea (Author) / Manninen, Bertha (Thesis director) / Kimberly, Kobojek (Committee member) / School of Criminology and Criminal Justice (Contributor) / School of Mathematical and Natural Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Chemiluminescent reagents, such as BlueStar® forensic reagent, are used during crime scene investigations to detect latent bloodstains as they react with the iron in blood to produce bright chemiluminescence. There are several substances that cause false positives with BlueStar® reagent, including plant peroxidases and certain metal compounds. These false positive substances are commonly seen in cosmetic products. The widespread availability and popularity of cosmetics makes it possible that false positive substances may be encountered at crime scenes and could potentially interfere with investigations. The cosmetic products chosen for this study included two of the following types of products at different price points: foundation, primer, moisturizer, cleanser, and setting powder. The ten cosmetic products were tested with BlueStar® forensic reagent in two rounds of testing on multiple surface types to mimic different ways investigators may encounter the products at crime scenes. The results of the tests were overall negative as the products did not produce any chemiluminescence, indicating that the products do not cause false positives with the BlueStar® forensic reagent and are not concern for investigators. As a majority of the products contain ingredients known to cause false positives with BlueStar®, the completely negative results raised several questions. More exploration of the interaction between cosmetic products and BlueStar® reagents needs to occur in order to clarify and confirm if cosmetics pose a risk to crime scene investigators.
ContributorsMaley, Samantha Bree (Author) / Kobojek, Kimberly (Thesis director) / Cahill, Thomas (Committee member) / School of Mathematical and Natural Sciences (Contributor) / School of Criminology and Criminal Justice (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
It is no surprise that crime has become an interest to people both nationally and globally. It is impossible to turn on a TV without hearing cable news talking about a bank robbery or a murder, or a political hearing of some sort. Crime TV shows are incredibly common—there are whole channels dedicated to just crime, and many prime-time TV shows deal with some form of crime, most often the law enforcement teams that interact with it. Movies and books about crime are also incredibly common—most movie theaters have at least one horror movie or psychological thriller on show at a given time, and books stores and libraries have entire sections about true crime and mysteries.
Crime has become an inescapable part of being a consumer and viewer in today’s society. The interest in crime, however, could not have just been created by the media or a few specific parties and gained the amount of attention that is has today. Crime has been of interest since ancient times, seen immortalized in art and literature with famous events like the death of Socrates and the assassination of Julius Caesar. However, only more modern advances in media and the growth in consumerism could have led to interest and commodification of crime as we see it today. Landmark cases like Ted Bundy and O.J. Simpson have contributed to the growth of the media landscape, but because of the cyclical nature of the news and consumer cycle, these cases would not differ much in the way that they would be covered today, even with the new methods of disseminating information that we have today, such as social media and news websites that are accessible by everyone. Crime as entertainment has been a product not just of the media and popular culture but also from American consumers who continue to give media and pop culture producers a consumer who wishes to view their content and to continue to further the interest in crime. Media and popular culture are not the only people to blame for the popularization of crime as a product; people in the United States, and globally, are just as much responsible for the creation of crime as entertainment.
Crime has become an inescapable part of being a consumer and viewer in today’s society. The interest in crime, however, could not have just been created by the media or a few specific parties and gained the amount of attention that is has today. Crime has been of interest since ancient times, seen immortalized in art and literature with famous events like the death of Socrates and the assassination of Julius Caesar. However, only more modern advances in media and the growth in consumerism could have led to interest and commodification of crime as we see it today. Landmark cases like Ted Bundy and O.J. Simpson have contributed to the growth of the media landscape, but because of the cyclical nature of the news and consumer cycle, these cases would not differ much in the way that they would be covered today, even with the new methods of disseminating information that we have today, such as social media and news websites that are accessible by everyone. Crime as entertainment has been a product not just of the media and popular culture but also from American consumers who continue to give media and pop culture producers a consumer who wishes to view their content and to continue to further the interest in crime. Media and popular culture are not the only people to blame for the popularization of crime as a product; people in the United States, and globally, are just as much responsible for the creation of crime as entertainment.
ContributorsCooke, Emilie (Author) / Kobojek, Kimberly (Thesis director) / Gordon, Karen (Committee member) / School of Criminology and Criminal Justice (Contributor) / School of Mathematical and Natural Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
Forensic science is the application of science to matters of law, especially criminal investigation and procedure. ForenSICK Science, on the other hand, is an educational YouTube channel. It was created in early 2019 after listening to two people on a podcast confidently preach surprisingly inaccurate information about forensic science. My goal in the creation of the channel was to give people the proper information regarding the practice. This goal grew to encompass several different fields including continued education practices, informal and nonformal learning, and combating “science speak.” Using YouTube as a tool in this journey was the first step in combating forensic inaccuracies.
ContributorsByrne, Mckenna Noel (Author) / Kobojek, Kimberly (Thesis director) / Wentzel, Bonnie (Committee member) / College of Health Solutions (Contributor) / School of Film, Dance and Theatre (Contributor) / School of Mathematical and Natural Sciences (Contributor) / Watts College of Public Service & Community Solut (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Fingermarks have been used by law enforcement agencies to identify suspects in criminal activity. Although fingermarks remain persistent over time, the degradation pattern of latent fingermarks remains unknown. Previous studies examined the morphology of friction ridges on a two-dimensional scale, but recently 3D technology has been employed to examine how the height dimension degrades overtime. The Sa statistic was formulated to monitor the aging process of friction ridge heights from 6 donors. Fingermarks were deposited on two nonporous substrates (glass or plastic) and aged under dark or light exposure for 98 days. Pressure, time of contact, and treatment of finger prior to deposition were held constant while temperature and humidity were monitored throughout the study. Experimental variables included substrate and light exposure. Females exhibited slower degradation than males. For fingermarks deposited on glass, faster degradation was seen under light exposure. This finding was consistent for fingermarks deposited on plastic, but instrument contamination may have been possible. Slower degradation was seen on glass under both light exposures. This study indicates the Sa statistic is valuable for assessing fingermark degradation of friction ridges. However, due to a small sample size and variability in the rate of degradation between donors, genders, under different lighting and substrate conditions, the age of latent fingermarks cannot be determined at this time.
ContributorsGrasman, Simona Jun (Co-author) / Grasman, Simona (Co-author) / Kobojek, Kimberly (Thesis director) / Mancenido, Michelle (Committee member) / School of Mathematical and Statistical Sciences (Contributor) / School of Mathematical and Natural Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
The purpose of this creative project was to create a forensic science program that accommodated Diné Philosophy and Culture. Indigenous representation is a key factor in promoting the advancement of the native ways of life. This thesis provides a culturally aware program that assists students to learn about taboo fields within the restrictions of the cultural teachings and traditions. This thesis developed a week-long forensics program targeted to Navajo middle school students with the cultural restriction in mind. During this process, the most difficult was integrating not only the taboos but also the foundations. At the end of this project, the most significant way to create an outreach program for Navajo students is by utilizing the Diné philosophy teaching models. This project is important because to create an effective science community there has to be equal representation for it to grow.
ContributorsJohnson, Elisabeth (Author) / Kobojek, Kimberly (Thesis director) / Chadwick, Deborah (Committee member) / School of Mathematical and Natural Sciences (Contributor) / College of Health Solutions (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
The culture surrounding death in America is one of science and silence. When possible, death is hidden away from the public view. When exposure to death is unavoidable, it is sensationalized, made into a spectacle. Our dying are put into hospice care, nursing homes, and other hidden spaces, or else they are plastered over the news and internet. So, we get one of two views of death: the sterile, silent death that happens in the presence of medical professionals or the bloody, tragic deaths that are constantly reported across news outlets and social media or sensationalized on entertainment platforms such as movies and video games. Entire genres of television and movies are created on the foundation of bloody deaths and we are exposed to the concept of death constantly.
Despite the consistent coverage of death on a large scale, the average person is not often exposed to death on a personal level in this day and age. The deaths we see on television or in the movies are not typically connected to people with whom we are attached and so we are not required to work through our emotional response and experience. We are afforded the space to be a casual observer in most of the deaths that we see—we do not need the emotional and mental tools to cope with death on a personal level. While this distance from death may be true of the American whole, it is not entirely generalizable. Professionals in select fields are required to deal with death on a much more regular basis than the average person, including, but not limited to, healthcare and forensic professionals. In these professions, death is a fundamental aspect of the job—either as an expected risk or a necessary precursor. These professionals deal intimately with death, its causes, and its effects on a regular basis because of their chose line of work and, in doing so, are regularly exposed to death and other trauma which has the potential to affect them on both a professional and personal level. In doing so, these professionals are required to, as scientists, analyze and record these experiences with death through the lens of objectivity. These professionals are expected to maintain a professional distance while also being required to give an empathetic response to other’s trauma. The potential effect of this secondary trauma on these professionals is only sharpened by the culture of machismo in these science-based fields that prevents many professionals from expressing emotions regarding their job and getting the social support they need from others within their community.
Despite the consistent coverage of death on a large scale, the average person is not often exposed to death on a personal level in this day and age. The deaths we see on television or in the movies are not typically connected to people with whom we are attached and so we are not required to work through our emotional response and experience. We are afforded the space to be a casual observer in most of the deaths that we see—we do not need the emotional and mental tools to cope with death on a personal level. While this distance from death may be true of the American whole, it is not entirely generalizable. Professionals in select fields are required to deal with death on a much more regular basis than the average person, including, but not limited to, healthcare and forensic professionals. In these professions, death is a fundamental aspect of the job—either as an expected risk or a necessary precursor. These professionals deal intimately with death, its causes, and its effects on a regular basis because of their chose line of work and, in doing so, are regularly exposed to death and other trauma which has the potential to affect them on both a professional and personal level. In doing so, these professionals are required to, as scientists, analyze and record these experiences with death through the lens of objectivity. These professionals are expected to maintain a professional distance while also being required to give an empathetic response to other’s trauma. The potential effect of this secondary trauma on these professionals is only sharpened by the culture of machismo in these science-based fields that prevents many professionals from expressing emotions regarding their job and getting the social support they need from others within their community.
ContributorsSandoval, Alicia Rose (Author) / Kobojek, Kimberly (Thesis director) / Watrous, Lisa (Committee member) / School of Mathematical and Natural Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-12