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Description
In this dissertation, two problems are addressed in the verification and control of Cyber-Physical Systems (CPS):

1) Falsification: given a CPS, and a property of interest that the CPS must satisfy under all allowed operating conditions, does the CPS violate, i.e. falsify, the property?

2) Conformance testing: given a model of a

In this dissertation, two problems are addressed in the verification and control of Cyber-Physical Systems (CPS):

1) Falsification: given a CPS, and a property of interest that the CPS must satisfy under all allowed operating conditions, does the CPS violate, i.e. falsify, the property?

2) Conformance testing: given a model of a CPS, and an implementation of that CPS on an embedded platform, how can we characterize the properties satisfied by the implementation, given the properties satisfied by the model?

Both problems arise in the context of Model-Based Design (MBD) of CPS: in MBD, the designers start from a set of formal requirements that the system-to-be-designed must satisfy.

A first model of the system is created.

Because it may not be possible to formally verify the CPS model against the requirements, falsification tries to verify whether the model satisfies the requirements by searching for behavior that violates them.

In the first part of this dissertation, I present improved methods for finding falsifying behaviors of CPS when properties are expressed in Metric Temporal Logic (MTL).

These methods leverage the notion of robust semantics of MTL formulae: if a falsifier exists, it is in the neighborhood of local minimizers of the robustness function.

The proposed algorithms compute descent directions of the robustness function in the space of initial conditions and input signals, and provably converge to local minima of the robustness function.

The initial model of the CPS is then iteratively refined by modeling previously ignored phenomena, adding more functionality, etc., with each refinement resulting in a new model.

Many of the refinements in the MBD process described above do not provide an a priori guaranteed relation between the successive models.

Thus, the second problem above arises: how to quantify the distance between two successive models M_n and M_{n+1}?

If M_n has been verified to satisfy the specification, can it be guaranteed that M_{n+1} also satisfies the same, or some closely related, specification?

This dissertation answers both questions for a general class of CPS, and properties expressed in MTL.
ContributorsAbbas, Houssam Y (Author) / Fainekos, Georgios (Thesis advisor) / Duman, Tolga (Thesis advisor) / Mittelmann, Hans (Committee member) / Tsakalis, Konstantinos (Committee member) / Arizona State University (Publisher)
Created2015
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Description
The apolipoprotein E (APOE) e4 genotype is the most prevalent known genetic risk factor for Alzheimer's disease (AD). In this paper, we examined the longitudinal effect of APOE e4 on hippocampal morphometry in Alzheimer's Disease Neuroimaging Initiative (ADNI). Generally, atrophy of hippocampus has more chance occurs in AD patients who

The apolipoprotein E (APOE) e4 genotype is the most prevalent known genetic risk factor for Alzheimer's disease (AD). In this paper, we examined the longitudinal effect of APOE e4 on hippocampal morphometry in Alzheimer's Disease Neuroimaging Initiative (ADNI). Generally, atrophy of hippocampus has more chance occurs in AD patients who carrying the APOE e4 allele than those who are APOE e4 noncarriers. Also, brain structure and function depend on APOE genotype not just for Alzheimer's disease patients but also in health elderly individuals, so APOE genotyping is considered critical in clinical trials of Alzheimer's disease. We used a large sample of elderly participants, with the help of a new automated surface registration system based on surface conformal parameterization with holomorphic 1-forms and surface fluid registration. In this system, we automatically segmented and constructed hippocampal surfaces from MR images at many different time points, such as 6 months, 1- and 2-year follow up. Between the two different hippocampal surfaces, we did the high-order correspondences, using a novel inverse consistent surface fluid registration method. At each time point, using Hotelling's T^2 test, we found significant morphological deformation in APOE e4 carriers relative to noncarriers in the entire cohort as well as in the non-demented (pooled MCI and control) subjects, affecting the left hippocampus more than the right, and this effect was more pronounced in e4 homozygotes than heterozygotes.
ContributorsLi, Bolun (Author) / Wang, Yalin (Thesis advisor) / Maciejewski, Ross (Committee member) / Liang, Jianming (Committee member) / Arizona State University (Publisher)
Created2015
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Description
Visual Question Answering (VQA) is an increasingly important multi-modal task where models must answer textual questions based on visual image inputs. Numerous VQA datasets have been proposed to train and evaluate models. However, existing benchmarks exhibit a unilateral focus on textual distribution shifts rather than joint shifts across modalities. This

Visual Question Answering (VQA) is an increasingly important multi-modal task where models must answer textual questions based on visual image inputs. Numerous VQA datasets have been proposed to train and evaluate models. However, existing benchmarks exhibit a unilateral focus on textual distribution shifts rather than joint shifts across modalities. This is suboptimal for properly assessing model robustness and generalization. To address this gap, a novel multi-modal VQA benchmark dataset is introduced for the first time. This dataset combines both visual and textual distribution shifts across training and test sets. Using this challenging benchmark exposes vulnerabilities in existing models relying on spurious correlations and overfitting to dataset biases. The novel dataset advances the field by enabling more robust model training and rigorous evaluation of multi-modal distribution shift generalization. In addition, a new few-shot multi-modal prompt fusion model is proposed to better adapt models for downstream VQA tasks. The model incorporates a prompt encoder module and dual-path design to align and fuse image and text prompts. This represents a novel prompt learning approach tailored for multi-modal learning across vision and language. Together, the introduced benchmark dataset and prompt fusion model address key limitations around evaluating and improving VQA model robustness. The work expands the methodology for training models resilient to multi-modal distribution shifts.
ContributorsJyothi Unni, Suraj (Author) / Liu, Huan (Thesis advisor) / Davalcu, Hasan (Committee member) / Bryan, Chris (Committee member) / Arizona State University (Publisher)
Created2023