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We Need to Talk About Robustness to Adversarial Attacks While Removing Spurious Dataset Biases

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Machine learning models can pick up biases and spurious correlations from training data and projects and amplify these biases during inference, thus posing significant challenges in real-world settings. One approach to mitigating this is a class of methods that can identify filter out bias-inducing samples from the training datasets to…

Machine learning models can pick up biases and spurious correlations from training data and projects and amplify these biases during inference, thus posing significant challenges in real-world settings. One approach to mitigating this is a class of methods that can identify filter out bias-inducing samples from the training datasets to force models to avoid being exposed to biases. However, the filtering leads to a considerable wastage of resources as most of the dataset created is discarded as biased. This work deals with avoiding the wastage of resources by identifying and quantifying the biases. I further elaborate on the implications of dataset filtering on robustness (to adversarial attacks) and generalization (to out-of-distribution samples). The findings suggest that while dataset filtering does help to improve OOD(Out-Of-Distribution) generalization, it has a significant negative impact on robustness to adversarial attacks. It also shows that transforming bias-inducing samples into adversarial samples (instead of eliminating them from the dataset) can significantly boost robustness without sacrificing generalization.
ContributorsSachdeva, Bhavdeep Singh (Author) / Baral, Chitta (Thesis advisor) / Liu, Huan (Committee member) / Yang, Yezhou (Committee member) / Arizona State University (Publisher)
Created2021
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Computational methods for knowledge integration in the analysis of large-scale biological networks

Description
As we migrate into an era of personalized medicine, understanding how bio-molecules interact with one another to form cellular systems is one of the key focus areas of systems biology. Several challenges such as the dynamic nature of cellular systems, uncertainty due to environmental influences, and the heterogeneity between individual…

As we migrate into an era of personalized medicine, understanding how bio-molecules interact with one another to form cellular systems is one of the key focus areas of systems biology. Several challenges such as the dynamic nature of cellular systems, uncertainty due to environmental influences, and the heterogeneity between individual patients render this a difficult task. In the last decade, several algorithms have been proposed to elucidate cellular systems from data, resulting in numerous data-driven hypotheses. However, due to the large number of variables involved in the process, many of which are unknown or not measurable, such computational approaches often lead to a high proportion of false positives. This renders interpretation of the data-driven hypotheses extremely difficult. Consequently, a dismal proportion of these hypotheses are subject to further experimental validation, eventually limiting their potential to augment existing biological knowledge. This dissertation develops a framework of computational methods for the analysis of such data-driven hypotheses leveraging existing biological knowledge. Specifically, I show how biological knowledge can be mapped onto these hypotheses and subsequently augmented through novel hypotheses. Biological hypotheses are learnt in three levels of abstraction -- individual interactions, functional modules and relationships between pathways, corresponding to three complementary aspects of biological systems. The computational methods developed in this dissertation are applied to high throughput cancer data, resulting in novel hypotheses with potentially significant biological impact.
ContributorsRamesh, Archana (Author) / Kim, Seungchan (Thesis advisor) / Langley, Patrick W (Committee member) / Baral, Chitta (Committee member) / Kiefer, Jeffrey (Committee member) / Arizona State University (Publisher)
Created2012