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- Creators: Li, Baoxin
- All Subjects: Computer Science
Description
Biological systems are complex in many dimensions as endless transportation and communication networks all function simultaneously. Our ability to intervene within both healthy and diseased systems is tied directly to our ability to understand and model core functionality. The progress in increasingly accurate and thorough high-throughput measurement technologies has provided a deluge of data from which we may attempt to infer a representation of the true genetic regulatory system. A gene regulatory network model, if accurate enough, may allow us to perform hypothesis testing in the form of computational experiments. Of great importance to modeling accuracy is the acknowledgment of biological contexts within the models -- i.e. recognizing the heterogeneous nature of the true biological system and the data it generates. This marriage of engineering, mathematics and computer science with systems biology creates a cycle of progress between computer simulation and lab experimentation, rapidly translating interventions and treatments for patients from the bench to the bedside. This dissertation will first discuss the landscape for modeling the biological system, explore the identification of targets for intervention in Boolean network models of biological interactions, and explore context specificity both in new graphical depictions of models embodying context-specific genomic regulation and in novel analysis approaches designed to reveal embedded contextual information. Overall, the dissertation will explore a spectrum of biological modeling with a goal towards therapeutic intervention, with both formal and informal notions of biological context, in such a way that will enable future work to have an even greater impact in terms of direct patient benefit on an individualized level.
ContributorsVerdicchio, Michael (Author) / Kim, Seungchan (Thesis advisor) / Baral, Chitta (Committee member) / Stolovitzky, Gustavo (Committee member) / Collofello, James (Committee member) / Arizona State University (Publisher)
Created2013
Description
Video denoising has been an important task in many multimedia and computer vision applications. Recent developments in the matrix completion theory and emergence of new numerical methods which can efficiently solve the matrix completion problem have paved the way for exploration of new techniques for some classical image processing tasks. Recent literature shows that many computer vision and image processing problems can be solved by using the matrix completion theory. This thesis explores the application of matrix completion in video denoising. A state-of-the-art video denoising algorithm in which the denoising task is modeled as a matrix completion problem is chosen for detailed study. The contribution of this thesis lies in both providing extensive analysis to bridge the gap in existing literature on matrix completion frame work for video denoising and also in proposing some novel techniques to improve the performance of the chosen denoising algorithm. The chosen algorithm is implemented for thorough analysis. Experiments and discussions are presented to enable better understanding of the problem. Instability shown by the algorithm at some parameter values in a particular case of low levels of pure Gaussian noise is identified. Artifacts introduced in such cases are analyzed. A novel way of grouping structurally-relevant patches is proposed to improve the algorithm. Experiments show that this technique is useful, especially in videos containing high amounts of motion. Based on the observation that matrix completion is not suitable for denoising patches containing relatively low amount of image details, a framework is designed to separate patches corresponding to low structured regions from a noisy image. Experiments are conducted by not subjecting such patches to matrix completion, instead denoising such patches in a different way. The resulting improvement in performance suggests that denoising low structured patches does not require a complex method like matrix completion and in fact it is counter-productive to subject such patches to matrix completion. These results also indicate the inherent limitation of matrix completion to deal with cases in which noise dominates the structural properties of an image. A novel method for introducing priorities to the ranked patches in matrix completion is also presented. Results showed that this method yields improved performance in general. It is observed that the artifacts in presence of low levels of pure Gaussian noise appear differently after introducing priorities to the patches and the artifacts occur at a wider range of parameter values. Results and discussion suggesting future ways to explore this problem are also presented.
ContributorsMaguluri, Hima Bindu (Author) / Li, Baoxin (Thesis advisor) / Turaga, Pavan (Committee member) / Claveau, Claude (Committee member) / Arizona State University (Publisher)
Created2013
Description
Threshold logic has been studied by at least two independent group of researchers. One group of researchers studied threshold logic with the intention of building threshold logic circuits. The earliest research to this end was done in the 1960's. The major work at that time focused on studying mathematical properties of threshold logic as no efficient circuit implementations of threshold logic were available. Recently many post-CMOS (Complimentary Metal Oxide Semiconductor) technologies that implement threshold logic have been proposed along with efficient CMOS implementations. This has renewed the effort to develop efficient threshold logic design automation techniques. This work contributes to this ongoing effort. Another group studying threshold logic did so, because the building block of neural networks - the Perceptron, is identical to the threshold element implementing a threshold function. Neural networks are used for various purposes as data classifiers. This work contributes tangentially to this field by proposing new methods and techniques to study and analyze functions implemented by a Perceptron After completion of the Human Genome Project, it has become evident that most biological phenomenon is not caused by the action of single genes, but due to the complex interaction involving a system of genes. In recent times, the `systems approach' for the study of gene systems is gaining popularity. Many different theories from mathematics and computer science has been used for this purpose. Among the systems approaches, the Boolean logic gene model has emerged as the current most popular discrete gene model. This work proposes a new gene model based on threshold logic functions (which are a subset of Boolean logic functions). The biological relevance and utility of this model is argued illustrated by using it to model different in-vivo as well as in-silico gene systems.
ContributorsLinge Gowda, Tejaswi (Author) / Vrudhula, Sarma (Thesis advisor) / Shrivastava, Aviral (Committee member) / Chatha, Karamvir (Committee member) / Kim, Seungchan (Committee member) / Arizona State University (Publisher)
Created2012
Description
Situations of sensory overload are steadily becoming more frequent as the ubiquity of technology approaches reality--particularly with the advent of socio-communicative smartphone applications, and pervasive, high speed wireless networks. Although the ease of accessing information has improved our communication effectiveness and efficiency, our visual and auditory modalities--those modalities that today's computerized devices and displays largely engage--have become overloaded, creating possibilities for distractions, delays and high cognitive load; which in turn can lead to a loss of situational awareness, increasing chances for life threatening situations such as texting while driving. Surprisingly, alternative modalities for information delivery have seen little exploration. Touch, in particular, is a promising candidate given that it is our largest sensory organ with impressive spatial and temporal acuity. Although some approaches have been proposed for touch-based information delivery, they are not without limitations including high learning curves, limited applicability and/or limited expression. This is largely due to the lack of a versatile, comprehensive design theory--specifically, a theory that addresses the design of touch-based building blocks for expandable, efficient, rich and robust touch languages that are easy to learn and use. Moreover, beyond design, there is a lack of implementation and evaluation theories for such languages. To overcome these limitations, a unified, theoretical framework, inspired by natural, spoken language, is proposed called Somatic ABC's for Articulating (designing), Building (developing) and Confirming (evaluating) touch-based languages. To evaluate the usefulness of Somatic ABC's, its design, implementation and evaluation theories were applied to create communication languages for two very unique application areas: audio described movies and motor learning. These applications were chosen as they presented opportunities for complementing communication by offloading information, typically conveyed visually and/or aurally, to the skin. For both studies, it was found that Somatic ABC's aided the design, development and evaluation of rich somatic languages with distinct and natural communication units.
ContributorsMcDaniel, Troy Lee (Author) / Panchanathan, Sethuraman (Thesis advisor) / Davulcu, Hasan (Committee member) / Li, Baoxin (Committee member) / Santello, Marco (Committee member) / Arizona State University (Publisher)
Created2012
Description
In this thesis, we consider the problem of fast and efficient indexing techniques for time sequences which evolve on manifold-valued spaces. Using manifolds is a convenient way to work with complex features that often do not live in Euclidean spaces. However, computing standard notions of geodesic distance, mean etc. can get very involved due to the underlying non-linearity associated with the space. As a result a complex task such as manifold sequence matching would require very large number of computations making it hard to use in practice. We believe that one can device smart approximation algorithms for several classes of such problems which take into account the geometry of the manifold and maintain the favorable properties of the exact approach. This problem has several applications in areas of human activity discovery and recognition, where several features and representations are naturally studied in a non-Euclidean setting. We propose a novel solution to the problem of indexing manifold-valued sequences by proposing an intrinsic approach to map sequences to a symbolic representation. This is shown to enable the deployment of fast and accurate algorithms for activity recognition, motif discovery, and anomaly detection. Toward this end, we present generalizations of key concepts of piece-wise aggregation and symbolic approximation for the case of non-Euclidean manifolds. Experiments show that one can replace expensive geodesic computations with much faster symbolic computations with little loss of accuracy in activity recognition and discovery applications. The proposed methods are ideally suited for real-time systems and resource constrained scenarios.
ContributorsAnirudh, Rushil (Author) / Turaga, Pavan (Thesis advisor) / Spanias, Andreas (Committee member) / Li, Baoxin (Committee member) / Arizona State University (Publisher)
Created2012
Design and development of an immersive virtual reality team trainer for advance cardiac life support
Description
Technology in the modern day has ensured that learning of skills and behavior may be both widely disseminated and cheaply available. An example of this is the concept of virtual reality (VR) training. Virtual Reality training ensures that learning can be provided often, in a safe simulated setting, and it may be delivered in a manner that makes it engaging while negating the need to purchase special equipment. This thesis presents a case study in the form of a time critical, team based medical scenario known as Advanced Cardiac Life Support (ACLS). A framework and methodology associated with the design of a VR trainer for ACLS is detailed. In addition, in order to potentially provide an engaging experience, the simulator was designed to incorporate immersive elements and a multimodal interface (haptic, visual, and auditory). A study was conducted to test two primary hypotheses namely: a meaningful transfer of skill is achieved from virtual reality training to real world mock codes and the presence of immersive components in virtual reality leads to an increase in the performance gained. The participant pool consisted of 54 clinicians divided into 9 teams of 6 members each. The teams were categorized into three treatment groups: immersive VR (3 teams), minimally immersive VR (3 teams), and control (3 teams). The study was conducted in 4 phases from a real world mock code pretest to assess baselines to a 30 minute VR training session culminating in a final mock code to assess the performance change from the baseline. The minimally immersive team was treated as control for the immersive components. The teams were graded, in both VR and mock code sessions, using the evaluation metric used in real world mock codes. The study revealed that the immersive VR groups saw greater performance gain from pretest to posttest than the minimally immersive and control groups in case of the VFib/VTach scenario (~20% to ~5%). Also the immersive VR groups had a greater performance gain than the minimally immersive groups from the first to the final session of VFib/VTach (29% to -13%) and PEA (27% to 15%).
ContributorsVankipuram, Akshay (Author) / Li, Baoxin (Thesis advisor) / Burleson, Winslow (Committee member) / Kahol, Kanav (Committee member) / Arizona State University (Publisher)
Created2012
Description
As we migrate into an era of personalized medicine, understanding how bio-molecules interact with one another to form cellular systems is one of the key focus areas of systems biology. Several challenges such as the dynamic nature of cellular systems, uncertainty due to environmental influences, and the heterogeneity between individual patients render this a difficult task. In the last decade, several algorithms have been proposed to elucidate cellular systems from data, resulting in numerous data-driven hypotheses. However, due to the large number of variables involved in the process, many of which are unknown or not measurable, such computational approaches often lead to a high proportion of false positives. This renders interpretation of the data-driven hypotheses extremely difficult. Consequently, a dismal proportion of these hypotheses are subject to further experimental validation, eventually limiting their potential to augment existing biological knowledge. This dissertation develops a framework of computational methods for the analysis of such data-driven hypotheses leveraging existing biological knowledge. Specifically, I show how biological knowledge can be mapped onto these hypotheses and subsequently augmented through novel hypotheses. Biological hypotheses are learnt in three levels of abstraction -- individual interactions, functional modules and relationships between pathways, corresponding to three complementary aspects of biological systems. The computational methods developed in this dissertation are applied to high throughput cancer data, resulting in novel hypotheses with potentially significant biological impact.
ContributorsRamesh, Archana (Author) / Kim, Seungchan (Thesis advisor) / Langley, Patrick W (Committee member) / Baral, Chitta (Committee member) / Kiefer, Jeffrey (Committee member) / Arizona State University (Publisher)
Created2012
Description
Social situational awareness, or the attentiveness to one's social surroundings, including the people, their interactions and their behaviors is a complex sensory-cognitive-motor task that requires one to be engaged thoroughly in understanding their social interactions. These interactions are formed out of the elements of human interpersonal communication including both verbal and non-verbal cues. While the verbal cues are instructive and delivered through speech, the non-verbal cues are mostly interpretive and requires the full attention of the participants to understand, comprehend and respond to them appropriately. Unfortunately certain situations are not conducive for a person to have complete access to their social surroundings, especially the non-verbal cues. For example, a person is who is blind or visually impaired may find that the non-verbal cues like smiling, head nod, eye contact, body gestures and facial expressions of their interaction partners are not accessible due to their sensory deprivation. The same could be said of people who are remotely engaged in a conversation and physically separated to have a visual access to one's body and facial mannerisms. This dissertation describes novel multimedia technologies to aid situations where it is necessary to mediate social situational information between interacting participants. As an example of the proposed system, an evidence-based model for understanding the accessibility problem faced by people who are blind or visually impaired is described in detail. From the derived model, a sleuth of sensing and delivery technologies that use state-of-the-art computer vision algorithms in combination with novel haptic interfaces are developed towards a) A Dyadic Interaction Assistant, capable of helping individuals who are blind to access important head and face based non-verbal communicative cues during one-on-one dyadic interactions, and b) A Group Interaction Assistant, capable of provide situational awareness about the interaction partners and their dynamics to a user who is blind, while also providing important social feedback about their own body mannerisms. The goal is to increase the effective social situational information that one has access to, with the conjuncture that a good awareness of one's social surroundings gives them the ability to understand and empathize with their interaction partners better. Extending the work from an important social interaction assistive technology, the need for enriched social situational awareness is everyday professional situations are also discussed, including, a) enriched remote interactions between physically separated interaction partners, and b) enriched communication between medical professionals during critical care procedures, towards enhanced patient safety. In the concluding remarks, this dissertation engages the readers into a science and technology policy discussion on the potential effect of a new technology like the social interaction assistant on the society. Discussing along the policy lines, social disability is highlighted as an important area that requires special attention from researchers and policy makers. Given that the proposed technology relies on wearable inconspicuous cameras, the discussion of privacy policies is extended to encompass newly evolving interpersonal interaction recorders, like the one presented in this dissertation.
ContributorsKrishna, Sreekar (Author) / Panchanathan, Sethuraman (Thesis advisor) / Black, John A. (Committee member) / Qian, Gang (Committee member) / Li, Baoxin (Committee member) / Shiota, Michelle (Committee member) / Arizona State University (Publisher)
Created2011
Description
Continuous advancements in biomedical research have resulted in the production of vast amounts of scientific data and literature discussing them. The ultimate goal of computational biology is to translate these large amounts of data into actual knowledge of the complex biological processes and accurate life science models. The ability to rapidly and effectively survey the literature is necessary for the creation of large scale models of the relationships among biomedical entities as well as hypothesis generation to guide biomedical research. To reduce the effort and time spent in performing these activities, an intelligent search system is required. Even though many systems aid in navigating through this wide collection of documents, the vastness and depth of this information overload can be overwhelming. An automated extraction system coupled with a cognitive search and navigation service over these document collections would not only save time and effort, but also facilitate discovery of the unknown information implicitly conveyed in the texts. This thesis presents the different approaches used for large scale biomedical named entity recognition, and the challenges faced in each. It also proposes BioEve: an integrative framework to fuse a faceted search with information extraction to provide a search service that addresses the user's desire for "completeness" of the query results, not just the top-ranked ones. This information extraction system enables discovery of important semantic relationships between entities such as genes, diseases, drugs, and cell lines and events from biomedical text on MEDLINE, which is the largest publicly available database of the world's biomedical journal literature. It is an innovative search and discovery service that makes it easier to search
avigate and discover knowledge hidden in life sciences literature. To demonstrate the utility of this system, this thesis also details a prototype enterprise quality search and discovery service that helps researchers with a guided step-by-step query refinement, by suggesting concepts enriched in intermediate results, and thereby facilitating the "discover more as you search" paradigm.
avigate and discover knowledge hidden in life sciences literature. To demonstrate the utility of this system, this thesis also details a prototype enterprise quality search and discovery service that helps researchers with a guided step-by-step query refinement, by suggesting concepts enriched in intermediate results, and thereby facilitating the "discover more as you search" paradigm.
ContributorsKanwar, Pradeep (Author) / Davulcu, Hasan (Thesis advisor) / Dinu, Valentin (Committee member) / Li, Baoxin (Committee member) / Arizona State University (Publisher)
Created2010
Description
The fields of pattern recognition and machine learning are on a fundamental quest to design systems that can learn the way humans do. One important aspect of human intelligence that has so far not been given sufficient attention is the capability of humans to express when they are certain about a decision, or when they are not. Machine learning techniques today are not yet fully equipped to be trusted with this critical task. This work seeks to address this fundamental knowledge gap. Existing approaches that provide a measure of confidence on a prediction such as learning algorithms based on the Bayesian theory or the Probably Approximately Correct theory require strong assumptions or often produce results that are not practical or reliable. The recently developed Conformal Predictions (CP) framework - which is based on the principles of hypothesis testing, transductive inference and algorithmic randomness - provides a game-theoretic approach to the estimation of confidence with several desirable properties such as online calibration and generalizability to all classification and regression methods. This dissertation builds on the CP theory to compute reliable confidence measures that aid decision-making in real-world problems through: (i) Development of a methodology for learning a kernel function (or distance metric) for optimal and accurate conformal predictors; (ii) Validation of the calibration properties of the CP framework when applied to multi-classifier (or multi-regressor) fusion; and (iii) Development of a methodology to extend the CP framework to continuous learning, by using the framework for online active learning. These contributions are validated on four real-world problems from the domains of healthcare and assistive technologies: two classification-based applications (risk prediction in cardiac decision support and multimodal person recognition), and two regression-based applications (head pose estimation and saliency prediction in images). The results obtained show that: (i) multiple kernel learning can effectively increase efficiency in the CP framework; (ii) quantile p-value combination methods provide a viable solution for fusion in the CP framework; and (iii) eigendecomposition of p-value difference matrices can serve as effective measures for online active learning; demonstrating promise and potential in using these contributions in multimedia pattern recognition problems in real-world settings.
ContributorsNallure Balasubramanian, Vineeth (Author) / Panchanathan, Sethuraman (Thesis advisor) / Ye, Jieping (Committee member) / Li, Baoxin (Committee member) / Vovk, Vladimir (Committee member) / Arizona State University (Publisher)
Created2010