Matching Items (5)
Filtering by
- Member of: ASU Electronic Theses and Dissertations
Description
Fibromyalgia (FM) is a chronic musculoskeletal disorder characterized by widespread pain, fatigue, and a variety of other comorbid physiological and psychological characteristics, including a deficit of positive affect. Recently, the focus of research on the pathophysiology of FM has considered the role of a number of genomic variants. In the current manuscript, case-control analyses did not support the hypothesis that FM patients would differ from other chronic pain groups in catechol-O-methyltransferase (COMT) and mu-opioid receptor (OPRM1) genotype. However, evidence is provided in support of the hypothesis that functional single nucleotide polymorphisms on the COMT and OPRM1 genes would be associated with risk and resilience, respectively, in a dual processing model of pain-related positive affective regulation in FM. Forty-six female patients with a physician-confirmed diagnosis of FM completed an electronic diary that included once-daily assessments of positive affect and soft tissue pain. Multilevel modeling yielded a significant gene X environment interaction, such that individuals with met/met genotype on COMT experienced a greater decline in positive affect as daily pain increased than did either val/met or val/val individuals. A gene X environment interaction for OPRM1 also emerged, indicating that individuals with at least one asp allele were more resilient to elevations in daily pain than those homozygous for the asn allele. In sum, the findings offer researchers ample reason to further investigate the contribution of the catecholamine and opioid systems, and their associated genomic variants, to the still poorly understood experience of FM.
ContributorsFinan, Patrick Hamilton (Author) / Zautra, Alex (Thesis advisor) / Davis, Mary (Committee member) / Lemery-Chalfant, Kathryn (Committee member) / Presson, Clark (Committee member) / Arizona State University (Publisher)
Created2011
Description
Opioid use in the United States is skyrocketing. Overdose deaths have increased 433% in
the last decade and will continue climbing. In addition to the mortality caused by illicit
opioid misuse, morbidity rates have also risen. People Who Inject Drugs (PWID)
demonstrate higher rates of Human Immunodeficiency Virus (HIV), Hepatitis C Virus
(HCV), Endocarditis, Persistent Abscesses, Staphylococcus Aureus (S. aureus, Staph)
and other skin infections. This thesis serves as (1) a systematic review of the differences
in health conditions experienced by PWID and (2) an examination of the trends in skin
and soft tissue infection from a small sample in Phoenix, Arizona. The author argues that
PWID suffer from an increased rate of comorbid conditions associated with substance
use. Targeted social work interventions could be useful in reducing the rates of disease
and their impact on the individual and community.
the last decade and will continue climbing. In addition to the mortality caused by illicit
opioid misuse, morbidity rates have also risen. People Who Inject Drugs (PWID)
demonstrate higher rates of Human Immunodeficiency Virus (HIV), Hepatitis C Virus
(HCV), Endocarditis, Persistent Abscesses, Staphylococcus Aureus (S. aureus, Staph)
and other skin infections. This thesis serves as (1) a systematic review of the differences
in health conditions experienced by PWID and (2) an examination of the trends in skin
and soft tissue infection from a small sample in Phoenix, Arizona. The author argues that
PWID suffer from an increased rate of comorbid conditions associated with substance
use. Targeted social work interventions could be useful in reducing the rates of disease
and their impact on the individual and community.
ContributorsCohen, William H (Author) / Mendoza, Natasha (Thesis advisor) / Wolfersteig, Wendy (Committee member) / McLoone, Claire (Committee member) / Arizona State University (Publisher)
Created2019
Description
There has been a rise in heroin use throughout the United States due to doctors increasingly prescribing painkillers to patients with chronic pain (Kanouse & Compton, 2015; Compton, Boyle, & Wargo, 2015). Individuals get addicted to painkillers and, when their doctor will no longer prescribe them, turn to alternative methods of relief; heroin is often their cheapest option (Kolodny, Courtwright, Hwang, Kreiner, Eadie, Clark, & Alexander 2015). Heroin users are three to four times more likely to die from overdose than other types of drug users (Darke & Hall, 2003). The purpose of this study is to determine the likelihood that heroin users successfully reenter the community upon release from prison in comparison to other types of drug users. There are several re-entry outcomes that can be considered “success”; this study measures success as an index of the quality of the returning offender’s familial relationships as well as recidivism. The data used for this analysis is the Serious and Violent Offender Reentry Initiative (SVORI). The sample consists of male offenders, aged 18 years and older, who have been convicted of and imprisoned for a serious or violent crime. Findings suggest familial social support does not have an effect on heroin use, but heroin use increases the risk of recidivism. These findings will provide a context for rehabilitation of heroin offenders and will launch future research focusing on the differences between heroin users and other types of drug users.
ContributorsGriffin, Amber (Author) / Wallace, Danielle (Thesis advisor) / Wright, Kevin (Committee member) / Chamberlain, Alyssa (Committee member) / Arizona State University (Publisher)
Created2016
Description
Opioid use rates and related deaths continue to be a public health crisis; while there are many contributing factors to opioid use disorders, criteria for diagnosis include problems related to social functioning. Previous research indicates that laboratory rats, which are frequently used as animal models of addiction-related behaviors, are capable of prosocial behavior. The following collection of studies were performed to determine the effects of heroin on prosocial behavior in rats, as well as the role of the insula in both self-administration of heroin and prosocial behaviors. All of the experiments were conducted utilizing an established model of prosocial behavior in rats in which a performing rat releases a cagemate from a restrainer. The occurrence of and latency to free the confined rat was recorded. After baseline rescuing behavior was established, rats were allowed to self-administer heroin (0.06 mg/kg/infusion i.v.), and subsequent experimental conditions were imposed.
Experimental conditions, in a series of different studies, included comparing heroin reinforcers with sucrose, chemogenetically modulating the insular cortex (both stimulatory and inhibitory processes) and administering excitotoxic lesions in the insula. There were significant differences in saving behaviors between heroin and sucrose groups demonstrating an opioid induced loss of prosocial behavior. Modulating the insula chemogenetically resulted in some restoration of these opioid related deficits, and insular lesions did not significantly impact prosocial behaviors, however, there were significant differences between rates of heroin intake in lesioned animals versus non-lesioned controls. Taken together, these results demonstrate the deleterious effects of heroin on prosocial behaviors and offer further support for the role of the insula in both addiction and social constructs.
Experimental conditions, in a series of different studies, included comparing heroin reinforcers with sucrose, chemogenetically modulating the insular cortex (both stimulatory and inhibitory processes) and administering excitotoxic lesions in the insula. There were significant differences in saving behaviors between heroin and sucrose groups demonstrating an opioid induced loss of prosocial behavior. Modulating the insula chemogenetically resulted in some restoration of these opioid related deficits, and insular lesions did not significantly impact prosocial behaviors, however, there were significant differences between rates of heroin intake in lesioned animals versus non-lesioned controls. Taken together, these results demonstrate the deleterious effects of heroin on prosocial behaviors and offer further support for the role of the insula in both addiction and social constructs.
ContributorsTomek, Seven Eli (Author) / Olive, Michael F (Thesis advisor) / Neisewander, Janet (Committee member) / Wynne, Clive (Committee member) / Comer, Sandra (Committee member) / Arizona State University (Publisher)
Created2020
Description
The opioid crisis has become one of the most persistent public health crises in America, killing over 100 people a day. The opioid crisis emerged in the late 1990s and 2000s when opioid overdoses began to dramatically increase due to prescription painkillers. Heroin subsequently became a popular drug that was obtained through illicit markets in 2010. More recently, fentanyl, a potent and illicitly manufactured synthetic opioid, has driven a notable increase in the number of opioid overdose deaths. The opioid crisis has impacted many communities across the country. However, some communities are more susceptible to higher rates of opioid use. In order to determine which neighborhoods in Tempe, Arizona are more vulnerable to opioid use the author uses Tempe Emergency Medical Services (EMS) calls for service data and American Community Survey data to address two research questions: 1) What sociodemographic factors at the census-tract level are associated with calls for service to opioid related incidents and 2) are aspects of the physical environment associated with calls for service to opioid related incidents (e.g. vacant units, lack of complete plumbing, multiple unit housing structures)? Understanding community-level risk and protective-factors is essential for furthering the discussion on interventions that aim to address problematic opioid use in vulnerable communities. The current study finds that communities that are economically disadvantaged, and have a higher percentage of units that are vacant have more EMS calls for service to opioid related incidents. However, counter to the proposed hypothesis of social disorganization theory, residential instability was associated with fewer calls for service to opioid related incidents (i.e. higher levels of residential transience). Additionally, racially and ethnically diverse communities had fewer calls for service to opioid related incidents albeit statistically non-significant. These findings have implications for future research and for possible policy implications directed at reducing opioid overdoses.
ContributorsWatts, Seth (Author) / White, Michael D (Thesis advisor) / Chamberlain, Alyssa W (Committee member) / Telep, Cody W (Committee member) / Arizona State University (Publisher)
Created2021