Matching Items (5)
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Description
Cancer is one of the leading causes of death in the world and represents a tremendous burden on patients, families and societies. S. Typhimurium strains are specifically attracted to compounds produced by cancer cells and could overcome the traditional therapeutic barrier. However, a major problem with using live attenuated Salmonella

Cancer is one of the leading causes of death in the world and represents a tremendous burden on patients, families and societies. S. Typhimurium strains are specifically attracted to compounds produced by cancer cells and could overcome the traditional therapeutic barrier. However, a major problem with using live attenuated Salmonella as anti-cancer agents is their toxicity at the dose required for therapeutic efficacy, but reducing the dose results in diminished efficacy. In this project, we explored novel means to reduce the toxicity of the recombinant attenuated Salmonella by genetically engineering those virulence factors to facilitate maximal colonization of tumor tissues and reduced fitness in normal tissues. We have constructed two sets of Salmonella strains. In the first set, each targeted gene was knocked out by deletion of the gene. In the second set, the predicted promoter region of each gene was replaced with a rhamnose-regulated promoter, which will cease the synthesis of these genes in vivo, a rhamnose-free environment.
ContributorsBenson, Lee Samuel (Author) / Kong, Wei (Thesis director) / Martin, Thomas (Committee member) / Lake, Douglas (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor) / Center for Infectious Diseases and Vaccinology (Contributor) / School of Life Sciences (Contributor)
Created2013-05
Description

Period Poverty is an issue affecting millions of people in the US alone, and in the face of this inequity, many public and private initiatives have been created to address this problem with varying degrees of success. By surveying students and interviewing public and community administrators, we have uncovered how

Period Poverty is an issue affecting millions of people in the US alone, and in the face of this inequity, many public and private initiatives have been created to address this problem with varying degrees of success. By surveying students and interviewing public and community administrators, we have uncovered how these systems can improve to most effectively meet the needs of the communities they seek to serve. While often the primary complaint of menstruators who utilize these resources are that they are often understocked, this paper explores many other improvements which students would benefit from - such as more streamlined communication systems, improved quality and variety of products, and more efficient operational relationships.

ContributorsChethikattil, Arya (Author) / Mesquita, Tomas (Co-author) / Meuth, Ryan (Thesis director) / Johnston, Holly (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor) / Computer Science and Engineering Program (Contributor)
Created2023-05
Description

American Sign Language (ASL) is a manual language that communicates through gestures, facial expressions, and body language. In the United States, there are over six million sign language users (Mitchell & Young, 2022). At Arizona State University, there is a limited offering of classes for undergraduate students to take sign

American Sign Language (ASL) is a manual language that communicates through gestures, facial expressions, and body language. In the United States, there are over six million sign language users (Mitchell & Young, 2022). At Arizona State University, there is a limited offering of classes for undergraduate students to take sign language; they can take up to four levels, which is satisfactory for degrees’ foreign language requirements. If students wish to proceed with their ASL education, they must transfer to a different university. The purpose of this study and subsequent research is to propose an ASL minor that can be established at ASU so that students can receive an in-depth education. Survey data was collected with the intention of determining how students felt about ASL and the addition of a potential minor. The survey findings, coupled with the secondary literature review, lead to the conclusion that establishing an American Sign Language minor is in the best interests of both the students and the University.

ContributorsAltaf, Haniyah (Author) / Gutierrez, Veronica (Thesis director) / Cheloha, Hannah (Committee member) / Ngo, Christina (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor) / Watts College of Public Service & Community Solut (Contributor) / Department of English (Contributor)
Created2023-05
Description

A brief history of the Mediterranean diet and its geographical origins as a meeting point for cultures will guide understanding of the construction of this specific dietary pattern. The nutrients and foods typical of the Mediterranean diet will be outlined as well as their health benefits, allowing for a deeper

A brief history of the Mediterranean diet and its geographical origins as a meeting point for cultures will guide understanding of the construction of this specific dietary pattern. The nutrients and foods typical of the Mediterranean diet will be outlined as well as their health benefits, allowing for a deeper analysis of the ways in which the Mediterranean diet is associated with reducing the risk of certain chronic diseases. The lifestyle choices and physical activity practiced adjacently to the diet will establish the positive synergistic effects of conviviality and moderate exercise on general human health. Contemporary movements in the Mediterranean region, like Slow Foods, aim to preserve traditional dietary and lifestyle choices. In comparison, the U.S. food system seems to be most shaped by the influences of globalization and industrialization. Economic and health-cost perspectives as well as the role of modern-day media in diet trends, body image, and food marketing will establish and deepen the complexities of food choices and health disparities in Western societies. The diagnosis of the Mediterranean Diet in the U.S. as a solution to poor general population health will be challenged and holistic perspectives on eating will provide an exploratory lens for understanding health and food choice as a modern-day consumer.

ContributorsMeyer, Terra (Author) / Levinson, Simin (Thesis director) / Vitullo, Juliann (Committee member) / Barrett, The Honors College (Contributor) / Department of Management and Entrepreneurship (Contributor) / Department of Psychology (Contributor)
Created2023-05
Description

Students who transfer to a university from a community college are a diverse, resilient group of individuals who often face many challenges and barriers upon transitioning from a 2-year institution to a 4-year institution. Due to their upper-division status upon arrival at the university, transfer students are often overlooked and

Students who transfer to a university from a community college are a diverse, resilient group of individuals who often face many challenges and barriers upon transitioning from a 2-year institution to a 4-year institution. Due to their upper-division status upon arrival at the university, transfer students are often overlooked and even unsupported throughout multiple aspects of the transfer process. To further understand the issues that are faced by transfer students throughout the transfer process, we conducted research to get a better understanding of exactly who transfer students are, what challenges they face, and how universities can better support these students so they are able to complete their baccalaureate. We compiled this research into an annotated bibliography and developed a presentation to discuss our findings, personal anecdotes, and the suggestions we have to help Barrett, the Honors College move towards a more transfer-receptive culture. All questions asked during the presentation have been documented.

ContributorsLoera, Cristian Peter (Author) / Autote, Aubreanna (Co-author) / Ingram-Waters, Mary (Thesis director) / Abril, Lauren (Committee member) / Hugh Downs School of Human Communication (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05