Matching Items (7)
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- All Subjects: Genetics
- All Subjects: Evolution & development
- Creators: Binsfeld, Allison
Description
Transgenic experiments in Drosophila have proven to be a useful tool aiding in the
determination of mammalian protein function. A CNS specific protein, dCORL is a
member of the Sno/Ski family. Sno acts as a switch between Dpp/dActivin signaling.
dCORL is involved in Dpp and dActivin signaling, but the two homologous mCORL
protein functions are unknown. Conducting transgenic experiments in the adult wings,
and third instar larval brains using mCORL1, mCORL2 and dCORL are used to provide
insight into the function of these proteins. These experiments show mCORL1 has a
different function from mCORL2 and dCORL when expressed in Drosophila. mCORL2
and dCORL have functional similarities that are likely conserved. Six amino acid
substitutions between mCORL1 and mCORL2/dCORL may be the reason for the
functional difference. The evolutionary implications of this research suggest the
conservation of a switch between Dpp/dActivin signaling that predates the divergence of
arthropods and vertebrates.
determination of mammalian protein function. A CNS specific protein, dCORL is a
member of the Sno/Ski family. Sno acts as a switch between Dpp/dActivin signaling.
dCORL is involved in Dpp and dActivin signaling, but the two homologous mCORL
protein functions are unknown. Conducting transgenic experiments in the adult wings,
and third instar larval brains using mCORL1, mCORL2 and dCORL are used to provide
insight into the function of these proteins. These experiments show mCORL1 has a
different function from mCORL2 and dCORL when expressed in Drosophila. mCORL2
and dCORL have functional similarities that are likely conserved. Six amino acid
substitutions between mCORL1 and mCORL2/dCORL may be the reason for the
functional difference. The evolutionary implications of this research suggest the
conservation of a switch between Dpp/dActivin signaling that predates the divergence of
arthropods and vertebrates.
ContributorsStinchfield, Michael J (Author) / Newfeld, Stuart J (Thesis advisor) / Capco, David (Committee member) / Laubichler, Manfred (Committee member) / Arizona State University (Publisher)
Created2019
DescriptionThis thesis summarizes the process of writing a children's book about achondroplasia directed at children without genetic disorders. The thesis also includes the children's book The Genetics of Little People that was created during the project.
ContributorsWatkins, Payton (Author) / Binsfeld, Allison (Co-author) / Wilson, Melissa (Thesis director) / Hunt-Brendish, Katherine (Committee member) / Barrett, The Honors College (Contributor) / Chemical Engineering Program (Contributor)
Created2022-05
Description
This thesis summarizes the process of writing a children's book about achondroplasia directed at children without genetic disorders. The thesis also includes the children's book The Genetics of Little People that was created during the project.
ContributorsWatkins, Payton (Author) / Binsfeld, Allison (Co-author) / Wilson, Melissa (Thesis director) / Hunt-Brendish, Katherine (Committee member) / Barrett, The Honors College (Contributor) / Chemical Engineering Program (Contributor)
Created2022-05
Description
This thesis summarizes the process of writing a children's book about achondroplasia directed at children without genetic disorders. The thesis also includes the children's book The Genetics of Little People that was created during the project.
ContributorsWatkins, Payton (Author) / Binsfeld, Allison (Co-author) / Wilson, Melissa (Thesis director) / Hunt-Brendish, Katherine (Committee member) / Barrett, The Honors College (Contributor) / Chemical Engineering Program (Contributor)
Created2022-05
Description
This thesis summarizes the process of writing a children's book about achondroplasia directed at children without genetic disorders. The thesis also includes the children's book The Genetics of Little People that was created during the project.
ContributorsBinsfeld, Allison (Author) / Watkins, Payton (Co-author) / Wilson, Melissa (Thesis director) / Hunt Brendish, Katherine (Committee member) / Barrett, The Honors College (Contributor) / School of Molecular Sciences (Contributor) / School of Human Evolution & Social Change (Contributor)
Created2022-05
ContributorsBinsfeld, Allison (Author) / Watkins, Payton (Co-author) / Wilson, Melissa (Thesis director) / Hunt Brendish, Katherine (Committee member) / Barrett, The Honors College (Contributor) / School of Molecular Sciences (Contributor)
Created2022-05
ContributorsBinsfeld, Allison (Author) / Watkins, Payton (Co-author) / Wilson, Melissa (Thesis director) / Hunt Brendish, Katherine (Committee member) / Barrett, The Honors College (Contributor) / School of Molecular Sciences (Contributor)
Created2022-05