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With millions of people living with a disease as restraining as migraines, there are no ways to diagnose them before they occur. In this study, a migraine model using nitroglycerin is used in rats to study the awake brain activity during the migraine state. In an attempt to search for a biomarker for the migraine state, we found multiple deviations in EEG brain activity across different bands. Firstly, there was a clear decrease in power in the delta, beta, alpha, and theta bands. A slight increase in power in the gamma and high frequency bands was also found, which is consistent with other pain-related studies12. Additionally, we searched for a decreased pain threshold in this deviation, in which we concluded that more data analysis is needed to eliminate the multiple potential noise influxes throughout each dataset. However, with this study we did find a clear change in brain activity, but a more detailed analysis will narrow down what this change could mean and how it impacts the migraine state.
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This study observed the effects of three different non-invasive nerve stimulation paradigms in human participants. The first study analyzed the safety and efficacy of transcutaneous auricular vagal nerve stimulation in healthy humans using a bilateral stimulation protocol with uniquely designed dry-hydrogel electrodes. Results demonstrate bilateral auricular vagal nerve stimulation has significant effects on specific parameters of autonomic activity and is safe and well tolerated. The second study analyzed the effects of non-invasive electrical stimulation of a region on the side of the neck that contains the Great Auricular Nerve and the Auricular Branch of the Vagus Nerve called the tympanomastoid fissure on golf hitting performance in healthy golfers. Results did not show significant effects on hitting performance or physiological activity, but the nerve stimulation had significant effects on reducing state-anxiety and improving the quality of feel of each shot. The third study analyzed the effects of non-invasive nerve stimulation of cervical nerves on the back of the neck on putting performance of yips-affected golfers. Results demonstrated that cervical nerve stimulation had significant effects on improving putting performance but did not have significant effects on physiological activity. Data from these studies show there are potential applications for non-invasive electrical nerve stimulation for healthy and athletic populations. Future research should also examine the effects of these stimulation methods in clinical populations.