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- All Subjects: Statistics
- Genre: Doctoral Dissertation
Description
Information divergence functions, such as the Kullback-Leibler divergence or the Hellinger distance, play a critical role in statistical signal processing and information theory; however estimating them can be challenge. Most often, parametric assumptions are made about the two distributions to estimate the divergence of interest. In cases where no parametric model fits the data, non-parametric density estimation is used. In statistical signal processing applications, Gaussianity is usually assumed since closed-form expressions for common divergence measures have been derived for this family of distributions. Parametric assumptions are preferred when it is known that the data follows the model, however this is rarely the case in real-word scenarios. Non-parametric density estimators are characterized by a very large number of parameters that have to be tuned with costly cross-validation. In this dissertation we focus on a specific family of non-parametric estimators, called direct estimators, that bypass density estimation completely and directly estimate the quantity of interest from the data. We introduce a new divergence measure, the $D_p$-divergence, that can be estimated directly from samples without parametric assumptions on the distribution. We show that the $D_p$-divergence bounds the binary, cross-domain, and multi-class Bayes error rates and, in certain cases, provides provably tighter bounds than the Hellinger divergence. In addition, we also propose a new methodology that allows the experimenter to construct direct estimators for existing divergence measures or to construct new divergence measures with custom properties that are tailored to the application. To examine the practical efficacy of these new methods, we evaluate them in a statistical learning framework on a series of real-world data science problems involving speech-based monitoring of neuro-motor disorders.
ContributorsWisler, Alan (Author) / Berisha, Visar (Thesis advisor) / Spanias, Andreas (Thesis advisor) / Liss, Julie (Committee member) / Bliss, Daniel (Committee member) / Arizona State University (Publisher)
Created2017
Description
This dissertation explores applications of machine learning methods in service of the design of screening tests, which are ubiquitous in applications from social work, to criminology, to healthcare. In the first part, a novel Bayesian decision theory framework is presented for designing tree-based adaptive tests. On an application to youth delinquency in Honduras, the method produces a 15-item instrument that is almost as accurate as a full-length 150+ item test. The framework includes specific considerations for the context in which the test will be administered, and provides uncertainty quantification around the trade-offs of shortening lengthy tests. In the second part, classification complexity is explored via theoretical and empirical results from statistical learning theory, information theory, and empirical data complexity measures. A simulation study that explicitly controls two key aspects of classification complexity is performed to relate the theoretical and empirical approaches. Throughout, a unified language and notation that formalizes classification complexity is developed; this same notation is used in subsequent chapters to discuss classification complexity in the context of a speech-based screening test. In the final part, the relative merits of task and feature engineering when designing a speech-based cognitive screening test are explored. Through an extensive classification analysis on a clinical speech dataset from patients with normal cognition and Alzheimer’s disease, the speech elicitation task is shown to have a large impact on test accuracy; carefully performed task and feature engineering are required for best results. A new framework for objectively quantifying speech elicitation tasks is introduced, and two methods are proposed for automatically extracting insights into the aspects of the speech elicitation task that are driving classification performance. The dissertation closes with recommendations for how to evaluate the obtained insights and use them to guide future design of speech-based screening tests.
ContributorsKrantsevich, Chelsea (Author) / Hahn, P. Richard (Thesis advisor) / Berisha, Visar (Committee member) / Lopes, Hedibert (Committee member) / Renaut, Rosemary (Committee member) / Zheng, Yi (Committee member) / Arizona State University (Publisher)
Created2023
Description
Eigenvalues of the Gram matrix formed from received data frequently appear in sufficient detection statistics for multi-channel detection with Generalized Likelihood Ratio (GLRT) and Bayesian tests. In a frequently presented model for passive radar, in which the null hypothesis is that the channels are independent and contain only complex white Gaussian noise and the alternative hypothesis is that the channels contain a common rank-one signal in the mean, the GLRT statistic is the largest eigenvalue $\lambda_1$ of the Gram matrix formed from data. This Gram matrix has a Wishart distribution. Although exact expressions for the distribution of $\lambda_1$ are known under both hypotheses, numerically calculating values of these distribution functions presents difficulties in cases where the dimension of the data vectors is large. This dissertation presents tractable methods for computing the distribution of $\lambda_1$ under both the null and alternative hypotheses through a technique of expanding known expressions for the distribution of $\lambda_1$ as inner products of orthogonal polynomials. These newly presented expressions for the distribution allow for computation of detection thresholds and receiver operating characteristic curves to arbitrary precision in floating point arithmetic. This represents a significant advancement over the state of the art in a problem that could previously only be addressed by Monte Carlo methods.
ContributorsJones, Scott, Ph.D (Author) / Cochran, Douglas (Thesis advisor) / Berisha, Visar (Committee member) / Bliss, Daniel (Committee member) / Kosut, Oliver (Committee member) / Richmond, Christ (Committee member) / Arizona State University (Publisher)
Created2019
Description
This dissertation centers on the development of Bayesian methods for learning differ- ent types of variation in switching nonlinear gene regulatory networks (GRNs). A new nonlinear and dynamic multivariate GRN model is introduced to account for different sources of variability in GRNs. The new model is aimed at more precisely capturing the complexity of GRN interactions through the introduction of time-varying kinetic order parameters, while allowing for variability in multiple model parameters. This model is used as the drift function in the development of several stochastic GRN mod- els based on Langevin dynamics. Six models are introduced which capture intrinsic and extrinsic noise in GRNs, thereby providing a full characterization of a stochastic regulatory system. A Bayesian hierarchical approach is developed for learning the Langevin model which best describes the noise dynamics at each time step. The trajectory of the state, which are the gene expression values, as well as the indicator corresponding to the correct noise model are estimated via sequential Monte Carlo (SMC) with a high degree of accuracy. To address the problem of time-varying regulatory interactions, a Bayesian hierarchical model is introduced for learning variation in switching GRN architectures with unknown measurement noise covariance. The trajectory of the state and the indicator corresponding to the network configuration at each time point are estimated using SMC. This work is extended to a fully Bayesian hierarchical model to account for uncertainty in the process noise covariance associated with each network architecture. An SMC algorithm with local Gibbs sampling is developed to estimate the trajectory of the state and the indicator correspond- ing to the network configuration at each time point with a high degree of accuracy. The results demonstrate the efficacy of Bayesian methods for learning information in switching nonlinear GRNs.
ContributorsVélez-Cruz, Nayely (Author) / Papandreou-Suppappola, Antonia (Thesis advisor) / Moraffah, Bahman (Committee member) / Tepedelenlioğlu, Cihan (Committee member) / Berisha, Visar (Committee member) / Arizona State University (Publisher)
Created2023