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- All Subjects: Statistics
- All Subjects: spatial statistics
- Genre: Academic theses
- Creators: Lan, Shiwei
- Creators: Wilson, Jeffrey
- Creators: Zhou, Shuang
Description
Many longitudinal studies, especially in clinical trials, suffer from missing data issues. Most estimation procedures assume that the missing values are ignorable or missing at random (MAR). However, this assumption leads to unrealistic simplification and is implausible for many cases. For example, an investigator is examining the effect of treatment on depression. Subjects are scheduled with doctors on a regular basis and asked questions about recent emotional situations. Patients who are experiencing severe depression are more likely to miss an appointment and leave the data missing for that particular visit. Data that are not missing at random may produce bias in results if the missing mechanism is not taken into account. In other words, the missing mechanism is related to the unobserved responses. Data are said to be non-ignorable missing if the probabilities of missingness depend on quantities that might not be included in the model. Classical pattern-mixture models for non-ignorable missing values are widely used for longitudinal data analysis because they do not require explicit specification of the missing mechanism, with the data stratified according to a variety of missing patterns and a model specified for each stratum. However, this usually results in under-identifiability, because of the need to estimate many stratum-specific parameters even though the eventual interest is usually on the marginal parameters. Pattern mixture models have the drawback that a large sample is usually required. In this thesis, two studies are presented. The first study is motivated by an open problem from pattern mixture models. Simulation studies from this part show that information in the missing data indicators can be well summarized by a simple continuous latent structure, indicating that a large number of missing data patterns may be accounted by a simple latent factor. Simulation findings that are obtained in the first study lead to a novel model, a continuous latent factor model (CLFM). The second study develops CLFM which is utilized for modeling the joint distribution of missing values and longitudinal outcomes. The proposed CLFM model is feasible even for small sample size applications. The detailed estimation theory, including estimating techniques from both frequentist and Bayesian perspectives is presented. Model performance and evaluation are studied through designed simulations and three applications. Simulation and application settings change from correctly-specified missing data mechanism to mis-specified mechanism and include different sample sizes from longitudinal studies. Among three applications, an AIDS study includes non-ignorable missing values; the Peabody Picture Vocabulary Test data have no indication on missing data mechanism and it will be applied to a sensitivity analysis; the Growth of Language and Early Literacy Skills in Preschoolers with Developmental Speech and Language Impairment study, however, has full complete data and will be used to conduct a robust analysis. The CLFM model is shown to provide more precise estimators, specifically on intercept and slope related parameters, compared with Roy's latent class model and the classic linear mixed model. This advantage will be more obvious when a small sample size is the case, where Roy's model experiences challenges on estimation convergence. The proposed CLFM model is also robust when missing data are ignorable as demonstrated through a study on Growth of Language and Early Literacy Skills in Preschoolers.
ContributorsZhang, Jun (Author) / Reiser, Mark R. (Thesis advisor) / Barber, Jarrett (Thesis advisor) / Kao, Ming-Hung (Committee member) / Wilson, Jeffrey (Committee member) / St Louis, Robert D. (Committee member) / Arizona State University (Publisher)
Created2013
Description
It is common in the analysis of data to provide a goodness-of-fit test to assess the performance of a model. In the analysis of contingency tables, goodness-of-fit statistics are frequently employed when modeling social science, educational or psychological data where the interest is often directed at investigating the association among multi-categorical variables. Pearson's chi-squared statistic is well-known in goodness-of-fit testing, but it is sometimes considered to produce an omnibus test as it gives little guidance to the source of poor fit once the null hypothesis is rejected. However, its components can provide powerful directional tests. In this dissertation, orthogonal components are used to develop goodness-of-fit tests for models fit to the counts obtained from the cross-classification of multi-category dependent variables. Ordinal categories are assumed. Orthogonal components defined on marginals are obtained when analyzing multi-dimensional contingency tables through the use of the QR decomposition. A subset of these orthogonal components can be used to construct limited-information tests that allow one to identify the source of lack-of-fit and provide an increase in power compared to Pearson's test. These tests can address the adverse effects presented when data are sparse. The tests rely on the set of first- and second-order marginals jointly, the set of second-order marginals only, and the random forest method, a popular algorithm for modeling large complex data sets. The performance of these tests is compared to the likelihood ratio test as well as to tests based on orthogonal polynomial components. The derived goodness-of-fit tests are evaluated with studies for detecting two- and three-way associations that are not accounted for by a categorical variable factor model with a single latent variable. In addition the tests are used to investigate the case when the model misspecification involves parameter constraints for large and sparse contingency tables. The methodology proposed here is applied to data from the 38th round of the State Survey conducted by the Institute for Public Policy and Michigan State University Social Research (2005) . The results illustrate the use of the proposed techniques in the context of a sparse data set.
ContributorsMilovanovic, Jelena (Author) / Young, Dennis (Thesis advisor) / Reiser, Mark R. (Thesis advisor) / Wilson, Jeffrey (Committee member) / Eubank, Randall (Committee member) / Yang, Yan (Committee member) / Arizona State University (Publisher)
Created2011
Description
As urban populations become increasingly dense, massive amounts of new 'big' data that characterize human activity are being made available and may be characterized as having a large volume of observations, being produced in real-time or near real-time, and including a diverse variety of information. In particular, spatial interaction (SI) data - a collection of human interactions across a set of origins and destination locations - present unique challenges for distilling big data into insight. Therefore, this dissertation identifies some of the potential and pitfalls associated with new sources of big SI data. It also evaluates methods for modeling SI to investigate the relationships that drive SI processes in order to focus on human behavior rather than data description.
A critical review of the existing SI modeling paradigms is first presented, which also highlights features of big data that are particular to SI data. Next, a simulation experiment is carried out to evaluate three different statistical modeling frameworks for SI data that are supported by different underlying conceptual frameworks. Then, two approaches are taken to identify the potential and pitfalls associated with two newer sources of data from New York City - bike-share cycling trips and taxi trips. The first approach builds a model of commuting behavior using a traditional census data set and then compares the results for the same model when it is applied to these newer data sources. The second approach examines how the increased temporal resolution of big SI data may be incorporated into SI models.
Several important results are obtained through this research. First, it is demonstrated that different SI models account for different types of spatial effects and that the Competing Destination framework seems to be the most robust for capturing spatial structure effects. Second, newer sources of big SI data are shown to be very useful for complimenting traditional sources of data, though they are not sufficient substitutions. Finally, it is demonstrated that the increased temporal resolution of new data sources may usher in a new era of SI modeling that allows us to better understand the dynamics of human behavior.
A critical review of the existing SI modeling paradigms is first presented, which also highlights features of big data that are particular to SI data. Next, a simulation experiment is carried out to evaluate three different statistical modeling frameworks for SI data that are supported by different underlying conceptual frameworks. Then, two approaches are taken to identify the potential and pitfalls associated with two newer sources of data from New York City - bike-share cycling trips and taxi trips. The first approach builds a model of commuting behavior using a traditional census data set and then compares the results for the same model when it is applied to these newer data sources. The second approach examines how the increased temporal resolution of big SI data may be incorporated into SI models.
Several important results are obtained through this research. First, it is demonstrated that different SI models account for different types of spatial effects and that the Competing Destination framework seems to be the most robust for capturing spatial structure effects. Second, newer sources of big SI data are shown to be very useful for complimenting traditional sources of data, though they are not sufficient substitutions. Finally, it is demonstrated that the increased temporal resolution of new data sources may usher in a new era of SI modeling that allows us to better understand the dynamics of human behavior.
ContributorsOshan, Taylor Matthew (Author) / Fotheringham, A. S. (Thesis advisor) / Farmer, Carson J.Q. (Committee member) / Rey, Sergio S.J. (Committee member) / Nelson, Trisalyn (Committee member) / Arizona State University (Publisher)
Created2017
Description
The Pearson and likelihood ratio statistics are well-known in goodness-of-fit testing and are commonly used for models applied to multinomial count data. When data are from a table formed by the cross-classification of a large number of variables, these goodness-of-fit statistics may have lower power and inaccurate Type I error rate due to sparseness. Pearson's statistic can be decomposed into orthogonal components associated with the marginal distributions of observed variables, and an omnibus fit statistic can be obtained as a sum of these components. When the statistic is a sum of components for lower-order marginals, it has good performance for Type I error rate and statistical power even when applied to a sparse table. In this dissertation, goodness-of-fit statistics using orthogonal components based on second- third- and fourth-order marginals were examined. If lack-of-fit is present in higher-order marginals, then a test that incorporates the higher-order marginals may have a higher power than a test that incorporates only first- and/or second-order marginals. To this end, two new statistics based on the orthogonal components of Pearson's chi-square that incorporate third- and fourth-order marginals were developed, and the Type I error, empirical power, and asymptotic power under different sparseness conditions were investigated. Individual orthogonal components as test statistics to identify lack-of-fit were also studied. The performance of individual orthogonal components to other popular lack-of-fit statistics were also compared. When the number of manifest variables becomes larger than 20, most of the statistics based on marginal distributions have limitations in terms of computer resources and CPU time. Under this problem, when the number manifest variables is larger than or equal to 20, the performance of a bootstrap based method to obtain p-values for Pearson-Fisher statistic, fit to confirmatory dichotomous variable factor analysis model, and the performance of Tollenaar and Mooijaart (2003) statistic were investigated.
ContributorsDassanayake, Mudiyanselage Maduranga Kasun (Author) / Reiser, Mark R. (Thesis advisor) / Kao, Ming-Hung (Committee member) / Wilson, Jeffrey (Committee member) / St. Louis, Robert (Committee member) / Kamarianakis, Ioannis (Committee member) / Arizona State University (Publisher)
Created2018
Description
Quadratic growth curves of 2nd degree polynomial are widely used in longitudinal studies. For a 2nd degree polynomial, the vertex represents the location of the curve in the XY plane. For a quadratic growth curve, we propose an approximate confidence region as well as the confidence interval for x and y-coordinates of the vertex using two methods, the gradient method and the delta method. Under some models, an indirect test on the location of the curve can be based on the intercept and slope parameters, but in other models, a direct test on the vertex is required. We present a quadratic-form statistic for a test of the null hypothesis that there is no shift in the location of the vertex in a linear mixed model. The statistic has an asymptotic chi-squared distribution. For 2nd degree polynomials of two independent samples, we present an approximate confidence region for the difference of vertices of two quadratic growth curves using the modified gradient method and delta method. Another chi-square test statistic is derived for a direct test on the vertex and is compared to an F test statistic for the indirect test. Power functions are derived for both the indirect F test and the direct chi-square test. We calculate the theoretical power and present a simulation study to investigate the power of the tests. We also present a simulation study to assess the influence of sample size, measurement occasions and nature of the random effects. The test statistics will be applied to the Tell Efficacy longitudinal study, in which sound identification scores and language protocol scores for children are modeled as quadratic growth curves for two independent groups, TELL and control curriculum. The interpretation of shift in the location of the vertices is also presented.
ContributorsYu, Wanchunzi (Author) / Reiser, Mark R. (Thesis advisor) / Barber, Jarrett (Committee member) / Kao, Ming-Hung (Committee member) / St Louis, Robert D (Committee member) / Wilson, Jeffrey (Committee member) / Arizona State University (Publisher)
Created2015
Description
Longitudinal data involving multiple subjects is quite popular in medical and social science areas. I consider generalized linear mixed models (GLMMs) applied to such longitudinal data, and the optimal design searching problem under such models. In this case, based on optimal design theory, the optimality criteria depend on the estimated parameters, which leads to local optimality. Moreover, the information matrix under a GLMM doesn't have a closed-form expression. My dissertation includes three topics related to this design problem. The first part is searching for locally optimal designs under GLMMs with longitudinal data. I apply penalized quasi-likelihood (PQL) method to approximate the information matrix and compare several approximations to show the superiority of PQL over other approximations. Under different local parameters and design restrictions, locally D- and A- optimal designs are constructed based on the approximation. An interesting finding is that locally optimal designs sometimes apply different designs to different subjects. Finally, the robustness of these locally optimal designs is discussed. In the second part, an unknown observational covariate is added to the previous model. With an unknown observational variable in the experiment, expected optimality criteria are considered. Under different assumptions of the unknown variable and parameter settings, locally optimal designs are constructed and discussed. In the last part, Bayesian optimal designs are considered under logistic mixed models. Considering different priors of the local parameters, Bayesian optimal designs are generated. Bayesian design under such a model is usually expensive in time. The running time in this dissertation is optimized to an acceptable amount with accurate results. I also discuss the robustness of these Bayesian optimal designs, which is the motivation of applying such an approach.
ContributorsShi, Yao (Author) / Stufken, John (Thesis advisor) / Kao, Ming-Hung (Thesis advisor) / Lan, Shiwei (Committee member) / Pan, Rong (Committee member) / Reiser, Mark (Committee member) / Arizona State University (Publisher)
Created2022
Description
This dissertation comprises two projects: (i) Multiple testing of local maxima for detection of peaks and change points with non-stationary noise, and (ii) Height distributions of critical points of smooth isotropic Gaussian fields: computations, simulations and asymptotics. The first project introduces a topological multiple testing method for one-dimensional domains to detect signals in the presence of non-stationary Gaussian noise. The approach involves conducting tests at local maxima based on two observation conditions: (i) the noise is smooth with unit variance and (ii) the noise is not smooth where kernel smoothing is applied to increase the signal-to-noise ratio (SNR). The smoothed signals are then standardized, which ensures that the variance of the new sequence's noise becomes one, making it possible to calculate $p$-values for all local maxima using random field theory. Assuming unimodal true signals with finite support and non-stationary Gaussian noise that can be repeatedly observed. The algorithm introduced in this work, demonstrates asymptotic strong control of the False Discovery Rate (FDR) and power consistency as the number of sequence repetitions and signal strength increase. Simulations indicate that FDR levels can also be controlled under non-asymptotic conditions with finite repetitions. The application of this algorithm to change point detection also guarantees FDR control and power consistency. The second project focuses on investigating the explicit and asymptotic height densities of critical points of smooth isotropic Gaussian random fields on both Euclidean space and spheres.The formulae are based on characterizing the distribution of the Hessian of the Gaussian field using the Gaussian orthogonally invariant (GOI) matrices and the Gaussian orthogonal ensemble (GOE) matrices, which are special cases of GOI matrices. However, as the dimension increases, calculating explicit formulae becomes computationally challenging. The project includes two simulation methods for these distributions. Additionally, asymptotic distributions are obtained by utilizing the asymptotic distribution of the eigenvalues (excluding the maximum eigenvalues) of the GOE matrix for large dimensions. However, when it comes to the maximum eigenvalue, the Tracy-Widom distribution is utilized. Simulation results demonstrate the close approximation between the asymptotic distribution and the real distribution when $N$ is sufficiently large.
Contributorsgu, shuang (Author) / Cheng, Dan (Thesis advisor) / Lopes, Hedibert (Committee member) / Fricks, John (Committee member) / Lan, Shiwei (Committee member) / Zheng, Yi (Committee member) / Arizona State University (Publisher)
Created2023
Description
This dissertation covers several topics in machine learning and causal inference. First, the question of “feature selection,” a common byproduct of regularized machine learning methods, is investigated theoretically in the context of treatment effect estimation. This involves a detailed review and extension of frameworks for estimating causal effects and in-depth theoretical study. Next, various computational approaches to estimating causal effects with machine learning methods are compared with these theoretical desiderata in mind. Several improvements to current methods for causal machine learning are identified and compelling angles for further study are pinpointed. Finally, a common method used for “explaining” predictions of machine learning algorithms, SHAP, is evaluated critically through a statistical lens.
ContributorsHerren, Andrew (Author) / Hahn, P Richard (Thesis advisor) / Kao, Ming-Hung (Committee member) / Lopes, Hedibert (Committee member) / McCulloch, Robert (Committee member) / Zhou, Shuang (Committee member) / Arizona State University (Publisher)
Created2023
Description
This dissertation develops versatile modeling tools to estimate causal effects when conditional unconfoundedness is not immediately satisfied. Chapter 2 provides a brief overview ofcommon techniques in causal inference, with a focus on models relevant to the data explored
in later chapters. The rest of the dissertation focuses on the development of novel “reduced
form” models which are designed to assess the particular challenges of different datasets.
Chapter 3 explores the question of whether or not forecasts of bankruptcy cause bankruptcy.
The question arises from the observation that companies issued going concern opinions were
more likely to go bankrupt in the following year, leading people to speculate that the opinions themselves caused the bankruptcy via a “self-fulfilling prophecy”. A Bayesian machine
learning sensitivity analysis is developed to answer this question. In exchange for additional
flexibility and fewer assumptions, this approach loses point identification of causal effects
and thus a sensitivity analysis is developed to study a wide range of plausible scenarios of
the causal effect of going concern opinions on bankruptcy. Reported in the simulations are
different performance metrics of the model in comparison with other popular methods and a
robust analysis of the sensitivity of the model to mis-specification. Results on empirical data
indicate that forecasts of bankruptcies likely do have a small causal effect.
Chapter 4 studies the effects of vaccination on COVID-19 mortality at the state level in
the United States. The dynamic nature of the pandemic complicates more straightforward
regression adjustments and invalidates many alternative models. The chapter comments on
the limitations of mechanistic approaches as well as traditional statistical methods to epidemiological data. Instead, a state space model is developed that allows the study of the
ever-changing dynamics of the pandemic’s progression. In the first stage, the model decomposes the observed mortality data into component surges, and later uses this information in
a semi-parametric regression model for causal analysis. Results are investigated thoroughly
for empirical justification and stress-tested in simulated settings.
ContributorsPapakostas, Demetrios (Author) / Hahn, Paul (Thesis advisor) / McCulloch, Robert (Committee member) / Zhou, Shuang (Committee member) / Kao, Ming-Hung (Committee member) / Lan, Shiwei (Committee member) / Arizona State University (Publisher)
Created2023
Description
Tracking disease cases is an essential task in public health; however, tracking the number of cases of a disease may be difficult not every infection can be recorded by public health authorities. Notably, this may happen with whole country measles case reports, even such countries with robust registration systems. Eilertson et al. (2019) propose using a state-space model combined with maximum likelihood methods for estimating measles transmission. A Bayesian approach that uses particle Markov Chain Monte Carlo (pMCMC) is proposed to estimate the parameters of the non-linear state-space model developed in Eilertson et al. (2019) and similar previous studies. This dissertation illustrates the performance of this approach by calculating posterior estimates of the model parameters and predictions of the unobserved states in simulations and case studies. Also, Iteration Filtering (IF2) is used as a support method to verify the Bayesian estimation and to inform the selection of prior distributions. In the second half of the thesis, a birth-death process is proposed to model the unobserved population size of a disease vector. This model studies the effect of a disease vector population size on a second affected population. The second population follows a non-homogenous Poisson process when conditioned on the vector process with a transition rate given by a scaled version of the vector population. The observation model also measures a potential threshold event when the host species population size surpasses a certain level yielding a higher transmission rate. A maximum likelihood procedure is developed for this model, which combines particle filtering with the Minorize-Maximization (MM) algorithm and extends the work of Crawford et al. (2014).
ContributorsMartinez Rivera, Wilmer Osvaldo (Author) / Fricks, John (Thesis advisor) / Reiser, Mark (Committee member) / Zhou, Shuang (Committee member) / Cheng, Dan (Committee member) / Lan, Shiwei (Committee member) / Arizona State University (Publisher)
Created2022