Matching Items (7)
Filtering by
- All Subjects: Neurobiology
- All Subjects: Convex Optimization
- Creators: Si, Jennie
- Member of: Theses and Dissertations
Description
The problem of systematically designing a control system continues to remain a subject of intense research. In this thesis, a very powerful control system design environment for Linear Time-Invariant (LTI) Multiple-Input Multiple-Output (MIMO) plants is presented. The environment has been designed to address a broad set of closed loop metrics and constraints; e.g. weighted H-infinity closed loop performance subject to closed loop frequency and/or time domain constraints (e.g. peak frequency response, peak overshoot, peak controls, etc.). The general problem considered - a generalized weighted mixed-sensitivity problem subject to constraints - permits designers to directly address and tradeoff multivariable properties at distinct loop breaking points; e.g. at plant outputs and at plant inputs. As such, the environment is particularly powerful for (poorly conditioned) multivariable plants. The Youla parameterization is used to parameterize the set of all stabilizing LTI proper controllers. This is used to convexify the general problem being addressed. Several bases are used to turn the resulting infinite-dimensional problem into a finite-dimensional problem for which there exist many efficient convex optimization algorithms. A simple cutting plane algorithm is used within the environment. Academic and physical examples are presented to illustrate the utility of the environment.
ContributorsPuttannaiah, Karan (Author) / Rodriguez, Armando A (Thesis advisor) / Tsakalis, Konstantinos S (Committee member) / Si, Jennie (Committee member) / Arizona State University (Publisher)
Created2013
Description
Learning by trial-and-error requires retrospective information that whether a past action resulted in a rewarded outcome. Previous outcome in turn may provide information to guide future behavioral adjustment. But the specific contribution of this information to learning a task and the neural representations during the trial-and-error learning process is not well understood. In this dissertation, such learning is analyzed by means of single unit neural recordings in the rats' motor agranular medial (AGm) and agranular lateral (AGl) while the rats learned to perform a directional choice task. Multichannel chronic recordings using implanted microelectrodes in the rat's brain were essential to this study. Also for fundamental scientific investigations in general and for some applications such as brain machine interface, the recorded neural waveforms need to be analyzed first to identify neural action potentials as basic computing units. Prior to analyzing and modeling the recorded neural signals, this dissertation proposes an advanced spike sorting system, the M-Sorter, to extract the action potentials from raw neural waveforms. The M-Sorter shows better or comparable performance compared with two other popular spike sorters under automatic mode. With the sorted action potentials in place, neuronal activity in the AGm and AGl areas in rats during learning of a directional choice task is examined. Systematic analyses suggest that rat's neural activity in AGm and AGl was modulated by previous trial outcomes during learning. Single unit based neural dynamics during task learning are described in detail in the dissertation. Furthermore, the differences in neural modulation between fast and slow learning rats were compared. The results show that the level of neural modulation of previous trial outcome is different in fast and slow learning rats which may in turn suggest an important role of previous trial outcome encoding in learning.
ContributorsYuan, Yu'an (Author) / Si, Jennie (Thesis advisor) / Buneo, Christopher (Committee member) / Santello, Marco (Committee member) / Chae, Junseok (Committee member) / Arizona State University (Publisher)
Created2014
Description
Animals learn to choose a proper action among alternatives according to the circumstance. Through trial-and-error, animals improve their odds by making correct association between their behavioral choices and external stimuli. While there has been an extensive literature on the theory of learning, it is still unclear how individual neurons and a neural network adapt as learning progresses. In this dissertation, single units in the medial and lateral agranular (AGm and AGl) cortices were recorded as rats learned a directional choice task. The task required the rat to make a left/right side lever press if a light cue appeared on the left/right side of the interface panel. Behavior analysis showed that rat's movement parameters during performance of directional choices became stereotyped very quickly (2-3 days) while learning to solve the directional choice problem took weeks to occur. The entire learning process was further broken down to 3 stages, each having similar number of recording sessions (days). Single unit based firing rate analysis revealed that 1) directional rate modulation was observed in both cortices; 2) the averaged mean rate between left and right trials in the neural ensemble each day did not change significantly among the three learning stages; 3) the rate difference between left and right trials of the ensemble did not change significantly either. Besides, for either left or right trials, the trial-to-trial firing variability of single neurons did not change significantly over the three stages. To explore the spatiotemporal neural pattern of the recorded ensemble, support vector machines (SVMs) were constructed each day to decode the direction of choice in single trials. Improved classification accuracy indicated enhanced discriminability between neural patterns of left and right choices as learning progressed. When using a restricted Boltzmann machine (RBM) model to extract features from neural activity patterns, results further supported the idea that neural firing patterns adapted during the three learning stages to facilitate the neural codes of directional choices. Put together, these findings suggest a spatiotemporal neural coding scheme in a rat AGl and AGm neural ensemble that may be responsible for and contributing to learning the directional choice task.
ContributorsMao, Hongwei (Author) / Si, Jennie (Thesis advisor) / Buneo, Christopher (Committee member) / Cao, Yu (Committee member) / Santello, Marco (Committee member) / Arizona State University (Publisher)
Created2014
Description
To uncover the neural correlates to go-directed behavior, single unit action potentials are considered fundamental computing units and have been examined by different analytical methodologies under a broad set of hypotheses. Using a behaving rat performing a directional choice learning task, we aim to study changes in rat's cortical neural patterns while he improved his task performance accuracy from chance to 80% or higher. Specifically, simultaneous multi-channel single unit neural recordings from the rat's agranular medial (AGm) and Agranular lateral (AGl) cortices were analyzed using joint peristimulus time histogram (JPSTHs), which effectively unveils firing coincidences in neural action potentials. My results based on data from six rats revealed that coincidences of pair-wise neural action potentials are higher when rats were performing the task than they were not at the learning stage, and this trend abated after the rats learned the task. Another finding is that the coincidences at the learning stage are stronger than that when the rats learned the task especially when they were performing the task. Therefore, this coincidence measure is the highest when the rats were performing the task at the learning stage. This may suggest that neural coincidences play a role in the coordination and communication among populations of neurons engaged in a purposeful act. Additionally, attention and working memory may have contributed to the modulation of neural coincidences during the designed task.
ContributorsCheng, Bing (Author) / Si, Jennie (Thesis advisor) / Chae, Junseok (Committee member) / Seo, Jae-Sun (Committee member) / Arizona State University (Publisher)
Created2014
Description
The RAS/MAPK (RAS/Mitogen Activated Protein Kinase) pathway is a highly conserved, canonical signaling cascade that is highly involved in cellular growth and proliferation as well as cell migration. As such, it plays an important role in development, specifically in development of the nervous system. Activation of ERK is indispensable for the differentiation of Embryonic Stem Cells (ESC) into neuronal precursors (Li z et al, 2006). ERK signaling has also shown to mediate Schwann cell myelination of the peripheral nervous system (PNS) as well as oligodendrocyte proliferation (Newbern et al, 2011). The class of developmental disorders that result in the dysregulation of RAS signaling are known as RASopathies. The molecular and cell-specific consequences of these various pathway mutations remain to be elucidated. While there is evidence for altered DNA transcription in RASopathies, there is little work examining the effects of the RASopathy-linked mutations on protein translation and post-translational modifications in vivo. RASopathies have phenotypic and molecular similarities to other disorders such as Fragile X Syndrome (FXS) and Tuberous Sclerosis (TSC) that show evidence of aberrant protein synthesis and affect related pathways. There are also well-defined downstream RAS pathway elements involved in translation. Additionally, aberrant corticospinal axon outgrowth has been observed in disease models of RASopathies (Xing et al, 2016). For these reasons, this present study examines a subset of proteins involved in translation and translational regulation in the context of RASopathy disease states. Results indicate that in both of the tested RASopathy model systems, there is altered mTOR expression. Additionally the loss of function model showed a decrease in rps6 activation. This data supports a role for the selective dysregulation of translational control elements in RASopathy models. This data also indicates that the primary candidate mechanism for control of altered translation in these modes is through the altered expression of mTOR.
ContributorsHilbert, Alexander Robert (Author) / Newbern, Jason (Thesis director) / Olive, M. Foster (Committee member) / Bjorklund, Reed (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
This dissertation examines modeling, design and control challenges associatedwith two classes of power converters: a direct current-direct current (DC-DC) step-down (buck)
regulator and a 3-phase (3-ϕ) 4-wire direct current-alternating current
(DC-AC) inverter. These are widely used for power transfer in a variety of industrial
and personal applications. This motivates the precise quantification of conditions
under which existing modeling and design methods yield satisfactory designs, and
the study of alternatives when they don’t. This dissertation describes a method
utilizing Fourier components of the input square wave and the inductor-capacitor (LC)
filter transfer function, which doesn’t require the small ripple approximation. Then,
trade-offs associated with the choice of the filter order are analyzed for integrated buck
converters with a constraint on their chip area. Design specifications which would
justify using a fourth or sixth order filter instead of the widely used second order
one are examined. Next, sampled-data (SD) control of a buck converter is analyzed.
Three methods for the digital controller design are studied: analog design followed
by discretization, direct digital design of a discretized plant, and a “lifting” based
method wherein the sampling time is incorporated in the design process by lifting
the continuous-time design plant before doing the controller design. Specifically,
controller performance is quantified by studying the induced-L2 norm of the closed
loop system for a range of switching/sampling frequencies. In the final segment of
this dissertation, the inner-outer control loop, employed in inverters with an
inductor-capacitor-inductor (LCL) output filter, is studied. Closed loop sensitivities for the
loop broken at the error and the control are examined, demonstrating that traditional
methods only address these properties for one loop-breaking point. New controllers
are then provided for improving both sets of properties.
ContributorsSarkar, Aratrik (Author) / Rodriguez, Armando A (Thesis advisor) / Si, Jennie (Committee member) / Mittelmann, Hans D (Committee member) / Tsakalis, Konstantinos (Committee member) / Arizona State University (Publisher)
Created2021
Description
Over the past few decades, there is an increase in demand for various ground robot applications such as warehouse management, surveillance, mapping, infrastructure inspection, etc. This steady increase in demand has led to a significant rise in the nonholonomic differential drive vehicles (DDV) research. Albeit extensive work has been done in developing various control laws for trajectory tracking, point stabilization, formation control, etc., there are still problems and critical questions in regards to design, modeling, and control of DDV’s - that need to be adequately addressed. In this thesis, three different dynamical models are considered that are formed by varying the input/output parameters of the DDV model. These models are analyzed to understand their stability, bandwidth, input-output coupling, and control design properties. Furthermore, a systematic approach has been presented to show the impact of design parameters such as mass, inertia, radius of the wheels, and center of gravity location on the dynamic and inner-loop (speed) control design properties. Subsequently, extensive simulation and hardware trade studies have been conductedto quantify the impact of design parameters and modeling variations on the performance of outer-loop cruise and position control (along a curve). In addition to this, detailed guidelines are provided for when a multi-input multi-output (MIMO) control strategy is advisable over a single-input single-output (SISO) control strategy; when a less stable plant is preferable over a more stable one in order to accommodate performance specifications. Additionally, a multi-robot trajectory tracking implementation based on receding horizon optimization approach is also presented. In most of the optimization-based trajectory tracking approaches found in the literature, only the constraints imposed by the kinematic model are incorporated into the problem. This thesis elaborates the fundamental problem associated with these methods and presents a systematic approach to understand and quantify when kinematic model based constraints are sufficient and when dynamic model-based constraints are necessary to obtain good tracking properties. Detailed instructions are given for designing and building the DDV based on performance specifications, and also, an open-source platform capable of handling high-speed multi-robot research is developed in C++.
ContributorsManne, Sai Sravan (Author) / Rodriguez, Armando A (Thesis advisor) / Si, Jennie (Committee member) / Berman, Spring (Committee member) / Arizona State University (Publisher)
Created2021