Matching Items (9)
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- All Subjects: Electric power system stability
- All Subjects: Neurobiology
- Creators: Si, Jennie
Description
Learning by trial-and-error requires retrospective information that whether a past action resulted in a rewarded outcome. Previous outcome in turn may provide information to guide future behavioral adjustment. But the specific contribution of this information to learning a task and the neural representations during the trial-and-error learning process is not well understood. In this dissertation, such learning is analyzed by means of single unit neural recordings in the rats' motor agranular medial (AGm) and agranular lateral (AGl) while the rats learned to perform a directional choice task. Multichannel chronic recordings using implanted microelectrodes in the rat's brain were essential to this study. Also for fundamental scientific investigations in general and for some applications such as brain machine interface, the recorded neural waveforms need to be analyzed first to identify neural action potentials as basic computing units. Prior to analyzing and modeling the recorded neural signals, this dissertation proposes an advanced spike sorting system, the M-Sorter, to extract the action potentials from raw neural waveforms. The M-Sorter shows better or comparable performance compared with two other popular spike sorters under automatic mode. With the sorted action potentials in place, neuronal activity in the AGm and AGl areas in rats during learning of a directional choice task is examined. Systematic analyses suggest that rat's neural activity in AGm and AGl was modulated by previous trial outcomes during learning. Single unit based neural dynamics during task learning are described in detail in the dissertation. Furthermore, the differences in neural modulation between fast and slow learning rats were compared. The results show that the level of neural modulation of previous trial outcome is different in fast and slow learning rats which may in turn suggest an important role of previous trial outcome encoding in learning.
ContributorsYuan, Yu'an (Author) / Si, Jennie (Thesis advisor) / Buneo, Christopher (Committee member) / Santello, Marco (Committee member) / Chae, Junseok (Committee member) / Arizona State University (Publisher)
Created2014
Description
Animals learn to choose a proper action among alternatives according to the circumstance. Through trial-and-error, animals improve their odds by making correct association between their behavioral choices and external stimuli. While there has been an extensive literature on the theory of learning, it is still unclear how individual neurons and a neural network adapt as learning progresses. In this dissertation, single units in the medial and lateral agranular (AGm and AGl) cortices were recorded as rats learned a directional choice task. The task required the rat to make a left/right side lever press if a light cue appeared on the left/right side of the interface panel. Behavior analysis showed that rat's movement parameters during performance of directional choices became stereotyped very quickly (2-3 days) while learning to solve the directional choice problem took weeks to occur. The entire learning process was further broken down to 3 stages, each having similar number of recording sessions (days). Single unit based firing rate analysis revealed that 1) directional rate modulation was observed in both cortices; 2) the averaged mean rate between left and right trials in the neural ensemble each day did not change significantly among the three learning stages; 3) the rate difference between left and right trials of the ensemble did not change significantly either. Besides, for either left or right trials, the trial-to-trial firing variability of single neurons did not change significantly over the three stages. To explore the spatiotemporal neural pattern of the recorded ensemble, support vector machines (SVMs) were constructed each day to decode the direction of choice in single trials. Improved classification accuracy indicated enhanced discriminability between neural patterns of left and right choices as learning progressed. When using a restricted Boltzmann machine (RBM) model to extract features from neural activity patterns, results further supported the idea that neural firing patterns adapted during the three learning stages to facilitate the neural codes of directional choices. Put together, these findings suggest a spatiotemporal neural coding scheme in a rat AGl and AGm neural ensemble that may be responsible for and contributing to learning the directional choice task.
ContributorsMao, Hongwei (Author) / Si, Jennie (Thesis advisor) / Buneo, Christopher (Committee member) / Cao, Yu (Committee member) / Santello, Marco (Committee member) / Arizona State University (Publisher)
Created2014
Description
To uncover the neural correlates to go-directed behavior, single unit action potentials are considered fundamental computing units and have been examined by different analytical methodologies under a broad set of hypotheses. Using a behaving rat performing a directional choice learning task, we aim to study changes in rat's cortical neural patterns while he improved his task performance accuracy from chance to 80% or higher. Specifically, simultaneous multi-channel single unit neural recordings from the rat's agranular medial (AGm) and Agranular lateral (AGl) cortices were analyzed using joint peristimulus time histogram (JPSTHs), which effectively unveils firing coincidences in neural action potentials. My results based on data from six rats revealed that coincidences of pair-wise neural action potentials are higher when rats were performing the task than they were not at the learning stage, and this trend abated after the rats learned the task. Another finding is that the coincidences at the learning stage are stronger than that when the rats learned the task especially when they were performing the task. Therefore, this coincidence measure is the highest when the rats were performing the task at the learning stage. This may suggest that neural coincidences play a role in the coordination and communication among populations of neurons engaged in a purposeful act. Additionally, attention and working memory may have contributed to the modulation of neural coincidences during the designed task.
ContributorsCheng, Bing (Author) / Si, Jennie (Thesis advisor) / Chae, Junseok (Committee member) / Seo, Jae-Sun (Committee member) / Arizona State University (Publisher)
Created2014
Description
With growing complexity of power grid interconnections, power systems may become increasingly vulnerable to low frequency oscillations (especially inter-area oscillations) and dependent on stabilizing controls using either local signals or wide-area signals to provide adequate damping. In recent years, the ability and potential to use wide-area signals for control purposes has increased since a significant investment has been made in the U. S. in deploying synchrophasor measurement technology. Fast and reliable communication systems are essential to enable the use of wide-area signals in controls. If wide-area signals find increased applicability in controls the security and reliability of power systems could be vulnerable to disruptions in communication systems. Even though numerous modern techniques have been developed to lower the probability of communication errors, communication networks cannot be designed to be always reliable. Given this background the motivation of this work is to build resiliency in the power grid controls to respond to failures in the communication network when wide-area control signals are used. In addition, this work also deals with the delay uncertainty associated with the wide-area signal transmission. In order to counteract the negative impact of communication failures on control effectiveness, two approaches are proposed and both approaches are motivated by considering the use of a robustly designed supplementary damping control (SDC) framework associated with a static VAr compensator (SVC). When there is no communication failure, the designed controller guarantees enhanced improvement in damping performance. When the wide-area signal in use is lost due to a communication failure, however, the resilient control provides the required damping of the inter-area oscillations by either utilizing another wide-area measurement through a healthy communication route or by simply utilizing an appropriate local control signal. Simulation results prove that with either of the proposed controls included, the system is stabilized regardless of communication failures, and thereby the reliability and sustainability of power systems is improved. The proposed approaches can be extended without loss of generality to the design of any resilient controller in cyber-physical engineering systems.
ContributorsZhang, Song (Author) / Vittal, Vijay (Thesis advisor) / Heydt, Gerald (Committee member) / Si, Jennie (Committee member) / Undrill, John (Committee member) / Arizona State University (Publisher)
Created2014
Description
Due to restructuring and open access to the transmission system, modern electric power systems are being operated closer to their operational limits. Additionally, the secure operational limits of modern power systems have become increasingly difficult to evaluate as the scale of the network and the number of transactions between utilities increase. To account for these challenges associated with the rapid expansion of electric power systems, dynamic equivalents have been widely applied for the purpose of reducing the computational effort of simulation-based transient security assessment. Dynamic equivalents are commonly developed using a coherency-based approach in which a retained area and an external area are first demarcated. Then the coherent generators in the external area are aggregated and replaced by equivalenced models, followed by network reduction and load aggregation. In this process, an improperly defined retained area can result in detrimental impacts on the effectiveness of the equivalents in preserving the dynamic characteristics of the original unreduced system. In this dissertation, a comprehensive approach has been proposed to determine an appropriate retained area boundary by including the critical generators in the external area that are tightly coupled with the initial retained area. Further-more, a systematic approach has also been investigated to efficiently predict the variation in generator slow coherency behavior when the system operating condition is subject to change. Based on this determination, the critical generators in the external area that are tightly coherent with the generators in the initial retained area are retained, resulting in a new retained area boundary. Finally, a novel hybrid dynamic equivalent, consisting of both a coherency-based equivalent and an artificial neural network (ANN)-based equivalent, has been proposed and analyzed. The ANN-based equivalent complements the coherency-based equivalent at all the retained area boundary buses, and it is designed to compensate for the discrepancy between the full system and the conventional coherency-based equivalent. The approaches developed have been validated on a large portion of the Western Electricity Coordinating Council (WECC) system and on a test case including a significant portion of the eastern interconnection.
ContributorsMa, Feng (Author) / Vittal, Vijay (Thesis advisor) / Tylavsky, Daniel (Committee member) / Heydt, Gerald (Committee member) / Si, Jennie (Committee member) / Ayyanar, Raja (Committee member) / Arizona State University (Publisher)
Created2011
Description
Contemporary methods for dynamic security assessment (DSA) mainly re-ly on time domain simulations to explore the influence of large disturbances in a power system. These methods are computationally intensive especially when the system operating point changes continually. The trajectory sensitivity method, when implemented and utilized as a complement to the existing DSA time domain simulation routine, can provide valuable insights into the system variation in re-sponse to system parameter changes. The implementation of the trajectory sensitivity analysis is based on an open source power system analysis toolbox called PSAT. Eight categories of sen-sitivity elements have been implemented and tested. The accuracy assessment of the implementation demonstrates the validity of both the theory and the imple-mentation. The computational burden introduced by the additional sensitivity equa-tions is relieved by two innovative methods: one is by employing a cluster to per-form the sensitivity calculations in parallel; the other one is by developing a mod-ified very dishonest Newton method in conjunction with the latest sparse matrix processing technology. The relation between the linear approximation accuracy and the perturba-tion size is also studied numerically. It is found that there is a fixed connection between the linear approximation accuracy and the perturbation size. Therefore this finding can serve as a general application guide to evaluate the accuracy of the linear approximation. The applicability of the trajectory sensitivity approach to a large realistic network has been demonstrated in detail. This research work applies the trajectory sensitivity analysis method to the Western Electricity Coordinating Council (WECC) system. Several typical power system dynamic security problems, in-cluding the transient angle stability problem, the voltage stability problem consid-ering load modeling uncertainty and the transient stability constrained interface real power flow limit calculation, have been addressed. Besides, a method based on the trajectory sensitivity approach and the model predictive control has been developed for determination of under frequency load shedding strategy for real time stability assessment. These applications have shown the great efficacy and accuracy of the trajectory sensitivity method in handling these traditional power system stability problems.
ContributorsHou, Guanji (Author) / Vittal, Vijay (Thesis advisor) / Heydt, Gerald (Committee member) / Tylavsky, Daniel (Committee member) / Si, Jennie (Committee member) / Arizona State University (Publisher)
Created2012
Description
In electric power systems, phasor measurement units (PMUs) are capable of providing synchronized voltage and current phasor measurements which are superior to conventional measurements collected by the supervisory control and data acquisition (SCADA) system in terms of resolution and accuracy. These measurements are known as synchrophasor measurements. Considerable research work has been done on the applications of PMU measurements based on the as-sumption that a high level of accuracy is obtained in the field. The study in this dissertation is conducted to address the basic issue concerning the accuracy of actual PMU measurements in the field. Synchronization is one of the important features of PMU measurements. However, the study presented in this dissertation reveals that the problem of faulty synchronization between measurements with the same time stamps from different PMUs exists. A Kalman filter model is proposed to analyze and calcu-late the time skew error caused by faulty synchronization. In order to achieve a high level of accuracy of PMU measurements, inno-vative methods are proposed to detect and identify system state changes or bad data which are reflected by changes in the measurements. This procedure is ap-plied as a key step in adaptive Kalman filtering of PMU measurements to over-come the insensitivity of a conventional Kalman filter. Calibration of PMU measurements is implemented in specific PMU instal-lation scenarios using transmission line (TL) parameters from operation planning data. The voltage and current correction factors calculated from the calibration procedure indicate the possible errors in PMU measurements. Correction factors can be applied in on-line calibration of PMU measurements. A study is conducted to address an important issue when integrating PMU measurements into state estimation. The reporting rate of PMU measurements is much higher than that of the measurements collected by the SCADA. The ques-tion of how to buffer PMU measurements is raised. The impact of PMU meas-urement buffer length on state estimation is discussed. A method based on hy-pothesis testing is proposed to determine the optimal buffer length of PMU meas-urements considering the two conflicting features of PMU measurements, i. e. un-certainty and variability. Results are presented for actual PMU synchrophasor measurements.
ContributorsZhang, Qing (Author) / Heydt, Gerald (Thesis advisor) / Vittal, Vijay (Thesis advisor) / Ayyanar, Raja (Committee member) / Si, Jennie (Committee member) / Arizona State University (Publisher)
Created2012
Description
Rasopathies are a family of developmental syndromes that exhibit craniofacial abnormalities, cognitive disabilities, developmental delay and increased risk of cancer. However, little is known about the pathogenesis of developmental defects in the nervous system. Frequently, gain-of-function mutations in the Ras/Raf/MEK/ERK cascade (aka ERK/MAPK) are associated with the observed pathogenesis. My research focuses on defining the relationship between increased ERK/MAPK signaling and its effects on the nervous system, specifically in the context of motor learning. Motor function depends on several neuroanatomically distinct regions, especially the spinal cord, cerebellum, striatum, and cerebral cortex. We tested whether hyperactivation of ERK/MAPK specifically in the cortex was sufficient to drive changes in motor function. We used a series of genetically modified mouse models and cre-lox technology to hyperactivate ERK/MAPK in the cerebral cortex. Nex:Cre/NeuroD6:Cre was employed to express a constitutively active MEK mutation throughout all layers of the cerebral cortex from an early stage of development. RBP4:Cre, caMEK only exhibited hyper activation in cortical glutamatergic neurons responsible for cortical output (neurons in layer V of the cerebral cortex). First, the two mouse strains were tested in an open field paradigm to assess global locomotor abilities and overall fitness for fine motor tasks. Next, a skilled motor reaching task was used to evaluate motor learning capabilities. The results show that Nex:Cre/NeuroD6:Cre, caMEK mutants do not learn the motor reaching task, although they performed normally on the open field task. Preliminary results suggest RBP4:Cre, caMEK mutants exhibit normal locomotor capabilities and a partial lack of learning. The difference in motor learning capabilities might be explained by the extent of altered connectivity in different regions of the corticospinal tract. Once we have identified the neuropathological effects of various layers in the cortex we will be able to determine whether therapeutic interventions are sufficient to reverse these learning defects.
ContributorsRoose, Cassandra Ann (Author) / Newbern, Jason M. (Thesis director) / Olive, Foster (Committee member) / Bjorklund, Reed (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
The RAS/MAPK (RAS/Mitogen Activated Protein Kinase) pathway is a highly conserved, canonical signaling cascade that is highly involved in cellular growth and proliferation as well as cell migration. As such, it plays an important role in development, specifically in development of the nervous system. Activation of ERK is indispensable for the differentiation of Embryonic Stem Cells (ESC) into neuronal precursors (Li z et al, 2006). ERK signaling has also shown to mediate Schwann cell myelination of the peripheral nervous system (PNS) as well as oligodendrocyte proliferation (Newbern et al, 2011). The class of developmental disorders that result in the dysregulation of RAS signaling are known as RASopathies. The molecular and cell-specific consequences of these various pathway mutations remain to be elucidated. While there is evidence for altered DNA transcription in RASopathies, there is little work examining the effects of the RASopathy-linked mutations on protein translation and post-translational modifications in vivo. RASopathies have phenotypic and molecular similarities to other disorders such as Fragile X Syndrome (FXS) and Tuberous Sclerosis (TSC) that show evidence of aberrant protein synthesis and affect related pathways. There are also well-defined downstream RAS pathway elements involved in translation. Additionally, aberrant corticospinal axon outgrowth has been observed in disease models of RASopathies (Xing et al, 2016). For these reasons, this present study examines a subset of proteins involved in translation and translational regulation in the context of RASopathy disease states. Results indicate that in both of the tested RASopathy model systems, there is altered mTOR expression. Additionally the loss of function model showed a decrease in rps6 activation. This data supports a role for the selective dysregulation of translational control elements in RASopathy models. This data also indicates that the primary candidate mechanism for control of altered translation in these modes is through the altered expression of mTOR.
ContributorsHilbert, Alexander Robert (Author) / Newbern, Jason (Thesis director) / Olive, M. Foster (Committee member) / Bjorklund, Reed (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05