Matching Items (7)
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- All Subjects: Speech Perception
- Creators: Azuma, Tamiko
Description
Two groups of cochlear implant (CI) listeners were tested for sound source localization and for speech recognition in complex listening environments. One group (n=11) wore bilateral CIs and, potentially, had access to interaural level difference (ILD) cues, but not interaural timing difference (ITD) cues. The second group (n=12) wore a single CI and had low-frequency, acoustic hearing in both the ear contralateral to the CI and in the implanted ear. These `hearing preservation' listeners, potentially, had access to ITD cues but not to ILD cues. At issue in this dissertation was the value of the two types of information about sound sources, ITDs and ILDs, for localization and for speech perception when speech and noise sources were separated in space. For Experiment 1, normal hearing (NH) listeners and the two groups of CI listeners were tested for sound source localization using a 13 loudspeaker array. For the NH listeners, the mean RMS error for localization was 7 degrees, for the bilateral CI listeners, 20 degrees, and for the hearing preservation listeners, 23 degrees. The scores for the two CI groups did not differ significantly. Thus, both CI groups showed equivalent, but poorer than normal, localization. This outcome using the filtered noise bands for the normal hearing listeners, suggests ILD and ITD cues can support equivalent levels of localization. For Experiment 2, the two groups of CI listeners were tested for speech recognition in noise when the noise sources and targets were spatially separated in a simulated `restaurant' environment and in two versions of a `cocktail party' environment. At issue was whether either CI group would show benefits from binaural hearing, i.e., better performance when the noise and targets were separated in space. Neither of the CI groups showed spatial release from masking. However, both groups showed a significant binaural advantage (a combination of squelch and summation), which also maintained separation of the target and noise, indicating the presence of some binaural processing or `unmasking' of speech in noise. Finally, localization ability in Experiment 1 was not correlated with binaural advantage in Experiment 2.
ContributorsLoiselle, Louise (Author) / Dorman, Michael F. (Thesis advisor) / Yost, William A. (Thesis advisor) / Azuma, Tamiko (Committee member) / Liss, Julie (Committee member) / Arizona State University (Publisher)
Created2013
Description
A multitude of individuals across the globe suffer from hearing loss and that number continues to grow. Cochlear implants, while having limitations, provide electrical input for users enabling them to "hear" and more fully interact socially with their environment. There has been a clinical shift to the bilateral placement of implants in both ears and to bimodal placement of a hearing aid in the contralateral ear if residual hearing is present. However, there is potentially more to subsequent speech perception for bilateral and bimodal cochlear implant users than the electric and acoustic input being received via these modalities. For normal listeners vision plays a role and Rosenblum (2005) points out it is a key feature of an integrated perceptual process. Logically, cochlear implant users should also benefit from integrated visual input. The question is how exactly does vision provide benefit to bilateral and bimodal users. Eight (8) bilateral and 5 bimodal participants received randomized experimental phrases previously generated by Liss et al. (1998) in auditory and audiovisual conditions. The participants recorded their perception of the input. Data were consequently analyzed for percent words correct, consonant errors, and lexical boundary error types. Overall, vision was found to improve speech perception for bilateral and bimodal cochlear implant participants. Each group experienced a significant increase in percent words correct when visual input was added. With vision bilateral participants reduced consonant place errors and demonstrated increased use of syllabic stress cues used in lexical segmentation. Therefore, results suggest vision might provide perceptual benefits for bilateral cochlear implant users by granting access to place information and by augmenting cues for syllabic stress in the absence of acoustic input. On the other hand vision did not provide the bimodal participants significantly increased access to place and stress cues. Therefore the exact mechanism by which bimodal implant users improved speech perception with the addition of vision is unknown. These results point to the complexities of audiovisual integration during speech perception and the need for continued research regarding the benefit vision provides to bilateral and bimodal cochlear implant users.
ContributorsLudwig, Cimarron (Author) / Liss, Julie (Thesis advisor) / Dorman, Michael (Committee member) / Azuma, Tamiko (Committee member) / Arizona State University (Publisher)
Created2015
Description
In the noise and commotion of daily life, people achieve effective communication partly because spoken messages are replete with redundant information. Listeners exploit available contextual, linguistic, phonemic, and prosodic cues to decipher degraded speech. When other cues are absent or ambiguous, phonemic and prosodic cues are particularly important because they help identify word boundaries, a process known as lexical segmentation. Individuals vary in the degree to which they rely on phonemic or prosodic cues for lexical segmentation in degraded conditions.
Deafened individuals who use a cochlear implant have diminished access to fine frequency information in the speech signal, and show resulting difficulty perceiving phonemic and prosodic cues. Auditory training on phonemic elements improves word recognition for some listeners. Little is known, however, about the potential benefits of prosodic training, or the degree to which individual differences in cue use affect outcomes.
The present study used simulated cochlear implant stimulation to examine the effects of phonemic and prosodic training on lexical segmentation. Participants completed targeted training with either phonemic or prosodic cues, and received passive exposure to the non-targeted cue. Results show that acuity to the targeted cue improved after training. In addition, both targeted attention and passive exposure to prosodic features led to increased use of these cues for lexical segmentation. Individual differences in degree and source of benefit point to the importance of personalizing clinical intervention to increase flexible use of a range of perceptual strategies for understanding speech.
Deafened individuals who use a cochlear implant have diminished access to fine frequency information in the speech signal, and show resulting difficulty perceiving phonemic and prosodic cues. Auditory training on phonemic elements improves word recognition for some listeners. Little is known, however, about the potential benefits of prosodic training, or the degree to which individual differences in cue use affect outcomes.
The present study used simulated cochlear implant stimulation to examine the effects of phonemic and prosodic training on lexical segmentation. Participants completed targeted training with either phonemic or prosodic cues, and received passive exposure to the non-targeted cue. Results show that acuity to the targeted cue improved after training. In addition, both targeted attention and passive exposure to prosodic features led to increased use of these cues for lexical segmentation. Individual differences in degree and source of benefit point to the importance of personalizing clinical intervention to increase flexible use of a range of perceptual strategies for understanding speech.
ContributorsHelms Tillery, Augusta Katherine (Author) / Liss, Julie M. (Thesis advisor) / Azuma, Tamiko (Committee member) / Brown, Christopher A. (Committee member) / Dorman, Michael F. (Committee member) / Utianski, Rene L. (Committee member) / Arizona State University (Publisher)
Created2015
Description
Distorted vowel production is a hallmark characteristic of dysarthric speech, irrespective of the underlying neurological condition or dysarthria diagnosis. A variety of acoustic metrics have been used to study the nature of vowel production deficits in dysarthria; however, not all demonstrate sensitivity to the exhibited deficits. Less attention has been paid to quantifying the vowel production deficits associated with the specific dysarthrias. Attempts to characterize the relationship between naturally degraded vowel production in dysarthria with overall intelligibility have met with mixed results, leading some to question the nature of this relationship. It has been suggested that aberrant vowel acoustics may be an index of overall severity of the impairment and not an "integral component" of the intelligibility deficit. A limitation of previous work detailing perceptual consequences of disordered vowel acoustics is that overall intelligibility, not vowel identification accuracy, has been the perceptual measure of interest. A series of three experiments were conducted to address the problems outlined herein. The goals of the first experiment were to identify subsets of vowel metrics that reliably distinguish speakers with dysarthria from non-disordered speakers and differentiate the dysarthria subtypes. Vowel metrics that capture vowel centralization and reduced spectral distinctiveness among vowels differentiated dysarthric from non-disordered speakers. Vowel metrics generally failed to differentiate speakers according to their dysarthria diagnosis. The second and third experiments were conducted to evaluate the relationship between degraded vowel acoustics and the resulting percept. In the second experiment, correlation and regression analyses revealed vowel metrics that capture vowel centralization and distinctiveness and movement of the second formant frequency were most predictive of vowel identification accuracy and overall intelligibility. The third experiment was conducted to evaluate the extent to which the nature of the acoustic degradation predicts the resulting percept. Results suggest distinctive vowel tokens are better identified and, likewise, better-identified tokens are more distinctive. Further, an above-chance level agreement between nature of vowel misclassification and misidentification errors was demonstrated for all vowels, suggesting degraded vowel acoustics are not merely an index of severity in dysarthria, but rather are an integral component of the resultant intelligibility disorder.
ContributorsLansford, Kaitlin L (Author) / Liss, Julie M (Thesis advisor) / Dorman, Michael F. (Committee member) / Azuma, Tamiko (Committee member) / Lotto, Andrew J (Committee member) / Arizona State University (Publisher)
Created2012
The neurobiology of sentence comprehension: an fMRI study of late American Sign Language acquisition
Description
Language acquisition is a phenomenon we all experience, and though it is well studied many questions remain regarding the neural bases of language. Whether a hearing speaker or Deaf signer, spoken and signed language acquisition (with eventual proficiency) develop similarly and share common neural networks. While signed language and spoken language engage completely different sensory modalities (visual-manual versus the more common auditory-oromotor) both languages share grammatical structures and contain syntactic intricacies innate to all languages. Thus, studies of multi-modal bilingualism (e.g. a native English speaker learning American Sign Language) can lead to a better understanding of the neurobiology of second language acquisition, and of language more broadly. For example, can the well-developed visual-spatial processing networks in English speakers support grammatical processing in sign language, as it relies heavily on location and movement? The present study furthers the understanding of the neural correlates of second language acquisition by studying late L2 normal hearing learners of American Sign Language (ASL). Twenty English speaking ASU students enrolled in advanced American Sign Language coursework participated in our functional Magnetic Resonance Imaging (fMRI) study. The aim was to identify the brain networks engaged in syntactic processing of ASL sentences in late L2 ASL learners. While many studies have addressed the neurobiology of acquiring a second spoken language, no previous study to our knowledge has examined the brain networks supporting syntactic processing in bimodal bilinguals. We examined the brain networks engaged while perceiving ASL sentences compared to ASL word lists, as well as written English sentences and word lists. We hypothesized that our findings in late bimodal bilinguals would largely coincide with the unimodal bilingual literature, but with a few notable differences including additional attention networks being engaged by ASL processing. Our results suggest that there is a high degree of overlap in sentence processing networks for ASL and English. There also are important differences in regards to the recruitment of speech comprehension, visual-spatial and domain-general brain networks. Our findings suggest that well-known sentence comprehension and syntactic processing regions for spoken languages are flexible and modality-independent.
ContributorsMickelsen, Soren Brooks (Co-author) / Johnson, Lisa (Co-author) / Rogalsky, Corianne (Thesis director) / Azuma, Tamiko (Committee member) / Howard, Pamela (Committee member) / Department of Speech and Hearing Science (Contributor) / School of Human Evolution and Social Change (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Working memory and cognitive functions contribute to speech recognition in normal hearing and hearing impaired listeners. In this study, auditory and cognitive functions are measured in young adult normal hearing, elderly normal hearing, and elderly cochlear implant subjects. The effects of age and hearing on the different measures are investigated. The correlations between auditory/cognitive functions and speech/music recognition are examined. The results may demonstrate which factors can better explain the variable performance across elderly cochlear implant users.
ContributorsKolberg, Courtney Elizabeth (Author) / Luo, Xin (Thesis director) / Azuma, Tamiko (Committee member) / Department of Speech and Hearing Science (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
The RAS/MAPK (RAS/Mitogen Activated Protein Kinase) pathway is a highly conserved, canonical signaling cascade that is highly involved in cellular growth and proliferation as well as cell migration. As such, it plays an important role in development, specifically in development of the nervous system. Activation of ERK is indispensable for the differentiation of Embryonic Stem Cells (ESC) into neuronal precursors (Li z et al, 2006). ERK signaling has also shown to mediate Schwann cell myelination of the peripheral nervous system (PNS) as well as oligodendrocyte proliferation (Newbern et al, 2011). The class of developmental disorders that result in the dysregulation of RAS signaling are known as RASopathies. The molecular and cell-specific consequences of these various pathway mutations remain to be elucidated. While there is evidence for altered DNA transcription in RASopathies, there is little work examining the effects of the RASopathy-linked mutations on protein translation and post-translational modifications in vivo. RASopathies have phenotypic and molecular similarities to other disorders such as Fragile X Syndrome (FXS) and Tuberous Sclerosis (TSC) that show evidence of aberrant protein synthesis and affect related pathways. There are also well-defined downstream RAS pathway elements involved in translation. Additionally, aberrant corticospinal axon outgrowth has been observed in disease models of RASopathies (Xing et al, 2016). For these reasons, this present study examines a subset of proteins involved in translation and translational regulation in the context of RASopathy disease states. Results indicate that in both of the tested RASopathy model systems, there is altered mTOR expression. Additionally the loss of function model showed a decrease in rps6 activation. This data supports a role for the selective dysregulation of translational control elements in RASopathy models. This data also indicates that the primary candidate mechanism for control of altered translation in these modes is through the altered expression of mTOR.
ContributorsHilbert, Alexander Robert (Author) / Newbern, Jason (Thesis director) / Olive, M. Foster (Committee member) / Bjorklund, Reed (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05