Matching Items (6)
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- All Subjects: Traumatic Brain Injury
- All Subjects: Infants
- Creators: LaBelle, Jeffrey
- Member of: Barrett, The Honors College Thesis/Creative Project Collection
Description
The purpose of this research was to determine and evaluate glutamate oxidase's ability to detect levels of glutamate as part of a working sensor capable of quantifying and detecting stress within the body in the case of adverse neurological events such as traumatic brain injury. Using electrochemical impedance spectroscopy (EIS), a linear dynamic range of glutamate was detected with a slope of 36.604 z/ohm/[pg/mL], a lower detection limit at 12.417 pg/mL, correlation of 0.97, and an optimal binding frequency of 117.20 Hz. After running through a frequency sweep the binding frequency was determined based on the highest consistent reproducibility and slope. The sensor was found to be specific against literature researched non-targets glucose, albumin, and epinephrine and working in dilutions of whole blood up to a concentration of 25%. With the implementation of Nafion, the sensor had a 250% improvement in signal and 155% improvement in correlation in 90% whole blood, illustrating the promise of a working blood sensor. Future work includes longitudinal studies and utilizing mesoporous carbon as the immobilization platform and incorporating this as part of a continuous, multiplexed blood sensor with glucose oxidase.
ContributorsLam, Alexandria Nicole (Author) / LaBelle, Jeffrey (Thesis director) / Ankeny, Casey (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
DescriptionMy main goal for my thesis is in conjunction with the research I started in the summer of 2010 regarding the creation of a TBI continuous-time sensor. Such goals include: characterizing the proteins in sensing targets while immobilized, while free in solution, and while in free solution in the blood.
ContributorsHaselwood, Brittney (Author) / LaBelle, Jeffrey (Thesis director) / Pizziconi, Vincent (Committee member) / Cook, Curtiss (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2011-12
Description
The Baby Friendly Hospital Initiative (BFHI) was created in 1991 with the goal to provide support and education to mothers on breastfeeding in order to increase the rate and duration of breastfeeding across the world. Despite being around for over 20 years, it has only been successfully incorporated into 245 hospitals in the United States as of 2015. Due to the many benefits this initiative brings to mothers, infants, and the hospitals themselves as well as being shown to increase the incidence, duration, and exclusivity of breastfeeding, the goal of this project was to create a mother friendly brochure sharing this. The brochure was created in order to spread the word of the BFHI to expecting mothers so that they are informed and able to use this information to not only improve their own child-birthing experience but also push for implementation in their delivering facilities. The brochure covers additional topics such as breastfeeding benefits and tips, lactation resources, and steps to incorporate into their own hospital stay if outside of a BFHI facility in order to get a few of the benefits that the Baby Friendly Initiative provides. The brochure was tested for clarity, effectiveness, and for overall reactions in a study conducted at a local women's clinic surveying expectant mothers through the use of a short survey. These results were used to make minor improvements to the brochure before moving on to plans of how to disseminate the brochure to more clinics within the Phoenix area. The dissemination of this brochure will share this important information with women of childbearing age and hopefully lead to greater knowledge and progress towards improved maternal and neonatal outcomes.
ContributorsGunnare, Chrystina Jean (Author) / Whisner, Corrie (Thesis director) / Bever, Jennie (Committee member) / Barrett, The Honors College (Contributor) / School of Nutrition and Health Promotion (Contributor)
Created2015-05
Description
Concussions and traumatic brain injuries are mechanical events which can derive from no specific activity or event. However, these injuries occur often during athletic and sporting events but many athletes experiencing these symptoms go undiagnosed and continue playing without proper medical attention. The current gold standard for diagnosing athletes with concussions is to have medical professionals on the sidelines of events to perform qualitative standardized assessments which may not be performed frequently enough and are not specialized for each athlete. The purpose of this report is to discuss a study sanctioned by Arizona State University's Project HoneyBee and additional affiliations to validate a third-party mouth guard device product to recognize and detect force impacts blown to an athlete's head during athletic activity. Current technology in health monitoring medical devices can allow users to apply this device as an additional safety mechanism for early concussion awareness and diagnosis. This report includes the materials and methods used for experimentation, the discussion of its results, and the complications which occurred and areas for improvement during the preliminary efforts of this project. Participants in the study were five non-varsity ASU Wrestling athletes who volunteered to wear a third-party mouth guard device during sparring contact at practice. Following a needed calibration period for the devices, results were recorded both through visual observation and with the mouth guard devices using an accelerometer and gyroscope. This study provided a sound understanding for the operation and functionality of the mouth guard devices. The mouth guard devices have the capability to provide fundamental avenues of research for future investigations.
ContributorsTielke, Austin Wyatt (Author) / Ross, Heather (Thesis director) / LaBelle, Jeffrey (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
As of today, there does not exist a cheap diagnostic for lactate for use in trauma centers. $671 billion are spent on trauma accidents and emergency rooms, with money focused on treatments such as YSI and ELISA, costing $1500 and $200, respectively. Gold disk electrodes were used to immobilize lactate dehydrogenase and glucose oxidase, with electrochemical impedance spectroscopy (EIS) used as the method for detection. Two lactate experimental runs were completed with data detailing a linear model and positive correlation for imaginary impedance and concentration, and one glucose experimental run was completed proving that a continuous system can be completed accounting for reaction and consumption using EIS, a process previously not done before.
ContributorsEltohamy, Omar Khaled (Author) / LaBelle, Jeffrey (Thesis director) / Lin, Chi-En (Committee member) / Harrington Bioengineering Program (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
Objectives: To measure nurses' knowledge of breastfeeding, assess nurses' attitudes towards perinatal substance abuse, and identify the perception of breastfeeding infants affected by neonatal abstinence syndrome (NAS). Design: Descriptive study. Setting: Online survey. Participants: Nurses (N=104) who are members of the Association of Women's Health, Obstetric, and Neonatal Nurses (AWHONN) and subscribe to their perinatal listserv were invited to participate via email. Methods: Participants completed a survey, which included a modified version of the Attitudes about Drug Abuse in Pregnancy (AADAP) questionnaire, knowledge questions, and a sociodemographic questionnaire. Statistical analysis was conducted. Results: Most nurses (88.46%) have cared for a newborn affected by NAS or their mother before, and every respondent has cared for an opioid-addicted patient. Most nurse respondents (82.69%) reported breastfeeding being a very common topic of discussion with patients, yet 78 (75%) reported being poorly prepared by nursing school in this topic. Despite this, the majority answered the knowledge questions correctly. Most respondents (94.23%) reported that they would assess the possibility of breastfeeding for women who used drugs during pregnancy, and 39.42% expressed that prenatal drug use should be considered child abuse. Conclusion: Despite feeling angry at mothers who perinatally abuse drugs, nurses recognize the benefits of breastfeeding for these patients. Self-assessment can help nurses identify personal bias and implement evidence-based nursing interventions
ContributorsCostello, Natalie Ann (Author) / Bever, Jennie (Thesis director) / Milowski, Meredith (Committee member) / Arizona State University. College of Nursing & Healthcare Innovation (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05