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Plasmodium Cost of Resistance and Life Stage Development within the Mosquito Vector

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Hundreds of thousands of people die annually from malaria; a protozoan of the genus Plasmodium is responsible for this mortality. The Plasmodium parasite undergoes several life stages within the mosquito vector, the transition between which require passage across the lumen

Hundreds of thousands of people die annually from malaria; a protozoan of the genus Plasmodium is responsible for this mortality. The Plasmodium parasite undergoes several life stages within the mosquito vector, the transition between which require passage across the lumen of the mosquito midgut. It has been observed that in about 15% of parasites that develop ookinetes in the mosquito abdomen, sporozoites never develop in the salivary glands, indicating that passage across the midgut lumen is a significant barrier in parasite development (Gamage-Mendis et al., 1993). We aim to investigate a possible correlation between passage through the midgut lumen and drug-resistance trends in Plasmodium falciparum parasites. This study contains a total of 1024 Anopheles mosquitoes: 187 Anopheles gambiae and 837 Anopheles funestus samples collected in high malaria transmission areas of Mozambique between March and June of 2016. Sanger sequencing will be used to determine the prevalence of known resistance alleles for anti-malarial drugs: chloroquine resistance transporter (pfcrt), multidrug resistance (pfmdr1) gene, dihydropteroate synthase (pfdhps) and dihydrofolate reductase (pfdhfr). We compare prevalence of resistance between abdomen and head/thorax in order to determine whether drug resistant parasites are disproportionately hindered during their passage through the midgut lumen. A statistically significant difference between resistance alleles in the two studied body sections supports the efficacy of new anti-malarial gene surveillance strategies in areas of high malaria transmission.

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2021-05

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(Be)longing and resisting: a narrative excavation of critical ontogeny

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The present study is a narrative representation of two individuals - one, a prison abolitionist living in the Phoenix area and, the other, myself as a writer and scholar - and their development of, negotiations with, desires for, and problematic

The present study is a narrative representation of two individuals - one, a prison abolitionist living in the Phoenix area and, the other, myself as a writer and scholar - and their development of, negotiations with, desires for, and problematic performances of critical dispositions within the contemporary social order. In initiating this research, I framed my process as an exploration of the ways in which people who commit themselves to organized counter-hegemonic movements have developed critical dispositions despite their immersion in the normative discourse of American public schools and the relentless public pedagogies of neoliberal subjectivity and psyche. In essence, I wondered how people had gained both the capacity to perceive - however fleetingly - an outside to doxic structuration and, more difficult yet, to sacrifice the psychic comfort these structures promise for the risky work of creating a more just social order. Via psychoanalytic understandings of identity and desire, these stories explore and represent the primordial learning, experiences, and traumas that guided my informants to resist or reject dominant ontological narratives and normative cultural scripts in order to explore and maintain space - albeit exilic - for their own axiological and ethical development and, ultimately, to take up positions of active, educative resistance.

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2012