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Degeneration in miniature: history of cell death and aging research in the twentieth century

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Once perceived as an unimportant occurrence in living organisms, cell degeneration was reconfigured as an important biological phenomenon in development, aging, health, and diseases in the twentieth century. This dissertation tells a twentieth-century history of scientific investigations on cell degeneration, including cell death and aging. By describing four central developments…

Once perceived as an unimportant occurrence in living organisms, cell degeneration was reconfigured as an important biological phenomenon in development, aging, health, and diseases in the twentieth century. This dissertation tells a twentieth-century history of scientific investigations on cell degeneration, including cell death and aging. By describing four central developments in cell degeneration research with the four major chapters, I trace the emergence of the degenerating cell as a scientific object, describe the generations of a variety of concepts, interpretations and usages associated with cell death and aging, and analyze the transforming influences of the rising cell degeneration research. Particularly, the four chapters show how the changing scientific practices about cellular life in embryology, cell culture, aging research, and molecular biology of Caenorhabditis elegans shaped the interpretations about cell degeneration in the twentieth-century as life-shaping, limit-setting, complex, yet regulated. These events created and consolidated important concepts in life sciences such as programmed cell death, the Hayflick limit, apoptosis, and death genes. These cases also transformed the material and epistemic practices about the end of cellular life subsequently and led to the formations of new research communities. The four cases together show the ways cell degeneration became a shared subject between molecular cell biology, developmental biology, gerontology, oncology, and pathology of degenerative diseases. These practices and perspectives created a special kind of interconnectivity between different fields and led to a level of interdisciplinarity within cell degeneration research by the early 1990s.
ContributorsJiang, Lijing (Author) / Maienschein, Jane (Thesis advisor) / Laubichler, Manfred (Thesis advisor) / Hurlbut, James (Committee member) / Creath, Richard (Committee member) / White, Michael (Committee member) / Arizona State University (Publisher)
Created2013
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Stress and maladaptive coping among police officers

Description
The relationship between stress and policing has long been established in literature. What is less clear, however, is what departments are doing to help officers deal with the stress that comes with the job. Looking at a small Southwestern police agency and using a modified version of Speilberger’s (1981) Police…

The relationship between stress and policing has long been established in literature. What is less clear, however, is what departments are doing to help officers deal with the stress that comes with the job. Looking at a small Southwestern police agency and using a modified version of Speilberger’s (1981) Police Stress Survey, the present study sought to examine stressors inherent to policing, as well as to identify departmental services that may be in place to help officers alleviate those stressors and whether or not police officers would choose to take part in the services that may be offered. The findings suggest that a shift in stress in policing is occurring with operational stressors being reported at higher levels than organizational stressors, contrary to previous research.
ContributorsPadilla, Kathleen (Author) / White, Michael (Thesis advisor) / Telep, Cody (Committee member) / Sweeten, Gary (Committee member) / Arizona State University (Publisher)
Created2016