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Description
Bexarotene (Targretin®) is an FDA approved drug used to treat cutaneous T-cell lymphoma (CTCL), as well as off-label treatments for various cancers and neurodegenerative diseases. Previous research has indicated that bexarotene has a specific affinity for retinoid X receptors (RXR), which allows bexarotene to act as a ligand-activated-transcription factor

Bexarotene (Targretin®) is an FDA approved drug used to treat cutaneous T-cell lymphoma (CTCL), as well as off-label treatments for various cancers and neurodegenerative diseases. Previous research has indicated that bexarotene has a specific affinity for retinoid X receptors (RXR), which allows bexarotene to act as a ligand-activated-transcription factor and in return control cell differentiation and proliferation. Bexarotene targets RXR homodimerization to drive transcription of tumor suppressing genes; however, adverse reactions occur simultaneously when bound to other nuclear receptors. In this study, we used novel bexarotene analogs throughout 5 iterations synthesized in the laboratory of Dr. Wagner to test for their potency and ability to bind RXR. The aim of our study is to quantitatively measure RXR homodimerization driven by bexarotene analogs using a yeast two-hybrid system. Our results suggests there to be several compounds with higher protein activity than bexarotene, particularly in generations 3.0 and 5.0. This higher affinity for RXR homodimers may help scientists identify a compound that will minimize adverse effects and toxicity of bexarotene and serve as a better cancer treatment alternative.
ContributorsSeto, David Hua (Author) / Marshall, Pamela (Thesis director) / Wagner, Carl (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Natural Sciences (Contributor) / School of Social and Behavioral Sciences (Contributor)
Created2015-05
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Description
Bexarotene is a commercially produced drug commonly known as Targetin presecribed to treat cutaneous T-cell lymphoma (CTCL). Bex mimics the actions of natural 9-cis retinoic acid in the body, which are derived from Vitamin A in the diet and boost the immune system. Bex has been shown to be effective

Bexarotene is a commercially produced drug commonly known as Targetin presecribed to treat cutaneous T-cell lymphoma (CTCL). Bex mimics the actions of natural 9-cis retinoic acid in the body, which are derived from Vitamin A in the diet and boost the immune system. Bex has been shown to be effective in the treatment of multiple types of cancer, including lung cancer. However, the disadvantages of using Bex include increased instances of hypothyroidism and excessive concentrations of blood triglycerides. If an analog of Bex can be developed which retains high affinity RXR binding similar to the 9-cis retinoic acid while exhibiting less interference for heterodimerization pathways, it would be of great clinical significance in improving the quality of life for patients with CTCL. This thesis will detail the biological profiling of additional novel (Generation Two) analogs, which are currently in submission for publication, as well as that of Generation Three analogs. The results from these studies reveal that specific alterations in the core structure of the Bex "parent" compound structure can have dramatic effects in modifying the biological activity of RXR agonists.
ContributorsYang, Joanna (Author) / Jurutka, Peter (Thesis director) / Wagner, Carl (Committee member) / Hibler, Elizabeth (Committee member) / Barrett, The Honors College (Contributor)
Created2012-05
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Description
As threats to Earth's biodiversity continue to evolve, an effective methodology to predict such threats is crucial to ensure the survival of living species. Organizations like the International Union for Conservation of Nature (IUCN) monitor the Earth's environmental networks to preserve the sanctity of terrestrial and marine life. The IUCN

As threats to Earth's biodiversity continue to evolve, an effective methodology to predict such threats is crucial to ensure the survival of living species. Organizations like the International Union for Conservation of Nature (IUCN) monitor the Earth's environmental networks to preserve the sanctity of terrestrial and marine life. The IUCN Red List of Threatened Species informs the conservation activities of governments as a world standard of species' risks of extinction. However, the IUCN's current methodology is, in some ways, inefficient given the immense volume of Earth's species and the laboriousness of its species' risk classification process. IUCN assessors can take years to classify a species' extinction risk, even as that species continues to decline. Therefore, to supplement the IUCN's classification process and thus bolster conservationist efforts for threatened species, a Random Forest model was constructed, trained on a group of fish species previously classified by the IUCN Red List. This Random Forest model both validates the IUCN Red List's classification method and offers a highly efficient, supplemental classification method for species' extinction risk. In addition, this Random Forest model is applicable to species with deficient data, which the IUCN Red List is otherwise unable to classify, thus engendering conservationist efforts for previously obscure species. Although this Random Forest model is built specifically for the trained fish species (Sparidae), the methodology can and should be extended to additional species.
ContributorsWoodyard, Megan (Author) / Broatch, Jennifer (Thesis director) / Polidoro, Beth (Committee member) / Mancenido, Michelle (Committee member) / School of Humanities, Arts, and Cultural Studies (Contributor) / School of Mathematical and Natural Sciences (Contributor) / College of Integrative Sciences and Arts (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
Desert ecosystems are one of the fastest urbanizing areas on the planet. This rapid shift has the potential to alter the abundances and species richness of herbivore and plant communities. Herbivores, for example, are expected to be more abundant in urban desert remnant parks located within cities due to anthropogenic

Desert ecosystems are one of the fastest urbanizing areas on the planet. This rapid shift has the potential to alter the abundances and species richness of herbivore and plant communities. Herbivores, for example, are expected to be more abundant in urban desert remnant parks located within cities due to anthropogenic activities that concentrate food resources and reduce native predator populations. Despite this assumption, previous research conducted around Phoenix has shown that top-down herbivory led to equally reduced plant biomass. It is unclear if this insignificant difference in herbivory at rural and urban sites is due to unaltered desert herbivore populations or altered activity levels that counteract abundance differences. Vertebrate herbivore populations were surveyed at four sites inside and four sites outside of the core of Phoenix during fall 2014 and spring 2015 in order to determine whether abundances and richness differ significantly between urban and rural sites. In order to survey species composition and abundance at these sites, 100 Sherman traps and 8 larger wire traps that are designed to attract and capture small vertebrates such as mice, rats, and squirrels, were set at each site for two consecutive trap nights. Results suggest that the commonly assumed effect of urbanization on herbivore abundances does not apply to small rodent herbivore populations in a desert city, as overall small rodent abundances were statistically similar regardless of location. Though a significant difference was not found for species richness, a significant difference between small rodent genera richness at these sites was observed.
ContributorsAlvarez Guevara, Jessica Noemi (Co-author) / Ball, Becky A. (Co-author, Thesis director) / Hall, Sharon J. (Co-author) / Bateman, Heather (Committee member) / School of Sustainability (Contributor) / School of Mathematical and Natural Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description

Pollution causes many health problems in the modern world and the desert climates struggle with pollution in unique ways. In the Sonoran Desert, the research was conducted with the purpose of expanding the knowledge of the topic in this area. A literature review was conducted based on air, soil and

Pollution causes many health problems in the modern world and the desert climates struggle with pollution in unique ways. In the Sonoran Desert, the research was conducted with the purpose of expanding the knowledge of the topic in this area. A literature review was conducted based on air, soil and noise pollution in the region. The Sonoran Desert has high levels of carcinogenic elements along with other pollutants due to the main industries of mining, agriculture and manufacturing. Overall, these findings show people in desert climates deal with high levels of pollutants.

ContributorsWest, Katherine (Author) / Hackney Price, Jennifer (Thesis director) / Savalli, Udo (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Natural Sciences (Contributor)
Created2023-05
Description

The ever-increasing importance of cancer and neurodegenerative diseases continues to grow as populations across the world are affected by death and aging. The vitamin A (RXR) and vitamin D (VDR) receptor pathways offer promising potential to aid in treatment of cancer and Alzheimer’s disease. This thesis discusses the potential application

The ever-increasing importance of cancer and neurodegenerative diseases continues to grow as populations across the world are affected by death and aging. The vitamin A (RXR) and vitamin D (VDR) receptor pathways offer promising potential to aid in treatment of cancer and Alzheimer’s disease. This thesis discusses the potential application of novel analogs of Bexarotene (RXR agonist), MeTC7 (a new potent VDR antagonist), and vitamin D as possible therapeutics for cancer and Alzheimer’s disease.

ContributorsHong, Jennifer (Author) / Jurutka, Peter (Thesis director) / Wagner, Carl (Committee member) / Marshall, Pamela (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Natural Sciences (Contributor)
Created2023-05
Description

There is no possibility for an ecological crisis without someone to be in crisis. The environment is not in danger as such, humanity’s ability to persist in it with well-being is. Thus, the ecological crisis is a human crisis, a crisis of meaning. Although ecology is required to understand and

There is no possibility for an ecological crisis without someone to be in crisis. The environment is not in danger as such, humanity’s ability to persist in it with well-being is. Thus, the ecological crisis is a human crisis, a crisis of meaning. Although ecology is required to understand and address these problems, we must understand the human condition if we wish to address them with any amount of seriousness or hope for success. We will be concerned with the relevance of hermeneutic practices in the study and practice of ecology. By hermeneutic practices, I mean the practices central to the human condition of world-building through perpetual interpretation and re-interpretation informed by one’s facticity. By the study and practice of ecology, I mean the education of ecology’s concepts within a scholastic, primarily university, setting and the usage of said concepts for the purpose of research or societal development respectively. I will argue that the study and practice of ecology would benefit from an inclusion of hermeneutics into its study in the scholastic system by way of developing nuanced understandings of oneself and their relation to the environment, thereby revealing new horizons of possibility in decision-making in society regarding the environment and oneself. To do this, I begin by using hermeneutic strategies in a reading of Gilgamesh to draw comparisons between Gilgamesh’s journey and the development of human society’s relationship to progress. Juxtaposing the concerns posited by the hermeneutic reading of Gilgamesh with Neil Postman’s claim that our contemporary understanding of the world is helpfully understood as what he calls a “Technopoly,” I argue technology has altered our orientation towards the environment in a way that falsely suggests hermeneutics has no place in ecology or any science. Exploring passages from Martin Heidegger, I then argue how humans’ fundamental relationship to interpretation makes hermeneutics the ground from which ecology is able to rise from. Further exploring passages from Heidegger’s work and exploring the etymology of the words “preserve” and “beforehand,” I argue that not only does hermeneutics allow for the study of ecology, but by studying ecology without it we are left in a state prime for mis-handling the Earth, thus making hermeneutics a crucial part of an education in ecology. I close by providing an example of using hermeneutic practices on two essays by Ralph Waldo Emerson to display how these hermeneutic practices could be used in conjunction with an education in ecology and illustrate the benefits therein.

ContributorsRusnak, Jared (Author) / Ramsey, Ramsey (Thesis director) / Poll, Elise (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Natural Sciences (Contributor) / School of Humanities, Arts, and Cultural Studies (Contributor)
Created2023-05
Description
The decision to disclose or not disclose information is a personal choice. When medical information is learned, a patient has to make decisions about disclosure. This qualitative research project has the goal of understanding how Latinx participants' cultural values, experiences from this community, and other factors influence the decision to

The decision to disclose or not disclose information is a personal choice. When medical information is learned, a patient has to make decisions about disclosure. This qualitative research project has the goal of understanding how Latinx participants' cultural values, experiences from this community, and other factors influence the decision to disclose in a romantic relationship. Twelve interviews were conducted using a semi-structured interview guide and the main themes found from analysis of the data cultural and relational influencers. This thesis serves as a resource for healthcare professionals to better understand their Latinx patient population in times where disclosure is encountered.
ContributorsPetersen, Claire (Author) / Cayetano, Catalina (Thesis director) / Flores, Valerie (Committee member) / Sellner, Erin (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Natural Sciences (Contributor)
Created2022-05
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Description

Aboveground-belowground relationships between vegetation and its associated soil biotic community play an important role in every terrestrial ecosystem for nutrient cycling and soil health maintenance. Deserts are especially sensitive to change and little is known about Sonoran Desert soil microbiota, while exotic herbaceous species are increasingly invading into the ecosystem

Aboveground-belowground relationships between vegetation and its associated soil biotic community play an important role in every terrestrial ecosystem for nutrient cycling and soil health maintenance. Deserts are especially sensitive to change and little is known about Sonoran Desert soil microbiota, while exotic herbaceous species are increasingly invading into the ecosystem with other harmful effects. In many other environments, soil communities have been associated with both plant species and plant functional type. The soil community food web depends on the sustenance brought by vegetation, and different soil community members are adapted to different diets. In this paper, we hypothesized that invasive plants would cause belowground soil communities to have greater abundance and lesser diversity than those under native, more locally established plants. To test this hypothesis, we selected four desert understory plant taxa: one native grass, one native forb, one invasive grass, and one invasive forb. We predicted that the invasive plants would be associated with a greater count of microarthropods per unit mass of soil but lesser microarthropod species diversity. The invasive plants were not statistically associated with a greater count of microarthropods per kilogram of soil nor lesser microarthropod species diversity. There was not a significant difference in abundance in the microarthropod categories between native and invasive plants, so the hypothesis was rejected. However, the invasive Erodium cicutarium was found to harbor high soil mite abundance, which warrants further study, and it is yet to be seen whether soil moisture and proximity to trees played a role in the data. The results of this study should help in generating more informed hypotheses regarding desert aboveground-belowground relationships.

ContributorsStern, Argon (Author) / Ball, Becky (Thesis director) / Sanin, Maria (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Natural Sciences (Contributor)
Created2022-05
Description
The use of genetic management in conservation has sparked much debate around the ethical and environmental impacts of the plans. A case study on the conservation of leopard frogs in Arizona was analyzed to better understand the benefits and issues surrounding genetic management plans. The first part of the case

The use of genetic management in conservation has sparked much debate around the ethical and environmental impacts of the plans. A case study on the conservation of leopard frogs in Arizona was analyzed to better understand the benefits and issues surrounding genetic management plans. The first part of the case focuses on the recent management plan for Chiricahua Leopard Frogs implemented by the Arizona Game and Fish Department. The goal of the plan is to better understand the genetic dynamics of the established Chiricahua Leopard Frog populations to develop a more effective management plan. The second part of the case focuses on the Arizona Game and Fish Department’s management of the Northern Leopard Frog. There was little success with the initial breed and release program of the native species, however a nonnative subspecies of Northern Leopard Frog was able to establish a thriving population. This case study exemplifies the many complications with genetic management plans and the importance of careful assessment of options when deciding on a genetic management plan. Despite the complexity of genetic management plans, it is an important method to consider when discussing the conservation of a species.
ContributorsTurpen, Alexa (Author) / Murphree, Julie (Thesis director) / Collins, James (Thesis director) / Owens, Audrey (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / College of Integrative Sciences and Arts (Contributor) / School of Mathematical and Natural Sciences (Contributor)
Created2024-05