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Breast cancer can be imaged at greater depths using photoacoustic imaging to differentiate between cancerous and non-cancerous tissue. Current photoacoustic modalities struggle to display images in real-time because of the required image reconstruction. In this work, we aim to create a real-time photoacoustic imaging system where the photoacoustic effect is

Breast cancer can be imaged at greater depths using photoacoustic imaging to differentiate between cancerous and non-cancerous tissue. Current photoacoustic modalities struggle to display images in real-time because of the required image reconstruction. In this work, we aim to create a real-time photoacoustic imaging system where the photoacoustic effect is detected through changes in index of refraction. To reach this aim, two methods are applied to visualize the acoustic waves including Schlieren optics and differential interference contrast microscopy. This combined approach provides a new tool for the widespread application in clinical settings.
ContributorsSmetanick, Derek (Author) / Burgett, Joshua (Co-author) / Smith, Barbara (Thesis director) / Muthuswamy, Jitendran (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor) / School of Life Sciences (Contributor)
Created2022-05
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From previous research, it has been observed that neural summation can be observed from reaction time tasks. This is observed through race models, as proposed by J.O. Miller. These models are referred to as “race models” as different stimuli “race” to extract a response during tasks. The race model is

From previous research, it has been observed that neural summation can be observed from reaction time tasks. This is observed through race models, as proposed by J.O. Miller. These models are referred to as “race models” as different stimuli “race” to extract a response during tasks. The race model is augmented by the Race Model Inequality, which claims the probability that two simultaneous signals will have a faster reaction time than the summation of the probabilities of two individual signals. When this inequality expression is violated, it indicates neural summation is occurring. In another study, researchers studied how the location of visual stimuli influences neural summation with tactile information, observing the visual stimuli from different distances and a mirrored reflection condition. However, results of the mirror condition did not follow the other visual conditions, offering unique properties. The mirrored case is examined more closely in this project, attempting to answer if the presence of a mirrored representation of the hand will affect reaction time during timed tasks, suggesting the occurrence of neural summation, and suggesting that a mirrored reflection of self is interpreted as an independent channel of information. This was measured by evaluating participants’ response time while manipulating the presence of a reflection and checking if they violate the race model. However, the results of this study indicated that the presence of a mirror does not have an effect in reaction time and therefore did not present the occurrence of neural summation

ContributorsFiroz, Fabiha (Author) / Helms Tillery, Steven (Thesis director) / Tanner, Justin (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor)
Created2022-05
Description

For the last two decades, a consistent statistic in the United States is that one out of every six people report experiencing at least one migraine every three months. The Neural Microsystems Laboratory at Arizona State University has developed a wireless implantable neurostimulator (WINS), which they believe can be used

For the last two decades, a consistent statistic in the United States is that one out of every six people report experiencing at least one migraine every three months. The Neural Microsystems Laboratory at Arizona State University has developed a wireless implantable neurostimulator (WINS), which they believe can be used to treat these widespread, episodic attacks. This device is about the size of a grain of rice and contains micro circuitry that generates an electric current when exposed to ultrasound. One problem facing the lab is that there is no process to place the WINS inside of the human body. For this Honors Thesis/Creative Project, I invented a tool that can be used to inject the WINS into the body, while addressing key issues of positioning, repositioning, and orientation. After testing was conducted on an artificial skin model and imaged with an optical microscope, the implantation tool proved to be successful. The tool made it easy to inject the WINS perpendicular to an artificial occipital nerve for every trial of the testing, also maintaining a proper alignment of the device so that it could receive maximum exposure to external ultrasound. Successful testing of this prototype shows that it is ready to be redesigned for mass production so that it can deliver the WINS to as many victims of migraine attacks as possible.

ContributorsVoeller, Oscar (Author) / Muthuswamy, Jitendran (Thesis director) / Towe, Bruce (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor)
Created2024-05
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Description
The development of computational systems known as brain-computer interfaces (BCIs) offers the possibility of allowing individuals disabled by neurological disorders such as Amyotrophic Lateral Sclerosis (ALS) and ischemic stroke the ability to perform relatively complex tasks such as communicating with others and walking. BCIs are closed-loop systems that record physiological

The development of computational systems known as brain-computer interfaces (BCIs) offers the possibility of allowing individuals disabled by neurological disorders such as Amyotrophic Lateral Sclerosis (ALS) and ischemic stroke the ability to perform relatively complex tasks such as communicating with others and walking. BCIs are closed-loop systems that record physiological signals from the brain and translate those signals into commands that control an external device such as a wheelchair or a robotic exoskeleton. Despite the potential for BCIs to vastly improve the lives of almost one billion people, one question arises: Just because we can use brain-computer interfaces, should we? The human brain is an embodiment of the mind, which is largely seen to determine a person's identity, so a number of ethical and philosophical concerns emerge over current and future uses of BCIs. These concerns include privacy, informed consent, autonomy, identity, enhancement, and justice. In this thesis, I focus on three of these issues: privacy, informed consent, and autonomy. The ultimate purpose of brain-computer interfaces is to provide patients with a greater degree of autonomy; thus, many of the ethical issues associated with BCIs are intertwined with autonomy. Currently, brain-computer interfaces exist mainly in the domain of medicine and medical research, but recently companies have started commercializing BCIs and providing them at affordable prices. These consumer-grade BCIs are primarily for non-medical purposes, and so they are beyond the scope of medicine. As BCIs become more widespread in the near future, it is crucial for interdisciplinary teams of ethicists, philosophers, engineers, and physicians to collaborate to address these ethical concerns now before BCIs become more commonplace.
ContributorsChu, Kevin Michael (Author) / Ankeny, Casey (Thesis director) / Robert, Jason (Committee member) / Frow, Emma (Committee member) / Harrington Bioengineering Program (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / Barrett, The Honors College (Contributor) / School for the Future of Innovation in Society (Contributor) / Lincoln Center for Applied Ethics (Contributor)
Created2016-05
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Description
Vagal Nerve Stimulation (VNS) has been shown to be a promising therapeutic technique in treating many neurological diseases, including epilepsy, stroke, traumatic brain injury, and migraine headache. The mechanisms by which VNS acts, however, are not fully understood but may involve changes in cerebral blood flow. The vagus nerve plays

Vagal Nerve Stimulation (VNS) has been shown to be a promising therapeutic technique in treating many neurological diseases, including epilepsy, stroke, traumatic brain injury, and migraine headache. The mechanisms by which VNS acts, however, are not fully understood but may involve changes in cerebral blood flow. The vagus nerve plays a significant role in the regulation of heart rate and cerebral blood flow that are altered during VNS. Here, we examined the effects of acute vagal nerve stimulation on both heart rate and cerebral blood flow. Laser Speckle Contrast Analysis (LASCA) was used to analyze the cerebral blood flow of male Long\u2014Evans rats. Results showed two distinct patterns of responses whereby animals either experienced a mild or severe decrease in heart rate during VNS. Further, animals that displayed mild heart rate decreases showed an increase in cerebral blood flow that persisted beyond VNS. Animals that displayed severe decreases showed a transient decrease in cerebral blood flow followed by an increase that was greater than that observed in mild animals but progressively decreased after VNS. The results suggest two distinct patterns of changes in both heart rate and cerebral blood flow that may be related to the intensity of VNS.
ContributorsHillebrand, Peter Timothy (Author) / Kleim, Jeffrey (Thesis director) / Helms Tillery, Stephen (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05