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Description
The efficacy of deep brain stimulation (DBS) in Parkinson's disease (PD) has been convincingly demonstrated in studies that compare motor performance with and without stimulation, but characterization of performance at intermediate stimulation amplitudes has been limited. This study investigated the effects of changing DBS amplitude in order to assess dose-response characteristics, inter-subject variability, consistency of effect across outcome measures, and day-to-day variability. Eight subjects with PD and bilateral DBS systems were evaluated at their clinically determined stimulation (CDS) and at three reduced amplitude conditions: approximately 70%, 30%, and 0% of the CDS (MOD, LOW, and OFF, respectively). Overall symptom severity and performance on a battery of motor tasks - gait, postural control, single-joint flexion-extension, postural tremor, and tapping - were assessed at each condition using the motor section of the Unified Parkinson's Disease Rating Scale (UPDRS-III) and quantitative measures. Data were analyzed to determine whether subjects demonstrated a threshold response (one decrement in stimulation resulted in ≥ 70% of the maximum change) or a graded response to reduced stimulation. Day-to-day variability was assessed using the CDS data from the three testing sessions. Although the cohort as a whole demonstrated a graded response on several measures, there was high variability across subjects, with subsets exhibiting graded, threshold, or minimal responses. Some subjects experienced greater variability in their CDS performance across the three days than the change induced by reducing stimulation. For several tasks, a subset of subjects exhibited improved performance at one or more of the reduced conditions. Reducing stimulation did not affect all subjects equally, nor did it uniformly affect each subject's performance across tasks. These results indicate that altered recruitment of neural structures can differentially affect motor capabilities and demonstrate the need for clinical consideration of the effects on multiple symptoms across several days when selecting DBS parameters.
ContributorsConovaloff, Alison (Author) / Abbas, James (Thesis advisor) / Krishnamurthi, Narayanan (Committee member) / Mahant, Padma (Committee member) / Jung, Ranu (Committee member) / Helms Tillery, Stephen (Committee member) / Arizona State University (Publisher)
Created2013
Description
Smoke entering a flight deck cabin has been an issue for commercial aircraft for many years. The issue for a flight crew is how to mitigate the smoke so that they can safely fly the aircraft. For this thesis, the feasibility of having a Negative Pressure System that utilizes the cabin altitude pressure and outside altitude pressure to remove smoke from a flight deck was studied. Existing procedures for flight crews call for a descent down to a safe level for depressurizing the aircraft before taking further action. This process takes crucial time that is critical to the flight crew's ability to keep aware of the situation. This process involves a flight crews coordination and fast thinking to manually take control of the aircraft; which has become increasing more difficult due to the advancements in aircraft automation. Unfortunately this is the only accepted procedure that is used by a flight crew. Other products merely displace the smoke. This displacement is after the time it takes for the flight crew to set up the smoke displacement unit with no guarantee that a flight crew will be able to see or use all of the aircraft's controls. The Negative Pressure System will work automatically and not only use similar components already found on the aircraft, but work in conjunction with the smoke detection system and pressurization system so smoke removal can begin without having to descend down to a lower altitude. In order for this system to work correctly many factors must be taken into consideration. The size of a flight deck varies from aircraft to aircraft, therefore the ability for the system to efficiently remove smoke from an aircraft is taken into consideration. For the system to be feasible on an aircraft the cost and weight must be taken into consideration as the added fuel consumption due to weight of the system may be the limiting factor for installing such a system on commercial aircraft.
ContributorsDavies, Russell (Author) / Rogers, Bradley (Thesis advisor) / Palmgren, Dale (Committee member) / Rajadas, John (Committee member) / Arizona State University (Publisher)
Created2013
Description
The friction condition is an important factor in controlling the compressing process in metalforming. The friction calibration maps (FCM) are widely used in estimating friction factors between the workpiece and die. However, in standard FEA, the friction condition is defined by friction coefficient factor (µ), while the FCM is used to a constant shear friction factors (m) to describe the friction condition. The purpose of this research is to find a method to convert the m factor to u factor, so that FEA can be used to simulate ring tests with µ. The research is carried out with FEA and Design of Experiment (DOE). FEA is used to simulate the ring compression test. A 2D quarter model is adopted as geometry model. A bilinear material model is used in nonlinear FEA. After the model is established, validation tests are conducted via the influence of Poisson's ratio on the ring compression test. It is shown that the established FEA model is valid especially if the Poisson's ratio is close to 0.5 in the setting of FEA. Material folding phenomena is present in this model, and µ factors are applied at all surfaces of the ring respectively. It is also found that the reduction ratio of the ring and the slopes of the FCM can be used to describe the deformation of the ring specimen. With the baseline FEA model, some formulas between the deformation parameters, material mechanical properties and µ factors are generated through the statistical analysis to the simulating results of the ring compression test. A method to substitute the m factor with µ factors for particular material by selecting and applying the µ factor in time sequence is found based on these formulas. By converting the m factor into µ factor, the cold forging can be simulated.
ContributorsKexiang (Author) / Shah, Jami (Thesis advisor) / Davidson, Joseph (Committee member) / Trimble, Steve (Committee member) / Arizona State University (Publisher)
Created2013
Description
Cancer is the second leading cause of death in the United States and novel methods of treating advanced malignancies are of high importance. Of these deaths, prostate cancer and breast cancer are the second most fatal carcinomas in men and women respectively, while pancreatic cancer is the fourth most fatal in both men and women. Developing new drugs for the treatment of cancer is both a slow and expensive process. It is estimated that it takes an average of 15 years and an expense of $800 million to bring a single new drug to the market. However, it is also estimated that nearly 40% of that cost could be avoided by finding alternative uses for drugs that have already been approved by the Food and Drug Administration (FDA). The research presented in this document describes the testing, identification, and mechanistic evaluation of novel methods for treating many human carcinomas using drugs previously approved by the FDA. A tissue culture plate-based screening of FDA approved drugs will identify compounds that can be used in combination with the protein TRAIL to induce apoptosis selectively in cancer cells. Identified leads will next be optimized using high-throughput microfluidic devices to determine the most effective treatment conditions. Finally, a rigorous mechanistic analysis will be conducted to understand how the FDA-approved drug mitoxantrone, sensitizes cancer cells to TRAIL-mediated apoptosis.
ContributorsTaylor, David (Author) / Rege, Kaushal (Thesis advisor) / Jayaraman, Arul (Committee member) / Nielsen, David (Committee member) / Kodibagkar, Vikram (Committee member) / Dai, Lenore (Committee member) / Arizona State University (Publisher)
Created2013
Description
Derived from the necessity to increase testing capabilities of hybrid rocket motor (HRM) propulsion systems for Daedalus Astronautics at Arizona State University, a small-scale motor and test stand were designed and developed to characterize all components of the system. The motor is designed for simple integration and setup, such that both the forward-end enclosure and end cap can be easily removed for rapid integration of components during testing. Each of the components of the motor is removable allowing for a broad range of testing capabilities. While examining injectors and their potential it is thought ideal to obtain the highest regression rates and overall motor performance possible. The oxidizer and fuel are N2O and hydroxyl-terminated polybutadiene (HTPB), respectively, due to previous experience and simplicity. The injector designs, selected for the same reasons, are designed such that they vary only in the swirl angle. This system provides the platform for characterizing the effects of varying said swirl angle on HRM performance.
ContributorsSummers, Matt H (Author) / Lee, Taewoo (Thesis advisor) / Chen, Kangping (Committee member) / Wells, Valana (Committee member) / Arizona State University (Publisher)
Created2013
Description
Doppler radar can be used to measure respiration and heart rate without contact and through obstacles. In this work, a Doppler radar architecture at 2.4 GHz and a new signal processing algorithm to estimate the respiration and heart rate are presented. The received signal is dominated by the transceiver noise, LO phase noise and clutter which reduces the signal-to-noise ratio of the desired signal. The proposed architecture and algorithm are used to mitigate these issues and obtain an accurate estimate of the heart and respiration rate. Quadrature low-IF transceiver architecture is adopted to resolve null point problem as well as avoid 1/f noise and DC offset due to mixer-LO coupling. Adaptive clutter cancellation algorithm is used to enhance receiver sensitivity coupled with a novel Pattern Search in Noise Subspace (PSNS) algorithm is used to estimate respiration and heart rate. PSNS is a modified MUSIC algorithm which uses the phase noise to enhance Doppler shift detection. A prototype system was implemented using off-the-shelf TI and RFMD transceiver and tests were conduct with eight individuals. The measured results shows accurate estimate of the cardio pulmonary signals in low-SNR conditions and have been tested up to a distance of 6 meters.
ContributorsKhunti, Hitesh Devshi (Author) / Kiaei, Sayfe (Thesis advisor) / Bakkaloglu, Bertan (Committee member) / Bliss, Daniel (Committee member) / Kitchen, Jennifer (Committee member) / Arizona State University (Publisher)
Created2013
Description
A cerebral aneurysm is a bulging of a blood vessel in the brain. Aneurysmal rupture affects 25,000 people each year and is associated with a 45% mortality rate. Therefore, it is critically important to treat cerebral aneurysms effectively before they rupture. Endovascular coiling is the most effective treatment for cerebral aneurysms. During coiling process, series of metallic coils are deployed into the aneurysmal sack with the intent of reaching a sufficient packing density (PD). Coils packing can facilitate thrombus formation and help seal off the aneurysm from circulation over time. While coiling is effective, high rates of treatment failure have been associated with basilar tip aneurysms (BTAs). Treatment failure may be related to geometrical features of the aneurysm. The purpose of this study was to investigate the influence of dome size, parent vessel (PV) angle, and PD on post-treatment aneurysmal hemodynamics using both computational fluid dynamics (CFD) and particle image velocimetry (PIV). Flows in four idealized BTA models with a combination of dome sizes and two different PV angles were simulated using CFD and then validated against PIV data. Percent reductions in post-treatment aneurysmal velocity and cross-neck (CN) flow as well as percent coverage of low wall shear stress (WSS) area were analyzed. In all models, aneurysmal velocity and CN flow decreased after coiling, while low WSS area increased. However, with increasing PD, further reductions were observed in aneurysmal velocity and CN flow, but minimal changes were observed in low WSS area. Overall, coil PD had the greatest impact while dome size has greater impact than PV angle on aneurysmal hemodynamics. These findings lead to a conclusion that combinations of treatment goals and geometric factor may play key roles in coil embolization treatment outcomes, and support that different treatment timing may be a critical factor in treatment optimization.
ContributorsIndahlastari, Aprinda (Author) / Frakes, David (Thesis advisor) / Chong, Brian (Committee member) / Muthuswamy, Jitendran (Committee member) / Arizona State University (Publisher)
Created2013
Description
When surgical resection becomes necessary to alleviate a patient's epileptiform activity, that patient is monitored by video synchronized with electrocorticography (ECoG) to determine the type and location of seizure focus. This provides a unique opportunity for researchers to gather neurophysiological data with high temporal and spatial resolution; these data are assessed prior to surgical resection to ensure the preservation of the patient's quality of life, e.g. avoid the removal of brain tissue required for speech processing. Currently considered the "gold standard" for the mapping of cortex, electrical cortical stimulation (ECS) involves the systematic activation of pairs of electrodes to localize functionally specific brain regions. This method has distinct limitations, which often includes pain experienced by the patient. Even in the best cases, the technique suffers from subjective assessments on the parts of both patients and physicians, and high inter- and intra-observer variability. Recent advances have been made as researchers have reported the localization of language areas through several signal processing methodologies, all necessitating patient participation in a controlled experiment. The development of a quantification tool to localize speech areas in which a patient is engaged in an unconstrained interpersonal conversation would eliminate the dependence of biased patient and reviewer input, as well as unnecessary discomfort to the patient. Post-hoc ECoG data were gathered from five patients with intractable epilepsy while each was engaged in a conversation with family members or clinicians. After the data were separated into different speech conditions, the power of each was compared to baseline to determine statistically significant activated electrodes. The results of several analytical methods are presented here. The algorithms did not yield language-specific areas exclusively, as broad activation of statistically significant electrodes was apparent across cortical areas. For one patient, 15 adjacent contacts along superior temporal gyrus (STG) and posterior part of the temporal lobe were determined language-significant through a controlled experiment. The task involved a patient lying in bed listening to repeated words, and yielded statistically significant activations that aligned with those of clinical evaluation. The results of this study do not support the hypothesis that unconstrained conversation may be used to localize areas required for receptive and productive speech, yet suggests a simple listening task may be an adequate alternative to direct cortical stimulation.
ContributorsLingo VanGilder, Jennapher (Author) / Helms Tillery, Stephen I (Thesis advisor) / Wahnoun, Remy (Thesis advisor) / Buneo, Christopher (Committee member) / Arizona State University (Publisher)
Created2013
Description
The development of advanced, anthropomorphic artificial hands aims to provide upper extremity amputees with improved functionality for activities of daily living. However, many state-of-the-art hands have a large number of degrees of freedom that can be challenging to control in an intuitive manner. Automated grip responses could be built into artificial hands in order to enhance grasp stability and reduce the cognitive burden on the user. To this end, three studies were conducted to understand how human hands respond, passively and actively, to unexpected perturbations of a grasped object along and about different axes relative to the hand. The first study investigated the effect of magnitude, direction, and axis of rotation on precision grip responses to unexpected rotational perturbations of a grasped object. A robust "catch-up response" (a rapid, pulse-like increase in grip force rate previously reported only for translational perturbations) was observed whose strength scaled with the axis of rotation. Using two haptic robots, we then investigated the effects of grip surface friction, axis, and direction of perturbation on precision grip responses for unexpected translational and rotational perturbations for three different hand-centric axes. A robust catch-up response was observed for all axes and directions for both translational and rotational perturbations. Grip surface friction had no effect on the stereotypical catch-up response. Finally, we characterized the passive properties of the precision grip-object system via robot-imposed impulse perturbations. The hand-centric axis associated with the greatest translational stiffness was different than that for rotational stiffness. This work expands our understanding of the passive and active features of precision grip, a hallmark of human dexterous manipulation. Biological insights such as these could be used to enhance the functionality of artificial hands and the quality of life for upper extremity amputees.
ContributorsDe Gregorio, Michael (Author) / Santos, Veronica J. (Thesis advisor) / Artemiadis, Panagiotis K. (Committee member) / Santello, Marco (Committee member) / Sugar, Thomas (Committee member) / Helms Tillery, Stephen I. (Committee member) / Arizona State University (Publisher)
Created2013
Description
Locomotion of microorganisms is commonly observed in nature and some aspects of their motion can be replicated by synthetic motors. Synthetic motors rely on a variety of propulsion mechanisms including auto-diffusiophoresis, auto-electrophoresis, and bubble generation. Regardless of the source of the locomotion, the motion of any motor can be characterized by the translational and rotational velocity and effective diffusivity. In a uniform environment the long-time motion of a motor can be fully characterized by the effective diffusivity. In this work it is shown that when motors possess both translational and rotational velocity the motor transitions from a short-time diffusivity to a long-time diffusivity at a time of pi/w. The short-time diffusivities are two to three orders of magnitude larger than the diffusivity of a Brownian sphere of the same size, increase linearly with concentration, and scale as v^2/2w. The measured long-time diffusivities are five times lower than the short-time diffusivities, scale as v^2/{2Dr [1 + (w/Dr )^2]}, and exhibit a maximum as a function of concentration. The variation of a colloid's velocity and effective diffusivity to its local environment (e.g. fuel concentration) suggests that the motors can accumulate in a bounded system, analogous to biological chemokinesis. Chemokinesis of organisms is the non-uniform equilibrium concentration that arises from a bounded random walk of swimming organisms in a chemical concentration gradient. In non-swimming organisms we term this response diffusiokinesis. We show that particles that migrate only by Brownian thermal motion are capable of achieving non-uniform pseudo equilibrium distribution in a diffusivity gradient. The concentration is a result of a bounded random-walk process where at any given time a larger percentage of particles can be found in the regions of low diffusivity than in regions of high diffusivity. Individual particles are not trapped in any given region but at equilibrium the net flux between regions is zero. For Brownian particles the gradient in diffusivity is achieved by creating a viscosity gradient in a microfluidic device. The distribution of the particles is described by the Fokker-Planck equation for variable diffusivity. The strength of the probe concentration gradient is proportional to the strength of the diffusivity gradient and inversely proportional to the mean probe diffusivity in the channel in accordance with the no flux condition at steady state. This suggests that Brownian colloids, natural or synthetic, will concentrate in a bounded system in response to a gradient in diffusivity and that the magnitude of the response is proportional to the magnitude of the gradient in diffusivity divided by the mean diffusivity in the channel.
ContributorsMarine, Nathan Arasmus (Author) / Posner, Jonathan D (Thesis advisor) / Adrian, Ronald J (Committee member) / Frakes, David (Committee member) / Phelan, Patrick E (Committee member) / Santos, Veronica J (Committee member) / Arizona State University (Publisher)
Created2013