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- All Subjects: recognition
- Creators: Conrad, Hanna Taylor
Description
Single molecule identification is one essential application area of nanotechnology. The application areas including DNA sequencing, peptide sequencing, early disease detection and other industrial applications such as quantitative and quantitative analysis of impurities, etc. The recognition tunneling technique we have developed shows that after functionalization of the probe and substrate of a conventional Scanning Tunneling Microscope with recognition molecules ("tethered molecule-pair" configuration), analyte molecules trapped in the gap that is formed by probe and substrate will bond with the reagent molecules. The stochastic bond formation/breakage fluctuations give insight into the nature of the intermolecular bonding at a single molecule-pair level. The distinct time domain and frequency domain features of tunneling signals were extracted from raw signals of analytes such as amino acids and their enantiomers. The Support Vector Machine (a machine-learning method) was used to do classification and predication based on the signal features generated by analytes, giving over 90% accuracy of separation of up to seven analytes. This opens up a new interface between chemistry and electronics with immediate implications for rapid Peptide/DNA sequencing and molecule identification at single molecule level.
ContributorsZhao, Yanan, 1986- (Author) / Lindsay, Stuart (Thesis advisor) / Nemanich, Robert (Committee member) / Qing, Quan (Committee member) / Ros, Robert (Committee member) / Zhang, Peiming (Committee member) / Arizona State University (Publisher)
Created2014
Description
Sepsis is a global health problem, and millions of people die annually from sepsis around the world (Centers for Disease Control and Prevention, 2018). The purpose of this literature review is to discuss the prevention, recognition, and treatment of sepsis as well as the need for more public health education to raise awareness of the significant burden of sepsis. It is difficult to recognize because there are several nonspecific symptoms, and there is not a comprehensive diagnostic tool. Diagnosis is based on evidence of infection, organ dysfunction, and clinical judgment (Fay et al., 2020). The definition of sepsis has evolved over the last three decades, though the most recent update is not widely accepted by all healthcare systems. There remains debate about treatment practices as well, including the following: whether one or multiple antibiotics should be used, which type of fluids should be used for rapid resuscitation, and the number of fluids that should be given to the patient. However, evidence agrees that treatment should be started within the first hour of symptom onset for the best chance of survival (Gyawali, Ramakrishna, & Dhamoon, 2019). Despite the significant burden that sepsis places on families, healthcare team members, and hospitals, there is not enough public awareness of the issue (Jabaley et al., 2018). There should be a greater push for public education using technology, social media, and mass media campaigns to increase awareness and prevention of infection.
ContributorsConrad, Hanna Taylor (Author) / Calvin, Samantha (Thesis director) / Merbergen, Callie (Committee member) / Edson College of Nursing and Health Innovation (Contributor) / Barrett, The Honors College (Contributor)
Created2020-12