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- Creators: Barrett, The Honors College
- Status: Published
Description
As the prevalence and awareness of Autism Spectrum Disorder (ASD) increases, so does the variety of treatment options for primary symptoms (social interaction, communication, behavior) and secondary symptoms (anxiety, hyperactivity, GI problems, and insomnia). Various treatments, from Adderall to Citalopram to Flax Seed Oil promise relief for these symptoms. However, very little research has actually been done on some of these treatments. Additionally, the research that has been done fails to compare these treatments against one another in terms of symptom relief. The Autism Treatment Effectiveness Survey, written by Dr. James Adams, director of the Autism/Asperger's Research Program at ASU, and graduate student/program coordinator Devon Coleman, aims to fill this gap. The survey numerically rates medications based on benefit and adverse effects, in addition to naming specific symptoms that are impacted by the treatments. However, the survey itself was retrospective in nature and requires further evidence to support its claims. Therefore, the purpose of this research paper is to evaluate evidence related to the results of the survey. After the performing an extensive literature review of over 70 different treatments, it appears that the findings of the Autism Treatment Effectiveness Survey are generally well supported. There were a few minor discrepancies regarding the primary benefitted symptom, but there was not enough of a conflict to discount the information from the survey. As research is still ongoing, conclusions cannot yet be drawn for Nutritional Supplements, although the current data looks promising.
ContributorsAnderson, Amy Lynn (Author) / Adams, James (Thesis director) / Coleman, Devon (Committee member) / School of Nutrition and Health Promotion (Contributor) / W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
Autism Spectrum Disorder is a disorder that makes learning, socializing and daily living much more challenging for affected children and adults because of their atypical behaviors. A few examples of these behaviors are repetitive movements, impulsive actions, inability to communicate in a social setting, and many more. There is a stigma behind autism that is caused by those who are not well informed on the disorder. These people lack information, and in the past, it was assumed that the disorder is caused by "bad parenting." The parents are then afraid of social shame brought upon them by their child and neglect or avoid a diagnosis for their child's disorder. This becomes a vicious cycle that has negative effects on the affected individuals and their loved ones. Neglect of a diagnosis may also be caused by misinformation interpreted by the parents as their child develops. The parents do not realize this child developing outside of normal behavioral patterns. Years of research have been done to attempt to alleviate the symptoms of autism and cure the disorder. The Autism and Asperger's Program at ASU has developed a year-long dietary plan that increases supplementation to alleviate nutritional deficiencies in participants with autism. These deficiencies include vitamins, minerals, essential fatty acids, sulfate, carnitine, and digestive enzymes such as sucrase, maltase, and lactase. The participants were also put on a gluten-free casein-free diet toward the end of the study. To test the effectiveness of the treatment, the Severity of Autism Scale (SAS) and Social Responsiveness Scales (SRS) were used. The SAS tested the overall severity of ASD participants by rating them from one to ten, ten being "very severe" in terms of ASD symptoms. The results of this scale were compared at the beginning of the study (day 0) and at the end of the study (day 365). The SRS tested the social responsiveness of participants in the form of overall SRS and five subscales that included awareness, cognition, communication, motivation, and mannerisms. These results were also compared at the beginning and end of the study. After analysis of the data, there seemed to be no correlation between age and severity of autism/social responsiveness of participants. There was also no statistically significant data to suggest that there was a correlation between gender and severity of autism/social responsiveness of participants. However, there was statistically significant evidence that the treatment group did improve over the non-treatment/delayed treatment group in both the SAS and SRS. Neither age nor gender had a significant effect on the effectiveness of the treatment. These positive findings suggest that the integrated dietary
utritional therapy was beneficial, and future research on dietary treatments for autism and other disorders is recommended. This may also further discoveries of affected epigenomes with regards to nutritional treatments in disorders like ASD. The epigenome is the methylation and demethylation of the genome that mediates gene expression.
utritional therapy was beneficial, and future research on dietary treatments for autism and other disorders is recommended. This may also further discoveries of affected epigenomes with regards to nutritional treatments in disorders like ASD. The epigenome is the methylation and demethylation of the genome that mediates gene expression.
ContributorsGutgsell, Crystal Megan (Author) / Adams, James (Thesis director) / Pollard, Elena (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Breast and other solid tumors exhibit high and varying degrees of intra-tumor heterogeneity resulting in targeted therapy resistance and other challenges that make the management and treatment of these diseases rather difficult. Due to the presence of admixtures of non-neoplastic cells with polyclonal cell populations, it is difficult to define cancer genomes in patient samples. By isolating tumor cells from normal cells, and enriching distinct clonal populations, clinically relevant genomic aberrations that drive disease can be identified in patients in vivo. An in-depth analysis of clonal architecture and tumor heterogeneity was performed in a stage II chemoradiation-naïve breast cancer from a sixty-five year old patient. DAPI-based DNA content measurements and DNA content-based flow sorting was used to to isolate nuclei from distinct clonal populations of diploid and aneuploid tumor cells in surgical tumor samples. We combined DNA content-based flow cytometry and ploidy analysis with high-definition array comparative genomic hybridization (aCGH) and next-generation sequencing technologies to interrogate the genomes of multiple biopsies from the breast cancer. The detailed profiles of ploidy, copy number aberrations and mutations were used to recreate and map the lineages present within the tumor. The clonal analysis revealed driver events for tumor progression (a heterozygous germline BRCA2 mutation converted to homozygosity within the tumor by a copy number event and the constitutive activation of Notch and Akt signaling pathways. The highlighted approach has broad implications in the study of tumor heterogeneity by providing a unique ultra-high resolution of polyclonal tumors that can advance effective therapies and clinical management of patients with this disease.
ContributorsLaughlin, Brady Scott (Author) / Ankeny, Casey (Thesis director) / Barrett, Michael (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor) / School for the Science of Health Care Delivery (Contributor)
Created2015-05
Description
This paper explains what factors influence mental health issues and what type of care is provided in various countries. The countries in this study will include the United States, Japan, Ethiopia and South Africa, all of which have varying degrees of ethnic diversity, economic status and understanding of mental health issues. It discusses the specific healthcare systems in each country, as well as the attitudes and problems associated with depression and schizophrenia, two prevalent mental health disorders. This paper examines the different ways that a diagnosis is reached for schizophrenia and major depression in these different countries, as well as what methods are used for treating individuals with these disorders. It will also examine the prominent notion that schizophrenia has better outcomes in developing countries than in places that have wider medical care available. It then discusses what treatments are available in each country, as well as social constructs that exist regarding those treatments in order to understand the ways that treatments can be expanded to improve outcomes. This paper will then examine the different outcomes of these mental health disorders that are common in each country, and conclude with ideas on how to make global mental health a reality.
ContributorsOlsen, Rachel Lindsay (Author) / Gaughan, Monica (Thesis director) / Wood, Reed (Committee member) / Barrett, The Honors College (Contributor) / School of Politics and Global Studies (Contributor) / School of Human Evolution and Social Change (Contributor) / Department of Psychology (Contributor)
Created2015-05
Description
The thesis outlines five feasible technologies that can be implemented to assist Arizona State University (ASU) in its attempt to increase its water sustainability practices. After collaborating with internal contacts from ASU's Sustainability department, a plan was initiated to research, inform, and recommend the best technological solution and potential vendor for ASU. Information on the vendor is included in the analysis describing the company's history, its service offerings, and application of the technology mentioned using case studies. Potential vendors were contact by phone and additional research was conducted using the each of the company's website to gather more information such a charts and graphs. ASU's current negotiations with its main vendor, Sustainable Water, assisted in establishing benchmarks needed to be able to compare other potential vendors. Each technology was researched extensively using metrics such as energy efficiency, aesthetics, footprint, purification capacity, and odor. The team had difficulties gathering specific data due to the hesitations of companies divulging proprietary information. As much information was gathered to analyze and provide a comparison with each vendor using a ranked and weighted system. Rating the technologies took into considerations the needs of ASU, the offerings of the potential vendor, and the technological capacities and capabilities. The technologies mentioned each had distinct features differing it from one another. However, each technology also had its tradeoffs. Ultimately, it was found that the most feasible, realistic and most aesthetically pleasing solution was Sustainable Water. After careful analysis, it is recommended to continue discussions with Sustainable Water to meet the needs and goals of ASU's water sustainability initiatives.
ContributorsReid, Tatiana (Co-author) / MacDonaldo, Ariane (Co-author) / Printezis, Antonios (Thesis director) / Alberhasky, JoEllen (Committee member) / Department of Supply Chain Management (Contributor) / Department of Finance (Contributor) / W. P. Carey School of Business (Contributor) / Department of Management and Entrepreneurship (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
Prison re-entry is a complicated process and is associated with a number of challenges for offenders to overcome. Unfortunately, many are not successful at navigating this process, and consequently, recidivism is a prevalent concern within the criminal justice system. These concerns are problematic with drug offenders, specifically, as this group is a quite pervasive component of the correctional population in America and one that tends to face more difficult experiences with reintegrating into society. In addition, a substantial need for substance abuse treatment in the community is in place for these offenders, yet is not necessarily readily available. This study examines the accessibility and nature of such treatment through the use of interviews with community treatment providers. It also assesses the barriers offenders face accessing help as well as potential solutions to these obstacles. The findings suggest that independence, support networks, resistance to treatment, motivation to change, rule conformity, mental illness, institutionalization, a lack of resources, and restrictions within the agencies that provide treatment are all significant factors in recovery. The results then demonstrate that treatment providers are able to provide incentives to bolster motivation, encourage healthy mindsets, help gain access to the resources that are available, and validate success through celebration in order to overcome these difficulties. The study may be limited by a potentially non-generalizable sample and a lack of specificity could be addressed by more expansive but focused research in the future as well as financial analyses to raise awareness regarding the severity of the situation.
ContributorsJohnson, Nicole Jolene (Author) / Chamberlain, Alyssa (Thesis director) / Wright, Kevin (Committee member) / School of Criminology and Criminal Justice (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
The purpose of this study is to explore the possible factors that influence how patients rate their dentists in the underserved communities and how commonly each factors are mentioned in the articles found from the systematic review. PubMed was used to search the articles with the keywords categorized into 5 different groups, they were: dental/oral, underserved, patient satisfaction, services provided and America. The search resulted in 123 articles and after critical appraisal and review, 19 full text articles were determined to be fully relevant to this project. A table of summarized results from the articles was created and factors of satisfaction from the articles were translated into a category which then was categorize into broader category based on relatedness. Sub-categories that were mentioned at least five times in the articles were cost, insurance acceptance, communication, interpersonal skills, number of treatments, fear/worry/anxiety and pain. According to the findings, quality in terms of interaction and interpersonal relationship between patients and the dentists was most mentioned compared to other factors when it comes to patient satisfaction. Other factors mentioned were external factors, pain, continuity, access, cost, technical qualities, efficiency, convenience, availability and environment. The purpose of this study has been met. The results in this project suggest that dentists in underserved communities could focus on changing the way they deliver their service if they want to improve patient retention and satisfaction.
ContributorsHnin, Ma Myat Thida (Author) / McCullough, Mac (Thesis director) / Riley, William (Committee member) / School of Life Sciences (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
This case study describes an adult patient whose brachial plexus injury was treated with various modalities and exercise. The participant of this study was a 76 year old female who sustained a brachial plexus injury during an elective reverse total shoulder arthroplasty. The initial evaluation reported only passive range of motion with 90 degrees shoulder flexion, 85 degrees abduction, and 30 degrees external rotation. Muscle testing yielded significantly limited wrist and digit extension strength. Testing of sensation found diminished protective sensation along the median nerve distribution, including the thumb, index finger, and middle finger. Occupational therapy was initiated for postoperative treatment of the shoulder as well as treatment of the brachial plexus palsy. Therapy consisted of static splinting for healing structures and sensory reeducation through massage, finding objects with the eyes occluded, and fluidotherapy. Additionally, various exercises and modalities for improving motion and strength were initiated, including proprioceptive neuromuscular reeducation, passive/active assist/active exercises, dynamic splinting, muscle stimulation, kinesio tape, functional activities, and tendon glides. After five months, active range of motion in the shoulder, elbow, and wrist was finally achieved and median nerve sensation had improved. After nine months, elbow motion was within normal limits and wrist motion had significantly improved. Upon muscle testing, the elbow, forearm, wrist, and hand had made significant gains in strength. However, shoulder strength and motion was still limited. Overall, treatment made a significant improvement in the patient’s functionality.
ContributorsMorlock, Callista (Author) / Ramos, Christopher (Thesis director) / Thomas, Karen (Committee member) / College of Health Solutions (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
ContributorsMayo, Joshua (Performer) / Wheeler, Thomas (Performer) / Dominguez, Ramon (Performer) / Tuijl-Goode, Remi (Performer) / Lehrer, Gave (Performer) / ASU Library. Music Library (Publisher)
Created2019-04-05
Description
This thesis examines the re-entry processes of individuals with mental health needs upon their release from prison. In order to uncover the resources that are provided to formerly incarcerated individuals with clinically diagnosed mental health issues, parole officers who have experience supervising individuals with mental health needs were interviewed. The purpose of the interviews was to understand the experiences parole officers have regarding current supervision practices that are used, as well as programming and treatment opportunities parole officers know are available to this population of re-entrants. Being aware of the resources that are provided to formerly incarcerated individuals with mental health needs will help identify how to improve supervision, programming, and treatment so as to better support this population. As research and literature on the re-entry experiences of individuals with mental health care needs have demonstrated the extensive privations this population experiences, interviewing parole officers will reveal the roles parole officers, treatment providers, and programming have in supporting this population upon their release from prison. Moreover, interviewing parole officers will help identify how to improve parole outcomes for re-entrants with clinically diagnosed mental health issues.
ContributorsWalden, Hannah (Author) / Chamberlain, Alyssa (Thesis director) / Wright, Kevin (Committee member) / Barrett, The Honors College (Contributor) / Dean, W.P. Carey School of Business (Contributor) / School of Criminology and Criminal Justice (Contributor)
Created2021-12