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- Creators: Electrical Engineering Program
Description
Pharmacokinetics describes the movement and processing of a drug in a body, while Pharmacodynamics describes the drug's effect on a given subject. Pharmacokinetic/Pharmacodynamic(Pk/Pd) models have become a fundamental tool when predicting bacterial behavior and drug development. In November of 2009, Katsube et al. published their paper detailing their Pk/Pd model for the drug Doripenem and the bacteria P. aeruginosa. In their paper, they determined that there is a dependent relationship between the drug's effectiveness and the dosing strategy of the drug. Therefore, this thesis has applied optimal control in order to optimize the drug's effectiveness, while not burdening the subject with the side effects of the drug. Optimal Control is a mathematical tool used to balance two competing factors. As a result, it has become a useful tool used to make decisions involving complex behavior. By using Optimal Control, the model will maximize the drug's effect on the bacterial population of P. aeruginosa, while minimizing the drug concentration of Doripenem. In doing so, our research will enable doctors and clinicians to maximize a drug's effectiveness on the body, while minimizing side effects.
ContributorsSawkins, Bryan Thomas (Author) / Camacho, Erika (Thesis director) / Wirkus, Stephen (Committee member) / School of Mathematical and Natural Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
This Creative Project was carried out in coordination with the capstone project, Around the Corner Imaging with Terahertz Waves. This capstone project deals with a system designed to implement Around the Corner, or Non Line-of-Sight (NLoS) Imaging. This document discusses the creation of a GUI using MATLAB to control the Terahertz Imaging system. The GUI was developed in response to a need for synchronization, ease of operation, easy parameter modification, and data management. Along the way, many design decisions were made ranging from choosing a software platform to determining how variables should be passed. These decisions and considerations are discussed in this document. The resulting GUI has measured up to the design criteria and will be able to be used by anyone wishing to use the Terahertz Imaging System for further research in the field of Around the Corner or NLoS Imaging.
ContributorsWood, Jacob Cannon (Author) / Trichopoulos, Georgios (Thesis director) / Aberle, James (Committee member) / Electrical Engineering Program (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
The purpose of this project is to analyze the MIT OpenCourseWare coffee can radar design and modify it to be better suited for drone based synthetic aperture radar (SAR) applications while maintaining the low-cost aspect of the original design. The MIT coffee can radar can function as a ranged radar, a Doppler radar, or as SAR. Through simulations and research, the suggestions for how to modify the radar resulted in swapping the coffee can monopole antennas for patch antenna arrays or helical ordinary end-fire antennas, adding an Arduino for automatic recording of output pulses, and switching from a breadboard construction to a PCB to shrink form factor and keep costs and construction time low.
ContributorsRivera, Danielle (Author) / Trichopoulos, Georgios (Thesis director) / Aberle, James (Committee member) / Department of Information Systems (Contributor) / Electrical Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2020-12