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- Creators: Harrington Bioengineering Program
- Creators: Mechanical and Aerospace Engineering Program
Description
Morphine is a commonly used analgesic in pain management. Opioid administration to a patient after surgery, such as spinal decompression surgery, can lead to adverse side effects. To demonstrate these adverse side effects could be decreased we created a model of how morphine and its metabolites are transported and excreted from the body. Using the of morphine and a standard compartment approach this thesis aimed at projecting pharmacokinetics trends of morphine overtime. A Matlab compartment model predicting the transport of morphine through the body can contribute to a better understanding of the concentrations at the systemic level, specifically with respect to a CSF, and what happens when you compare an intravenous injection to a local delivery. Other studies and models commonly utilized patient data over small periods of time2,3,5. An extended period of time will provide information into morphine’s time course after surgery. This model focuses on a compartmentalization of the major organs and the use of a simple Mechalis-Menten enzyme kinetics for the metabolites in the liver. Our results show a CSF concentration of about 1.086×〖10〗^(-12) nmol/L in 6 weeks and 1.0097×〖10〗^(-12) nmol/L in 12 weeks. The concentration profiles in this model are similar to what was expected. The implications of this suggest that patients who reported effects of morphine paste, a locally administered opioid, weeks after the surgery were due to other reasons. In creating a model we can determine important variables and dosage information. This information allows for a greater understanding of what is happening in the body and how to improve surgical outcomes. We propose this study has implications in general research in the pharmacokinetics and dynamics of pharmacology through the body.
ContributorsJacobs, Danielle Renee (Author) / Caplan, Michael (Thesis director) / Giers, Morgan (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor)
Created2014-05
Description
The use of saliva sampling as a noninvasive way for drug analysis as well as the monitoring systems within the body has become increasingly important in recent research. Because of the growing interest in saliva, this project proposes a way to analyze sodium ion concentration in a saliva solution based on its fluorescence level when in the presence of a sodium indicator dye and recorded with a smartphone camera. The dyed sample was placed in a specially designed housing to exclude all ambient light from the images. A source light of known wavelength was used to excite the fluorescent dye and the smartphone camera images recorded the emission light wavelengths. After analysis of the images using ImageJ, it was possible to create a model to determine the level of fluorescence based on sodium ion concentration. The smartphone camera image model was compared to readings from a standard fluorescence plate recorder to test the accuracy of the model. The study found that the model was accurate within 5 % as compared to the fluorescence plate recorder. Based on the results, it was concluded that the method and resulting model proposed in this study is a valid was to analyze saliva or other solutions for their sodium ion concentration via images recorded by a smartphone camera.
ContributorsSmith, Catherine Julia (Author) / Antonio, Garcia (Thesis director) / Caplan, Michael (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor)
Created2014-05
Description
The action/adventure game Grad School: HGH is the final, extended version of a BME Prototyping class project in which the goal was to produce a zombie-themed game that teaches biomedical engineering concepts. The gameplay provides fast paced, exciting, and mildly addicting rooms that the player must battle and survive through, followed by an engineering puzzle that must be solved in order to advance to the next room. The objective of this project was to introduce the core concepts of BME to prospective students, rather than attempt to teach an entire BME curriculum. Based on user testing at various phases in the project, we concluded that the gameplay was engaging enough to keep most users' interest through the educational puzzles, and the potential for expanding this project to reach an even greater audience is vast.
ContributorsNitescu, George (Co-author) / Medawar, Alexandre (Co-author) / Spano, Mark (Thesis director) / LaBelle, Jeffrey (Committee member) / Guiang, Kristoffer (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor)
Created2014-05
Description
Monatomic gases are ideal working mediums for Brayton cycle systems due to their favorable thermodynamic properties. Closed Brayton cycle systems make use of these monatomic gases to increase system performance and thermal efficiency. Open Brayton cycles, on the other hand, operate with primarily diatomic and polyatomic gases from air and combustion products, which have less favorable properties. The focus of this study is to determine if monatomic gases can be utilized in an open Brayton cycle system, in a way that increases the overall performance, but is still cost effective.
Two variations on open cycle Brayton systems were analyzed, consisting of an “airborne” thrust producing propulsion system, and a “ground-based” power generation system. Both of these systems have some mole fraction of He, Ne, or Ar injected into the flow path at the inlet, and some fraction of monatomic gas recuperated and at the nozzle exit to be re-circulated through the system. This creates a working medium of an air-monatomic gas mixture before the combustor, and a combustion products-monatomic gas mixture after combustor. The system’s specific compressor work, specific turbine work, specific net power output, and thermal efficiency were analyzed for each case. The most dominant metric for performance is the thermal efficiency (η_sys), which showed a significant increase as the mole fraction of monatomic gas increased for all three gas types. With a mole fraction of 0.15, there was a 2-2.5% increase in the airborne system, and a 1.75% increase of the ground-based system. This confirms that “spiking” any open Brayton system with monatomic gas will lead to an increase in performance. Additionally, both systems showed an increase in compressor and turbine work for a set temperature difference with He and Ne, which can additionally lead to longer component lifecycles with less frequent maintenance checks.
The cost analysis essentially compares the operating cost of a standard system with the operating cost of the monatomic gas “spiked” system, while keeping the internal mass flow rate and total power output the same. This savings is denoted as a percent of the standard system with %NCS. This metric lumps the cost ratio of the monatomic gas and fuel (MGC/FC) with the fraction of recuperated monatomic gas (RF) into an effective cost ratio that represents the cost per second of monatomic gas injected into the system. Without recuperation, the results showed there is no mole fraction of any monatomic gas type that yields a positive %NCS for a reasonable range of current MGC/FC values. Integrating recuperation machinery in an airborne system is hugely impractical, effectively meaning that the use of monatomic gas in this case is not feasible. For a ground-based system on the other hand, recuperation is much more practical. The ground-based system showed that a RF value of at least 50% for He, 89% for Ne, and 94% for Ar is needed for positive savings. This shows that monatomic gas could theoretically be used cost effectively in a ground-based, power-generating open Brayton system. With an injected monatomic gas mole fraction of 0.15, and full 100% recuperation, there is a net cost savings of about 3.75% in this ground-based system.
Two variations on open cycle Brayton systems were analyzed, consisting of an “airborne” thrust producing propulsion system, and a “ground-based” power generation system. Both of these systems have some mole fraction of He, Ne, or Ar injected into the flow path at the inlet, and some fraction of monatomic gas recuperated and at the nozzle exit to be re-circulated through the system. This creates a working medium of an air-monatomic gas mixture before the combustor, and a combustion products-monatomic gas mixture after combustor. The system’s specific compressor work, specific turbine work, specific net power output, and thermal efficiency were analyzed for each case. The most dominant metric for performance is the thermal efficiency (η_sys), which showed a significant increase as the mole fraction of monatomic gas increased for all three gas types. With a mole fraction of 0.15, there was a 2-2.5% increase in the airborne system, and a 1.75% increase of the ground-based system. This confirms that “spiking” any open Brayton system with monatomic gas will lead to an increase in performance. Additionally, both systems showed an increase in compressor and turbine work for a set temperature difference with He and Ne, which can additionally lead to longer component lifecycles with less frequent maintenance checks.
The cost analysis essentially compares the operating cost of a standard system with the operating cost of the monatomic gas “spiked” system, while keeping the internal mass flow rate and total power output the same. This savings is denoted as a percent of the standard system with %NCS. This metric lumps the cost ratio of the monatomic gas and fuel (MGC/FC) with the fraction of recuperated monatomic gas (RF) into an effective cost ratio that represents the cost per second of monatomic gas injected into the system. Without recuperation, the results showed there is no mole fraction of any monatomic gas type that yields a positive %NCS for a reasonable range of current MGC/FC values. Integrating recuperation machinery in an airborne system is hugely impractical, effectively meaning that the use of monatomic gas in this case is not feasible. For a ground-based system on the other hand, recuperation is much more practical. The ground-based system showed that a RF value of at least 50% for He, 89% for Ne, and 94% for Ar is needed for positive savings. This shows that monatomic gas could theoretically be used cost effectively in a ground-based, power-generating open Brayton system. With an injected monatomic gas mole fraction of 0.15, and full 100% recuperation, there is a net cost savings of about 3.75% in this ground-based system.
ContributorsBernaud, Ryan Clark (Author) / Dahm, Werner (Thesis director) / Wells, Valana (Committee member) / Mechanical and Aerospace Engineering Program (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
Traumatic brain injury (TBI) is a major concern in public health due to its prevalence and effect. Every year, about 1.7 million TBIs are reported [7]. According to the According to the Centers for Disease Control and Prevention (CDC), 5.5% of all emergency department visits, hospitalizations, and deaths from 2002 to 2006 are due to TBI [8]. The brain's natural defense, the Blood Brain Barrier (BBB), prevents the entry of most substances into the brain through the blood stream, including medicines administered to treat TBI [11]. TBI may cause the breakdown of the BBB, and may result in increased permeability, providing an opportunity for NPs to enter the brain [3,4]. Dr. Stabenfeldt's lab has previously established that intravenously injected nanoparticles (NP) will accumulate near the injury site after focal brain injury [4]. The current project focuses on confirmation of the accumulation or extravasation of NPs after brain injury using 2-photon microscopy. Specifically, the project used controlled cortical impact injury induced mice models that were intravenously injected with 40nm NPs post-injury. The MATLAB code seeks to analyze the brain images through registration, segmentation, and intensity measurement and evaluate if fluorescent NPs will accumulate in the extravascular tissue of injured mice models. The code was developed with 2D bicubic interpolation, subpixel image registration, drawn dimension segmentation and fixed dimension segmentation, and dynamic image analysis. A statistical difference was found between the extravascular tissue of injured and uninjured mouse models. This statistical difference proves that the NPs do extravasate through the permeable cranial blood vessels in injured cranial tissue.
ContributorsIrwin, Jacob Aleksandr (Author) / Stabenfeldt, Sarah (Thesis director) / Bharadwaj, Vimala (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
Compressed sensing magnetic resonance spectroscopic imaging (MRSI) is a noninvasive and in vivo potential diagnostic technique for cancer imaging. This technique undersamples the distribution of specific cancer biomarkers within an MR image as well as changes in the temporal dimension and subsequently reconstructs the missing data. This technique has been shown to retain a high level of fidelity even with an acceleration factor of 5. Currently there exist several different scanner types that each have their separate analytical methods in MATLAB. A graphical user interface (GUI) was created to facilitate a single computing platform for these different scanner types in order to improve the ease and efficiency with which researchers and clinicians interact with this technique. A GUI was successfully created for both prospective and retrospective MRSI data analysis. This GUI retained the original high fidelity of the reconstruction technique and gave the user the ability to load data, load reference images, display intensity maps, display spectra mosaics, generate a mask, display the mask, display kspace and save the corresponding spectra, reconstruction, and mask files. Parallelization of the reconstruction algorithm was explored but implementation was ultimately unsuccessful. Future work could consist of integrating this parallelization method, adding intensity overlay functionality and improving aesthetics.
ContributorsLammers, Luke Michael (Author) / Kodibagkar, Vikram (Thesis director) / Hu, Harry (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Energy efficient optimal formation control of a multiple quadrotor UAV system with uncertain payload
Description
This thesis presents the design and simulation of an energy efficient controller for a system of three drones transporting a payload in a net. The object ensnared in the net is represented as a mass connected by massless stiff springs to each drone. Both a pole-placement approach and an optimal control approach are used to design a trajectory controller for the system. Results are simulated for a single drone and the three drone system both without and with payload.
ContributorsHayden, Alexander (Author) / Grewal, Anoop (Thesis director) / Berman, Spring (Committee member) / Barrett, The Honors College (Contributor) / Mechanical and Aerospace Engineering Program (Contributor) / Historical, Philosophical & Religious Studies, Sch (Contributor)
Created2022-05
Description
This paper describes the development of a software tool used to automate the preliminary design of aircraft wing structure. By taking wing planform and aircraft weight as inputs, the tool is able to predict loads that will be experienced by the wing. An iterative process is then used to select optimal material thicknesses for each section of the design to minimize total structural weight. The load analysis checks for tensile failure as well as Euler buckling when considering if a given wing structure is valid. After running a variety of test cases with the tool it was found that wing structure of small-scale aircraft is predominantly buckling driven. This is problematic because commonly used weight estimation equations are based on large scale aircraft with strength driven wing designs. Thus, if these equations are applied to smaller aircraft, resulting weight estimates are often much lower than reality. The use of a physics-based approach to preliminary sizing could greatly improve the accuracy of weight predictions and accelerate the design process.
ContributorsKolesov, Nikolay (Author) / Takahashi, Timothy (Thesis director) / Patel, Jay (Committee member) / Kosaraju, Srinivas (Committee member) / Mechanical and Aerospace Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2019-12
Description
Human potential is characterized by our ability to think flexibly and develop novel solutions to problems. In cognitive neuroscience, problem solving is studied using various tasks. For example, IQ can be tested using the RAVEN, which measures abstract reasoning. Analytical problem solving can be tested using algebra, and insight can be tested using a nine-dot test. Our class of problem-solving tasks blends analytical and insight processes. This can be done by measuring multiply-constrained problem solving (MCPS). MCPS occurs when an individual problem has several solutions, but when grouped with simultaneous problems only one correct solution presents itself. The most common test for MCPS is known at the CRAT, or compound remote associate task. For example, when given the three target words “water, skate, and cream” there are many compound associates that can be assigned each of the target words individually (i.e. salt-water, roller-skate, whipped-cream), but only one that works with all three (ice-water, ice-skate, ice-cream).
This thesis is a tutorial for a MATLAB user-interface, known as EEGLAB. Cognitive and neural correlates of analytical and insight processes were evaluated and analyzed in the CRAT using EEG. It was hypothesized that different EEG signals will be measured for analytical versus insight problem solving, primarily observed in the gamma wave production. The data was interpreted using EEGLAB, which allows psychological processes to be quantified based on physiological response. I have written a tutorial showing how to process the EEG signal through filtering, extracting epochs, artifact detection, independent component analysis, and the production of a time – frequency plot. This project has combined my interest in psychology with my knowledge of engineering and expand my knowledge of bioinstrumentation.
This thesis is a tutorial for a MATLAB user-interface, known as EEGLAB. Cognitive and neural correlates of analytical and insight processes were evaluated and analyzed in the CRAT using EEG. It was hypothesized that different EEG signals will be measured for analytical versus insight problem solving, primarily observed in the gamma wave production. The data was interpreted using EEGLAB, which allows psychological processes to be quantified based on physiological response. I have written a tutorial showing how to process the EEG signal through filtering, extracting epochs, artifact detection, independent component analysis, and the production of a time – frequency plot. This project has combined my interest in psychology with my knowledge of engineering and expand my knowledge of bioinstrumentation.
ContributorsCobban, Morgan Elizabeth (Author) / Brewer, Gene (Thesis director) / Ellis, Derek (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
The purpose of this project was to create an algorithm to improve firearm aiming. In order to do so, a simulation of exterior ballistics – the bullet’s behavior between the firearm muzzle and the target – was created in MATLAB. The simulation of bullet trajectory included consideration of three forces: gravity, air drag, and Coriolis ‘force’. An overall equation of motion for the bullet in flight, comprising the effects of the aforementioned forces, was constructed using formulae and theory given in R. L. McCoy’s Modern Exterior Ballistics. For the project, a reference frame was defined based on firearm muzzle and target positions, and an aim vector described by two angles was defined to describe the direction of the firearm’s barrel. The simulations of bullet trajectory take into account eleven parameters: the two aim angles, initial bullet speed (commonly referred to as muzzle velocity), 3-D Cartesian components of wind velocity, air density, bullet diameter, bullet mass, latitude of the firing area, and azimuth of fire (a quantified compass direction of fire).
The user inputs target position, muzzle position, and estimated environmental parameters to the system. Then, an aim vector would be calculated to hit the target under estimated conditions. Because the eleven trajectory parameters likely cannot all be precisely known, this solution will have some error. In real life, the system would use feedback from real shots of a firearm to correct for this error. For this project, a real-world proxy simulation was created that had built-in random error and variations in the parameters. The correction algorithm uses the error data from all previous shots to calculate adjustments to the original aim vector, so that each successive shot becomes more accurate. The system was tested with specifications of a common rifle platform, with estimated parameters and variations for a location in Tempe, AZ (since data for an urban area is readily available compared to a point in the wilderness). Results from this testing revealed that the system can “hit” a 2-meter-radius circular target in under 30 shots. When the errors and variations in parameters were halved for the real-world stand-in simulation, the system could “hit” a circular target with 0.55 meter radius in less than 25 shots. After analysis, it was found that the corrected aim angles converged on values, suggesting that the correction algorithm functions as intended (taking into account all past shots). Generally, it was found that any reduction of the means and standard deviations of parameter error improved the ability of the system to hit smaller targets, or hit the same target with less shots.
The user inputs target position, muzzle position, and estimated environmental parameters to the system. Then, an aim vector would be calculated to hit the target under estimated conditions. Because the eleven trajectory parameters likely cannot all be precisely known, this solution will have some error. In real life, the system would use feedback from real shots of a firearm to correct for this error. For this project, a real-world proxy simulation was created that had built-in random error and variations in the parameters. The correction algorithm uses the error data from all previous shots to calculate adjustments to the original aim vector, so that each successive shot becomes more accurate. The system was tested with specifications of a common rifle platform, with estimated parameters and variations for a location in Tempe, AZ (since data for an urban area is readily available compared to a point in the wilderness). Results from this testing revealed that the system can “hit” a 2-meter-radius circular target in under 30 shots. When the errors and variations in parameters were halved for the real-world stand-in simulation, the system could “hit” a circular target with 0.55 meter radius in less than 25 shots. After analysis, it was found that the corrected aim angles converged on values, suggesting that the correction algorithm functions as intended (taking into account all past shots). Generally, it was found that any reduction of the means and standard deviations of parameter error improved the ability of the system to hit smaller targets, or hit the same target with less shots.
ContributorsReyes, Joshua De Leon (Author) / Grewal, Anoop Singh (Thesis director) / Murthy, Raghavendra N. (Committee member) / Mechanical and Aerospace Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05