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Xerostomia and the Microbiome of the Mouth

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Is it possible to treat the mouth as a natural environment, and determine new methods to keep the microbiome in check? The need for biodiversity in health may suggest that every species carries out a specific function that is required to maintain equilibrium and homeostasis within the oral cavity. Furthermore,…

Is it possible to treat the mouth as a natural environment, and determine new methods to keep the microbiome in check? The need for biodiversity in health may suggest that every species carries out a specific function that is required to maintain equilibrium and homeostasis within the oral cavity. Furthermore, the relationship between the microbiome and its host is mutually beneficial because the host is providing microbes with an environment in which they can flourish and, in turn, keep their host healthy. Reviewing examples of larger scale environmental shifts could provide a window by which scientists can make hypotheses. Certain medications and healthcare treatments have been proven to cause xerostomia. This disorder is characterized by a dry mouth, and known to be associated with a change in the composition, and reduction, of saliva. Two case studies performed by Bardow et al, and Leal et al, tested and studied the relationships of certain medications and confirmed their side effects on the salivary glands [2,3]. Their results confirmed a relationship between specific medicines, and the correlating complaints of xerostomia. In addition, Vissink et al conducted case studies that helped to further identify how radiotherapy causes hyposalivation of the salivary glands [4]. Specifically patients that have been diagnosed with oral cancer, and are treated by radiotherapy, have been diagnosed with xerostomia. As stated prior, studies have shown that patients having an ecologically balanced and diverse microbiome tend to have healthier mouths. The oral cavity is like any biome, consisting of commensalism within itself and mutualism with its host. Due to the decreased salivary output, caused by xerostomia, increased parasitic bacteria build up within the oral cavity thus causing dental disease. Every human body contains a personalized microbiome that is essential to maintaining health but capable of eliciting disease. The Human Oral Microbiomics Database (HOMD) is a set of reference 16S rRNA gene sequences. These are then used to define individual human oral taxa. By conducting metagenomic experiments at the molecular and cellular level, scientists can identify and label micro species that inhabit the mouth during parasitic outbreaks or a shifting of the microbiome. Because the HOMD is incomplete, so is our ability to cure, or prevent, oral disease. The purpose of the thesis is to research what is known about xerostomia and its effects on the complex microbiome of the oral cavity. It is important that researchers determine whether this particular perspective is worth considering. In addition, the goal is to create novel experiments for treatment and prevention of dental diseases.
ContributorsHalcomb, Michael Jordan (Author) / Chen, Qiang (Thesis director) / Steele, Kelly (Committee member) / Barrett, The Honors College (Contributor) / College of Letters and Sciences (Contributor)
Created2015-05
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Reforming the NCAA: How the governing body of intercollegiate athletics should handle student-athletes into the future

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My thesis project, "Reforming the NCAA: How the governing body of intercollegiate athletics should handle student-athletes into the future," sets out to create a working blueprint for how the NCAA should handle the relationship between student-athletes, universities, and the NCAA from this point forward. The NCAA has come under fire…

My thesis project, "Reforming the NCAA: How the governing body of intercollegiate athletics should handle student-athletes into the future," sets out to create a working blueprint for how the NCAA should handle the relationship between student-athletes, universities, and the NCAA from this point forward. The NCAA has come under fire in the past 10 years for its failure to meet modern social constructs and provide student-athletes with the resources necessary to achieving a successful educational and athletic experience, and through my thesis, I formulated reforms the NCAA can adopt and enact to respond to the growing issues within intercollegiate athletics. I began the process last spring with my thesis director as we selected a topic together, and I researched a variety of topics relating to current NCAA issues throughout the summer and fall. In the fall, I outlined sources I hoped to interview, and I conducted interviews over winter break. I spent the first two months of 2015 writing and refining my thesis, and through March, I created a PowerPoint presentation I used to defend my thesis project. During the process, I met with my thesis director at critical junctures to discuss the direction of the project and to determine how to find a delicate balance between creating attainable goals for reform and overstepping my boundaries. After a successful thesis defense, I made small revisions to the thesis and had my project re-approved by my director and second reader. In the coming weeks after submitting my thesis, I plan on exploring the possibility of having my thesis published and received critiques from those in the industry who follow collegiate athletics closely.
ContributorsCrowley, Kerry O Shea (Author) / McGuire, Tim (Thesis director) / Kurland, Brett (Committee member) / College of Letters and Sciences (Contributor) / Walter Cronkite School of Journalism and Mass Communication (Contributor) / Barrett, The Honors College (Contributor)
Created2015-05
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The Elimination of Olympic Nonrevenue Sports: Unforeseen Consequences

Description

The purpose of this paper is to raise awareness about the problem nonrevenue sports face today by analyzing the key factors of the failing Division 1 model and providing some unforeseen consequences in the elimination of nonrevenue sports. The first section will explore the elimination and financial trends of NCAA…

The purpose of this paper is to raise awareness about the problem nonrevenue sports face today by analyzing the key factors of the failing Division 1 model and providing some unforeseen consequences in the elimination of nonrevenue sports. The first section will explore the elimination and financial trends of NCAA Division 1 in a historical and contemporary context. The second section will provide the deep-rooted problems associated with collegiate sports. Lastly, the third section will analyze unforeseen consequences for athletic departments that should be accounted for when contemplating the elimination of a nonrevenue program.
ContributorsBelshay, Cade Michael (Author) / Eaton, John (Thesis director) / Mowka, Michael (Committee member) / Department of Finance (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05

NIL in 2023: The Current Impact of NIL and Optimal Approaches for Stakeholders

Description

The NCAA’s legalization of athletes to profit off of their own name, image, and likeness (NIL) was met with mixed response from fans of collegiate sports. A popular talking point among people against NIL was that its legalization would cause talented athletes to “follow the money” and increase the recruiting…

The NCAA’s legalization of athletes to profit off of their own name, image, and likeness (NIL) was met with mixed response from fans of collegiate sports. A popular talking point among people against NIL was that its legalization would cause talented athletes to “follow the money” and increase the recruiting quality at schools where NIL opportunities were plentiful. In essence, a theoretical “talent gap” would form due to this movement of athlete talent. The goal of this paper is to determine the talent gap’s existence or lack thereof while also setting stakeholders directly involved with NIL deals (colleges, businesses, companies) up for success in the age of NIL. This was executed first through the issuance of a survey that collected five categories of data: fandom and interest in college sports, industry sector interest, NIL preferences (structure, money, form), NIL recruiting preferences, and demographics. Following this collection of survey data, recruiting and transfer data for the years 2011-2023 was obtained and analyzed to determine the influence of specific variables in the recruiting process. The survey used in this paper was sent out to over 300 Arizona State University students from Dr. Eaton’s fall semester marketing class, with 158 participants filtered out in order to exclusively measure the responses of students with a similar perspective to athletes. The recruiting and transfer data was derived from the recruiting websites 247 Sports, Rivals, and On3 sports, with On3 Sports additionally providing NIL valuation estimates. Findings from the survey and recruiting data analysis could neither prove or disprove the existence of the theorized athletic talent gap. Results suggest that football or basketball program prestige is the true primary driver of talent movement, not NIL. Businesses looking to issue NIL deals should focus on the marketing obligations and payment structure of the deal rather than payment value, as money does not significantly influence the decision to take an NIL deal offer.
ContributorsSchmelzeis, Paul (Author) / Eaton, John (Thesis director) / Lee, Christopher (Committee member) / Barrett, The Honors College (Contributor) / Department of Marketing (Contributor) / Department of Finance (Contributor)
Created2023-05

Schmelzeis_Spring_2023.pdf

ContributorsSchmelzeis, Paul (Author) / Eaton, John (Thesis director) / Lee, Christopher (Committee member) / Barrett, The Honors College (Contributor) / Department of Marketing (Contributor) / Department of Finance (Contributor)
Created2023-05

Paul Schmelzeis Thesis Defense Presentation.pdf

ContributorsSchmelzeis, Paul (Author) / Eaton, John (Thesis director) / Lee, Christopher (Committee member) / Barrett, The Honors College (Contributor) / Department of Marketing (Contributor) / Department of Finance (Contributor)
Created2023-05