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Description
This purpose of this thesis study was to examine variables of the "War on Cancer" frame, loss-gain prime, and patient gender on treatment decision for advanced cancer patients. A total of 291 participants (141 females) participated in an online survey experiment and were randomly assigned to one of eight possible conditions, each of which were comprised of a combination of one of two levels for three total independent variables: war frame ("War on Cancer" frame or neutral frame), loss-gain prime (loss prime or gain prime), and patient gender (female or male). Each of the three variables were operationalized to determine whether or not the exposure to the war on cancer paradigm, loss-frame language, or male patient gender would increase the likelihood of a participant choosing a more aggressive cancer treatment. Participants read a patient scenario and were asked to respond to questions related to motivating factors. Participants were then asked to report preference for one of two treatment decisions. Participants were then asked to provide brief demographic information in addition to responding to questions about military history, war attitudes, and cancer history. The aforementioned manipulations sought to determine whether exposure to various factors would make a substantive difference in final treatment decision. Contrary to the predicted results, participants in the war frame condition (M = 3.85, SD = 1.48) were more likely to choose the pursuit of palliative care (as opposed to aggressive treatment) than participants in the neutral frame condition (M = 3.54, SD = 1.23). Ultimately, these significant findings suggest that there is practical information to be gained from treatment presentation manipulations. By arming healthcare providers with a more pointed understanding of the nuances of treatment presentation, we can hope to empower patients, their loved ones, and healthcare providers entrenched in the world of cancer treatment.
ContributorsKnowles, Madelyn Ann (Author) / Kwan, Virginia S. Y. (Thesis director) / Presson, Clark (Committee member) / Salamone, Damien (Committee member) / Department of Psychology (Contributor) / School of Human Evolution and Social Change (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Menopause is associated with a wide array of negative symptoms. As average lifespan increases due to advances in healthcare and technology, more women are spending a larger portion of their lives in a menopausal state low in estrogen and progesterone. Hormone therapies such as Conjugated Equine Estrogens (CEE) and the bioidentical estrogen, 17-estradiol (E2), are commonly prescribed to treat the negative symptoms of menopause. Our laboratory has previously shown that CEE has differential effects on cognitive ability depending on whether menopause is transitional (VCD) or surgical (ovariectomy, OVX). Further, the negative impact of CEE on cognitive function in a transitional ovary-intact model of menopause was associated with high levels of serum androstenedione; the primary hormone circulating in a follicle-deplete menopausal state. Here, we investigate the cognitive effects of these two common hormone therapies separately, and in conjunction with the hormone androstenedione, in a "blank-slate" OVX mouse model. We assessed cognitive ability using two behavioral tasks such at the Water Radial Arm Maze (WRAM, measuring spatial working and reference memory) and the Morris water maze (MM, measuring spatial reference memory). In the WRAM, every treatment group saw impaired performance compared to Vehicle but the combination group of E2 plus Androstenedione. In the MM, the combination group of E2 plus Androstenedione actually enhanced performance in the maze compared to every other comparable group. Translationally, these results suggest that CEE given in the presence of an androstenedione-dominant hormone milieu is impairing to cognition, E2 in this same manner is not. These results yield valuable insight into optimal hormone therapies for menopausal women.
ContributorsGranger, Steven Jay (Author) / Bimonte-Nelson, Heather (Thesis director) / Presson, Clark (Committee member) / Hiroi, Sheri (Committee member) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Prospective memory is defined as remembering to carry out specified actions in the future. Research has suggested that prospective memory retrieval is reliant on multiple cognitive processes to function, and the ways in which these different processes are used is dependent on a variety of variables relating to the prospective memory task at hand. The current study focuses on the strength of the association between the prospective
memory cue and the prospective memory intention. Based on literature suggesting that aspects of prospective memory are reliant on executive control functioning, the current study examined the possibility that executive control depletion would affect prospective memory ability on subsequent tasks. Results showed that depletion of executive control resources, measured objectively, did not impair prospective memory in either a low or
high cue-association condition. However, participants‟ subjective assessment of their own fatigue correlated significantly with their subsequent prospective memory performance, regardless of association condition. The results of the study indicate that depletion studies that fail to account for both objective and subjective measures suffer from an unclear interpretation of effects, and that recognition of perceived expectancies
of cognitive resource limitation can assist in improving prospective memory ability.
memory cue and the prospective memory intention. Based on literature suggesting that aspects of prospective memory are reliant on executive control functioning, the current study examined the possibility that executive control depletion would affect prospective memory ability on subsequent tasks. Results showed that depletion of executive control resources, measured objectively, did not impair prospective memory in either a low or
high cue-association condition. However, participants‟ subjective assessment of their own fatigue correlated significantly with their subsequent prospective memory performance, regardless of association condition. The results of the study indicate that depletion studies that fail to account for both objective and subjective measures suffer from an unclear interpretation of effects, and that recognition of perceived expectancies
of cognitive resource limitation can assist in improving prospective memory ability.
ContributorsCook, Carson (Author) / Brewer, Gene (Thesis director) / Presson, Clark (Committee member) / Homa, Donald (Committee member) / Barrett, The Honors College (Contributor) / College of Liberal Arts and Sciences (Contributor)
Created2012-12