Matching Items (5)
Filtering by

Clear all filters

136509-Thumbnail Image.png
Description
The primary objective of this research project is to develop dual layered polymeric microparticles with a tunable delayed release profile. Poly(L-lactic acid) (PLA) and poly(lactic-co-glycolic acid) (PLGA) phase separate in a double emulsion process due to differences in hydrophobicity, which allows for the synthesis of double-walled microparticles with a PLA

The primary objective of this research project is to develop dual layered polymeric microparticles with a tunable delayed release profile. Poly(L-lactic acid) (PLA) and poly(lactic-co-glycolic acid) (PLGA) phase separate in a double emulsion process due to differences in hydrophobicity, which allows for the synthesis of double-walled microparticles with a PLA shell surrounding the PLGA core. The microparticles were loaded with bovine serum albumin (BSA) and different volumes of ethanol were added to the PLA shell phase to alter the porosity and release characteristics of the BSA. Different amounts of ethanol varied the total loading percentage of the BSA, the release profile, surface morphology, size distribution, and the localization of the protein within the particles. Scanning electron microscopy images detailed the surface morphology of the different particles. Loading the particles with fluorescently tagged insulin and imaging the particles through confocal microscopy supported the localization of the protein inside the particle. The study suggest that ethanol alters the release characteristics of the loaded BSA encapsulated in the microparticles supporting the use of a polar, protic solvent as a tool for tuning the delayed release profile of biological proteins.
ContributorsFauer, Chase Alexander (Author) / Stabenfeldt, Sarah (Thesis director) / Ankeny, Casey (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor)
Created2015-05
Description

The goal of this research project is to create a Mathcad template file capable of statistically modelling the effects of mean and standard deviation on a microparticle batch characterized by the log normal distribution model. Such a file can be applied during manufacturing to explore tolerances and increase cost and

The goal of this research project is to create a Mathcad template file capable of statistically modelling the effects of mean and standard deviation on a microparticle batch characterized by the log normal distribution model. Such a file can be applied during manufacturing to explore tolerances and increase cost and time effectiveness. Theoretical data for the time to 60% drug release and the slope and intercept of the log-log plot were collected and subjected to statistical analysis in JMP. Since the scope of this project focuses on microparticle surface degradation drug release with no drug diffusion, the characteristic variables relating to the slope (n = diffusional release exponent) and the intercept (k = kinetic constant) do not directly apply to the distribution model within the scope of the research. However, these variables are useful for analysis when the Mathcad template is applied to other types of drug release models.

ContributorsHan, Priscilla (Author) / Vernon, Brent (Thesis director) / Nickle, Jacob (Committee member) / Harrington Bioengineering Program (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description

A friend of mine once told me that coding is like doing magic, and frankly, I am inclined to agree. With a keyboard, a development environment, and a little bit of language skill, you can build an entire world. Despite being heavily rooted in logic, math, and science, there is

A friend of mine once told me that coding is like doing magic, and frankly, I am inclined to agree. With a keyboard, a development environment, and a little bit of language skill, you can build an entire world. Despite being heavily rooted in logic, math, and science, there is a certain mystery to it, a sense of illusion and wizardry. The sense of pride and power that comes from successfully finishing an app, program, or website is like no other. I recently watched the film Ex Machina (Alex Garland, 2014) for the first time, and I was struck by one of the lines. In thinking about the success of his creation and what that means for the world, he says, “I’m not a man, I’m God.” And although I wouldn’t say that is exactly how I feel when I turn in a coding assignment, I understand the sentiment. This thesis is going to be a bit different than the one I thought I was going to write. When I started this, I thought it would be about an amazing coding project I had completed. I would write about all the beautiful code and the nitty gritty of the technical aspects. But, the project that I intended to create is not the project I ended up with, and I couldn’t be happier. I finished with something a lot more meaningful, a lot more interdisciplinary, and a lot more me. In this essay and the accompanying coding project, I aim to take you on the journey of building my own piece of digital culture, an app titled “Exposed.” I begin by discussing how the motivation to create Exposed came from the desire to stop using an app made by an internet celebrity and how the values of Gen Z and their relationship with technology influenced and guided the creation of the app. Then I examine the relationship between code and the coder, and how external factors such as being a woman in technology impacts project development. Then I explain the results of the coding process and outline how Exposed turned out. Finally, I consider the meaning of digital culture and how it functions in the creation of Exposed. Along the way this project became extremely personal. I found that the deeper I dove into making the code work, the more I learned about myself and my relationship to technology. If I promise to be honest with you, will you promise to listen to what I have to say?

ContributorsRimsza, Melissa (Author) / Olson, Loren (Thesis director) / Moran, Stacey (Committee member) / Barrett, The Honors College (Contributor) / The Design School (Contributor) / Arts, Media and Engineering Sch T (Contributor) / Walter Cronkite School of Journalism and Mass Comm (Contributor)
Created2023-05
ContributorsRimsza, Melissa (Author) / Olson, Loren (Thesis director) / Moran, Stacey (Committee member) / Barrett, The Honors College (Contributor) / The Design School (Contributor) / Arts, Media and Engineering Sch T (Contributor) / Walter Cronkite School of Journalism and Mass Comm (Contributor)
Created2023-05
ContributorsRimsza, Melissa (Author) / Olson, Loren (Thesis director) / Moran, Stacey (Committee member) / Barrett, The Honors College (Contributor) / The Design School (Contributor) / Arts, Media and Engineering Sch T (Contributor) / Walter Cronkite School of Journalism and Mass Comm (Contributor)
Created2023-05