Polymer drug delivery system offers a key to a glaring issue in modern administration routes of drugs and biologics. Poly(lactic-co-glycolic acid) (PLGA) can be used to encapsulate drugs and biologics and deliver them into the patient, which allows high local concentration (compared to current treatment methods), protection of the cargo from the bodily environment, and reduction in systemic side effects. This experiment used a single emulsion technique to encapsulate L-tyrosine in PLGA microparticles and UV spectrophotometry to analyze the drug release over a period of one week. The release assay found that for the tested samples, the released amount is distinct initially, but is about the same after 4 days, and they generally follow the same normalized percent released pattern. The experiment could continue with testing more samples, test the same samples for a longer duration, and look into higher w/w concentrations such as 20% or 50%.

The goal of this research project is to create a Mathcad template file capable of statistically modelling the effects of mean and standard deviation on a microparticle batch characterized by the log normal distribution model. Such a file can be applied during manufacturing to explore tolerances and increase cost and time effectiveness. Theoretical data for the time to 60% drug release and the slope and intercept of the log-log plot were collected and subjected to statistical analysis in JMP. Since the scope of this project focuses on microparticle surface degradation drug release with no drug diffusion, the characteristic variables relating to the slope (n = diffusional release exponent) and the intercept (k = kinetic constant) do not directly apply to the distribution model within the scope of the research. However, these variables are useful for analysis when the Mathcad template is applied to other types of drug release models.

A friend of mine once told me that coding is like doing magic, and frankly, I am inclined to agree. With a keyboard, a development environment, and a little bit of language skill, you can build an entire world. Despite being heavily rooted in logic, math, and science, there is a certain mystery to it, a sense of illusion and wizardry. The sense of pride and power that comes from successfully finishing an app, program, or website is like no other. I recently watched the film Ex Machina (Alex Garland, 2014) for the first time, and I was struck by one of the lines. In thinking about the success of his creation and what that means for the world, he says, “I’m not a man, I’m God.” And although I wouldn’t say that is exactly how I feel when I turn in a coding assignment, I understand the sentiment. This thesis is going to be a bit different than the one I thought I was going to write. When I started this, I thought it would be about an amazing coding project I had completed. I would write about all the beautiful code and the nitty gritty of the technical aspects. But, the project that I intended to create is not the project I ended up with, and I couldn’t be happier. I finished with something a lot more meaningful, a lot more interdisciplinary, and a lot more me. In this essay and the accompanying coding project, I aim to take you on the journey of building my own piece of digital culture, an app titled “Exposed.” I begin by discussing how the motivation to create Exposed came from the desire to stop using an app made by an internet celebrity and how the values of Gen Z and their relationship with technology influenced and guided the creation of the app. Then I examine the relationship between code and the coder, and how external factors such as being a woman in technology impacts project development. Then I explain the results of the coding process and outline how Exposed turned out. Finally, I consider the meaning of digital culture and how it functions in the creation of Exposed. Along the way this project became extremely personal. I found that the deeper I dove into making the code work, the more I learned about myself and my relationship to technology. If I promise to be honest with you, will you promise to listen to what I have to say?