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- Creators: Arizona State University
Description
A medical control system, a real-time controller, uses a predictive model of human physiology for estimation and controlling of drug concentration in the human body. Artificial Pancreas (AP) is an example of the control system which regulates blood glucose in T1D patients. The predictive model in the control system such as Bergman Minimal Model (BMM) is based on physiological modeling technique which separates the body into the number of anatomical compartments and each compartment's effect on body system is determined by their physiological parameters. These models are less accurate due to unaccounted physiological factors effecting target values. Estimation of a large number of physiological parameters through optimization algorithm is computationally expensive and stuck in local minima. This work evaluates a machine learning(ML) framework which has an ML model guided through physiological models. A support vector regression model guided through modified BMM is implemented for estimation of blood glucose levels. Physical activity and Endogenous glucose production are key factors that contribute in the increased hypoglycemia events thus, this work modifies Bergman Minimal Model ( Bergman et al. 1981) for more accurate estimation of blood glucose levels. Results show that the SVR outperformed BMM by 0.164 average RMSE for 7 different patients in the free-living scenario. This computationally inexpensive data driven model can potentially learn parameters more accurately with time. In conclusion, advised prediction model is promising in modeling the physiology elements in living systems.
ContributorsAgrawal, Anurag (Author) / Gupta, Sandeep K. S. (Thesis advisor) / Banerjee, Ayan (Committee member) / Kudva, Yogish (Committee member) / Arizona State University (Publisher)
Created2017
Description
A major challenge in automated text analysis is that different words are used for related concepts. Analyzing text at the surface level would treat related concepts (i.e. actors, actions, targets, and victims) as different objects, potentially missing common narrative patterns. Generalized concepts are used to overcome this problem. Generalization may result into word sense disambiguation failing to find similarity. This is addressed by taking into account contextual synonyms. Concept discovery based on contextual synonyms reveal information about the semantic roles of the words leading to concepts. Merger engine generalize the concepts so that it can be used as features in learning algorithms.
ContributorsKedia, Nitesh (Author) / Davulcu, Hasan (Thesis advisor) / Corman, Steve R (Committee member) / Li, Baoxin (Committee member) / Arizona State University (Publisher)
Created2015