Matching Items (21)
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- All Subjects: Machine Learning
- Genre: Doctoral Dissertation
- Creators: Li, Baoxin
Description
Surgery as a profession requires significant training to improve both clinical decision making and psychomotor proficiency. In the medical knowledge domain, tools have been developed, validated, and accepted for evaluation of surgeons' competencies. However, assessment of the psychomotor skills still relies on the Halstedian model of apprenticeship, wherein surgeons are observed during residency for judgment of their skills. Although the value of this method of skills assessment cannot be ignored, novel methodologies of objective skills assessment need to be designed, developed, and evaluated that augment the traditional approach. Several sensor-based systems have been developed to measure a user's skill quantitatively, but use of sensors could interfere with skill execution and thus limit the potential for evaluating real-life surgery. However, having a method to judge skills automatically in real-life conditions should be the ultimate goal, since only with such features that a system would be widely adopted. This research proposes a novel video-based approach for observing surgeons' hand and surgical tool movements in minimally invasive surgical training exercises as well as during laparoscopic surgery. Because our system does not require surgeons to wear special sensors, it has the distinct advantage over alternatives of offering skills assessment in both learning and real-life environments. The system automatically detects major skill-measuring features from surgical task videos using a computing system composed of a series of computer vision algorithms and provides on-screen real-time performance feedback for more efficient skill learning. Finally, the machine-learning approach is used to develop an observer-independent composite scoring model through objective and quantitative measurement of surgical skills. To increase effectiveness and usability of the developed system, it is integrated with a cloud-based tool, which automatically assesses surgical videos upload to the cloud.
ContributorsIslam, Gazi (Author) / Li, Baoxin (Thesis advisor) / Liang, Jianming (Thesis advisor) / Dinu, Valentin (Committee member) / Greenes, Robert (Committee member) / Smith, Marshall (Committee member) / Kahol, Kanav (Committee member) / Patel, Vimla L. (Committee member) / Arizona State University (Publisher)
Created2013
Description
In many fields one needs to build predictive models for a set of related machine learning tasks, such as information retrieval, computer vision and biomedical informatics. Traditionally these tasks are treated independently and the inference is done separately for each task, which ignores important connections among the tasks. Multi-task learning aims at simultaneously building models for all tasks in order to improve the generalization performance, leveraging inherent relatedness of these tasks. In this thesis, I firstly propose a clustered multi-task learning (CMTL) formulation, which simultaneously learns task models and performs task clustering. I provide theoretical analysis to establish the equivalence between the CMTL formulation and the alternating structure optimization, which learns a shared low-dimensional hypothesis space for different tasks. Then I present two real-world biomedical informatics applications which can benefit from multi-task learning. In the first application, I study the disease progression problem and present multi-task learning formulations for disease progression. In the formulations, the prediction at each point is a regression task and multiple tasks at different time points are learned simultaneously, leveraging the temporal smoothness among the tasks. The proposed formulations have been tested extensively on predicting the progression of the Alzheimer's disease, and experimental results demonstrate the effectiveness of the proposed models. In the second application, I present a novel data-driven framework for densifying the electronic medical records (EMR) to overcome the sparsity problem in predictive modeling using EMR. The densification of each patient is a learning task, and the proposed algorithm simultaneously densify all patients. As such, the densification of one patient leverages useful information from other patients.
ContributorsZhou, Jiayu (Author) / Ye, Jieping (Thesis advisor) / Mittelmann, Hans (Committee member) / Li, Baoxin (Committee member) / Wang, Yalin (Committee member) / Arizona State University (Publisher)
Created2014
Description
Many learning models have been proposed for various tasks in visual computing. Popular examples include hidden Markov models and support vector machines. Recently, sparse-representation-based learning methods have attracted a lot of attention in the computer vision field, largely because of their impressive performance in many applications. In the literature, many of such sparse learning methods focus on designing or application of some learning techniques for certain feature space without much explicit consideration on possible interaction between the underlying semantics of the visual data and the employed learning technique. Rich semantic information in most visual data, if properly incorporated into algorithm design, should help achieving improved performance while delivering intuitive interpretation of the algorithmic outcomes. My study addresses the problem of how to explicitly consider the semantic information of the visual data in the sparse learning algorithms. In this work, we identify four problems which are of great importance and broad interest to the community. Specifically, a novel approach is proposed to incorporate label information to learn a dictionary which is not only reconstructive but also discriminative; considering the formation process of face images, a novel image decomposition approach for an ensemble of correlated images is proposed, where a subspace is built from the decomposition and applied to face recognition; based on the observation that, the foreground (or salient) objects are sparse in input domain and the background is sparse in frequency domain, a novel and efficient spatio-temporal saliency detection algorithm is proposed to identify the salient regions in video; and a novel hidden Markov model learning approach is proposed by utilizing a sparse set of pairwise comparisons among the data, which is easier to obtain and more meaningful, consistent than tradition labels, in many scenarios, e.g., evaluating motion skills in surgical simulations. In those four problems, different types of semantic information are modeled and incorporated in designing sparse learning algorithms for the corresponding visual computing tasks. Several real world applications are selected to demonstrate the effectiveness of the proposed methods, including, face recognition, spatio-temporal saliency detection, abnormality detection, spatio-temporal interest point detection, motion analysis and emotion recognition. In those applications, data of different modalities are involved, ranging from audio signal, image to video. Experiments on large scale real world data with comparisons to state-of-art methods confirm the proposed approaches deliver salient advantages, showing adding those semantic information dramatically improve the performances of the general sparse learning methods.
ContributorsZhang, Qiang (Author) / Li, Baoxin (Thesis advisor) / Turaga, Pavan (Committee member) / Wang, Yalin (Committee member) / Ye, Jieping (Committee member) / Arizona State University (Publisher)
Created2014
Description
Multi-label learning, which deals with data associated with multiple labels simultaneously, is ubiquitous in real-world applications. To overcome the curse of dimensionality in multi-label learning, in this thesis I study multi-label dimensionality reduction, which extracts a small number of features by removing the irrelevant, redundant, and noisy information while considering the correlation among different labels in multi-label learning. Specifically, I propose Hypergraph Spectral Learning (HSL) to perform dimensionality reduction for multi-label data by exploiting correlations among different labels using a hypergraph. The regularization effect on the classical dimensionality reduction algorithm known as Canonical Correlation Analysis (CCA) is elucidated in this thesis. The relationship between CCA and Orthonormalized Partial Least Squares (OPLS) is also investigated. To perform dimensionality reduction efficiently for large-scale problems, two efficient implementations are proposed for a class of dimensionality reduction algorithms, including canonical correlation analysis, orthonormalized partial least squares, linear discriminant analysis, and hypergraph spectral learning. The first approach is a direct least squares approach which allows the use of different regularization penalties, but is applicable under a certain assumption; the second one is a two-stage approach which can be applied in the regularization setting without any assumption. Furthermore, an online implementation for the same class of dimensionality reduction algorithms is proposed when the data comes sequentially. A Matlab toolbox for multi-label dimensionality reduction has been developed and released. The proposed algorithms have been applied successfully in the Drosophila gene expression pattern image annotation. The experimental results on some benchmark data sets in multi-label learning also demonstrate the effectiveness and efficiency of the proposed algorithms.
ContributorsSun, Liang (Author) / Ye, Jieping (Thesis advisor) / Li, Baoxin (Committee member) / Liu, Huan (Committee member) / Mittelmann, Hans D. (Committee member) / Arizona State University (Publisher)
Created2011
Description
The performance of most of the visual computing tasks depends on the quality of the features extracted from the raw data. Insightful feature representation increases the performance of many learning algorithms by exposing the underlying explanatory factors of the output for the unobserved input. A good representation should also handle anomalies in the data such as missing samples and noisy input caused by the undesired, external factors of variation. It should also reduce the data redundancy. Over the years, many feature extraction processes have been invented to produce good representations of raw images and videos.
The feature extraction processes can be categorized into three groups. The first group contains processes that are hand-crafted for a specific task. Hand-engineering features requires the knowledge of domain experts and manual labor. However, the feature extraction process is interpretable and explainable. Next group contains the latent-feature extraction processes. While the original feature lies in a high-dimensional space, the relevant factors for a task often lie on a lower dimensional manifold. The latent-feature extraction employs hidden variables to expose the underlying data properties that cannot be directly measured from the input. Latent features seek a specific structure such as sparsity or low-rank into the derived representation through sophisticated optimization techniques. The last category is that of deep features. These are obtained by passing raw input data with minimal pre-processing through a deep network. Its parameters are computed by iteratively minimizing a task-based loss.
In this dissertation, I present four pieces of work where I create and learn suitable data representations. The first task employs hand-crafted features to perform clinically-relevant retrieval of diabetic retinopathy images. The second task uses latent features to perform content-adaptive image enhancement. The third task ranks a pair of images based on their aestheticism. The goal of the last task is to capture localized image artifacts in small datasets with patch-level labels. For both these tasks, I propose novel deep architectures and show significant improvement over the previous state-of-art approaches. A suitable combination of feature representations augmented with an appropriate learning approach can increase performance for most visual computing tasks.
The feature extraction processes can be categorized into three groups. The first group contains processes that are hand-crafted for a specific task. Hand-engineering features requires the knowledge of domain experts and manual labor. However, the feature extraction process is interpretable and explainable. Next group contains the latent-feature extraction processes. While the original feature lies in a high-dimensional space, the relevant factors for a task often lie on a lower dimensional manifold. The latent-feature extraction employs hidden variables to expose the underlying data properties that cannot be directly measured from the input. Latent features seek a specific structure such as sparsity or low-rank into the derived representation through sophisticated optimization techniques. The last category is that of deep features. These are obtained by passing raw input data with minimal pre-processing through a deep network. Its parameters are computed by iteratively minimizing a task-based loss.
In this dissertation, I present four pieces of work where I create and learn suitable data representations. The first task employs hand-crafted features to perform clinically-relevant retrieval of diabetic retinopathy images. The second task uses latent features to perform content-adaptive image enhancement. The third task ranks a pair of images based on their aestheticism. The goal of the last task is to capture localized image artifacts in small datasets with patch-level labels. For both these tasks, I propose novel deep architectures and show significant improvement over the previous state-of-art approaches. A suitable combination of feature representations augmented with an appropriate learning approach can increase performance for most visual computing tasks.
ContributorsChandakkar, Parag Shridhar (Author) / Li, Baoxin (Thesis advisor) / Yang, Yezhou (Committee member) / Turaga, Pavan (Committee member) / Davulcu, Hasan (Committee member) / Arizona State University (Publisher)
Created2017
Description
Computer vision technology automatically extracts high level, meaningful information from visual data such as images or videos, and the object recognition and detection algorithms are essential in most computer vision applications. In this dissertation, we focus on developing algorithms used for real life computer vision applications, presenting innovative algorithms for object segmentation and feature extraction for objects and actions recognition in video data, and sparse feature selection algorithms for medical image analysis, as well as automated feature extraction using convolutional neural network for blood cancer grading.
To detect and classify objects in video, the objects have to be separated from the background, and then the discriminant features are extracted from the region of interest before feeding to a classifier. Effective object segmentation and feature extraction are often application specific, and posing major challenges for object detection and classification tasks. In this dissertation, we address effective object flow based ROI generation algorithm for segmenting moving objects in video data, which can be applied in surveillance and self driving vehicle areas. Optical flow can also be used as features in human action recognition algorithm, and we present using optical flow feature in pre-trained convolutional neural network to improve performance of human action recognition algorithms. Both algorithms outperform the state-of-the-arts at their time.
Medical images and videos pose unique challenges for image understanding mainly due to the fact that the tissues and cells are often irregularly shaped, colored, and textured, and hand selecting most discriminant features is often difficult, thus an automated feature selection method is desired. Sparse learning is a technique to extract the most discriminant and representative features from raw visual data. However, sparse learning with \textit{L1} regularization only takes the sparsity in feature dimension into consideration; we improve the algorithm so it selects the type of features as well; less important or noisy feature types are entirely removed from the feature set. We demonstrate this algorithm to analyze the endoscopy images to detect unhealthy abnormalities in esophagus and stomach, such as ulcer and cancer. Besides sparsity constraint, other application specific constraints and prior knowledge may also need to be incorporated in the loss function in sparse learning to obtain the desired results. We demonstrate how to incorporate similar-inhibition constraint, gaze and attention prior in sparse dictionary selection for gastroscopic video summarization that enable intelligent key frame extraction from gastroscopic video data. With recent advancement in multi-layer neural networks, the automatic end-to-end feature learning becomes feasible. Convolutional neural network mimics the mammal visual cortex and can extract most discriminant features automatically from training samples. We present using convolutinal neural network with hierarchical classifier to grade the severity of Follicular Lymphoma, a type of blood cancer, and it reaches 91\% accuracy, on par with analysis by expert pathologists.
Developing real world computer vision applications is more than just developing core vision algorithms to extract and understand information from visual data; it is also subject to many practical requirements and constraints, such as hardware and computing infrastructure, cost, robustness to lighting changes and deformation, ease of use and deployment, etc.The general processing pipeline and system architecture for the computer vision based applications share many similar design principles and architecture. We developed common processing components and a generic framework for computer vision application, and a versatile scale adaptive template matching algorithm for object detection. We demonstrate the design principle and best practices by developing and deploying a complete computer vision application in real life, building a multi-channel water level monitoring system, where the techniques and design methodology can be generalized to other real life applications. The general software engineering principles, such as modularity, abstraction, robust to requirement change, generality, etc., are all demonstrated in this research.
To detect and classify objects in video, the objects have to be separated from the background, and then the discriminant features are extracted from the region of interest before feeding to a classifier. Effective object segmentation and feature extraction are often application specific, and posing major challenges for object detection and classification tasks. In this dissertation, we address effective object flow based ROI generation algorithm for segmenting moving objects in video data, which can be applied in surveillance and self driving vehicle areas. Optical flow can also be used as features in human action recognition algorithm, and we present using optical flow feature in pre-trained convolutional neural network to improve performance of human action recognition algorithms. Both algorithms outperform the state-of-the-arts at their time.
Medical images and videos pose unique challenges for image understanding mainly due to the fact that the tissues and cells are often irregularly shaped, colored, and textured, and hand selecting most discriminant features is often difficult, thus an automated feature selection method is desired. Sparse learning is a technique to extract the most discriminant and representative features from raw visual data. However, sparse learning with \textit{L1} regularization only takes the sparsity in feature dimension into consideration; we improve the algorithm so it selects the type of features as well; less important or noisy feature types are entirely removed from the feature set. We demonstrate this algorithm to analyze the endoscopy images to detect unhealthy abnormalities in esophagus and stomach, such as ulcer and cancer. Besides sparsity constraint, other application specific constraints and prior knowledge may also need to be incorporated in the loss function in sparse learning to obtain the desired results. We demonstrate how to incorporate similar-inhibition constraint, gaze and attention prior in sparse dictionary selection for gastroscopic video summarization that enable intelligent key frame extraction from gastroscopic video data. With recent advancement in multi-layer neural networks, the automatic end-to-end feature learning becomes feasible. Convolutional neural network mimics the mammal visual cortex and can extract most discriminant features automatically from training samples. We present using convolutinal neural network with hierarchical classifier to grade the severity of Follicular Lymphoma, a type of blood cancer, and it reaches 91\% accuracy, on par with analysis by expert pathologists.
Developing real world computer vision applications is more than just developing core vision algorithms to extract and understand information from visual data; it is also subject to many practical requirements and constraints, such as hardware and computing infrastructure, cost, robustness to lighting changes and deformation, ease of use and deployment, etc.The general processing pipeline and system architecture for the computer vision based applications share many similar design principles and architecture. We developed common processing components and a generic framework for computer vision application, and a versatile scale adaptive template matching algorithm for object detection. We demonstrate the design principle and best practices by developing and deploying a complete computer vision application in real life, building a multi-channel water level monitoring system, where the techniques and design methodology can be generalized to other real life applications. The general software engineering principles, such as modularity, abstraction, robust to requirement change, generality, etc., are all demonstrated in this research.
ContributorsCao, Jun (Author) / Li, Baoxin (Thesis advisor) / Liu, Huan (Committee member) / Zhang, Yu (Committee member) / Zhang, Junshan (Committee member) / Arizona State University (Publisher)
Created2018
Description
Online health forums provide a convenient channel for patients, caregivers, and medical professionals to share their experience, support and encourage each other, and form health communities. The fast growing content in health forums provides a large repository for people to seek valuable information. A forum user can issue a keyword query to search health forums regarding to some specific questions, e.g., what treatments are effective for a disease symptom? A medical researcher can discover medical knowledge in a timely and large-scale fashion by automatically aggregating the latest evidences emerging in health forums.
This dissertation studies how to effectively discover information in health forums. Several challenges have been identified. First, the existing work relies on the syntactic information unit, such as a sentence, a post, or a thread, to bind different pieces of information in a forum. However, most of information discovery tasks should be based on the semantic information unit, a patient. For instance, given a keyword query that involves the relationship between a treatment and side effects, it is expected that the matched keywords refer to the same patient. In this work, patient-centered mining is proposed to mine patient semantic information units. In a patient information unit, the health information, such as diseases, symptoms, treatments, effects, and etc., is connected by the corresponding patient.
Second, the information published in health forums has varying degree of quality. Some information includes patient-reported personal health experience, while others can be hearsay. In this work, a context-aware experience extraction framework is proposed to mine patient-reported personal health experience, which can be used for evidence-based knowledge discovery or finding patients with similar experience.
At last, the proposed patient-centered and experience-aware mining framework is used to build a patient health information database for effectively discovering adverse drug reactions (ADRs) from health forums. ADRs have become a serious health problem and even a leading cause of death in the United States. Health forums provide valuable evidences in a large scale and in a timely fashion through the active participation of patients, caregivers, and doctors. Empirical evaluation shows the effectiveness of the proposed approach.
This dissertation studies how to effectively discover information in health forums. Several challenges have been identified. First, the existing work relies on the syntactic information unit, such as a sentence, a post, or a thread, to bind different pieces of information in a forum. However, most of information discovery tasks should be based on the semantic information unit, a patient. For instance, given a keyword query that involves the relationship between a treatment and side effects, it is expected that the matched keywords refer to the same patient. In this work, patient-centered mining is proposed to mine patient semantic information units. In a patient information unit, the health information, such as diseases, symptoms, treatments, effects, and etc., is connected by the corresponding patient.
Second, the information published in health forums has varying degree of quality. Some information includes patient-reported personal health experience, while others can be hearsay. In this work, a context-aware experience extraction framework is proposed to mine patient-reported personal health experience, which can be used for evidence-based knowledge discovery or finding patients with similar experience.
At last, the proposed patient-centered and experience-aware mining framework is used to build a patient health information database for effectively discovering adverse drug reactions (ADRs) from health forums. ADRs have become a serious health problem and even a leading cause of death in the United States. Health forums provide valuable evidences in a large scale and in a timely fashion through the active participation of patients, caregivers, and doctors. Empirical evaluation shows the effectiveness of the proposed approach.
ContributorsLiu, Yunzhong (Author) / Chen, Yi (Thesis advisor) / Liu, Huan (Thesis advisor) / Li, Baoxin (Committee member) / Davulcu, Hasan (Committee member) / Arizona State University (Publisher)
Created2016
Description
The rapid growth of social media in recent years provides a large amount of user-generated visual objects, e.g., images and videos. Advanced semantic understanding approaches on such visual objects are desired to better serve applications such as human-machine interaction, image retrieval, etc. Semantic visual attributes have been proposed and utilized in multiple visual computing tasks to bridge the so-called "semantic gap" between extractable low-level feature representations and high-level semantic understanding of the visual objects.
Despite years of research, there are still some unsolved problems on semantic attribute learning. First, real-world applications usually involve hundreds of attributes which requires great effort to acquire sufficient amount of labeled data for model learning. Second, existing attribute learning work for visual objects focuses primarily on images, with semantic analysis on videos left largely unexplored.
In this dissertation I conduct innovative research and propose novel approaches to tackling the aforementioned problems. In particular, I propose robust and accurate learning frameworks on both attribute ranking and prediction by exploring the correlation among multiple attributes and utilizing various types of label information. Furthermore, I propose a video-based skill coaching framework by extending attribute learning to the video domain for robust motion skill analysis. Experiments on various types of applications and datasets and comparisons with multiple state-of-the-art baseline approaches confirm that my proposed approaches can achieve significant performance improvements for the general attribute learning problem.
Despite years of research, there are still some unsolved problems on semantic attribute learning. First, real-world applications usually involve hundreds of attributes which requires great effort to acquire sufficient amount of labeled data for model learning. Second, existing attribute learning work for visual objects focuses primarily on images, with semantic analysis on videos left largely unexplored.
In this dissertation I conduct innovative research and propose novel approaches to tackling the aforementioned problems. In particular, I propose robust and accurate learning frameworks on both attribute ranking and prediction by exploring the correlation among multiple attributes and utilizing various types of label information. Furthermore, I propose a video-based skill coaching framework by extending attribute learning to the video domain for robust motion skill analysis. Experiments on various types of applications and datasets and comparisons with multiple state-of-the-art baseline approaches confirm that my proposed approaches can achieve significant performance improvements for the general attribute learning problem.
ContributorsChen, Lin (Author) / Li, Baoxin (Thesis advisor) / Turaga, Pavan (Committee member) / Wang, Yalin (Committee member) / Liu, Huan (Committee member) / Arizona State University (Publisher)
Created2016
Description
The widespread adoption of computer vision models is often constrained by the issue of domain mismatch. Models that are trained with data belonging to one distribution, perform poorly when tested with data from a different distribution. Variations in vision based data can be attributed to the following reasons, viz., differences in image quality (resolution, brightness, occlusion and color), changes in camera perspective, dissimilar backgrounds and an inherent diversity of the samples themselves. Machine learning techniques like transfer learning are employed to adapt computational models across distributions. Domain adaptation is a special case of transfer learning, where knowledge from a source domain is transferred to a target domain in the form of learned models and efficient feature representations.
The dissertation outlines novel domain adaptation approaches across different feature spaces; (i) a linear Support Vector Machine model for domain alignment; (ii) a nonlinear kernel based approach that embeds domain-aligned data for enhanced classification; (iii) a hierarchical model implemented using deep learning, that estimates domain-aligned hash values for the source and target data, and (iv) a proposal for a feature selection technique to reduce cross-domain disparity. These adaptation procedures are tested and validated across a range of computer vision applications like object classification, facial expression recognition, digit recognition, and activity recognition. The dissertation also provides a unique perspective of domain adaptation literature from the point-of-view of linear, nonlinear and hierarchical feature spaces. The dissertation concludes with a discussion on the future directions for research that highlight the role of domain adaptation in an era of rapid advancements in artificial intelligence.
The dissertation outlines novel domain adaptation approaches across different feature spaces; (i) a linear Support Vector Machine model for domain alignment; (ii) a nonlinear kernel based approach that embeds domain-aligned data for enhanced classification; (iii) a hierarchical model implemented using deep learning, that estimates domain-aligned hash values for the source and target data, and (iv) a proposal for a feature selection technique to reduce cross-domain disparity. These adaptation procedures are tested and validated across a range of computer vision applications like object classification, facial expression recognition, digit recognition, and activity recognition. The dissertation also provides a unique perspective of domain adaptation literature from the point-of-view of linear, nonlinear and hierarchical feature spaces. The dissertation concludes with a discussion on the future directions for research that highlight the role of domain adaptation in an era of rapid advancements in artificial intelligence.
ContributorsDemakethepalli Venkateswara, Hemanth (Author) / Panchanathan, Sethuraman (Thesis advisor) / Li, Baoxin (Committee member) / Davulcu, Hasan (Committee member) / Ye, Jieping (Committee member) / Chakraborty, Shayok (Committee member) / Arizona State University (Publisher)
Created2017
Description
Imaging genetics is an emerging and promising technique that investigates how genetic variations affect brain development, structure, and function. By exploiting disorder-related neuroimaging phenotypes, this class of studies provides a novel direction to reveal and understand the complex genetic mechanisms. Oftentimes, imaging genetics studies are challenging due to the relatively small number of subjects but extremely high-dimensionality of both imaging data and genomic data. In this dissertation, I carry on my research on imaging genetics with particular focuses on two tasks---building predictive models between neuroimaging data and genomic data, and identifying disorder-related genetic risk factors through image-based biomarkers. To this end, I consider a suite of structured sparse methods---that can produce interpretable models and are robust to overfitting---for imaging genetics. With carefully-designed sparse-inducing regularizers, different biological priors are incorporated into learning models. More specifically, in the Allen brain image--gene expression study, I adopt an advanced sparse coding approach for image feature extraction and employ a multi-task learning approach for multi-class annotation. Moreover, I propose a label structured-based two-stage learning framework, which utilizes the hierarchical structure among labels, for multi-label annotation. In the Alzheimer's disease neuroimaging initiative (ADNI) imaging genetics study, I employ Lasso together with EDPP (enhanced dual polytope projections) screening rules to fast identify Alzheimer's disease risk SNPs. I also adopt the tree-structured group Lasso with MLFre (multi-layer feature reduction) screening rules to incorporate linkage disequilibrium information into modeling. Moreover, I propose a novel absolute fused Lasso model for ADNI imaging genetics. This method utilizes SNP spatial structure and is robust to the choice of reference alleles of genotype coding. In addition, I propose a two-level structured sparse model that incorporates gene-level networks through a graph penalty into SNP-level model construction. Lastly, I explore a convolutional neural network approach for accurate predicting Alzheimer's disease related imaging phenotypes. Experimental results on real-world imaging genetics applications demonstrate the efficiency and effectiveness of the proposed structured sparse methods.
ContributorsYang, Tao (Author) / Ye, Jieping (Thesis advisor) / Xue, Guoliang (Thesis advisor) / He, Jingrui (Committee member) / Li, Baoxin (Committee member) / Li, Jing (Committee member) / Arizona State University (Publisher)
Created2017