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Description
Multi-label learning, which deals with data associated with multiple labels simultaneously, is ubiquitous in real-world applications. To overcome the curse of dimensionality in multi-label learning, in this thesis I study multi-label dimensionality reduction, which extracts a small number of features by removing the irrelevant, redundant, and noisy information while considering

Multi-label learning, which deals with data associated with multiple labels simultaneously, is ubiquitous in real-world applications. To overcome the curse of dimensionality in multi-label learning, in this thesis I study multi-label dimensionality reduction, which extracts a small number of features by removing the irrelevant, redundant, and noisy information while considering the correlation among different labels in multi-label learning. Specifically, I propose Hypergraph Spectral Learning (HSL) to perform dimensionality reduction for multi-label data by exploiting correlations among different labels using a hypergraph. The regularization effect on the classical dimensionality reduction algorithm known as Canonical Correlation Analysis (CCA) is elucidated in this thesis. The relationship between CCA and Orthonormalized Partial Least Squares (OPLS) is also investigated. To perform dimensionality reduction efficiently for large-scale problems, two efficient implementations are proposed for a class of dimensionality reduction algorithms, including canonical correlation analysis, orthonormalized partial least squares, linear discriminant analysis, and hypergraph spectral learning. The first approach is a direct least squares approach which allows the use of different regularization penalties, but is applicable under a certain assumption; the second one is a two-stage approach which can be applied in the regularization setting without any assumption. Furthermore, an online implementation for the same class of dimensionality reduction algorithms is proposed when the data comes sequentially. A Matlab toolbox for multi-label dimensionality reduction has been developed and released. The proposed algorithms have been applied successfully in the Drosophila gene expression pattern image annotation. The experimental results on some benchmark data sets in multi-label learning also demonstrate the effectiveness and efficiency of the proposed algorithms.
ContributorsSun, Liang (Author) / Ye, Jieping (Thesis advisor) / Li, Baoxin (Committee member) / Liu, Huan (Committee member) / Mittelmann, Hans D. (Committee member) / Arizona State University (Publisher)
Created2011
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Description
Real-world environments are characterized by non-stationary and continuously evolving data. Learning a classification model on this data would require a framework that is able to adapt itself to newer circumstances. Under such circumstances, transfer learning has come to be a dependable methodology for improving classification performance with reduced training costs

Real-world environments are characterized by non-stationary and continuously evolving data. Learning a classification model on this data would require a framework that is able to adapt itself to newer circumstances. Under such circumstances, transfer learning has come to be a dependable methodology for improving classification performance with reduced training costs and without the need for explicit relearning from scratch. In this thesis, a novel instance transfer technique that adapts a "Cost-sensitive" variation of AdaBoost is presented. The method capitalizes on the theoretical and functional properties of AdaBoost to selectively reuse outdated training instances obtained from a "source" domain to effectively classify unseen instances occurring in a different, but related "target" domain. The algorithm is evaluated on real-world classification problems namely accelerometer based 3D gesture recognition, smart home activity recognition and text categorization. The performance on these datasets is analyzed and evaluated against popular boosting-based instance transfer techniques. In addition, supporting empirical studies, that investigate some of the less explored bottlenecks of boosting based instance transfer methods, are presented, to understand the suitability and effectiveness of this form of knowledge transfer.
ContributorsVenkatesan, Ashok (Author) / Panchanathan, Sethuraman (Thesis advisor) / Li, Baoxin (Committee member) / Ye, Jieping (Committee member) / Arizona State University (Publisher)
Created2011
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Description
Surgery as a profession requires significant training to improve both clinical decision making and psychomotor proficiency. In the medical knowledge domain, tools have been developed, validated, and accepted for evaluation of surgeons' competencies. However, assessment of the psychomotor skills still relies on the Halstedian model of apprenticeship, wherein surgeons are

Surgery as a profession requires significant training to improve both clinical decision making and psychomotor proficiency. In the medical knowledge domain, tools have been developed, validated, and accepted for evaluation of surgeons' competencies. However, assessment of the psychomotor skills still relies on the Halstedian model of apprenticeship, wherein surgeons are observed during residency for judgment of their skills. Although the value of this method of skills assessment cannot be ignored, novel methodologies of objective skills assessment need to be designed, developed, and evaluated that augment the traditional approach. Several sensor-based systems have been developed to measure a user's skill quantitatively, but use of sensors could interfere with skill execution and thus limit the potential for evaluating real-life surgery. However, having a method to judge skills automatically in real-life conditions should be the ultimate goal, since only with such features that a system would be widely adopted. This research proposes a novel video-based approach for observing surgeons' hand and surgical tool movements in minimally invasive surgical training exercises as well as during laparoscopic surgery. Because our system does not require surgeons to wear special sensors, it has the distinct advantage over alternatives of offering skills assessment in both learning and real-life environments. The system automatically detects major skill-measuring features from surgical task videos using a computing system composed of a series of computer vision algorithms and provides on-screen real-time performance feedback for more efficient skill learning. Finally, the machine-learning approach is used to develop an observer-independent composite scoring model through objective and quantitative measurement of surgical skills. To increase effectiveness and usability of the developed system, it is integrated with a cloud-based tool, which automatically assesses surgical videos upload to the cloud.
ContributorsIslam, Gazi (Author) / Li, Baoxin (Thesis advisor) / Liang, Jianming (Thesis advisor) / Dinu, Valentin (Committee member) / Greenes, Robert (Committee member) / Smith, Marshall (Committee member) / Kahol, Kanav (Committee member) / Patel, Vimla L. (Committee member) / Arizona State University (Publisher)
Created2013
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Description
Drosophila melanogaster, as an important model organism, is used to explore the mechanism which governs cell differentiation and embryonic development. Understanding the mechanism will help to reveal the effects of genes on other species or even human beings. Currently, digital camera techniques make high quality Drosophila gene expression imaging possible.

Drosophila melanogaster, as an important model organism, is used to explore the mechanism which governs cell differentiation and embryonic development. Understanding the mechanism will help to reveal the effects of genes on other species or even human beings. Currently, digital camera techniques make high quality Drosophila gene expression imaging possible. On the other hand, due to the advances in biology, gene expression images which can reveal spatiotemporal patterns are generated in a high-throughput pace. Thus, an automated and efficient system that can analyze gene expression will become a necessary tool for investigating the gene functions, interactions and developmental processes. One investigation method is to compare the expression patterns of different developmental stages. Recently, however, the expression patterns are manually annotated with rough stage ranges. The work of annotation requires professional knowledge from experienced biologists. Hence, how to transfer the domain knowledge in biology into an automated system which can automatically annotate the patterns provides a challenging problem for computer scientists. In this thesis, the problem of stage annotation for Drosophila embryo is modeled in the machine learning framework. Three sparse learning algorithms and one ensemble algorithm are used to attack the problem. The sparse algorithms are Lasso, group Lasso and sparse group Lasso. The ensemble algorithm is based on a voting method. Besides that the proposed algorithms can annotate the patterns to stages instead of stage ranges with high accuracy; the decimal stage annotation algorithm presents a novel way to annotate the patterns to decimal stages. In addition, some analysis on the algorithm performance are made and corresponding explanations are given. Finally, with the proposed system, all the lateral view BDGP and FlyFish images are annotated and several interesting applications of decimal stage value are revealed.
ContributorsPan, Cheng (Author) / Ye, Jieping (Thesis advisor) / Li, Baoxin (Committee member) / Farin, Gerald (Committee member) / Arizona State University (Publisher)
Created2012
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Description
As we migrate into an era of personalized medicine, understanding how bio-molecules interact with one another to form cellular systems is one of the key focus areas of systems biology. Several challenges such as the dynamic nature of cellular systems, uncertainty due to environmental influences, and the heterogeneity between individual

As we migrate into an era of personalized medicine, understanding how bio-molecules interact with one another to form cellular systems is one of the key focus areas of systems biology. Several challenges such as the dynamic nature of cellular systems, uncertainty due to environmental influences, and the heterogeneity between individual patients render this a difficult task. In the last decade, several algorithms have been proposed to elucidate cellular systems from data, resulting in numerous data-driven hypotheses. However, due to the large number of variables involved in the process, many of which are unknown or not measurable, such computational approaches often lead to a high proportion of false positives. This renders interpretation of the data-driven hypotheses extremely difficult. Consequently, a dismal proportion of these hypotheses are subject to further experimental validation, eventually limiting their potential to augment existing biological knowledge. This dissertation develops a framework of computational methods for the analysis of such data-driven hypotheses leveraging existing biological knowledge. Specifically, I show how biological knowledge can be mapped onto these hypotheses and subsequently augmented through novel hypotheses. Biological hypotheses are learnt in three levels of abstraction -- individual interactions, functional modules and relationships between pathways, corresponding to three complementary aspects of biological systems. The computational methods developed in this dissertation are applied to high throughput cancer data, resulting in novel hypotheses with potentially significant biological impact.
ContributorsRamesh, Archana (Author) / Kim, Seungchan (Thesis advisor) / Langley, Patrick W (Committee member) / Baral, Chitta (Committee member) / Kiefer, Jeffrey (Committee member) / Arizona State University (Publisher)
Created2012
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Description
The fields of pattern recognition and machine learning are on a fundamental quest to design systems that can learn the way humans do. One important aspect of human intelligence that has so far not been given sufficient attention is the capability of humans to express when they are certain about

The fields of pattern recognition and machine learning are on a fundamental quest to design systems that can learn the way humans do. One important aspect of human intelligence that has so far not been given sufficient attention is the capability of humans to express when they are certain about a decision, or when they are not. Machine learning techniques today are not yet fully equipped to be trusted with this critical task. This work seeks to address this fundamental knowledge gap. Existing approaches that provide a measure of confidence on a prediction such as learning algorithms based on the Bayesian theory or the Probably Approximately Correct theory require strong assumptions or often produce results that are not practical or reliable. The recently developed Conformal Predictions (CP) framework - which is based on the principles of hypothesis testing, transductive inference and algorithmic randomness - provides a game-theoretic approach to the estimation of confidence with several desirable properties such as online calibration and generalizability to all classification and regression methods. This dissertation builds on the CP theory to compute reliable confidence measures that aid decision-making in real-world problems through: (i) Development of a methodology for learning a kernel function (or distance metric) for optimal and accurate conformal predictors; (ii) Validation of the calibration properties of the CP framework when applied to multi-classifier (or multi-regressor) fusion; and (iii) Development of a methodology to extend the CP framework to continuous learning, by using the framework for online active learning. These contributions are validated on four real-world problems from the domains of healthcare and assistive technologies: two classification-based applications (risk prediction in cardiac decision support and multimodal person recognition), and two regression-based applications (head pose estimation and saliency prediction in images). The results obtained show that: (i) multiple kernel learning can effectively increase efficiency in the CP framework; (ii) quantile p-value combination methods provide a viable solution for fusion in the CP framework; and (iii) eigendecomposition of p-value difference matrices can serve as effective measures for online active learning; demonstrating promise and potential in using these contributions in multimedia pattern recognition problems in real-world settings.
ContributorsNallure Balasubramanian, Vineeth (Author) / Panchanathan, Sethuraman (Thesis advisor) / Ye, Jieping (Committee member) / Li, Baoxin (Committee member) / Vovk, Vladimir (Committee member) / Arizona State University (Publisher)
Created2010
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Description
Emotion recognition in conversation has applications within numerous domains such as affective computing and medicine. Recent methods for emotion recognition jointly utilize conversational data over several modalities including audio, video, and text. However, state-of-the-art frameworks for this task do not focus on the feature extraction and feature fusion steps of

Emotion recognition in conversation has applications within numerous domains such as affective computing and medicine. Recent methods for emotion recognition jointly utilize conversational data over several modalities including audio, video, and text. However, state-of-the-art frameworks for this task do not focus on the feature extraction and feature fusion steps of this process. This thesis aims to improve the state-of-the-art method by incorporating two components to better accomplish these steps. By doing so, we are able to produce improved representations for the text modality and better model the relationships between all modalities. This paper proposes two methods which focus on these concepts and provide improved accuracy over the state-of-the-art framework for multimodal emotion recognition in dialogue.
ContributorsRawal, Siddharth (Author) / Baral, Chitta (Thesis director) / Shah, Shrikant (Committee member) / Computer Science and Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
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Description
Medical records are increasingly being recorded in the form of electronic health records (EHRs), with a significant amount of patient data recorded as unstructured natural language text. Consequently, being able to extract and utilize clinical data present within these records is an important step in furthering clinical care. One important

Medical records are increasingly being recorded in the form of electronic health records (EHRs), with a significant amount of patient data recorded as unstructured natural language text. Consequently, being able to extract and utilize clinical data present within these records is an important step in furthering clinical care. One important aspect within these records is the presence of prescription information. Existing techniques for extracting prescription information — which includes medication names, dosages, frequencies, reasons for taking, and mode of administration — from unstructured text have focused on the application of rule- and classifier-based methods. While state-of-the-art systems can be effective in extracting many types of information, they require significant effort to develop hand-crafted rules and conduct effective feature engineering. This paper presents the use of a bidirectional LSTM with CRF tagging model initialized with precomputed word embeddings for extracting prescription information from sentences without requiring significant feature engineering. The experimental results, run on the i2b2 2009 dataset, achieve an F1 macro measure of 0.8562, and scores above 0.9449 on four of the six categories, indicating significant potential for this model.
ContributorsRawal, Samarth Chetan (Author) / Baral, Chitta (Thesis director) / Anwar, Saadat (Committee member) / Computer Science and Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
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Description
Feature embeddings differ from raw features in the sense that the former obey certain properties like notion of similarity/dissimilarity in it's embedding space. word2vec is a preeminent example in this direction, where the similarity in the embedding space is measured in terms of the cosine similarity. Such language embedding models

Feature embeddings differ from raw features in the sense that the former obey certain properties like notion of similarity/dissimilarity in it's embedding space. word2vec is a preeminent example in this direction, where the similarity in the embedding space is measured in terms of the cosine similarity. Such language embedding models have seen numerous applications in both language and vision community as they capture the information in the modality (English language) efficiently. Inspired by these language models, this work focuses on learning embedding spaces for two visual computing tasks, 1. Image Hashing 2. Zero Shot Learning. The training set was used to learn embedding spaces over which similarity/dissimilarity is measured using several distance metrics like hamming / euclidean / cosine distances. While the above-mentioned language models learn generic word embeddings, in this work task specific embeddings were learnt which can be used for Image Retrieval and Classification separately.

Image Hashing is the task of mapping images to binary codes such that some notion of user-defined similarity is preserved. The first part of this work focuses on designing a new framework that uses the hash-tags associated with web images to learn the binary codes. Such codes can be used in several applications like Image Retrieval and Image Classification. Further, this framework requires no labelled data, leaving it very inexpensive. Results show that the proposed approach surpasses the state-of-art approaches by a significant margin.

Zero-shot classification is the task of classifying the test sample into a new class which was not seen during training. This is possible by establishing a relationship between the training and the testing classes using auxiliary information. In the second part of this thesis, a framework is designed that trains using the handcrafted attribute vectors and word vectors but doesn’t require the expensive attribute vectors during test time. More specifically, an intermediate space is learnt between the word vector space and the image feature space using the hand-crafted attribute vectors. Preliminary results on two zero-shot classification datasets show that this is a promising direction to explore.
ContributorsGattupalli, Jaya Vijetha (Author) / Li, Baoxin (Thesis advisor) / Yang, Yezhou (Committee member) / Venkateswara, Hemanth (Committee member) / Arizona State University (Publisher)
Created2019
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Description
Machine learning models and in specific, neural networks, are well known for being inscrutable in nature. From image classification tasks and generative techniques for data augmentation, to general purpose natural language models, neural networks are currently the algorithm of preference that is riding the top of the current artificial intelligence

Machine learning models and in specific, neural networks, are well known for being inscrutable in nature. From image classification tasks and generative techniques for data augmentation, to general purpose natural language models, neural networks are currently the algorithm of preference that is riding the top of the current artificial intelligence (AI) wave, having experienced the greatest boost in popularity above any other machine learning solution. However, due to their inscrutable design based on the optimization of millions of parameters, it is ever so complex to understand how their decision is influenced nor why (and when) they fail. While some works aim at explaining neural network decisions or making systems to be inherently interpretable the great majority of state of the art machine learning works prioritize performance over interpretability effectively becoming black boxes. Hence, there is still uncertainty in the decision boundaries of these already deployed solutions whose predictions should still be analyzed and taken with care. This becomes even more important when these models are used on sensitive scenarios such as medicine, criminal justice, settings with native inherent social biases or where egregious mispredictions can negatively impact the system or human trust down the line. Thus, the aim of this work is to provide a comprehensive analysis on the failure modes of the state of the art neural networks from three domains: large image classifiers and their misclassifications, generative adversarial networks when used for data augmentation and transformer networks applied to structured representations and reasoning about actions and change.
ContributorsOlmo Hernandez, Alberto (Author) / Kambhampati, Subbarao (Thesis advisor) / Liu, Huan (Committee member) / Li, Baoxin (Committee member) / Sengupta, Sailik (Committee member) / Arizona State University (Publisher)
Created2022