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Description
Infants born before 37 weeks of pregnancy are considered to be preterm. Typically, preterm infants have to be strictly monitored since they are highly susceptible to health problems like hypoxemia (low blood oxygen level), apnea, respiratory issues, cardiac problems, neurological problems as well as an increased chance of long-term health issues such as cerebral palsy, asthma and sudden infant death syndrome. One of the leading health complications in preterm infants is bradycardia - which is defined as the slower than expected heart rate, generally beating lower than 60 beats per minute. Bradycardia is often accompanied by low oxygen levels and can cause additional long term health problems in the premature infant.The implementation of a non-parametric method to predict the onset of brady- cardia is presented. This method assumes no prior knowledge of the data and uses kernel density estimation to predict the future onset of bradycardia events. The data is preprocessed, and then analyzed to detect the peaks in the ECG signals, following which different kernels are implemented to estimate the shared underlying distribu- tion of the data. The performance of the algorithm is evaluated using various metrics and the computational challenges and methods to overcome them are also discussed.
It is observed that the performance of the algorithm with regards to the kernels used are consistent with the theoretical performance of the kernel as presented in a previous work. The theoretical approach has also been automated in this work and the various implementation challenges have been addressed.
It is observed that the performance of the algorithm with regards to the kernels used are consistent with the theoretical performance of the kernel as presented in a previous work. The theoretical approach has also been automated in this work and the various implementation challenges have been addressed.
ContributorsMitra, Sinjini (Author) / Papandreou-Suppappola, Antonia (Thesis advisor) / Moraffah, Bahman (Thesis advisor) / Turaga, Pavan (Committee member) / Arizona State University (Publisher)
Created2020
Description
Cameras have become commonplace with wide-ranging applications of phone photography, computer vision, and medical imaging. With a growing need to reduce size and costs while maintaining image quality, the need to look past traditional style of cameras is becoming more apparent. Several non-traditional cameras have shown to be promising options for size-constraint applications, and while they may offer several advantages, they also usually are limited by image quality degradation due to optical or a need to reconstruct a captured image. In this thesis, we take a look at three of these non-traditional cameras: a pinhole camera, a diffusion-mask lensless camera, and an under-display camera (UDC).
For each of these cases, I present a feasible image restoration pipeline to correct for their particular limitations. For the pinhole camera, I present an early pipeline to allow for practical pinhole photography by reducing noise levels caused by low-light imaging, enhancing exposure levels, and sharpening the blur caused by the pinhole. For lensless cameras, we explore a neural network architecture that performs joint image reconstruction and point spread function (PSF) estimation to robustly recover images captured with multiple PSFs from different cameras. Using adversarial learning, this approach achieves improved reconstruction results that do not require explicit knowledge of the PSF at test-time and shows an added improvement in the reconstruction model’s ability to generalize to variations in the camera’s PSF. This allows lensless cameras to be utilized in a wider range of applications that require multiple cameras without the need to explicitly train a separate model for each new camera. For UDCs, we utilize a multi-stage approach to correct for low light transmission, blur, and haze. This pipeline uses a PyNET deep neural network architecture to perform a majority of the restoration, while additionally using a traditional optimization approach which is then fused in a learned manner in the second stage to improve high-frequency features. I show results from this novel fusion approach that is on-par with the state of the art.
For each of these cases, I present a feasible image restoration pipeline to correct for their particular limitations. For the pinhole camera, I present an early pipeline to allow for practical pinhole photography by reducing noise levels caused by low-light imaging, enhancing exposure levels, and sharpening the blur caused by the pinhole. For lensless cameras, we explore a neural network architecture that performs joint image reconstruction and point spread function (PSF) estimation to robustly recover images captured with multiple PSFs from different cameras. Using adversarial learning, this approach achieves improved reconstruction results that do not require explicit knowledge of the PSF at test-time and shows an added improvement in the reconstruction model’s ability to generalize to variations in the camera’s PSF. This allows lensless cameras to be utilized in a wider range of applications that require multiple cameras without the need to explicitly train a separate model for each new camera. For UDCs, we utilize a multi-stage approach to correct for low light transmission, blur, and haze. This pipeline uses a PyNET deep neural network architecture to perform a majority of the restoration, while additionally using a traditional optimization approach which is then fused in a learned manner in the second stage to improve high-frequency features. I show results from this novel fusion approach that is on-par with the state of the art.
ContributorsRego, Joshua D (Author) / Jayasuriya, Suren (Thesis advisor) / Blain Christen, Jennifer (Thesis advisor) / Turaga, Pavan (Committee member) / Arizona State University (Publisher)
Created2020
Description
Elucidation of Antigen-Antibody (Ag-Ab) interactions is critical to the understanding of humoral immune responses to pathogenic infection. B cells are crucial components of the immune system that generate highly specific antibodies, such as IgG, towards epitopes on antigens. Serum IgG molecules carry specific molecular recognition information concerning the antigens that initiated their production. If one could read it, this information can be used to predict B cell epitopes on target antigens in order to design effective epitope driven vaccines, therapies and serological assays. Immunosignature technology captures the specific information content of serum IgG from infected and uninfected individuals on high density microarrays containing ~105 nearly random peptide sequences. Although the sequences of the peptides are chosen to evenly cover amino acid sequence space, the pattern of serum IgG binding to the array contains a consistent signature associated with each specific disease (e.g., Valley fever, influenza) among many individuals. Here, the disease specific but agnostic behavior of the technology has been explored by profiling molecular recognition information for five pathogens causing life threatening infectious diseases (e.g. DENV, WNV, HCV, HBV, and T.cruzi). This was done by models developed using a machine learning algorithm to model the sequence dependence of the humoral immune responses as measured by the peptide arrays. It was shown that the disease specific binding information could be accurately related to the peptide sequences used on the array by the machine learning (ML) models. Importantly, it was demonstrated that the ML models could identify or predict known linear epitopes on antigens of the four viruses. Moreover, the models identified potential novel linear epitopes on antigens of the four viruses (each has 4-10 proteins in the proteome) and of T.cruzi (a eukaryotic parasite which has over 12,000 proteins in its proteome). Finally, the predicted epitopes were tested in serum IgG binding assays such as ELISAs. Unfortunately, the assay results were inconsistent due to problems with peptide/surface interactions. In a separate study for the development of antibody recruiting molecules (ARMs) to combat microbial infections, 10 peptides from the high density peptide arrays were tested in IgG binding assays using sera of healthy individuals to find a set of antibody binding termini (ABT, a ligand that binds to a variable region of the IgG). It was concluded that one peptide (peptide 7) may be used as a potential ABT. Overall, these findings demonstrate the applications of the immunosignature technology ranging from developing tools to predict linear epitopes on pathogens of small to large proteomes to the identification of an ABT for ARMs.
ContributorsCHOWDHURY, ROBAYET (Author) / Woodbury, Neal (Thesis advisor) / LaBaer, Joshua (Committee member) / Sulc, Petr (Committee member) / Arizona State University (Publisher)
Created2020
Description
In many biological research studies, including speech analysis, clinical research, and prediction studies, the validity of the study is dependent on the effectiveness of the training data set to represent the target population. For example, in speech analysis, if one is performing emotion classification based on speech, the performance of the classifier is mainly dependent on the number and quality of the training data set. For small sample sizes and unbalanced data, classifiers developed in this context may be focusing on the differences in the training data set rather than emotion (e.g., focusing on gender, age, and dialect).
This thesis evaluates several sampling methods and a non-parametric approach to sample sizes required to minimize the effect of these nuisance variables on classification performance. This work specifically focused on speech analysis applications, and hence the work was done with speech features like Mel-Frequency Cepstral Coefficients (MFCC) and Filter Bank Cepstral Coefficients (FBCC). The non-parametric divergence (D_p divergence) measure was used to study the difference between different sampling schemes (Stratified and Multistage sampling) and the changes due to the sentence types in the sampling set for the process.
This thesis evaluates several sampling methods and a non-parametric approach to sample sizes required to minimize the effect of these nuisance variables on classification performance. This work specifically focused on speech analysis applications, and hence the work was done with speech features like Mel-Frequency Cepstral Coefficients (MFCC) and Filter Bank Cepstral Coefficients (FBCC). The non-parametric divergence (D_p divergence) measure was used to study the difference between different sampling schemes (Stratified and Multistage sampling) and the changes due to the sentence types in the sampling set for the process.
ContributorsMariajohn, Aaquila (Author) / Berisha, Visar (Thesis advisor) / Spanias, Andreas (Committee member) / Liss, Julie (Committee member) / Arizona State University (Publisher)
Created2020
Description
Languages, specially gestural and sign languages, are best learned in immersive environments with rich feedback. Computer-Aided Language Learning (CALL) solu- tions for spoken languages have successfully incorporated some feedback mechanisms, but no such solution exists for signed languages. Computer Aided Sign Language Learning (CASLL) is a recent and promising field of research which is made feasible by advances in Computer Vision and Sign Language Recognition(SLR). Leveraging existing SLR systems for feedback based learning is not feasible because their decision processes are not human interpretable and do not facilitate conceptual feedback to learners. Thus, fundamental research is needed towards designing systems that are modular and explainable. The explanations from these systems can then be used to produce feedback to aid in the learning process.
In this work, I present novel approaches for the recognition of location, movement and handshape that are components of American Sign Language (ASL) using both wrist-worn sensors as well as webcams. Finally, I present Learn2Sign(L2S), a chat- bot based AI tutor that can provide fine-grained conceptual feedback to learners of ASL using the modular recognition approaches. L2S is designed to provide feedback directly relating to the fundamental concepts of ASL using an explainable AI. I present the system performance results in terms of Precision, Recall and F-1 scores as well as validation results towards the learning outcomes of users. Both retention and execution tests for 26 participants for 14 different ASL words learned using learn2sign is presented. Finally, I also present the results of a post-usage usability survey for all the participants. In this work, I found that learners who received live feedback on their executions improved their execution as well as retention performances. The average increase in execution performance was 28% points and that for retention was 4% points.
In this work, I present novel approaches for the recognition of location, movement and handshape that are components of American Sign Language (ASL) using both wrist-worn sensors as well as webcams. Finally, I present Learn2Sign(L2S), a chat- bot based AI tutor that can provide fine-grained conceptual feedback to learners of ASL using the modular recognition approaches. L2S is designed to provide feedback directly relating to the fundamental concepts of ASL using an explainable AI. I present the system performance results in terms of Precision, Recall and F-1 scores as well as validation results towards the learning outcomes of users. Both retention and execution tests for 26 participants for 14 different ASL words learned using learn2sign is presented. Finally, I also present the results of a post-usage usability survey for all the participants. In this work, I found that learners who received live feedback on their executions improved their execution as well as retention performances. The average increase in execution performance was 28% points and that for retention was 4% points.
ContributorsPaudyal, Prajwal (Author) / Gupta, Sandeep (Thesis advisor) / Banerjee, Ayan (Committee member) / Hsiao, Ihan (Committee member) / Azuma, Tamiko (Committee member) / Yang, Yezhou (Committee member) / Arizona State University (Publisher)
Created2020
Description
Social media has become an important means of user-centered information sharing and communications in a gamut of domains, including news consumption, entertainment, marketing, public relations, and many more. The low cost, easy access, and rapid dissemination of information on social media draws a large audience but also exacerbate the wide propagation of disinformation including fake news, i.e., news with intentionally false information. Disinformation on social media is growing fast in volume and can have detrimental societal effects. Despite the importance of this problem, our understanding of disinformation in social media is still limited. Recent advancements of computational approaches on detecting disinformation and fake news have shown some early promising results. Novel challenges are still abundant due to its complexity, diversity, dynamics, multi-modality, and costs of fact-checking or annotation.
Social media data opens the door to interdisciplinary research and allows one to collectively study large-scale human behaviors otherwise impossible. For example, user engagements over information such as news articles, including posting about, commenting on, or recommending the news on social media, contain abundant rich information. Since social media data is big, incomplete, noisy, unstructured, with abundant social relations, solely relying on user engagements can be sensitive to noisy user feedback. To alleviate the problem of limited labeled data, it is important to combine contents and this new (but weak) type of information as supervision signals, i.e., weak social supervision, to advance fake news detection.
The goal of this dissertation is to understand disinformation by proposing and exploiting weak social supervision for learning with little labeled data and effectively detect disinformation via innovative research and novel computational methods. In particular, I investigate learning with weak social supervision for understanding disinformation with the following computational tasks: bringing the heterogeneous social context as auxiliary information for effective fake news detection; discovering explanations of fake news from social media for explainable fake news detection; modeling multi-source of weak social supervision for early fake news detection; and transferring knowledge across domains with adversarial machine learning for cross-domain fake news detection. The findings of the dissertation significantly expand the boundaries of disinformation research and establish a novel paradigm of learning with weak social supervision that has important implications in broad applications in social media.
Social media data opens the door to interdisciplinary research and allows one to collectively study large-scale human behaviors otherwise impossible. For example, user engagements over information such as news articles, including posting about, commenting on, or recommending the news on social media, contain abundant rich information. Since social media data is big, incomplete, noisy, unstructured, with abundant social relations, solely relying on user engagements can be sensitive to noisy user feedback. To alleviate the problem of limited labeled data, it is important to combine contents and this new (but weak) type of information as supervision signals, i.e., weak social supervision, to advance fake news detection.
The goal of this dissertation is to understand disinformation by proposing and exploiting weak social supervision for learning with little labeled data and effectively detect disinformation via innovative research and novel computational methods. In particular, I investigate learning with weak social supervision for understanding disinformation with the following computational tasks: bringing the heterogeneous social context as auxiliary information for effective fake news detection; discovering explanations of fake news from social media for explainable fake news detection; modeling multi-source of weak social supervision for early fake news detection; and transferring knowledge across domains with adversarial machine learning for cross-domain fake news detection. The findings of the dissertation significantly expand the boundaries of disinformation research and establish a novel paradigm of learning with weak social supervision that has important implications in broad applications in social media.
ContributorsShu, Kai (Author) / Liu, Huan (Thesis advisor) / Bernard, H. Russell (Committee member) / Maciejewski, Ross (Committee member) / Xue, Guoliang (Committee member) / Arizona State University (Publisher)
Created2020
Description
The recent increase in users of cellular networks necessitates the use of new technologies to meet this demand. Massive multiple input multiple output (MIMO) communication systems have great potential for increasing the network capacity of the emerging 5G+ cellular networks. However, leveraging the multiplexing and beamforming gains from these large-scale MIMO systems requires the channel knowlege between each antenna and each user. Obtaining channel information on such a massive scale is not feasible with the current technology available due to the complexity of such large systems. Recent research shows that deep learning methods can lead to interesting gains for massive MIMO systems by mapping the channel information from the uplink frequency band to the channel information for the downlink frequency band as well as between antennas at nearby locations. This thesis presents the research to develop a deep learning based channel mapping proof-of-concept prototype.
Due to deep neural networks' need of large training sets for accurate performance, this thesis outlines the design and implementation of an autonomous channel measurement system to analyze the performance of the proposed deep learning based channel mapping concept. This system obtains channel magnitude measurements from eight antennas autonomously using a mobile robot carrying a transmitter which receives wireless commands from the central computer connected to the static receiver system. The developed autonomous channel measurement system is capable of obtaining accurate and repeatable channel magnitude measurements. It is shown that the proposed deep learning based channel mapping system accurately predicts channel information containing few multi-path effects.
Due to deep neural networks' need of large training sets for accurate performance, this thesis outlines the design and implementation of an autonomous channel measurement system to analyze the performance of the proposed deep learning based channel mapping concept. This system obtains channel magnitude measurements from eight antennas autonomously using a mobile robot carrying a transmitter which receives wireless commands from the central computer connected to the static receiver system. The developed autonomous channel measurement system is capable of obtaining accurate and repeatable channel magnitude measurements. It is shown that the proposed deep learning based channel mapping system accurately predicts channel information containing few multi-path effects.
ContributorsBooth, Jayden Charles (Author) / Spanias, Andreas (Thesis advisor) / Alkhateeb, Ahmed (Thesis advisor) / Ewaisha, Ahmed (Committee member) / Arizona State University (Publisher)
Created2020
Description
In the last decade deep learning based models have revolutionized machine learning and computer vision applications. However, these models are data-hungry and training them is a time-consuming process. In addition, when deep neural networks are updated to augment their prediction space with new data, they run into the problem of catastrophic forgetting, where the model forgets previously learned knowledge as it overfits to the newly available data. Incremental learning algorithms enable deep neural networks to prevent catastrophic forgetting by retaining knowledge of previously observed data while also learning from newly available data.
This thesis presents three models for incremental learning; (i) Design of an algorithm for generative incremental learning using a pre-trained deep neural network classifier; (ii) Development of a hashing based clustering algorithm for efficient incremental learning; (iii) Design of a student-teacher coupled neural network to distill knowledge for incremental learning. The proposed algorithms were evaluated using popular vision datasets for classification tasks. The thesis concludes with a discussion about the feasibility of using these techniques to transfer information between networks and also for incremental learning applications.
This thesis presents three models for incremental learning; (i) Design of an algorithm for generative incremental learning using a pre-trained deep neural network classifier; (ii) Development of a hashing based clustering algorithm for efficient incremental learning; (iii) Design of a student-teacher coupled neural network to distill knowledge for incremental learning. The proposed algorithms were evaluated using popular vision datasets for classification tasks. The thesis concludes with a discussion about the feasibility of using these techniques to transfer information between networks and also for incremental learning applications.
ContributorsPatil, Rishabh (Author) / Venkateswara, Hemanth (Thesis advisor) / Panchanathan, Sethuraman (Thesis advisor) / McDaniel, Troy (Committee member) / Arizona State University (Publisher)
Created2020
Description
Traumatic injuries are the leading cause of death in children under 18, with head trauma being the leading cause of death in children below 5. A large but unknown number of traumatic injuries are non-accidental, i.e. inflicted. The lack of sensitivity and specificity required to diagnose Abusive Head Trauma (AHT) from radiological studies results in putting the children at risk of re-injury and death. Modern Deep Learning techniques can be utilized to detect Abusive Head Trauma using Computer Tomography (CT) scans. Training models using these techniques are only a part of building AI-driven Computer-Aided Diagnostic systems. There are challenges in deploying the models to make them highly available and scalable.
The thesis models the domain of Abusive Head Trauma using Deep Learning techniques and builds an AI-driven System at scale using best Software Engineering Practices. It has been done in collaboration with Phoenix Children Hospital (PCH). The thesis breaks down AHT into sub-domains of Medical Knowledge, Data Collection, Data Pre-processing, Image Generation, Image Classification, Building APIs, Containers and Kubernetes. Data Collection and Pre-processing were done at PCH with the help of trauma researchers and radiologists. Experiments are run using Deep Learning models such as DCGAN (for Image Generation), Pretrained 2D and custom 3D CNN classifiers for the classification tasks. The trained models are exposed as APIs using the Flask web framework, contained using Docker and deployed on a Kubernetes cluster.
The results are analyzed based on the accuracy of the models, the feasibility of their implementation as APIs and load testing the Kubernetes cluster. They suggest the need for Data Annotation at the Slice level for CT scans and an increase in the Data Collection process. Load Testing reveals the auto-scalability feature of the cluster to serve a high number of requests.
The thesis models the domain of Abusive Head Trauma using Deep Learning techniques and builds an AI-driven System at scale using best Software Engineering Practices. It has been done in collaboration with Phoenix Children Hospital (PCH). The thesis breaks down AHT into sub-domains of Medical Knowledge, Data Collection, Data Pre-processing, Image Generation, Image Classification, Building APIs, Containers and Kubernetes. Data Collection and Pre-processing were done at PCH with the help of trauma researchers and radiologists. Experiments are run using Deep Learning models such as DCGAN (for Image Generation), Pretrained 2D and custom 3D CNN classifiers for the classification tasks. The trained models are exposed as APIs using the Flask web framework, contained using Docker and deployed on a Kubernetes cluster.
The results are analyzed based on the accuracy of the models, the feasibility of their implementation as APIs and load testing the Kubernetes cluster. They suggest the need for Data Annotation at the Slice level for CT scans and an increase in the Data Collection process. Load Testing reveals the auto-scalability feature of the cluster to serve a high number of requests.
ContributorsVikram, Aditya (Author) / Sanchez, Javier Gonzalez (Thesis advisor) / Gaffar, Ashraf (Thesis advisor) / Findler, Michael (Committee member) / Arizona State University (Publisher)
Created2020
Description
Humans have a great ability to recognize objects in different environments irrespective of their variations. However, the same does not apply to machine learning models which are unable to generalize to images of objects from different domains. The generalization of these models to new data is constrained by the domain gap. Many factors such as image background, image resolution, color, camera perspective and variations in the objects are responsible for the domain gap between the training data (source domain) and testing data (target domain). Domain adaptation algorithms aim to overcome the domain gap between the source and target domains and learn robust models that can perform well across both the domains.
This thesis provides solutions for the standard problem of unsupervised domain adaptation (UDA) and the more generic problem of generalized domain adaptation (GDA). The contributions of this thesis are as follows. (1) Certain and Consistent Domain Adaptation model for closed-set unsupervised domain adaptation by aligning the features of the source and target domain using deep neural networks. (2) A multi-adversarial deep learning model for generalized domain adaptation. (3) A gating model that detects out-of-distribution samples for generalized domain adaptation.
The models were tested across multiple computer vision datasets for domain adaptation.
The dissertation concludes with a discussion on the proposed approaches and future directions for research in closed set and generalized domain adaptation.
This thesis provides solutions for the standard problem of unsupervised domain adaptation (UDA) and the more generic problem of generalized domain adaptation (GDA). The contributions of this thesis are as follows. (1) Certain and Consistent Domain Adaptation model for closed-set unsupervised domain adaptation by aligning the features of the source and target domain using deep neural networks. (2) A multi-adversarial deep learning model for generalized domain adaptation. (3) A gating model that detects out-of-distribution samples for generalized domain adaptation.
The models were tested across multiple computer vision datasets for domain adaptation.
The dissertation concludes with a discussion on the proposed approaches and future directions for research in closed set and generalized domain adaptation.
ContributorsNagabandi, Bhadrinath (Author) / Panchanathan, Sethuraman (Thesis advisor) / Venkateswara, Hemanth (Thesis advisor) / McDaniel, Troy (Committee member) / Arizona State University (Publisher)
Created2020