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In many classication problems data samples cannot be collected easily, example in drug trials, biological experiments and study on cancer patients. In many situations the data set size is small and there are many outliers. When classifying such data, example cancer vs normal patients the consequences of mis-classication are probably

In many classication problems data samples cannot be collected easily, example in drug trials, biological experiments and study on cancer patients. In many situations the data set size is small and there are many outliers. When classifying such data, example cancer vs normal patients the consequences of mis-classication are probably more important than any other data type, because the data point could be a cancer patient or the classication decision could help determine what gene might be over expressed and perhaps a cause of cancer. These mis-classications are typically higher in the presence of outlier data points. The aim of this thesis is to develop a maximum margin classier that is suited to address the lack of robustness of discriminant based classiers (like the Support Vector Machine (SVM)) to noise and outliers. The underlying notion is to adopt and develop a natural loss function that is more robust to outliers and more representative of the true loss function of the data. It is demonstrated experimentally that SVM's are indeed susceptible to outliers and that the new classier developed, here coined as Robust-SVM (RSVM), is superior to all studied classier on the synthetic datasets. It is superior to the SVM in both the synthetic and experimental data from biomedical studies and is competent to a classier derived on similar lines when real life data examples are considered.
ContributorsGupta, Sidharth (Author) / Kim, Seungchan (Thesis advisor) / Welfert, Bruno (Committee member) / Li, Baoxin (Committee member) / Arizona State University (Publisher)
Created2011
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Description
A medical control system, a real-time controller, uses a predictive model of human physiology for estimation and controlling of drug concentration in the human body. Artificial Pancreas (AP) is an example of the control system which regulates blood glucose in T1D patients. The predictive model in the control system

A medical control system, a real-time controller, uses a predictive model of human physiology for estimation and controlling of drug concentration in the human body. Artificial Pancreas (AP) is an example of the control system which regulates blood glucose in T1D patients. The predictive model in the control system such as Bergman Minimal Model (BMM) is based on physiological modeling technique which separates the body into the number of anatomical compartments and each compartment's effect on body system is determined by their physiological parameters. These models are less accurate due to unaccounted physiological factors effecting target values. Estimation of a large number of physiological parameters through optimization algorithm is computationally expensive and stuck in local minima. This work evaluates a machine learning(ML) framework which has an ML model guided through physiological models. A support vector regression model guided through modified BMM is implemented for estimation of blood glucose levels. Physical activity and Endogenous glucose production are key factors that contribute in the increased hypoglycemia events thus, this work modifies Bergman Minimal Model ( Bergman et al. 1981) for more accurate estimation of blood glucose levels. Results show that the SVR outperformed BMM by 0.164 average RMSE for 7 different patients in the free-living scenario. This computationally inexpensive data driven model can potentially learn parameters more accurately with time. In conclusion, advised prediction model is promising in modeling the physiology elements in living systems.
ContributorsAgrawal, Anurag (Author) / Gupta, Sandeep K. S. (Thesis advisor) / Banerjee, Ayan (Committee member) / Kudva, Yogish (Committee member) / Arizona State University (Publisher)
Created2017
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Description
The three-dimensional flow contained in a rapidly rotating circular

split cylinder is studied numerically solving the Navier--Stokes

equations. The cylinder is completely filled with fluid

and is split at the midplane. Three different types of boundary

conditions were imposed, leading to a variety of instabilities and

complex flow dynamics.

The first configuration has a strong

The three-dimensional flow contained in a rapidly rotating circular

split cylinder is studied numerically solving the Navier--Stokes

equations. The cylinder is completely filled with fluid

and is split at the midplane. Three different types of boundary

conditions were imposed, leading to a variety of instabilities and

complex flow dynamics.

The first configuration has a strong background rotation and a small

differential rotation between the two halves. The axisymmetric flow

was first studied identifying boundary layer instabilities which

produce inertial waves under some conditions. Limit cycle states and

quasiperiodic states were found, including some period doubling

bifurcations. Then, a three-dimensional study was conducted

identifying low and high azimuthal wavenumber rotating waves due to

G’ortler and Tollmien–-Schlichting type instabilities. Over most of

the parameter space considered, quasiperiodic states were found where

both types of instabilities were present.

In the second configuration, both cylinder halves are in exact

counter-rotation, producing an O(2) symmetry in the system. The basic state flow dynamic

is dominated by the shear layer created

in the midplane. By changing the speed rotation and the aspect ratio

of the cylinder, the flow loses symmetries in a variety of ways

creating static waves, rotating waves, direction reversing waves and

slow-fast pulsing waves. The bifurcations, including infinite-period

bifurcations, were characterized and the flow dynamics was elucidated.

Additionally, preliminary experimental results for this case are

presented.

In the third set up, with oscillatory boundary conditions, inertial

wave beams were forced imposing a range of frequencies. These beams

emanate from the corner of the cylinder and from the split at the

midplane, leading to destructive/constructive interactions which

produce peaks in vorticity for some specific frequencies. These

frequencies are shown to be associated with the resonant Kelvin

modes. Furthermore, a study of the influence of imposing a phase

difference between the oscillations of the two halves of the cylinder

led to the interesting result that different Kelvin

modes can be excited depending on the phase difference.
ContributorsGutierrez Castillo, Paloma (Author) / Lopez, Juan M. (Thesis advisor) / Herrmann, Marcus (Committee member) / Platte, Rodrigo (Committee member) / Welfert, Bruno (Committee member) / Tang, Wenbo (Committee member) / Arizona State University (Publisher)
Created2017
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Description
Ontologies play an important role in storing and exchanging digitized data. As the need for semantic web information grows, organizations from around the globe has defined ontologies in different domains to better represent the data. But different organizations define ontologies of the same entity in their own way. Finding ontologies

Ontologies play an important role in storing and exchanging digitized data. As the need for semantic web information grows, organizations from around the globe has defined ontologies in different domains to better represent the data. But different organizations define ontologies of the same entity in their own way. Finding ontologies of the same entity in different fields and domains has become very important for unifying and improving interoperability of data between these multiple domains. Many different techniques have been used over the year, including human assisted, automated and hybrid. In recent years with the availability of many machine learning techniques, researchers are trying to apply these techniques to solve the ontology alignment problem across different domains. In this study I have looked into the use of different machine learning techniques such as Support Vector Machine, Stochastic Gradient Descent, Random Forest etc. for solving ontology alignment problem with some of the most commonly used datasets found from the famous Ontology Alignment Evaluation Initiative (OAEI). I have proposed a method OntoAlign which demonstrates the importance of using different types of similarity measures for feature extraction from ontology data in order to achieve better results for ontology alignment.
ContributorsNasim, Tariq M (Author) / Bansal, Srividya (Thesis advisor) / Mehlhase, Alexandra (Committee member) / Banerjee, Ayan (Committee member) / Arizona State University (Publisher)
Created2022
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Description
The advancement and marked increase in the use of computing devices in health care for large scale and personal medical use has transformed the field of medicine and health care into a data rich domain. This surge in the availability of data has allowed domain experts to investigate, study and

The advancement and marked increase in the use of computing devices in health care for large scale and personal medical use has transformed the field of medicine and health care into a data rich domain. This surge in the availability of data has allowed domain experts to investigate, study and discover inherent patterns in diseases from new perspectives and in turn, further the field of medicine. Storage and analysis of this data in real time aids in enhancing the response time and efficiency of doctors and health care specialists. However, due to the time critical nature of most life- threatening diseases, there is a growing need to make informed decisions prior to the occurrence of any fatal outcome. Alongside time sensitivity, analyzing data specific to diseases and their effects on an individual basis leads to more efficient prognosis and rapid deployment of cures. The primary challenge in addressing both of these issues arises from the time varying and time sensitive nature of the data being studied and in the ability to successfully predict anomalous events using only observed data.This dissertation introduces adaptive machine learning algorithms that aid in the prediction of anomalous situations arising due to abnormalities present in patients diagnosed with certain types of diseases. Emphasis is given to the adaptation and development of algorithms based on an individual basis to further the accuracy of all predictions made. The main objectives are to learn the underlying representation of the data using empirical methods and enhance it using domain knowledge. The learned model is then utilized as a guide for statistical machine learning methods to predict the occurrence of anomalous events in the near future. Further enhancement of the learned model is achieved by means of tuning the objective function of the algorithm to incorporate domain knowledge. Along with anomaly forecasting using multi-modal data, this dissertation also investigates the use of univariate time series data towards the prediction of onset of diseases using Bayesian nonparametrics.
ContributorsDas, Subhasish (Author) / Gupta, Sandeep K.S. (Thesis advisor) / Banerjee, Ayan (Committee member) / Indic, Premananda (Committee member) / Papandreou-Suppappola, Antonia (Committee member) / Arizona State University (Publisher)
Created2022
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Description
Time series forecasting is the prediction of future data after analyzing the past data for temporal trends. This work investigates two fields of time series forecasting in the form of Stock Data Prediction and the Opioid Incident Prediction. In this thesis, the Stock Data Prediction Problem investigates methods which could

Time series forecasting is the prediction of future data after analyzing the past data for temporal trends. This work investigates two fields of time series forecasting in the form of Stock Data Prediction and the Opioid Incident Prediction. In this thesis, the Stock Data Prediction Problem investigates methods which could predict the trends in the NYSE and NASDAQ stock markets for ten different companies, nine of which are part of the Dow Jones Industrial Average (DJIA). A novel deep learning model which uses a Generative Adversarial Network (GAN) is used to predict future data and the results are compared with the existing regression techniques like Linear, Huber, and Ridge regression and neural network models such as Long-Short Term Memory (LSTMs) models.

In this thesis, the Opioid Incident Prediction Problem investigates methods which could predict the location of future opioid overdose incidences using the past opioid overdose incidences data. A similar deep learning model is used to predict the location of the future overdose incidences given the two datasets of the past incidences (Connecticut and Cincinnati Opioid incidence datasets) and compared with the existing neural network models such as Convolution LSTMs, Attention-based Convolution LSTMs, and Encoder-Decoder frameworks. Experimental results on the above-mentioned datasets for both the problems show the superiority of the proposed architectures over the standard statistical models.
ContributorsThomas, Kevin, M.S (Author) / Sen, Arunabha (Thesis advisor) / Davulcu, Hasan (Committee member) / Banerjee, Ayan (Committee member) / Arizona State University (Publisher)
Created2019
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Description
Languages, specially gestural and sign languages, are best learned in immersive environments with rich feedback. Computer-Aided Language Learning (CALL) solu- tions for spoken languages have successfully incorporated some feedback mechanisms, but no such solution exists for signed languages. Computer Aided Sign Language Learning (CASLL) is a recent and promising field

Languages, specially gestural and sign languages, are best learned in immersive environments with rich feedback. Computer-Aided Language Learning (CALL) solu- tions for spoken languages have successfully incorporated some feedback mechanisms, but no such solution exists for signed languages. Computer Aided Sign Language Learning (CASLL) is a recent and promising field of research which is made feasible by advances in Computer Vision and Sign Language Recognition(SLR). Leveraging existing SLR systems for feedback based learning is not feasible because their decision processes are not human interpretable and do not facilitate conceptual feedback to learners. Thus, fundamental research is needed towards designing systems that are modular and explainable. The explanations from these systems can then be used to produce feedback to aid in the learning process.

In this work, I present novel approaches for the recognition of location, movement and handshape that are components of American Sign Language (ASL) using both wrist-worn sensors as well as webcams. Finally, I present Learn2Sign(L2S), a chat- bot based AI tutor that can provide fine-grained conceptual feedback to learners of ASL using the modular recognition approaches. L2S is designed to provide feedback directly relating to the fundamental concepts of ASL using an explainable AI. I present the system performance results in terms of Precision, Recall and F-1 scores as well as validation results towards the learning outcomes of users. Both retention and execution tests for 26 participants for 14 different ASL words learned using learn2sign is presented. Finally, I also present the results of a post-usage usability survey for all the participants. In this work, I found that learners who received live feedback on their executions improved their execution as well as retention performances. The average increase in execution performance was 28% points and that for retention was 4% points.
ContributorsPaudyal, Prajwal (Author) / Gupta, Sandeep (Thesis advisor) / Banerjee, Ayan (Committee member) / Hsiao, Ihan (Committee member) / Azuma, Tamiko (Committee member) / Yang, Yezhou (Committee member) / Arizona State University (Publisher)
Created2020
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Description
Humans have an excellent ability to analyze and process information from multiple domains. They also possess the ability to apply the same decision-making process when the situation is familiar with their previous experience.

Inspired by human's ability to remember past experiences and apply the same when a similar situation occurs,

Humans have an excellent ability to analyze and process information from multiple domains. They also possess the ability to apply the same decision-making process when the situation is familiar with their previous experience.

Inspired by human's ability to remember past experiences and apply the same when a similar situation occurs, the research community has attempted to augment memory with Neural Network to store the previously learned information. Together with this, the community has also developed mechanisms to perform domain-specific weight switching to handle multiple domains using a single model. Notably, the two research fields work independently, and the goal of this dissertation is to combine their capabilities.

This dissertation introduces a Neural Network module augmented with two external memories, one allowing the network to read and write the information and another to perform domain-specific weight switching. Two learning tasks are proposed in this work to investigate the model performance - solving mathematics operations sequence and action based on color sequence identification. A wide range of experiments with these two tasks verify the model's learning capabilities.
ContributorsPatel, Deep Chittranjan (Author) / Ben Amor, Hani (Thesis advisor) / Banerjee, Ayan (Committee member) / McDaniel, Troy (Committee member) / Arizona State University (Publisher)
Created2020
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Description
To optimize solar cell performance, it is necessary to properly design the doping profile in the absorber layer of the solar cell. For CdTe solar cells, Cu is used for providing p-type doping. Hence, having an estimator that, given the diffusion parameter set (time and Temperature) and the doping concentration

To optimize solar cell performance, it is necessary to properly design the doping profile in the absorber layer of the solar cell. For CdTe solar cells, Cu is used for providing p-type doping. Hence, having an estimator that, given the diffusion parameter set (time and Temperature) and the doping concentration at the junction, gives the junction depth of the absorber layer, is essential in the design process of CdTe solar cells (and other cell technologies). In this work it is called a forward (direct) estimation process. The backward (inverse) problem then is the one in which, given the junction depth and the desired concentration of Cu doping at the CdTe/CdS heterointerface, the estimator gives the time and/or the Temperature needed to achieve the desired doping profiles. This is called a backward (inverse) estimation process. Such estimators, both forward and backward, do not exist in the literature for solar cell technology. To train the Machine Learning (ML) estimator, it is necessary to first generate a large set of data that are obtained by using the PVRD-FASP Solver, which has been validated via comparison with experimental values. Note that this big dataset needs to be generated only once. Next, one uses Machine Learning (ML), Deep Learning (DL) and Artificial Intelligence (AI) to extract the actual Cu doping profiles that result from the process of diffusion, annealing, and cool-down in the fabrication sequence of CdTe solar cells. Two deep learning neural network models are used: (1) Multilayer Perceptron Artificial Neural Network (MLPANN) model using a Keras Application Programmable Interface (API) with TensorFlow backend, and (2) Radial Basis Function Network (RBFN) model to predict the Cu doping profiles for different Temperatures and durations of the annealing process. Excellent agreement between the simulated results obtained with the PVRD-FASP Solver and the predicted values is obtained. It is important to mention here that it takes a significant amount of time to generate the Cu doping profiles given the initial conditions using the PVRD-FASP Solver, because solving the drift-diffusion-reaction model is mathematically a stiff problem and leads to numerical instabilities if the time steps are not small enough, which, in turn, affects the time needed for completion of one simulation run. The generation of the same with Machine Learning (ML) is almost instantaneous and can serve as an excellent simulation tool to guide future fabrication of optimal doping profiles in CdTe solar cells.
ContributorsSalman, Ghaith (Author) / Vasileska, Dragica (Thesis advisor) / Goodnick, Stephen M. (Thesis advisor) / Ringhofer, Christian (Committee member) / Banerjee, Ayan (Committee member) / Arizona State University (Publisher)
Created2021