Matching Items (36)
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- All Subjects: Machine Learning
- Creators: Electrical Engineering Program
- Creators: Papandreou-Suppappola, Antonia
- Member of: Theses and Dissertations
- Member of: Barrett, The Honors College Thesis/Creative Project Collection
Description
The healthcare system in this country is currently unacceptable. New technologies may contribute to reducing cost and improving outcomes. Early diagnosis and treatment represents the least risky option for addressing this issue. Such a technology needs to be inexpensive, highly sensitive, highly specific, and amenable to adoption in a clinic. This thesis explores an immunodiagnostic technology based on highly scalable, non-natural sequence peptide microarrays designed to profile the humoral immune response and address the healthcare problem. The primary aim of this thesis is to explore the ability of these arrays to map continuous (linear) epitopes. I discovered that using a technique termed subsequence analysis where epitopes could be decisively mapped to an eliciting protein with high success rate. This led to the discovery of novel linear epitopes from Plasmodium falciparum (Malaria) and Treponema palladium (Syphilis), as well as validation of previously discovered epitopes in Dengue and monoclonal antibodies. Next, I developed and tested a classification scheme based on Support Vector Machines for development of a Dengue Fever diagnostic, achieving higher sensitivity and specificity than current FDA approved techniques. The software underlying this method is available for download under the BSD license. Following this, I developed a kinetic model for immunosignatures and tested it against existing data driven by previously unexplained phenomena. This model provides a framework and informs ways to optimize the platform for maximum stability and efficiency. I also explored the role of sequence composition in explaining an immunosignature binding profile, determining a strong role for charged residues that seems to have some predictive ability for disease. Finally, I developed a database, software and indexing strategy based on Apache Lucene for searching motif patterns (regular expressions) in large biological databases. These projects as a whole have advanced knowledge of how to approach high throughput immunodiagnostics and provide an example of how technology can be fused with biology in order to affect scientific and health outcomes.
ContributorsRicher, Joshua Amos (Author) / Johnston, Stephen A. (Thesis advisor) / Woodbury, Neal (Committee member) / Stafford, Phillip (Committee member) / Papandreou-Suppappola, Antonia (Committee member) / Arizona State University (Publisher)
Created2014
Description
This dissertation presents the development of structural health monitoring and prognostic health management methodologies for complex structures and systems in the field of mechanical engineering. To overcome various challenges historically associated with complex structures and systems such as complicated sensing mechanisms, noisy information, and large-size datasets, a hybrid monitoring framework comprising of solid mechanics concepts and data mining technologies is developed. In such a framework, the solid mechanics simulations provide additional intuitions to data mining techniques reducing the dependence of accuracy on the training set, while the data mining approaches fuse and interpret information from the targeted system enabling the capability for real-time monitoring with efficient computation.
In the case of structural health monitoring, ultrasonic guided waves are utilized for damage identification and localization in complex composite structures. Signal processing and data mining techniques are integrated into the damage localization framework, and the converted wave modes, which are induced by the thickness variation due to the presence of delamination, are used as damage indicators. This framework has been validated through experiments and has shown sufficient accuracy in locating delamination in X-COR sandwich composites without the need of baseline information. Besides the localization of internal damage, the Gaussian process machine learning technique is integrated with finite element method as an online-offline prediction model to predict crack propagation with overloads under biaxial loading conditions; such a probabilistic prognosis model, with limited number of training examples, has shown increased accuracy over state-of-the-art techniques in predicting crack retardation behaviors induced by overloads. In the case of system level management, a monitoring framework built using a multivariate Gaussian model as basis is developed to evaluate the anomalous condition of commercial aircrafts. This method has been validated using commercial airline data and has shown high sensitivity to variations in aircraft dynamics and pilot operations. Moreover, this framework was also tested on simulated aircraft faults and its feasibility for real-time monitoring was demonstrated with sufficient computation efficiency.
This research is expected to serve as a practical addition to the existing literature while possessing the potential to be adopted in realistic engineering applications.
In the case of structural health monitoring, ultrasonic guided waves are utilized for damage identification and localization in complex composite structures. Signal processing and data mining techniques are integrated into the damage localization framework, and the converted wave modes, which are induced by the thickness variation due to the presence of delamination, are used as damage indicators. This framework has been validated through experiments and has shown sufficient accuracy in locating delamination in X-COR sandwich composites without the need of baseline information. Besides the localization of internal damage, the Gaussian process machine learning technique is integrated with finite element method as an online-offline prediction model to predict crack propagation with overloads under biaxial loading conditions; such a probabilistic prognosis model, with limited number of training examples, has shown increased accuracy over state-of-the-art techniques in predicting crack retardation behaviors induced by overloads. In the case of system level management, a monitoring framework built using a multivariate Gaussian model as basis is developed to evaluate the anomalous condition of commercial aircrafts. This method has been validated using commercial airline data and has shown high sensitivity to variations in aircraft dynamics and pilot operations. Moreover, this framework was also tested on simulated aircraft faults and its feasibility for real-time monitoring was demonstrated with sufficient computation efficiency.
This research is expected to serve as a practical addition to the existing literature while possessing the potential to be adopted in realistic engineering applications.
ContributorsLi, Guoyi (Ph.D.) (Author) / Chattopadhyay, Aditi (Thesis advisor) / Mignolet, Marc (Committee member) / Papandreou-Suppappola, Antonia (Committee member) / Yekani Fard, Masoud (Committee member) / Jiang, Hanqing (Committee member) / Arizona State University (Publisher)
Created2019
Leveraging Machine Learning and Wireless Sensing for Robot Localization - Location Variance Analysis
Description
Object localization is used to determine the location of a device, an important aspect of applications ranging from autonomous driving to augmented reality. Commonly-used localization techniques include global positioning systems (GPS), simultaneous localization and mapping (SLAM), and positional tracking, but all of these methodologies have drawbacks, especially in high traffic indoor or urban environments. Using recent improvements in the field of machine learning, this project proposes a new method of localization using networks with several wireless transceivers and implemented without heavy computational loads or high costs. This project aims to build a proof-of-concept prototype and demonstrate that the proposed technique is feasible and accurate.
Modern communication networks heavily depend upon an estimate of the communication channel, which represents the distortions that a transmitted signal takes as it moves towards a receiver. A channel can become quite complicated due to signal reflections, delays, and other undesirable effects and, as a result, varies significantly with each different location. This localization system seeks to take advantage of this distinctness by feeding channel information into a machine learning algorithm, which will be trained to associate channels with their respective locations. A device in need of localization would then only need to calculate a channel estimate and pose it to this algorithm to obtain its location.
As an additional step, the effect of location noise is investigated in this report. Once the localization system described above demonstrates promising results, the team demonstrates that the system is robust to noise on its location labels. In doing so, the team demonstrates that this system could be implemented in a continued learning environment, in which some user agents report their estimated (noisy) location over a wireless communication network, such that the model can be implemented in an environment without extensive data collection prior to release.
Modern communication networks heavily depend upon an estimate of the communication channel, which represents the distortions that a transmitted signal takes as it moves towards a receiver. A channel can become quite complicated due to signal reflections, delays, and other undesirable effects and, as a result, varies significantly with each different location. This localization system seeks to take advantage of this distinctness by feeding channel information into a machine learning algorithm, which will be trained to associate channels with their respective locations. A device in need of localization would then only need to calculate a channel estimate and pose it to this algorithm to obtain its location.
As an additional step, the effect of location noise is investigated in this report. Once the localization system described above demonstrates promising results, the team demonstrates that the system is robust to noise on its location labels. In doing so, the team demonstrates that this system could be implemented in a continued learning environment, in which some user agents report their estimated (noisy) location over a wireless communication network, such that the model can be implemented in an environment without extensive data collection prior to release.
ContributorsChang, Roger (Co-author) / Kann, Trevor (Co-author) / Alkhateeb, Ahmed (Thesis director) / Bliss, Daniel (Committee member) / Electrical Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
At present, the vast majority of human subjects with neurological disease are still diagnosed through in-person assessments and qualitative analysis of patient data. In this paper, we propose to use Topological Data Analysis (TDA) together with machine learning tools to automate the process of Parkinson’s disease classification and severity assessment. An automated, stable, and accurate method to evaluate Parkinson’s would be significant in streamlining diagnoses of patients and providing families more time for corrective measures. We propose a methodology which incorporates TDA into analyzing Parkinson’s disease postural shifts data through the representation of persistence images. Studying the topology of a system has proven to be invariant to small changes in data and has been shown to perform well in discrimination tasks. The contributions of the paper are twofold. We propose a method to 1) classify healthy patients from those afflicted by disease and 2) diagnose the severity of disease. We explore the use of the proposed method in an application involving a Parkinson’s disease dataset comprised of healthy-elderly, healthy-young and Parkinson’s disease patients.
ContributorsRahman, Farhan Nadir (Co-author) / Nawar, Afra (Co-author) / Turaga, Pavan (Thesis director) / Krishnamurthi, Narayanan (Committee member) / Electrical Engineering Program (Contributor) / Computer Science and Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Epilepsy affects numerous people around the world and is characterized by recurring seizures, prompting the ability to predict them so precautionary measures may be employed. One promising algorithm extracts spatiotemporal correlation based features from intracranial electroencephalography signals for use with support vector machines. The robustness of this methodology is tested through a sensitivity analysis. Doing so also provides insight about how to construct more effective feature vectors.
ContributorsMa, Owen (Author) / Bliss, Daniel (Thesis director) / Berisha, Visar (Committee member) / Barrett, The Honors College (Contributor) / Electrical Engineering Program (Contributor)
Created2015-05
Description
This paper introduces a wireless reconfigurable “button-type” pressure sensor system, via machine learning, for gait analysis application. The pressure sensor system consists of an array of independent button-type pressure sensing units interfaced with a remote computer. The pressure sensing unit contains pressure-sensitive resistors, readout electronics, and a wireless Bluetooth module, which are assembled within footprint of 40 × 25 × 6mm3. The small-footprint, low-profile sensors are populated onto a shoe insole, like buttons, to collect temporal pressure data. The pressure sensing unit measures pressures up to 2,000 kPa while maintaining an error under 10%. The reconfigurable pressure sensor array reduces the total power consumption of the system by 50%, allowing extended period of operation, up to 82.5 hrs. A robust machine learning program identifies the optimal pressure sensing units in any given configuration at an accuracy of up to 98%.
ContributorsBooth, Jayden Charles (Author) / Chae, Junseok (Thesis director) / Chen, Ang (Committee member) / Electrical Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2018-12
Description
This thesis is a proposition for an addition to an engineering project that involves creating a heads up display for a scuba diving mask which displays important safety information. The premise of this thesis includes three different features: distress, distance, and direction. The distress feature is to alert a diver that their “buddy diver” is having an emergency and is requiring attention. Distance and direction are intended to be included on the heads up display, informing the diver of the relative location of their “buddy diver” in case they have lost sight of them. A set of requirements was created to find the most practical solutions. From these requirements and extensive research, three potential methods of underwater communication were found; electromagnetic waves in the radio frequency range, optical waves, and acoustic waves. Of these three methods, acoustic waves were found to be most feasible for the scope of this project. Using modems and transducers, an acoustic signal is able to be sent from one diver to another in order to detect relative location as well as send a message of distress. Ultimately, two possible concepts were designed, with one deemed as most advantageous. This concept engages the use of four transponders that have the ability to transmit and receive high frequencies, minimizes blind spots, and is small enough to not cause discomfort or be obstructive to the divers experience. Due to the nature of this application, the team is able to propose a path of development for a compact communication system between scuba divers.
ContributorsNossaman, Grace (Co-author) / Hocken, Chase (Co-author) / Padilla, Bryan (Co-author) / Richmond, Christ D. (Thesis director) / Baumann, Alicia (Committee member) / Electrical Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
This thesis is a proposition for an addition to an engineering project that involves creating a heads up display for a scuba diving mask which displays important safety information. The premise of this thesis includes three different features: distress, distance, and direction. The distress feature is to alert a diver that their “buddy diver” is having an emergency and is requiring attention. Distance and direction are intended to be included on the heads up display, informing the diver of the relative location of their “buddy diver” in case they have lost sight of them. A set of requirements was created to find the most practical solutions. From these requirements and extensive research, three different methods of underwater communication were found, but only one, acoustics, was feasible for the scope of this project. Using modems and transducers, an acoustic signal is able to be sent from one diver to another in order to detect relative location as well as send a message of distress. Ultimately, two possible concepts were designed, with one deemed as most advantageous. This concept engages the use of four transponders that have the ability to transmit and receive high frequencies, minimizes blind spots, and is small enough to not cause discomfort or be obstructive to the divers experience.
ContributorsHocken, Chase (Co-author) / Nossaman, Grace (Co-author) / Padilla, Bryan (Co-author) / Richmond, Christ D (Thesis director) / Baumann, Alicia (Committee member) / Electrical Engineering Program (Contributor) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
This thesis is a proposition for an addition to an engineering project that involves creating a heads up display for a scuba diving mask which displays important safety information. The premise of this thesis includes three different features: distress, distance, and direction. The distress feature is to alert a diver that their “buddy diver” is having an emergency and is requiring attention. Distance and direction are intended to be included on the heads up display, informing the diver of the relative location of their “buddy diver” in case they have lost sight of them. A set of requirements was created to find the most practical solutions. From these requirements and extensive research, three potential methods of underwater communication were found; electromagnetic waves in the radio frequency range, optical waves, and acoustic waves. Of these three methods, acoustic waves were found to be most feasible for the scope of this project. Using modems and transducers, an acoustic signal is able to be sent from one diver to another in order to detect relative location as well as send a message of distress. Ultimately, two possible concepts were designed, with one deemed as most advantageous. This concept engages the use of four transponders that have the ability to transmit and receive high frequencies, minimizes blind spots, and is small enough to not cause discomfort or be obstructive to the divers experience. Due to the nature of this application, the team is able to propose a path of development for a compact communication system between scuba divers.
ContributorsPadilla, Bryan (Co-author) / Nossaman, Grace (Co-author) / Hocken, Chase (Co-author) / Richmond, Christ D. (Thesis director) / Baumann, Alicia (Committee member) / Electrical Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
Biological and biomedical measurements, when adequately analyzed and processed, can be used to impart quantitative diagnosis during primary health care consultation to improve patient adherence to recommended treatments. For example, analyzing neural recordings from neurostimulators implanted in patients with neurological disorders can be used by a physician to adjust detrimental stimulation parameters to improve treatment. As another example, biosequences, such as sequences from peptide microarrays obtained from a biological sample, can potentially provide pre-symptomatic diagnosis for infectious diseases when processed to associate antibodies to specific pathogens or infectious agents. This work proposes advanced statistical signal processing and machine learning methodologies to assess neurostimulation from neural recordings and to extract diagnostic information from biosequences.
For locating specific cognitive and behavioral information in different regions of the brain, neural recordings are processed using sequential Bayesian filtering methods to detect and estimate both the number of neural sources and their corresponding parameters. Time-frequency based feature selection algorithms are combined with adaptive machine learning approaches to suppress physiological and non-physiological artifacts present in neural recordings. Adaptive processing and unsupervised clustering methods applied to neural recordings are also used to suppress neurostimulation artifacts and classify between various behavior tasks to assess the level of neurostimulation in patients.
For pathogen detection and identification, random peptide sequences and their properties are first uniquely mapped to highly-localized signals and their corresponding parameters in the time-frequency plane. Time-frequency signal processing methods are then applied to estimate antigenic determinants or epitope candidates for detecting and identifying potential pathogens.
For locating specific cognitive and behavioral information in different regions of the brain, neural recordings are processed using sequential Bayesian filtering methods to detect and estimate both the number of neural sources and their corresponding parameters. Time-frequency based feature selection algorithms are combined with adaptive machine learning approaches to suppress physiological and non-physiological artifacts present in neural recordings. Adaptive processing and unsupervised clustering methods applied to neural recordings are also used to suppress neurostimulation artifacts and classify between various behavior tasks to assess the level of neurostimulation in patients.
For pathogen detection and identification, random peptide sequences and their properties are first uniquely mapped to highly-localized signals and their corresponding parameters in the time-frequency plane. Time-frequency signal processing methods are then applied to estimate antigenic determinants or epitope candidates for detecting and identifying potential pathogens.
ContributorsMaurer, Alexander Joseph (Author) / Papandreou-Suppappola, Antonia (Thesis advisor) / Bliss, Daniel (Committee member) / Chakrabarti, Chaitali (Committee member) / Kovvali, Narayan (Committee member) / Arizona State University (Publisher)
Created2016