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- Creators: Berisha, Visar
- Member of: Theses and Dissertations
- Status: Published
Description
Epilepsy affects numerous people around the world and is characterized by recurring seizures, prompting the ability to predict them so precautionary measures may be employed. One promising algorithm extracts spatiotemporal correlation based features from intracranial electroencephalography signals for use with support vector machines. The robustness of this methodology is tested through a sensitivity analysis. Doing so also provides insight about how to construct more effective feature vectors.
ContributorsMa, Owen (Author) / Bliss, Daniel (Thesis director) / Berisha, Visar (Committee member) / Barrett, The Honors College (Contributor) / Electrical Engineering Program (Contributor)
Created2015-05
Description
Divergence functions are both highly useful and fundamental to many areas in information theory and machine learning, but require either parametric approaches or prior knowledge of labels on the full data set. This paper presents a method to estimate the divergence between two data sets in the absence of fully labeled data. This semi-labeled case is common in many domains where labeling data by hand is expensive or time-consuming, or wherever large data sets are present. The theory derived in this paper is demonstrated on a simulated example, and then applied to a feature selection and classification problem from pathological speech analysis.
ContributorsGilton, Davis Leland (Author) / Berisha, Visar (Thesis director) / Cochran, Douglas (Committee member) / Electrical Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
This work details the bootstrap estimation of a nonparametric information divergence measure, the Dp divergence measure, using a power law model. To address the challenge posed by computing accurate divergence estimates given finite size data, the bootstrap approach is used in conjunction with a power law curve to calculate an asymptotic value of the divergence estimator. Monte Carlo estimates of Dp are found for increasing values of sample size, and a power law fit is used to relate the divergence estimates as a function of sample size. The fit is also used to generate a confidence interval for the estimate to characterize the quality of the estimate. We compare the performance of this method with the other estimation methods. The calculated divergence is applied to the binary classification problem. Using the inherent relation between divergence measures and classification error rate, an analysis of the Bayes error rate of several data sets is conducted using the asymptotic divergence estimate.
ContributorsKadambi, Pradyumna Sanjay (Author) / Berisha, Visar (Thesis director) / Bliss, Daniel (Committee member) / Electrical Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
This dissertation centers on the development of Bayesian methods for learning differ- ent types of variation in switching nonlinear gene regulatory networks (GRNs). A new nonlinear and dynamic multivariate GRN model is introduced to account for different sources of variability in GRNs. The new model is aimed at more precisely capturing the complexity of GRN interactions through the introduction of time-varying kinetic order parameters, while allowing for variability in multiple model parameters. This model is used as the drift function in the development of several stochastic GRN mod- els based on Langevin dynamics. Six models are introduced which capture intrinsic and extrinsic noise in GRNs, thereby providing a full characterization of a stochastic regulatory system. A Bayesian hierarchical approach is developed for learning the Langevin model which best describes the noise dynamics at each time step. The trajectory of the state, which are the gene expression values, as well as the indicator corresponding to the correct noise model are estimated via sequential Monte Carlo (SMC) with a high degree of accuracy. To address the problem of time-varying regulatory interactions, a Bayesian hierarchical model is introduced for learning variation in switching GRN architectures with unknown measurement noise covariance. The trajectory of the state and the indicator corresponding to the network configuration at each time point are estimated using SMC. This work is extended to a fully Bayesian hierarchical model to account for uncertainty in the process noise covariance associated with each network architecture. An SMC algorithm with local Gibbs sampling is developed to estimate the trajectory of the state and the indicator correspond- ing to the network configuration at each time point with a high degree of accuracy. The results demonstrate the efficacy of Bayesian methods for learning information in switching nonlinear GRNs.
ContributorsVélez-Cruz, Nayely (Author) / Papandreou-Suppappola, Antonia (Thesis advisor) / Moraffah, Bahman (Committee member) / Tepedelenlioğlu, Cihan (Committee member) / Berisha, Visar (Committee member) / Arizona State University (Publisher)
Created2023
Description
Linear-regression estimators have become widely accepted as a reliable statistical tool in predicting outcomes. Because linear regression is a long-established procedure, the properties of linear-regression estimators are well understood and can be trained very quickly. Many estimators exist for modeling linear relationships, each having ideal conditions for optimal performance. The differences stem from the introduction of a bias into the parameter estimation through the use of various regularization strategies. One of the more popular ones is ridge regression which uses ℓ2-penalization of the parameter vector. In this work, the proposed graph regularized linear estimator is pitted against the popular ridge regression when the parameter vector is known to be dense. When additional knowledge that parameters are smooth with respect to a graph is available, it can be used to improve the parameter estimates. To achieve this goal an additional smoothing penalty is introduced into the traditional loss function of ridge regression. The mean squared error(m.s.e) is used as a performance metric and the analysis is presented for fixed design matrices having a unit covariance matrix. The specific problem setup enables us to study the theoretical conditions where the graph regularized estimator out-performs the ridge estimator. The eigenvectors of the laplacian matrix indicating the graph of connections between the various dimensions of the parameter vector form an integral part of the analysis. Experiments have been conducted on simulated data to compare the performance of the two estimators for laplacian matrices of several types of graphs – complete, star, line and 4-regular. The experimental results indicate that the theory can possibly be extended to more general settings taking smoothness, a concept defined in this work, into consideration.
ContributorsSajja, Akarshan (Author) / Dasarathy, Gautam (Thesis advisor) / Berisha, Visar (Committee member) / Yang, Yingzhen (Committee member) / Arizona State University (Publisher)
Created2022
Description
Severe forms of mental illness, such as schizophrenia and bipolar disorder, are debilitating conditions that negatively impact an individual's quality of life. Additionally, they are often difficult and expensive to diagnose and manage, placing a large burden on society. Mental illness is typically diagnosed by the use of clinical interviews and a set of neuropsychiatric batteries; a key component of nearly all of these evaluations is some spoken language task. Clinicians have long used speech and language production as a proxy for neurological health, but most of these assessments are subjective in nature. Meanwhile, technological advancements in speech and natural language processing have grown exponentially over the past decade, increasing the capacity of computer models to assess particular aspects of speech and language. For this reason, many have seen an opportunity to leverage signal processing and machine learning applications to objectively assess clinical speech samples in order to automatically compute objective measures of neurological health. This document summarizes several contributions to expand upon this body of research. Mainly, there is still a large gap between the theoretical power of computational language models and their actual use in clinical applications. One of the largest concerns is the limited and inconsistent reliability of speech and language features used in models for assessing specific aspects of mental health; numerous methods may exist to measure the same or similar constructs and lead researchers to different conclusions in different studies. To address this, a novel measurement model based on a theoretical framework of speech production is used to motivate feature selection, while also performing a smoothing operation on features across several domains of interest. Then, these composite features are used to perform a much wider range of analyses than is typical of previous studies, looking at everything from diagnosis to functional competency assessments. Lastly, potential improvements to address practical implementation challenges associated with the use of speech and language technology in a real-world environment are investigated. The goal of this work is to demonstrate the ability of speech and language technology to aid clinical practitioners toward improvements in quality of life outcomes for their patients.
ContributorsVoleti, Rohit Nihar Uttam (Author) / Berisha, Visar (Thesis advisor) / Liss, Julie M (Thesis advisor) / Turaga, Pavan (Committee member) / Spanias, Andreas (Committee member) / Arizona State University (Publisher)
Created2022
Description
This paper serves to report the research performed towards detecting PD and the effects of medication through the use of machine learning and finger tapping data collected through mobile devices. The primary objective for this research is to prototype a PD classification model and a medication classification model that predict the following: the individual’s disease status and the medication intake time relative to performing the finger-tapping activity, respectively.
ContributorsGin, Taylor (Author) / McCarthy, Alexandra (Co-author) / Berisha, Visar (Thesis director) / Baumann, Alicia (Committee member) / Barrett, The Honors College (Contributor) / Electrical Engineering Program (Contributor)
Created2022-05
Description
This paper serves to report the research performed towards detecting PD and the effects of medication through the use of machine learning and finger tapping data collected through mobile devices. The primary objective for this research is to prototype a PD classification model and a medication classification model that predict the following: the individual’s disease status and the medication intake time relative to performing the finger-tapping activity, respectively.
ContributorsMcCarthy, Alexandra (Author) / Gin, Taylor (Co-author) / Berisha, Visar (Thesis director) / Baumann, Alicia (Committee member) / Barrett, The Honors College (Contributor) / Electrical Engineering Program (Contributor)
Created2022-05
Description
This dissertation explores applications of machine learning methods in service of the design of screening tests, which are ubiquitous in applications from social work, to criminology, to healthcare. In the first part, a novel Bayesian decision theory framework is presented for designing tree-based adaptive tests. On an application to youth delinquency in Honduras, the method produces a 15-item instrument that is almost as accurate as a full-length 150+ item test. The framework includes specific considerations for the context in which the test will be administered, and provides uncertainty quantification around the trade-offs of shortening lengthy tests. In the second part, classification complexity is explored via theoretical and empirical results from statistical learning theory, information theory, and empirical data complexity measures. A simulation study that explicitly controls two key aspects of classification complexity is performed to relate the theoretical and empirical approaches. Throughout, a unified language and notation that formalizes classification complexity is developed; this same notation is used in subsequent chapters to discuss classification complexity in the context of a speech-based screening test. In the final part, the relative merits of task and feature engineering when designing a speech-based cognitive screening test are explored. Through an extensive classification analysis on a clinical speech dataset from patients with normal cognition and Alzheimer’s disease, the speech elicitation task is shown to have a large impact on test accuracy; carefully performed task and feature engineering are required for best results. A new framework for objectively quantifying speech elicitation tasks is introduced, and two methods are proposed for automatically extracting insights into the aspects of the speech elicitation task that are driving classification performance. The dissertation closes with recommendations for how to evaluate the obtained insights and use them to guide future design of speech-based screening tests.
ContributorsKrantsevich, Chelsea (Author) / Hahn, P. Richard (Thesis advisor) / Berisha, Visar (Committee member) / Lopes, Hedibert (Committee member) / Renaut, Rosemary (Committee member) / Zheng, Yi (Committee member) / Arizona State University (Publisher)
Created2023
Description
The past decade witnessed the success of deep learning models in various applications of computer vision and natural language processing. This success can be predominantly attributed to the (i) availability of large amounts of training data; (ii) access of domain aware knowledge; (iii) i.i.d assumption between the train and target distributions and (iv) belief on existing metrics as reliable indicators of performance. When any of these assumptions are violated, the models exhibit brittleness producing adversely varied behavior. This dissertation focuses on methods for accurate model design and characterization that enhance process reliability when certain assumptions are not met. With the need to safely adopt artificial intelligence tools in practice, it is vital to build reliable failure detectors that indicate regimes where the model must not be invoked. To that end, an error predictor trained with a self-calibration objective is developed to estimate loss consistent with the underlying model. The properties of the error predictor are described and their utility in supporting introspection via feature importances and counterfactual explanations is elucidated. While such an approach can signal data regime changes, it is critical to calibrate models using regimes of inlier (training) and outlier data to prevent under- and over-generalization in models i.e., incorrectly identifying inliers as outliers and vice-versa. By identifying the space for specifying inliers and outliers, an anomaly detector that can effectively flag data of varying semantic complexities in medical imaging is next developed. Uncertainty quantification in deep learning models involves identifying sources of failure and characterizing model confidence to enable actionability. A training strategy is developed that allows the accurate estimation of model uncertainties and its benefits are demonstrated for active learning and generalization gap prediction. This helps identify insufficiently sampled regimes and representation insufficiency in models. In addition, the task of deep inversion under data scarce scenarios is considered, which in practice requires a prior to control the optimization. By identifying limitations in existing work, data priors powered by generative models and deep model priors are designed for audio restoration. With relevant empirical studies on a variety of benchmarks, the need for such design strategies is demonstrated.
ContributorsNarayanaswamy, Vivek Sivaraman (Author) / Spanias, Andreas (Thesis advisor) / J. Thiagarajan, Jayaraman (Committee member) / Berisha, Visar (Committee member) / Tepedelenlioğlu, Cihan (Committee member) / Arizona State University (Publisher)
Created2023