Matching Items (14)
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- All Subjects: Machine Learning
- Genre: Masters Thesis
- Creators: Bansal, Ajay
- Creators: Yang, Yezhou
Description
Alzheimer's Disease (AD) is the most common form of dementia observed in elderly patients and has significant social-economic impact. There are many initiatives which aim to capture leading causes of AD. Several genetic, imaging, and biochemical markers are being explored to monitor progression of AD and explore treatment and detection options. The primary focus of this thesis is to identify key biomarkers to understand the pathogenesis and prognosis of Alzheimer's Disease. Feature selection is the process of finding a subset of relevant features to develop efficient and robust learning models. It is an active research topic in diverse areas such as computer vision, bioinformatics, information retrieval, chemical informatics, and computational finance. In this work, state of the art feature selection algorithms, such as Student's t-test, Relief-F, Information Gain, Gini Index, Chi-Square, Fisher Kernel Score, Kruskal-Wallis, Minimum Redundancy Maximum Relevance, and Sparse Logistic regression with Stability Selection have been extensively exploited to identify informative features for AD using data from Alzheimer's Disease Neuroimaging Initiative (ADNI). An integrative approach which uses blood plasma protein, Magnetic Resonance Imaging, and psychometric assessment scores biomarkers has been explored. This work also analyzes the techniques to handle unbalanced data and evaluate the efficacy of sampling techniques. Performance of feature selection algorithm is evaluated using the relevance of derived features and the predictive power of the algorithm using Random Forest and Support Vector Machine classifiers. Performance metrics such as Accuracy, Sensitivity and Specificity, and area under the Receiver Operating Characteristic curve (AUC) have been used for evaluation. The feature selection algorithms best suited to analyze AD proteomics data have been proposed. The key biomarkers distinguishing healthy and AD patients, Mild Cognitive Impairment (MCI) converters and non-converters, and healthy and MCI patients have been identified.
ContributorsDubey, Rashmi (Author) / Ye, Jieping (Thesis advisor) / Wang, Yalin (Committee member) / Wu, Tong (Committee member) / Arizona State University (Publisher)
Created2012
Description
Graph theory is a critical component of computer science and software engineering, with algorithms concerning graph traversal and comprehension powering much of the largest problems in both industry and research. Engineers and researchers often have an accurate view of their target graph, however they struggle to implement a correct, and efficient, search over that graph.
To facilitate rapid, correct, efficient, and intuitive development of graph based solutions we propose a new programming language construct - the search statement. Given a supra-root node, a procedure which determines the children of a given parent node, and optional definitions of the fail-fast acceptance or rejection of a solution, the search statement can conduct a search over any graph or network. Structurally, this statement is modelled after the common switch statement and is put into a largely imperative/procedural context to allow for immediate and intuitive development by most programmers. The Go programming language has been used as a foundation and proof-of-concept of the search statement. A Go compiler is provided which implements this construct.
To facilitate rapid, correct, efficient, and intuitive development of graph based solutions we propose a new programming language construct - the search statement. Given a supra-root node, a procedure which determines the children of a given parent node, and optional definitions of the fail-fast acceptance or rejection of a solution, the search statement can conduct a search over any graph or network. Structurally, this statement is modelled after the common switch statement and is put into a largely imperative/procedural context to allow for immediate and intuitive development by most programmers. The Go programming language has been used as a foundation and proof-of-concept of the search statement. A Go compiler is provided which implements this construct.
ContributorsHenderson, Christopher (Author) / Bansal, Ajay (Thesis advisor) / Lindquist, Timothy (Committee member) / Acuna, Ruben (Committee member) / Arizona State University (Publisher)
Created2018
Description
Handwritten documents have gained popularity in various domains including education and business. A key task in analyzing a complex document is to distinguish between various content types such as text, math, graphics, tables and so on. For example, one such aspect could be a region on the document with a mathematical expression; in this case, the label would be math. This differentiation facilitates the performance of specific recognition tasks depending on the content type. We hypothesize that the recognition accuracy of the subsequent tasks such as textual, math, and shape recognition will increase, further leading to a better analysis of the document.
Content detection on handwritten documents assigns a particular class to a homogeneous portion of the document. To complete this task, a set of handwritten solutions was digitally collected from middle school students located in two different geographical regions in 2017 and 2018. This research discusses the methods to collect, pre-process and detect content type in the collected handwritten documents. A total of 4049 documents were extracted in the form of image, and json format; and were labelled using an object labelling software with tags being text, math, diagram, cross out, table, graph, tick mark, arrow, and doodle. The labelled images were fed to the Tensorflow’s object detection API to learn a neural network model. We show our results from two neural networks models, Faster Region-based Convolutional Neural Network (Faster R-CNN) and Single Shot detection model (SSD).
Content detection on handwritten documents assigns a particular class to a homogeneous portion of the document. To complete this task, a set of handwritten solutions was digitally collected from middle school students located in two different geographical regions in 2017 and 2018. This research discusses the methods to collect, pre-process and detect content type in the collected handwritten documents. A total of 4049 documents were extracted in the form of image, and json format; and were labelled using an object labelling software with tags being text, math, diagram, cross out, table, graph, tick mark, arrow, and doodle. The labelled images were fed to the Tensorflow’s object detection API to learn a neural network model. We show our results from two neural networks models, Faster Region-based Convolutional Neural Network (Faster R-CNN) and Single Shot detection model (SSD).
ContributorsFaizaan, Shaik Mohammed (Author) / VanLehn, Kurt (Thesis advisor) / Cheema, Salman Shaukat (Thesis advisor) / Yang, Yezhou (Committee member) / Arizona State University (Publisher)
Created2018
Description
Reinforcement learning (RL) is a powerful methodology for teaching autonomous agents complex behaviors and skills. A critical component in most RL algorithms is the reward function -- a mathematical function that provides numerical estimates for desirable and undesirable states. Typically, the reward function must be hand-designed by a human expert and, as a result, the scope of a robot's autonomy and ability to safely explore and learn in new and unforeseen environments is constrained by the specifics of the designed reward function. In this thesis, I design and implement a stateful collision anticipation model with powerful predictive capability based upon my research of sequential data modeling and modern recurrent neural networks. I also develop deep reinforcement learning methods whose rewards are generated by self-supervised training and intrinsic signals. The main objective is to work towards the development of resilient robots that can learn to anticipate and avoid damaging interactions by combining visual and proprioceptive cues from internal sensors. The introduced solutions are inspired by pain pathways in humans and animals, because such pathways are known to guide decision-making processes and promote self-preservation. A new "robot dodge ball' benchmark is introduced in order to test the validity of the developed algorithms in dynamic environments.
ContributorsRichardson, Trevor W (Author) / Ben Amor, Heni (Thesis advisor) / Yang, Yezhou (Committee member) / Srivastava, Siddharth (Committee member) / Arizona State University (Publisher)
Created2018
Description
Alzheimer’s disease (AD), is a chronic neurodegenerative disease that usually starts slowly and gets worse over time. It is the cause of 60% to 70% of cases of dementia. There is growing interest in identifying brain image biomarkers that help evaluate AD risk pre-symptomatically. High-dimensional non-linear pattern classification methods have been applied to structural magnetic resonance images (MRI’s) and used to discriminate between clinical groups in Alzheimers progression. Using Fluorodeoxyglucose (FDG) positron emission tomography (PET) as the pre- ferred imaging modality, this thesis develops two independent machine learning based patch analysis methods and uses them to perform six binary classification experiments across different (AD) diagnostic categories. Specifically, features were extracted and learned using dimensionality reduction and dictionary learning & sparse coding by taking overlapping patches in and around the cerebral cortex and using them as fea- tures. Using AdaBoost as the preferred choice of classifier both methods try to utilize 18F-FDG PET as a biological marker in the early diagnosis of Alzheimer’s . Addi- tional we investigate the involvement of rich demographic features (ApoeE3, ApoeE4 and Functional Activities Questionnaires (FAQ)) in classification. The experimental results on Alzheimer’s Disease Neuroimaging initiative (ADNI) dataset demonstrate the effectiveness of both the proposed systems. The use of 18F-FDG PET may offer a new sensitive biomarker and enrich the brain imaging analysis toolset for studying the diagnosis and prognosis of AD.
ContributorsSrivastava, Anant (Author) / Wang, Yalin (Thesis advisor) / Bansal, Ajay (Thesis advisor) / Liang, Jianming (Committee member) / Arizona State University (Publisher)
Created2017
Description
Ensemble learning methods like bagging, boosting, adaptive boosting, stacking have traditionally shown promising results in improving the predictive accuracy in classification. These techniques have recently been widely used in various domains and applications owing to the improvements in computational efficiency and distributed computing advances. However, with the advent of wide variety of applications of machine learning techniques to class imbalance problems, further focus is needed to evaluate, improve and optimize other performance measures such as sensitivity (true positive rate) and specificity (true negative rate) in classification. This thesis demonstrates a novel approach to evaluate and optimize the performance measures (specifically sensitivity and specificity) using ensemble learning methods for classification that can be especially useful in class imbalanced datasets. In this thesis, ensemble learning methods (specifically bagging and boosting) are used to optimize the performance measures (sensitivity and specificity) on a UC Irvine (UCI) 130 hospital diabetes dataset to predict if a patient will be readmitted to the hospital based on various feature vectors. From the experiments conducted, it can be empirically concluded that, by using ensemble learning methods, although accuracy does improve to some margin, both sensitivity and specificity are optimized significantly and consistently over different cross validation approaches. The implementation and evaluation has been done on a subset of the large UCI 130 hospital diabetes dataset. The performance measures of ensemble learners are compared to the base machine learning classification algorithms such as Naive Bayes, Logistic Regression, k Nearest Neighbor, Decision Trees and Support Vector Machines.
ContributorsBahl, Neeraj Dharampal (Author) / Bansal, Ajay (Thesis advisor) / Amresh, Ashish (Committee member) / Bansal, Srividya (Committee member) / Arizona State University (Publisher)
Created2017
Description
Machine learning methodologies are widely used in almost all aspects of software engineering. An effective machine learning model requires large amounts of data to achieve high accuracy. The data used for classification is mostly labeled, which is difficult to obtain. The dataset requires both high costs and effort to accurately label the data into different classes. With abundance of data, it becomes necessary that all the data should be labeled for its proper utilization and this work focuses on reducing the labeling effort for large dataset. The thesis presents a comparison of different classifiers performance to test if small set of labeled data can be utilized to build accurate models for high prediction rate. The use of small dataset for classification is then extended to active machine learning methodology where, first a one class classifier will predict the outliers in the data and then the outlier samples are added to a training set for support vector machine classifier for labeling the unlabeled data. The labeling of dataset can be scaled up to avoid manual labeling and building more robust machine learning methodologies.
ContributorsBatra, Salil (Author) / Femiani, John (Thesis advisor) / Amresh, Ashish (Thesis advisor) / Bansal, Ajay (Committee member) / Arizona State University (Publisher)
Created2017
Description
Learning from high dimensional biomedical data attracts lots of attention recently. High dimensional biomedical data often suffer from the curse of dimensionality and have imbalanced class distributions. Both of these features of biomedical data, high dimensionality and imbalanced class distributions, are challenging for traditional machine learning methods and may affect the model performance. In this thesis, I focus on developing learning methods for the high-dimensional imbalanced biomedical data. In the first part, a sparse canonical correlation analysis (CCA) method is presented. The penalty terms is used to control the sparsity of the projection matrices of CCA. The sparse CCA method is then applied to find patterns among biomedical data sets and labels, or to find patterns among different data sources. In the second part, I discuss several learning problems for imbalanced biomedical data. Note that traditional learning systems are often biased when the biomedical data are imbalanced. Therefore, traditional evaluations such as accuracy may be inappropriate for such cases. I then discuss several alternative evaluation criteria to evaluate the learning performance. For imbalanced binary classification problems, I use the undersampling based classifiers ensemble (UEM) strategy to obtain accurate models for both classes of samples. A small sphere and large margin (SSLM) approach is also presented to detect rare abnormal samples from a large number of subjects. In addition, I apply multiple feature selection and clustering methods to deal with high-dimensional data and data with highly correlated features. Experiments on high-dimensional imbalanced biomedical data are presented which illustrate the effectiveness and efficiency of my methods.
ContributorsYang, Tao (Author) / Ye, Jieping (Thesis advisor) / Wang, Yalin (Committee member) / Davulcu, Hasan (Committee member) / Arizona State University (Publisher)
Created2013
Description
Frontend development often involves the repetitive and time-consuming task of transforming a Graphical User interface (GUI) design into Frontend Code. The GUI design could either be an image or a design created on tools like Figma, Sketch, etc. This process can be particularly challenging when the website designs are experimental and undergo multiple iterations before the final version gets deployed. In such cases, developers work with the designers to make continuous changes and improve the look and feel of the website. This can lead to a lot of reworks and a poorly managed codebase that requires significant developer resources. To tackle this problem, researchers are exploring ways to automate the process of transforming image designs into functional websites instantly. This thesis explores the use of machine learning, specifically Recurrent Neural networks (RNN) to generate an intermediate code from an image design and then compile it into a React web frontend code. By utilizing this approach, designers can essentially transform an image design into a functional website, granting them creative freedom and the ability to present working prototypes to stockholders in real-time. To overcome the limitations of existing publicly available datasets, the thesis places significant emphasis on generating synthetic datasets. As part of this effort, the research proposes a novel method to double the size of the pix2code [2] dataset by incorporating additional complex HTML elements such as login forms, carousels, and cards. This approach has the potential to enhance the quality and diversity of training data available for machine learning models. Overall, the proposed approach offers a promising solution to the repetitive and time-consuming task of transforming GUI designs into frontend code.
ContributorsSingh, Ajitesh Janardan (Author) / Bansal, Ajay (Thesis advisor) / Mehlhase, Alexandra (Committee member) / Baron, Tyler (Committee member) / Arizona State University (Publisher)
Created2023
Description
Question answering is a challenging problem and a long term goal of Artificial Intelligence. There are many approaches proposed to solve this problem, including end to end machine learning systems, Information Retrieval based approaches and Textual Entailment. Despite being popular, these methods find difficulty in solving problems that require multi level reasoning and combining independent pieces of knowledge, for example, a question like "What adaptation is necessary in intertidal ecosystems but not in reef ecosystems?'', requires the system to consider qualities, behaviour or features of an organism living in an intertidal ecosystem and compare with that of an organism in a reef ecosystem to find the answer. The proposed solution is to solve a genre of questions, which is questions based on "Adaptation, Variation and Behavior in Organisms", where there are various different independent sets of knowledge required for answering questions along with reasoning. This method is implemented using Answer Set Programming and Natural Language Inference (which is based on machine learning ) for finding which of the given options is more probable to be the answer by matching it with the knowledge base. To evaluate this approach, a dataset of questions and a knowledge base in the domain of "Adaptation, Variation and Behavior in Organisms" is created.
ContributorsBatni, Vaishnavi (Author) / Baral, Chitta (Thesis advisor) / Anwar, Saadat (Committee member) / Yang, Yezhou (Committee member) / Arizona State University (Publisher)
Created2019