Matching Items (17)
Filtering by
- All Subjects: Politics
- Creators: School of Social and Behavioral Sciences
- Creators: Woodall, Gina
- Creators: Department of Information Systems
- Resource Type: Text
- Status: Published
Description
Bexarotene (Targretin®) is an FDA approved drug used to treat cutaneous T-cell lymphoma (CTCL), as well as off-label treatments for various cancers and neurodegenerative diseases. Previous research has indicated that bexarotene has a specific affinity for retinoid X receptors (RXR), which allows bexarotene to act as a ligand-activated-transcription factor and in return control cell differentiation and proliferation. Bexarotene targets RXR homodimerization to drive transcription of tumor suppressing genes; however, adverse reactions occur simultaneously when bound to other nuclear receptors. In this study, we used novel bexarotene analogs throughout 5 iterations synthesized in the laboratory of Dr. Wagner to test for their potency and ability to bind RXR. The aim of our study is to quantitatively measure RXR homodimerization driven by bexarotene analogs using a yeast two-hybrid system. Our results suggests there to be several compounds with higher protein activity than bexarotene, particularly in generations 3.0 and 5.0. This higher affinity for RXR homodimers may help scientists identify a compound that will minimize adverse effects and toxicity of bexarotene and serve as a better cancer treatment alternative.
ContributorsSeto, David Hua (Author) / Marshall, Pamela (Thesis director) / Wagner, Carl (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Natural Sciences (Contributor) / School of Social and Behavioral Sciences (Contributor)
Created2015-05
Description
Bexarotene is a commercially produced drug commonly known as Targetin presecribed to treat cutaneous T-cell lymphoma (CTCL). Bex mimics the actions of natural 9-cis retinoic acid in the body, which are derived from Vitamin A in the diet and boost the immune system. Bex has been shown to be effective in the treatment of multiple types of cancer, including lung cancer. However, the disadvantages of using Bex include increased instances of hypothyroidism and excessive concentrations of blood triglycerides. If an analog of Bex can be developed which retains high affinity RXR binding similar to the 9-cis retinoic acid while exhibiting less interference for heterodimerization pathways, it would be of great clinical significance in improving the quality of life for patients with CTCL. This thesis will detail the biological profiling of additional novel (Generation Two) analogs, which are currently in submission for publication, as well as that of Generation Three analogs. The results from these studies reveal that specific alterations in the core structure of the Bex "parent" compound structure can have dramatic effects in modifying the biological activity of RXR agonists.
ContributorsYang, Joanna (Author) / Jurutka, Peter (Thesis director) / Wagner, Carl (Committee member) / Hibler, Elizabeth (Committee member) / Barrett, The Honors College (Contributor)
Created2012-05
Description
We were interested in whether or not certain demographics, such as gender, age, education level, and academic major, would affect an individual's political awareness. In particular, we hypothesized that Political Science majors would have a higher level of political awareness than Non-Political Science majors. In an in-person survey, we asked participants on the Arizona State University, Tempe campus a series of nine questions measuring government structure and procedure, current politics, and policy issues. Our findings concluded that, within our sample: 1) on average, Political Science majors outperformed Non-Political Science majors 2) education level appears to be positively associated with political awareness 3) like education, age appears to be positively associated with political awareness, however, there seemed to be a peak at 21 years of age 4) males outperformed females, as suggested by research studying the gender gap in political knowledge. Because our sample population was not randomly selected, and this report focuses on descriptive statistics, we cannot generalize or comment on our findings' statistical significance. However, many of our findings are supported by current research and, with further specification, may be of interest to university officials who seek to measure the political knowledge and awareness of various demographic groups on campus.
ContributorsTaylor, Kaela (Co-author) / Leung, Emily (Co-author) / Lennon, Tara (Thesis director) / Woodall, Gina (Committee member) / Barrett, The Honors College (Contributor) / W. P. Carey School of Business (Contributor) / School of International Letters and Cultures (Contributor) / School of Politics and Global Studies (Contributor) / Department of Information Systems (Contributor) / School of Accountancy (Contributor)
Created2014-05
Description
This thesis explores a method of how political information could be distributed to the public and asks the question, what is the best way to provide voters with all of the information they need to cast an informed vote? It involved the creation of a website, www.azleglive.info, which republishes state legislative data in interactive and visually condensed formats and asked users to compare it to the existing Arizona State Legislature website on the metrics of depth of information, usability, and clarity. It also asked what resources users would utilize in order to cast a vote in the next election. Ultimately, the majority of users determined that the new website added needed usability and clarity to available legislative information, but that both websites would be useful when voting. In conclusion, the responsibility of disseminating useful information to voters is most likely to be effective when distributed among a variety of sources.
ContributorsJosephson, Zachary (Co-author) / Umaretiya, Amy (Co-author) / Jones, Ruth (Thesis director) / Woodall, Gina (Committee member) / Civil, Environmental and Sustainable Engineering Programs (Contributor) / School of Politics and Global Studies (Contributor) / Computer Science and Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
The contemporary Democratic Party has departed from their roots protecting working-class issues in favor of neoliberal ideology protecting the professional class; however, recent surges in progressive campaigns demonstrate the desire to move past this elitist ideology for New Deal-like policies, namely, young people. By utilizing the works of Thomas Frank and Anand Giridharadas to analyze the faults of the DNC, I then make case for the path forward that is more inclusive of young people and older members Black, Indigenous, Latino, Asian, and LGBTQ+ communities with progressive policies to "bringing the party home."
ContributorsThompson, Makayla Lynn (Author) / Gruber, Diane (Thesis director) / Ron, Amit (Committee member) / School of Social and Behavioral Sciences (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description
This study aims to gain a better understanding of the potential influence that perceived levels of attractiveness impose on individuals’ perceptions of male and female candidates’ competency and favorability. I utilized a quasi-experimental design that had a total of 603 respondents, all of which were current students at Arizona State University. The experimental design of the study consisted of the same pre-test, and post-test questionnaire, with a randomly assigned experimental group viewing a video regarding the halo effect, and a randomly assigned control group viewing a neutral video with no comment on attractiveness and its inherent effects. The results demonstrate insignificant findings in regard to candidate favorability and attractiveness, but one significant finding revealed itself in regard to competency. Hypothesis 6 (H6) identified an unexpected, yet statistically significant finding when concerning the ‘above average’ female candidate and respondents’ perception of her competency. This suggests that individuals may be more inclined to favorably perceive the competency of an attractive female candidate when they are aware of their implicit biases that accompany increased levels of attractiveness. This study offers insight into whether perceived level of attractiveness affects evaluations of male and female politicians.
ContributorsAndrade, Madison Antoinette (Author) / Woodall, Gina (Thesis director) / Kenney, Patrick (Committee member) / Sanford School of Social and Family Dynamics (Contributor) / School of Politics and Global Studies (Contributor) / Barrett, The Honors College (Contributor)
Created2020-12
Description
Alexis de Tocqueville, French political theorist and scientist, theorized in the 19th century that “France cannot reform except through revolution” (Heisbourg, 2016). As France continues to face a strained economy with high unemployment and stalled growth, the OECD recommends that France should implement labor reform “to promote job growth” (OECD, 2015). Labor reform refers to removing labor protections for French employees, resulting in an increase in firing and hiring flexibility for employers.
Recent governments in France have failed to bring about meaningful labor reform, faced with opposition in the streets or within their own political party. The election of Emanuel Macron, viewed as a political outsider who had never held elected office created his own political party, En Marche, seemed like the catalyst to lasting economic reform. However, if high unemployment and slow economic growth to comparable economies have been concerns for France since the beginning of the 21st century, why were past governments unsuccessful in implementing legislative actions to address labor reform?
This paper will argue that the election of Macron and the establishment of En Marche was caused by a shift in power that allowed Macron enough support to sway the political landscape of France and implement labor market reform. This largely has to do with the power struggle between France’s Outsiders, “those without secure employment, Insiders, “those with secure employment” and the Upscale group, “employers, the upper middle class, and the business and financial community” (Rudea, 2007). However, the degree and preservation of Macron’s reform plans are threatened by Insiders who have been stripped of employee protections.
Recent governments in France have failed to bring about meaningful labor reform, faced with opposition in the streets or within their own political party. The election of Emanuel Macron, viewed as a political outsider who had never held elected office created his own political party, En Marche, seemed like the catalyst to lasting economic reform. However, if high unemployment and slow economic growth to comparable economies have been concerns for France since the beginning of the 21st century, why were past governments unsuccessful in implementing legislative actions to address labor reform?
This paper will argue that the election of Macron and the establishment of En Marche was caused by a shift in power that allowed Macron enough support to sway the political landscape of France and implement labor market reform. This largely has to do with the power struggle between France’s Outsiders, “those without secure employment, Insiders, “those with secure employment” and the Upscale group, “employers, the upper middle class, and the business and financial community” (Rudea, 2007). However, the degree and preservation of Macron’s reform plans are threatened by Insiders who have been stripped of employee protections.
ContributorsLoonam, Daniel Francis (Author) / Thomson, Henry (Thesis director) / Kirsch, Robert (Committee member) / Department of Information Systems (Contributor) / Department of Finance (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
The United States is in a period of political turmoil and polarization. New technologies have matured over the last ten years, which have transformed an individual’s relationship with society and government. The emergence of these technologies has revolutionized access to both information and misinformation. Skills such as bias recognition and critical thinking are more imperative than in any other time to separate truth from false or misleading information. Meanwhile, education has not evolved with these changes. The average individual is more likely to come to uninformed conclusions and less likely to listen to differing perspectives. Moreover, technology is further complicating and compounding other issues in the political process. All of this is manifesting in division among the American people who elect more polarized politicians who increasingly fail to find avenues for compromise.
In an effort to address these trends, we founded a student organization, The Political Literates, to fight political apathy by delivering political news in an easy to understand and unbiased manner. Inspired by our experience with this organization, we combine our insights with research to paint a new perspective on the state of the American political system.
This thesis analyzes various issues identified through our observations and research, with a heavy emphasis on using examples from the 2016 election. Our focus is how new technologies like data analytics, the Internet, smartphones, and social media are changing politics by driving political and social transformation. We identify and analyze five core issues that have been amplified by new technology, hindering the effectiveness of elections and further increasing political polarization:
● Gerrymandering which skews partisan debate by forcing politicians to pander to ideologically skewed districts.
● Consolidation of media companies which affects the diversity of how news is shared.
● Repeal of the Fairness Doctrine which allowed media to become more partisan.
● The Citizens United Ruling which skews power away from average voters in elections.
● A Failing Education System which does not prepare Americans to be civically engaged and to avoid being swayed by biased or untrue media.
Based on our experiment with the Political Literates and our research, we call for improving how critical thinking and civics is taught in the American education system. Critical thought and civics must be developed pervasively. With this, more people would be able to form more sophisticated views by listening to others to learn rather than win, listening less to irrelevant information, and forming a culture with more engagement in politics. Through this re-enlightenment, many of America’s other problems may evaporate or become more actionable.
In an effort to address these trends, we founded a student organization, The Political Literates, to fight political apathy by delivering political news in an easy to understand and unbiased manner. Inspired by our experience with this organization, we combine our insights with research to paint a new perspective on the state of the American political system.
This thesis analyzes various issues identified through our observations and research, with a heavy emphasis on using examples from the 2016 election. Our focus is how new technologies like data analytics, the Internet, smartphones, and social media are changing politics by driving political and social transformation. We identify and analyze five core issues that have been amplified by new technology, hindering the effectiveness of elections and further increasing political polarization:
● Gerrymandering which skews partisan debate by forcing politicians to pander to ideologically skewed districts.
● Consolidation of media companies which affects the diversity of how news is shared.
● Repeal of the Fairness Doctrine which allowed media to become more partisan.
● The Citizens United Ruling which skews power away from average voters in elections.
● A Failing Education System which does not prepare Americans to be civically engaged and to avoid being swayed by biased or untrue media.
Based on our experiment with the Political Literates and our research, we call for improving how critical thinking and civics is taught in the American education system. Critical thought and civics must be developed pervasively. With this, more people would be able to form more sophisticated views by listening to others to learn rather than win, listening less to irrelevant information, and forming a culture with more engagement in politics. Through this re-enlightenment, many of America’s other problems may evaporate or become more actionable.
ContributorsStenseth, Kyle (Co-author) / Tumas, Trevor (Co-author) / Mokwa, Michael (Thesis director) / Eaton, John (Committee member) / Department of Information Systems (Contributor) / Department of Supply Chain Management (Contributor) / Sandra Day O'Connor College of Law (Contributor) / Watts College of Public Service & Community Solut (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
What is a “Good Economy”? Analysis of Economic Metrics & Their Political Impact on the United States
Description
The goal of this research paper is to analyze how we define economic success and how that affects large corporations and consumers. This paper asks the questions: What do we define as a good economy? What metrics are currently utilized? And how do perceptions of a good economy influence politics? Overall, the research seeks to identify common economic and financial fallacies held by the average citizen and offer alternative methods of how socio-economic information is presented to the consumers. Consumers play a major role in the market, and the information they receive has a considerable impact on their behaviors. Determining why the present economic analysis is used is the first step in finding ways to improve the system. Observing past political and economic trends and relating them to current issues is necessary for finding future solutions.
ContributorsTosca, Carlos (Author) / Brian, Jennifer (Thesis director) / Sadusky, Brian (Committee member) / Department of Information Systems (Contributor) / Department of Finance (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
In this undergraduate thesis, I explore the relationship between politics and popular culture through an ethnography of Justice League Arizona, a cosplay ensemble devoted to costumed civic activism. While existing scholarship addresses cosplay ensembles and political theory, there is very little that examines how the act of cosplay can be a form of politics and what the impact of that interpretation has on both individuals and the community at large. Through both participant observation and interviews with members of the ensemble, I discovered that cosplay has the ability to intensify aspects of the self, the ability to expose new aspects of the self, and the ability to bring one closer to a particular character. I also found cosplay to be political through the sensibility and situated knowledge that proves to be in practice during cosplay, ultimately having the power to be used as a form of political resistance.
ContributorsBurrus, Ella Rene (Author) / Mack, Robert (Thesis director) / Behl, Natasha (Committee member) / School of Social and Behavioral Sciences (Contributor) / Herberger Institute for Design and the Arts (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12