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- All Subjects: deep learning
- Creators: Wu, Teresa
- Creators: Cao, Yu
Description
In healthcare facilities, health information systems (HISs) are used to serve different purposes. The radiology department adopts multiple HISs in managing their operations and patient care. In general, the HISs that touch radiology fall into two categories: tracking HISs and archive HISs. Electronic Health Records (EHR) is a typical tracking HIS, which tracks the care each patient receives at multiple encounters and facilities. Archive HISs are typically specialized databases to store large-size data collected as part of the patient care. A typical example of an archive HIS is the Picture Archive and Communication System (PACS), which provides economical storage and convenient access to diagnostic images from multiple modalities. How to integrate such HISs and best utilize their data remains a challenging problem due to the disparity of HISs as well as high-dimensionality and heterogeneity of the data. My PhD dissertation research includes three inter-connected and integrated topics and focuses on designing integrated HISs and further developing statistical models and machine learning algorithms for process and patient care improvement.
Topic 1: Design of super-HIS and tracking of quality of care (QoC). My research developed an information technology that integrates multiple HISs in radiology, and proposed QoC metrics defined upon the data that measure various dimensions of care. The DDD assisted the clinical practices and enabled an effective intervention for reducing lengthy radiologist turnaround times for patients.
Topic 2: Monitoring and change detection of QoC data streams for process improvement. With the super-HIS in place, high-dimensional data streams of QoC metrics are generated. I developed a statistical model for monitoring high- dimensional data streams that integrated Singular Vector Decomposition (SVD) and process control. The algorithm was applied to QoC metrics data, and additionally extended to another application of monitoring traffic data in communication networks.
Topic 3: Deep transfer learning of archive HIS data for computer-aided diagnosis (CAD). The novelty of the CAD system is the development of a deep transfer learning algorithm that combines the ideas of transfer learning and multi- modality image integration under the deep learning framework. Our system achieved high accuracy in breast cancer diagnosis compared with conventional machine learning algorithms.
Topic 1: Design of super-HIS and tracking of quality of care (QoC). My research developed an information technology that integrates multiple HISs in radiology, and proposed QoC metrics defined upon the data that measure various dimensions of care. The DDD assisted the clinical practices and enabled an effective intervention for reducing lengthy radiologist turnaround times for patients.
Topic 2: Monitoring and change detection of QoC data streams for process improvement. With the super-HIS in place, high-dimensional data streams of QoC metrics are generated. I developed a statistical model for monitoring high- dimensional data streams that integrated Singular Vector Decomposition (SVD) and process control. The algorithm was applied to QoC metrics data, and additionally extended to another application of monitoring traffic data in communication networks.
Topic 3: Deep transfer learning of archive HIS data for computer-aided diagnosis (CAD). The novelty of the CAD system is the development of a deep transfer learning algorithm that combines the ideas of transfer learning and multi- modality image integration under the deep learning framework. Our system achieved high accuracy in breast cancer diagnosis compared with conventional machine learning algorithms.
ContributorsWang, Kun (Author) / Li, Jing (Thesis advisor) / Wu, Teresa (Committee member) / Pan, Rong (Committee member) / Zwart, Christine M. (Committee member) / Arizona State University (Publisher)
Created2018
Description
Deep learning (DL) has proved itself be one of the most important developements till date with far reaching impacts in numerous fields like robotics, computer vision, surveillance, speech processing, machine translation, finance, etc. They are now widely used for countless applications because of their ability to generalize real world data, robustness to noise in previously unseen data and high inference accuracy. With the ability to learn useful features from raw sensor data, deep learning algorithms have out-performed tradinal AI algorithms and pushed the boundaries of what can be achieved with AI. In this work, we demonstrate the power of deep learning by developing a neural network to automatically detect cough instances from audio recorded in un-constrained environments. For this, 24 hours long recordings from 9 dierent patients is collected and carefully labeled by medical personel. A pre-processing algorithm is proposed to convert event based cough dataset to a more informative dataset with start and end of coughs and also introduce data augmentation for regularizing the training procedure. The proposed neural network achieves 92.3% leave-one-out accuracy on data captured in real world.
Deep neural networks are composed of multiple layers that are compute/memory intensive. This makes it difficult to execute these algorithms real-time with low power consumption using existing general purpose computers. In this work, we propose hardware accelerators for a traditional AI algorithm based on random forest trees and two representative deep convolutional neural networks (AlexNet and VGG). With the proposed acceleration techniques, ~ 30x performance improvement was achieved compared to CPU for random forest trees. For deep CNNS, we demonstrate that much higher performance can be achieved with architecture space exploration using any optimization algorithms with system level performance and area models for hardware primitives as inputs and goal of minimizing latency with given resource constraints. With this method, ~30GOPs performance was achieved for Stratix V FPGA boards.
Hardware acceleration of DL algorithms alone is not always the most ecient way and sucient to achieve desired performance. There is a huge headroom available for performance improvement provided the algorithms are designed keeping in mind the hardware limitations and bottlenecks. This work achieves hardware-software co-optimization for Non-Maximal Suppression (NMS) algorithm. Using the proposed algorithmic changes and hardware architecture
With CMOS scaling coming to an end and increasing memory bandwidth bottlenecks, CMOS based system might not scale enough to accommodate requirements of more complicated and deeper neural networks in future. In this work, we explore RRAM crossbars and arrays as compact, high performing and energy efficient alternative to CMOS accelerators for deep learning training and inference. We propose and implement RRAM periphery read and write circuits and achieved ~3000x performance improvement in online dictionary learning compared to CPU.
This work also examines the realistic RRAM devices and their non-idealities. We do an in-depth study of the effects of RRAM non-idealities on inference accuracy when a pretrained model is mapped to RRAM based accelerators. To mitigate this issue, we propose Random Sparse Adaptation (RSA), a novel scheme aimed at tuning the model to take care of the faults of the RRAM array on which it is mapped. Our proposed method can achieve inference accuracy much higher than what traditional Read-Verify-Write (R-V-W) method could achieve. RSA can also recover lost inference accuracy 100x ~ 1000x faster compared to R-V-W. Using 32-bit high precision RSA cells, we achieved ~10% higher accuracy using fautly RRAM arrays compared to what can be achieved by mapping a deep network to an 32 level RRAM array with no variations.
Deep neural networks are composed of multiple layers that are compute/memory intensive. This makes it difficult to execute these algorithms real-time with low power consumption using existing general purpose computers. In this work, we propose hardware accelerators for a traditional AI algorithm based on random forest trees and two representative deep convolutional neural networks (AlexNet and VGG). With the proposed acceleration techniques, ~ 30x performance improvement was achieved compared to CPU for random forest trees. For deep CNNS, we demonstrate that much higher performance can be achieved with architecture space exploration using any optimization algorithms with system level performance and area models for hardware primitives as inputs and goal of minimizing latency with given resource constraints. With this method, ~30GOPs performance was achieved for Stratix V FPGA boards.
Hardware acceleration of DL algorithms alone is not always the most ecient way and sucient to achieve desired performance. There is a huge headroom available for performance improvement provided the algorithms are designed keeping in mind the hardware limitations and bottlenecks. This work achieves hardware-software co-optimization for Non-Maximal Suppression (NMS) algorithm. Using the proposed algorithmic changes and hardware architecture
With CMOS scaling coming to an end and increasing memory bandwidth bottlenecks, CMOS based system might not scale enough to accommodate requirements of more complicated and deeper neural networks in future. In this work, we explore RRAM crossbars and arrays as compact, high performing and energy efficient alternative to CMOS accelerators for deep learning training and inference. We propose and implement RRAM periphery read and write circuits and achieved ~3000x performance improvement in online dictionary learning compared to CPU.
This work also examines the realistic RRAM devices and their non-idealities. We do an in-depth study of the effects of RRAM non-idealities on inference accuracy when a pretrained model is mapped to RRAM based accelerators. To mitigate this issue, we propose Random Sparse Adaptation (RSA), a novel scheme aimed at tuning the model to take care of the faults of the RRAM array on which it is mapped. Our proposed method can achieve inference accuracy much higher than what traditional Read-Verify-Write (R-V-W) method could achieve. RSA can also recover lost inference accuracy 100x ~ 1000x faster compared to R-V-W. Using 32-bit high precision RSA cells, we achieved ~10% higher accuracy using fautly RRAM arrays compared to what can be achieved by mapping a deep network to an 32 level RRAM array with no variations.
ContributorsMohanty, Abinash (Author) / Cao, Yu (Thesis advisor) / Seo, Jae-Sun (Committee member) / Vrudhula, Sarma (Committee member) / Chakrabarti, Chaitali (Committee member) / Arizona State University (Publisher)
Created2018
Description
The current Enterprise Requirements and Acquisition Model (ERAM), a discrete event simulation of the major tasks and decisions within the DoD acquisition system, identifies several what-if intervention strategies to improve program completion time. However, processes that contribute to the program acquisition completion time were not explicitly identified in the simulation study. This research seeks to determine the acquisition processes that contribute significantly to total simulated program time in the acquisition system for all programs reaching Milestone C. Specifically, this research examines the effect of increased scope management, technology maturity, and decreased variation and mean process times in post-Design Readiness Review contractor activities by performing additional simulation analyses. Potential policies are formulated from the results to further improve program acquisition completion time.
ContributorsWorger, Danielle Marie (Author) / Wu, Teresa (Thesis director) / Shunk, Dan (Committee member) / Wirthlin, J. Robert (Committee member) / Industrial, Systems (Contributor) / Barrett, The Honors College (Contributor)
Created2013-05
Description
In recent years, Artificial Intelligence (AI) (e.g., Deep Neural Networks (DNNs), Transformer) has shown great success in real-world applications due to its superior performance in various cognitive tasks. The impressive performance achieved by AI models normally accompanies the cost of enormous model size and high computational complexity, which significantly hampers their implementation on resource-limited Cyber-Physical Systems (CPS), Internet-of-Things (IoT), or Edge systems due to their tightly constrained energy, computing, size, and memory budget. Thus, the urgent demand for enhancing the \textbf{Efficiency} of DNN has drawn significant research interests across various communities.
Motivated by the aforementioned concerns, this doctoral research has been mainly focusing on Enabling Deep Learning at Edge: From Efficient and Dynamic Inference to On-Device Learning. Specifically, from the inference perspective, this dissertation begins by investigating a hardware-friendly model compression method that effectively reduces the size of AI model while simultaneously achieving improved speed on edge devices. Additionally, due to the fact that diverse resource constraints of different edge devices, this dissertation further explores dynamic inference, which allows for real-time tuning of inference model size, computation, and latency to accommodate the limitations of each edge device. Regarding efficient on-device learning, this dissertation starts by analyzing memory usage during transfer learning training. Based on this analysis, a novel framework called "Reprogramming Network'' (Rep-Net) is introduced that offers a fresh perspective on the on-device transfer learning problem. The Rep-Net enables on-device transferlearning by directly learning to reprogram the intermediate features of a pre-trained model. Lastly, this dissertation studies an efficient continual learning algorithm that facilitates learning multiple tasks without the risk of forgetting previously acquired knowledge. In practice, through the exploration of task correlation, an interesting phenomenon is observed that the intermediate features are highly correlated between tasks with the self-supervised pre-trained model. Building upon this observation, a novel approach called progressive task-correlated layer freezing is proposed to gradually freeze a subset of layers with the highest correlation ratios for each task leading to training efficiency.
ContributorsYang, Li (Author) / Fan, Deliang (Thesis advisor) / Seo, Jae-Sun (Committee member) / Zhang, Junshan (Committee member) / Cao, Yu (Committee member) / Arizona State University (Publisher)
Created2023
Description
In this thesis, the applications of deep learning in the analysis, detection and classification of medical imaging datasets were studied, with a focus on datasets having a limited sample size. A combined machine learning-deep learning model was designed to classify one small dataset, prostate cancer provided by Mayo Clinic, Arizona. Deep learning model was implemented to extract imaging features followed by machine learning classifier for prostate cancer diagnosis. The results were compared against models trained on texture-based features, namely gray level co-occurrence matrix (GLCM) and Gabor. Some of the challenges of performing diagnosis on medical imaging datasets with limited sample sizes, have been identified. Lastly, a set of future works have been proposed. Keywords: Deep learning, radiology, transfer learning, convolutional neural network.
ContributorsSarkar, Suryadipto (Author) / Wu, Teresa (Thesis advisor) / Papandreou-Suppappola, Antonia (Committee member) / Silva, Alvin (Committee member) / Arizona State University (Publisher)
Created2021
Description
Over the past few decades, medical imaging is becoming important in medicine for disease diagnosis, prognosis, treatment assessment and health monitoring. As medical imaging has progressed, imaging biomarkers are being rapidly developed for early diagnosis and staging of disease. Detecting and segmenting objects from images are often the first steps in quantitative measurement of these biomarkers. While large objects can often be automatically or semi-automatically delineated, segmenting small objects (blobs) is challenging. The small object of particular interest in this dissertation are glomeruli from kidney magnetic resonance (MR) images. This problem has its unique challenges. First of all, the size of glomeruli is extremely small and very similar with noises from images. Second, there are massive of glomeruli in kidney, e.g. over 1 million glomeruli in human kidney, and the intensity distribution is heterogenous. A third recognized issue is that a large portion of glomeruli are overlapping and touched in images. The goal of this dissertation is to develop computational algorithms to identify and discover glomeruli related imaging biomarkers. The first phase is to develop a U-net joint with Hessian based Difference of Gaussians (UH-DoG) blob detector. Joining effort from deep learning alleviates the over-detection issue from Hessian analysis. Next, as extension of UH-DoG, a small blob detector using Bi-Threshold Constrained Adaptive Scales (BTCAS) is proposed. Deep learning is treated as prior of Difference of Gaussian (DoG) to improve its efficiency. By adopting BTCAS, under-segmentation issue of deep learning is addressed. The second phase is to develop a denoising convexity-consistent Blob Generative Adversarial Network (BlobGAN). BlobGAN could achieve high denoising performance and selectively denoise the image without affecting the blobs. These detectors are validated on datasets of 2D fluorescent images, 3D synthetic images, 3D MR (18 mice, 3 humans) images and proved to be outperforming the competing detectors. In the last phase, a Fréchet Descriptors Distance based Coreset approach (FDD-Coreset) is proposed for accelerating BlobGAN’s training. Experiments have shown that BlobGAN trained on FDD-Coreset not only significantly reduces the training time, but also achieves higher denoising performance and maintains approximate performance of blob identification compared with training on entire dataset.
ContributorsXu, Yanzhe (Author) / Wu, Teresa (Thesis advisor) / Iquebal, Ashif (Committee member) / Yan, Hao (Committee member) / Beeman, Scott (Committee member) / Arizona State University (Publisher)
Created2022
Description
Deep learning is a sub-field of machine learning in which models are developed to imitate the workings of the human brain in processing data and creating patterns for decision making. This dissertation is focused on developing deep learning models for medical imaging analysis of different modalities for different tasks including detection, segmentation and classification. Imaging modalities including digital mammography (DM), magnetic resonance imaging (MRI), positron emission tomography (PET) and computed tomography (CT) are studied in the dissertation for various medical applications. The first phase of the research is to develop a novel shallow-deep convolutional neural network (SD-CNN) model for improved breast cancer diagnosis. This model takes one type of medical image as input and synthesizes different modalities for additional feature sources; both original image and synthetic image are used for feature generation. This proposed architecture is validated in the application of breast cancer diagnosis and proved to be outperforming the competing models. Motivated by the success from the first phase, the second phase focuses on improving medical imaging synthesis performance with advanced deep learning architecture. A new architecture named deep residual inception encoder-decoder network (RIED-Net) is proposed. RIED-Net has the advantages of preserving pixel-level information and cross-modality feature transferring. The applicability of RIED-Net is validated in breast cancer diagnosis and Alzheimer’s disease (AD) staging. Recognizing medical imaging research often has multiples inter-related tasks, namely, detection, segmentation and classification, my third phase of the research is to develop a multi-task deep learning model. Specifically, a feature transfer enabled multi-task deep learning model (FT-MTL-Net) is proposed to transfer high-resolution features from segmentation task to low-resolution feature-based classification task. The application of FT-MTL-Net on breast cancer detection, segmentation and classification using DM images is studied. As a continuing effort on exploring the transfer learning in deep models for medical application, the last phase is to develop a deep learning model for both feature transfer and knowledge from pre-training age prediction task to new domain of Mild cognitive impairment (MCI) to AD conversion prediction task. It is validated in the application of predicting MCI patients’ conversion to AD with 3D MRI images.
ContributorsGao, Fei (Author) / Wu, Teresa (Thesis advisor) / Li, Jing (Committee member) / Yan, Hao (Committee member) / Patel, Bhavika (Committee member) / Arizona State University (Publisher)
Created2019
Description
The advances of Deep Learning (DL) achieved recently have successfully demonstrated its great potential of surpassing or close to human-level performance across multiple domains. Consequently, there exists a rising demand to deploy state-of-the-art DL algorithms, e.g., Deep Neural Networks (DNN), in real-world applications to release labors from repetitive work. On the one hand, the impressive performance achieved by the DNN normally accompanies with the drawbacks of intensive memory and power usage due to enormous model size and high computation workload, which significantly hampers their deployment on the resource-limited cyber-physical systems or edge devices. Thus, the urgent demand for enhancing the inference efficiency of DNN has also great research interests across various communities. On the other hand, scientists and engineers still have insufficient knowledge about the principles of DNN which makes it mostly be treated as a black-box. Under such circumstance, DNN is like "the sword of Damocles" where its security or fault-tolerance capability is an essential concern which cannot be circumvented.
Motivated by the aforementioned concerns, this dissertation comprehensively investigates the emerging efficiency and security issues of DNNs, from both software and hardware design perspectives. From the efficiency perspective, as the foundation technique for efficient inference of target DNN, the model compression via quantization is elaborated. In order to maximize the inference performance boost, the deployment of quantized DNN on the revolutionary Computing-in-Memory based neural accelerator is presented in a cross-layer (device/circuit/system) fashion. From the security perspective, the well known adversarial attack is investigated spanning from its original input attack form (aka. Adversarial example generation) to its parameter attack variant.
Motivated by the aforementioned concerns, this dissertation comprehensively investigates the emerging efficiency and security issues of DNNs, from both software and hardware design perspectives. From the efficiency perspective, as the foundation technique for efficient inference of target DNN, the model compression via quantization is elaborated. In order to maximize the inference performance boost, the deployment of quantized DNN on the revolutionary Computing-in-Memory based neural accelerator is presented in a cross-layer (device/circuit/system) fashion. From the security perspective, the well known adversarial attack is investigated spanning from its original input attack form (aka. Adversarial example generation) to its parameter attack variant.
Contributorshe, zhezhi (Author) / Fan, Deliang (Thesis advisor) / Chakrabarti, Chaitali (Committee member) / Cao, Yu (Committee member) / Seo, Jae-Sun (Committee member) / Arizona State University (Publisher)
Created2020
Description
Rapid development of computer vision applications such as image recognition and object detection has been enabled by the emerging deep learning technologies. To improve the accuracy further, deeper and wider neural networks with diverse architecture are proposed for better feature extraction. Though the performance boost is impressive, only marginal improvement can be achieved with significantly increased computational overhead. One solution is to compress the exploding-sized model by dropping less important weights or channels. This is an effective solution that has been well explored. However, by utilizing the rich relation information of the data, one can also improve the accuracy with reasonable overhead. This work makes progress toward efficient and accurate visual tasks including detection, prediction and understanding by using relations.
For object detection, a novel approach, Graph Assisted Reasoning (GAR), is proposed to utilize a heterogeneous graph to model object-object relations and object-scene relations. GAR fuses the features from neighboring object nodes as well as scene nodes. In this way, GAR produces better recognition than that produced from individual object nodes. Moreover, compared to previous approaches using Recurrent Neural Network (RNN), GAR's light-weight and low-coupling architecture further facilitate its integration into the object detection module.
For trajectories prediction, a novel approach, namely Diverse Attention RNN (DAT-RNN), is proposed to handle the diversity of trajectories and modeling of neighboring relations. DAT-RNN integrates both temporal and spatial relations to improve the prediction under various circumstances.
Last but not least, this work presents a novel relation implication-enhanced (RIE) approach that improves relation detection through relation direction and implication. With the relation implication, the SGG model is exposed to more ground truth information and thus mitigates the overfitting problem of the biased datasets. Moreover, the enhancement with relation implication is compatible with various context encoding schemes.
Comprehensive experiments on benchmarking datasets demonstrate the efficacy of the proposed approaches.
For object detection, a novel approach, Graph Assisted Reasoning (GAR), is proposed to utilize a heterogeneous graph to model object-object relations and object-scene relations. GAR fuses the features from neighboring object nodes as well as scene nodes. In this way, GAR produces better recognition than that produced from individual object nodes. Moreover, compared to previous approaches using Recurrent Neural Network (RNN), GAR's light-weight and low-coupling architecture further facilitate its integration into the object detection module.
For trajectories prediction, a novel approach, namely Diverse Attention RNN (DAT-RNN), is proposed to handle the diversity of trajectories and modeling of neighboring relations. DAT-RNN integrates both temporal and spatial relations to improve the prediction under various circumstances.
Last but not least, this work presents a novel relation implication-enhanced (RIE) approach that improves relation detection through relation direction and implication. With the relation implication, the SGG model is exposed to more ground truth information and thus mitigates the overfitting problem of the biased datasets. Moreover, the enhancement with relation implication is compatible with various context encoding schemes.
Comprehensive experiments on benchmarking datasets demonstrate the efficacy of the proposed approaches.
ContributorsLi, Zheng (Author) / Cao, Yu (Thesis advisor) / Chakrabarti, Chaitali (Committee member) / Seo, Jae-Sun (Committee member) / Fan, Deliang (Committee member) / Arizona State University (Publisher)
Created2020
Description
High-dimensional data is omnipresent in modern industrial systems. An imaging sensor in a manufacturing plant a can take images of millions of pixels or a sensor may collect months of data at very granular time steps. Dimensionality reduction techniques are commonly used for dealing with such data. In addition, outliers typically exist in such data, which may be of direct or indirect interest given the nature of the problem that is being solved. Current research does not address the interdependent nature of dimensionality reduction and outliers. Some works ignore the existence of outliers altogether—which discredits the robustness of these methods in real life—while others provide suboptimal, often band-aid solutions. In this dissertation, I propose novel methods to achieve outlier-awareness in various dimensionality reduction methods. The problem is considered from many different angles depend- ing on the dimensionality reduction technique used (e.g., deep autoencoder, tensors), the nature of the application (e.g., manufacturing, transportation) and the outlier structure (e.g., sparse point anomalies, novelties).
ContributorsSergin, Nurettin Dorukhan (Author) / Yan, Hao (Thesis advisor) / Li, Jing (Committee member) / Wu, Teresa (Committee member) / Tsung, Fugee (Committee member) / Arizona State University (Publisher)
Created2021