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- All Subjects: robotics
Description
Robotic rehabilitation for upper limb post-stroke recovery is a developing technology. However, there are major issues in the implementation of this type of rehabilitation, issues which decrease efficacy. Two of the major solutions currently being explored to the upper limb post-stroke rehabilitation problem are the use of socially assistive rehabilitative robots, robots which directly interact with patients, and the use of exoskeleton-based systems of rehabilitation. While there is great promise in both of these techniques, they currently lack sufficient efficacy to objectively justify their costs. The overall efficacy to both of these techniques is about the same as conventional therapy, yet each has higher overhead costs that conventional therapy does. However there are associated long-term cost savings in each case, meaning that the actual current viability of either of these techniques is somewhat nebulous. In both cases, the problems which decrease technique viability are largely related to joint action, the interaction between robot and human in completing specific tasks, and issues in robot adaptability that make joint action difficult. As such, the largest part of current research into rehabilitative robotics aims to make robots behave in more "human-like" manners or to bypass the joint action problem entirely.
ContributorsRamakrishna, Vijay Kambhampati (Author) / Helms Tillery, Stephen (Thesis director) / Buneo, Christopher (Committee member) / Barrett, The Honors College (Contributor) / Economics Program in CLAS (Contributor) / W. P. Carey School of Business (Contributor) / School of Life Sciences (Contributor)
Created2015-05
Description
Soft continuum robots with the ability to bend, twist, elongate, and shorten, similar to octopus arms, have many potential applications, such as dexterous manipulation and navigation through unstructured, dynamic environments. Novel soft materials such as smart hydrogels, which change volume and other properties in response to stimuli such as temperature, pH, and chemicals, can potentially be used to construct soft robots that achieve self-regulated adaptive reconfiguration through on-demand dynamic control of local properties. However, the design of controllers for soft continuum robots is challenging due to their high-dimensional configuration space and the complexity of modeling soft actuator dynamics. To address these challenges, this dissertation presents two different model-based control approaches for robots with distributed soft actuators and sensors and validates the approaches in simulations and physical experiments. It is demonstrated that by choosing an appropriate dynamical model and designing a decentralized controller based on this model, such robots can be controlled to achieve diverse types of complex configurations. The first approach consists of approximating the dynamics of the system, including its actuators, as a linear state-space model in order to apply optimal robust control techniques such as H∞ state-feedback and H∞ output-feedback methods. These techniques are designed to utilize the decentralized control structure of the robot and its distributed sensing and actuation to achieve vibration control and trajectory tracking. The approach is validated in simulation on an Euler-Bernoulli dynamic model of a hydrogel based cantilevered robotic arm and in experiments with a hydrogel-actuated miniature 2-DOF manipulator. The second approach is developed for soft continuum robots with dynamics that can be modeled using Cosserat rod theory. An inverse dynamics control approach is implemented on the Cosserat model of the robot for tracking configurations that include bending, torsion, shear, and extension deformations. The decentralized controller structure facilitates its implementation on robot arms composed of independently-controllable segments that have local sensing and actuation. This approach is validated on simulated 3D robot arms and on an actual silicone robot arm with distributed pneumatic actuation, for which the inverse dynamics problem is solved in simulation and the computed control outputs are applied to the robot in real-time.
ContributorsDoroudchi, Azadeh (Author) / Berman, Spring (Thesis advisor) / Tsakalis, Konstantinos (Committee member) / Si, Jennie (Committee member) / Marvi, Hamid (Committee member) / Arizona State University (Publisher)
Created2022
Description
This dissertation focuses on reinforcement learning (RL) controller design aiming for real-life applications in continuous state and control problems. It involves three major research investigations in the aspect of design, analysis, implementation, and evaluation. The application case addresses automatically configuring robotic prosthesis impedance parameters. Major contributions of the dissertation include the following. 1) An “echo control” using the intact knee profile as target is designed to overcome the limitation of a designer prescribed robotic knee profile. 2) Collaborative multiagent reinforcement learning (cMARL) is proposed to directly take into account human influence in the robot control design. 3) A phased actor in actor-critic (PAAC) reinforcement learning method is developed to reduce learning variance in RL. The design of an “echo control” is based on a new formulation of direct heuristic dynamic programming (dHDP) for tracking control of a robotic knee prosthesis to mimic the intact knee profile. A systematic simulation of the proposed control is provided using a human-robot system simulation in OpenSim. The tracking controller is then tested on able-bodied and amputee subjects. This is the first real-time human testing of RL tracking control of a robotic knee to mirror the profile of an intact knee. The cMARL is a new solution framework for the human-prosthesis collaboration (HPC) problem. This is the first attempt at considering human influence on human-robot walking with the presence of a reinforcement learning controlled lower limb prosthesis. Results show that treating the human and robot as coupled and collaborating agents and using an estimated human adaptation in robot control design help improve human walking performance. The above studies have demonstrated great potential of RL control in solving continuous problems. To solve more complex real-life tasks with multiple control inputs and high dimensional state space, high variance, low data efficiency, slow learning or even instability are major roadblocks to be addressed. A novel PAAC method is proposed to improve learning performance in policy gradient RL by accounting for both Q value and TD error in actor updates. Systematical and comprehensive demonstrations show its effectiveness by qualitative analysis and quantitative evaluation in DeepMind Control Suite.
ContributorsWu, Ruofan (Author) / Si, Jennie (Thesis advisor) / Huang, He (Committee member) / Santello, Marco (Committee member) / Papandreou- Suppappola, Antonia (Committee member) / Arizona State University (Publisher)
Created2023
Description
Human-robot interactions can often be formulated as general-sum differential games where the equilibrial policies are governed by Hamilton-Jacobi-Isaacs (HJI) equations. Solving HJI PDEs faces the curse of dimensionality (CoD). While physics-informed neural networks (PINNs) alleviate CoD in solving PDEs with smooth solutions, they fall short in learning discontinuous solutions due to their sampling nature. This causes PINNs to have poor safety performance when they are applied to approximate values that are discontinuous due to state constraints. This dissertation aims to improve the safety performance of PINN-based value and policy models. The first contribution of the dissertation is to develop learning methods to approximate discontinuous values. Specifically, three solutions are developed: (1) hybrid learning uses both supervisory and PDE losses, (2) value-hardening solves HJIs with increasing Lipschitz constant on the constraint violation penalty, and (3) the epigraphical technique lifts the value to a higher-dimensional state space where it becomes continuous. Evaluations through 5D and 9D vehicle and 13D drone simulations reveal that the hybrid method outperforms others in terms of generalization and safety performance. The second contribution is a learning-theoretical analysis of PINN for value and policy approximation. Specifically, by extending the neural tangent kernel (NTK) framework, this dissertation explores why the choice of activation function significantly affects the PINN generalization performance, and why the inclusion of supervisory costate data improves the safety performance. The last contribution is a series of extensions of the hybrid PINN method to address real-time parameter estimation problems in incomplete-information games. Specifically, a Pontryagin-mode PINN is developed to avoid costly computation for supervisory data. The key idea is the introduction of a costate loss, which is cheap to compute yet effectively enables the learning of important value changes and policies in space-time. Building upon this, a Pontryagin-mode neural operator is developed to achieve state-of-the-art (SOTA) safety performance across a set of differential games with parametric state constraints. This dissertation demonstrates the utility of the resultant neural operator in estimating player constraint parameters during incomplete-information games.
ContributorsZhang, Lei (Author) / Ren, Yi (Thesis advisor) / Si, Jennie (Committee member) / Berman, Spring (Committee member) / Zhang, Wenlong (Committee member) / Xu, Zhe (Committee member) / Arizona State University (Publisher)
Created2024
Description
Unmanned aerial vehicles (UAVs) are widely used in many applications because of their small size, great mobility and hover performance. This has been a consequence of the fast development of electronics, cheap lightweight flight controllers for accurate positioning and cameras. This thesis describes modeling, control and design of an oblique-cross-quadcopter platform for indoor-environments.
One contribution of the work was the design of a new printed-circuit-board (PCB) flight controller (called MARK3). Key features/capabilities are as follows:
(1) a Teensy 3.2 microcontroller with 168MHz overclock –used for communications, full-state estimation and inner-outer loop hierarchical rate-angle-speed-position control,
(2) an on-board MEMS inertial-measurement-unit (IMU) which includes an LSM303D (3DOF-accelerometer and magnetometer), an L3GD20 (3DOF-gyroscope) and a BMP180 (barometer) for attitude estimation (barometer/magnetometer not used),
(3) 6 pulse-width-modulator (PWM) output pins supports up to 6 rotors
(4) 8 PWM input pins support up to 8-channel 2.4 GHz transmitter/receiver for manual control,
(5) 2 5V servo extension outputs for other requirements (e.g. gimbals),
(6) 2 universal-asynchronous-receiver-transmitter (UART) serial ports - used by flight controller to process data from Xbee; can be used for accepting outer-loop position commands from NVIDIA TX2 (future work),
(7) 1 I2C-serial-protocol two-wire port for additional modules (used to read data from IMU at 400 Hz),
(8) a 20-pin port for Xbee telemetry module connection; permits Xbee transceiver on desktop PC to send position/attitude commands to Xbee transceiver on quadcopter.
The quadcopter platform consists of the new MARK3 PCB Flight Controller, an ATG-250 carbon-fiber frame (250 mm), a DJI Snail propulsion-system (brushless-three-phase-motor, electronic-speed-controller (ESC) and propeller), an HTC VIVE Tracker and RadioLink R9DS 9-Channel 2.4GHz Receiver. This platform is completely compatible with the HTC VIVE Tracking System (HVTS) which has 7ms latency, submillimeter accuracy and a much lower price compared to other millimeter-level tracking systems.
The thesis describes nonlinear and linear modeling of the quadcopter’s 6DOF rigid-body dynamics and brushless-motor-actuator dynamics. These are used for hierarchical-classical-control-law development near hover. The HVTS was used to demonstrate precision hover-control and path-following. Simulation and measured flight-data are shown to be similar. This work provides a foundation for future precision multi-quadcopter formation-flight-control.
One contribution of the work was the design of a new printed-circuit-board (PCB) flight controller (called MARK3). Key features/capabilities are as follows:
(1) a Teensy 3.2 microcontroller with 168MHz overclock –used for communications, full-state estimation and inner-outer loop hierarchical rate-angle-speed-position control,
(2) an on-board MEMS inertial-measurement-unit (IMU) which includes an LSM303D (3DOF-accelerometer and magnetometer), an L3GD20 (3DOF-gyroscope) and a BMP180 (barometer) for attitude estimation (barometer/magnetometer not used),
(3) 6 pulse-width-modulator (PWM) output pins supports up to 6 rotors
(4) 8 PWM input pins support up to 8-channel 2.4 GHz transmitter/receiver for manual control,
(5) 2 5V servo extension outputs for other requirements (e.g. gimbals),
(6) 2 universal-asynchronous-receiver-transmitter (UART) serial ports - used by flight controller to process data from Xbee; can be used for accepting outer-loop position commands from NVIDIA TX2 (future work),
(7) 1 I2C-serial-protocol two-wire port for additional modules (used to read data from IMU at 400 Hz),
(8) a 20-pin port for Xbee telemetry module connection; permits Xbee transceiver on desktop PC to send position/attitude commands to Xbee transceiver on quadcopter.
The quadcopter platform consists of the new MARK3 PCB Flight Controller, an ATG-250 carbon-fiber frame (250 mm), a DJI Snail propulsion-system (brushless-three-phase-motor, electronic-speed-controller (ESC) and propeller), an HTC VIVE Tracker and RadioLink R9DS 9-Channel 2.4GHz Receiver. This platform is completely compatible with the HTC VIVE Tracking System (HVTS) which has 7ms latency, submillimeter accuracy and a much lower price compared to other millimeter-level tracking systems.
The thesis describes nonlinear and linear modeling of the quadcopter’s 6DOF rigid-body dynamics and brushless-motor-actuator dynamics. These are used for hierarchical-classical-control-law development near hover. The HVTS was used to demonstrate precision hover-control and path-following. Simulation and measured flight-data are shown to be similar. This work provides a foundation for future precision multi-quadcopter formation-flight-control.
ContributorsLu, Shi (Author) / Rodriguez, Armando A. (Thesis advisor) / Tsakalis, Konstantinos (Committee member) / Si, Jennie (Committee member) / Arizona State University (Publisher)
Created2018
Description
Proprioception is the sense of body position, movement, force, and effort. Loss of proprioception can affect planning and control of limb and body movements, negatively impacting activities of daily living and quality of life. Assessments employing planar robots have shown that proprioceptive sensitivity is directionally dependent within the horizontal plane however, few studies have looked at proprioceptive sensitivity in 3d space. In addition, the extent to which proprioceptive sensitivity is modifiable by factors such as exogenous neuromodulation is unclear. To investigate proprioceptive sensitivity in 3d we developed a novel experimental paradigm employing a 7-DoF robot arm, which enables reliable testing of arm proprioception along arbitrary paths in 3d space, including vertical motion which has previously been neglected. A participant’s right arm was coupled to a trough held by the robot that stabilized the wrist and forearm, allowing for changes in configuration only at the elbow and shoulder. Sensitivity to imposed displacements of the endpoint of the arm were evaluated using a “same/different” task, where participant’s hands were moved 1-4 cm from a previously visited reference position. A measure of sensitivity (d’) was compared across 6 movement directions and between 2 postures. For all directions, sensitivity increased monotonically as the distance from the reference location increased. Sensitivity was also shown to be anisotropic (directionally dependent) which has implications for our understanding of the planning and control of reaching movements in 3d space.
The effect of neuromodulation on proprioceptive sensitivity was assessed using transcutaneous electrical nerve stimulation (TENS), which has been shown to have beneficial effects on human cognitive and sensorimotor performance in other contexts. In this pilot study the effects of two frequencies (30hz and 300hz) and three electrode configurations were examined. No effect of electrode configuration was found, however sensitivity with 30hz stimulation was significantly lower than with 300hz stimulation (which was similar to sensitivity without stimulation). Although TENS was shown to modulate proprioceptive sensitivity, additional experiments are required to determine if TENS can produce enhancement rather than depression of sensitivity which would have positive implications for rehabilitation of proprioceptive deficits arising from stroke and other disorders.
The effect of neuromodulation on proprioceptive sensitivity was assessed using transcutaneous electrical nerve stimulation (TENS), which has been shown to have beneficial effects on human cognitive and sensorimotor performance in other contexts. In this pilot study the effects of two frequencies (30hz and 300hz) and three electrode configurations were examined. No effect of electrode configuration was found, however sensitivity with 30hz stimulation was significantly lower than with 300hz stimulation (which was similar to sensitivity without stimulation). Although TENS was shown to modulate proprioceptive sensitivity, additional experiments are required to determine if TENS can produce enhancement rather than depression of sensitivity which would have positive implications for rehabilitation of proprioceptive deficits arising from stroke and other disorders.
ContributorsKlein, Joshua (Author) / Buneo, Christopher (Thesis advisor) / Helms-Tillery, Stephen (Committee member) / Kleim, Jeffrey (Committee member) / Santello, Marco (Committee member) / Arizona State University (Publisher)
Created2018
Description
Wearable assistive devices have been greatly improved thanks to advancements made in soft robotics, even creation soft extra arms for paralyzed patients. Grasping remains an active area of research of soft extra limbs. Soft robotics allow the creation of grippers that due to their inherit compliance making them lightweight, safer for human interactions, more robust in unknown environments and simpler to control than their rigid counterparts. A current problem in soft robotics is the lack of seamless integration of soft grippers into wearable devices, which is in part due to the use of elastomeric materials used for the creation of most of these grippers. This work introduces fabric-reinforced textile actuators (FRTA). The selection of materials, design logic of the fabric reinforcement layer and fabrication method are discussed. The relationship between the fabric reinforcement characteristics and the actuator deformation is studied and experimentally verified. The FRTA are made of a combination of a hyper-elastic fabric material with a stiffer fabric reinforcement on top. In this thesis, the design, fabrication, and evaluation of FRTAs are explored. It is shown that by varying the geometry of the reinforcement layer, a variety of motion can be achieve such as axial extension, radial expansion, bending, and twisting along its central axis. Multi-segmented actuators can be created by tailoring different sections of fabric-reinforcements together in order to generate a combination of motions to perform specific tasks. The applicability of this actuators for soft grippers is demonstrated by designing and providing preliminary evaluation of an anthropomorphic soft robotic hand capable of grasping daily living objects of various size and shapes.
ContributorsLopez Arellano, Francisco Javier (Author) / Santello, Marco (Thesis advisor) / Zhang, Wenlong (Thesis advisor) / Buneo, Christopher (Committee member) / Arizona State University (Publisher)
Created2019
Description
Long-term monitoring of deep brain structures using microelectrode implants is critical for the success of emerging clinical applications including cortical neural prostheses, deep brain stimulation and other neurobiology studies such as progression of disease states, learning and memory, brain mapping etc. However, current microelectrode technologies are not capable enough of reaching those clinical milestones given their inconsistency in performance and reliability in long-term studies. In all the aforementioned applications, it is important to understand the limitations & demands posed by technology as well as biological processes. Recent advances in implantable Micro Electro Mechanical Systems (MEMS) technology have tremendous potential and opens a plethora of opportunities for long term studies which were not possible before. The overall goal of the project is to develop large scale autonomous, movable, micro-scale interfaces which can seek and monitor/stimulate large ensembles of precisely targeted neurons and neuronal networks that can be applied for brain mapping in behaving animals. However, there are serious technical (fabrication) challenges related to packaging and interconnects, examples of which include: lack of current industry standards in chip-scale packaging techniques for silicon chips with movable microstructures, incompatible micro-bonding techniques to elongate current micro-electrode length to reach deep brain structures, inability to achieve hermetic isolation of implantable devices from biological tissue and fluids (i.e. cerebrospinal fluid (CSF), blood, etc.). The specific aims are to: 1) optimize & automate chip scale packaging of MEMS devices with unique requirements not amenable to conventional industry standards with respect to bonding, process temperature and pressure in order to achieve scalability 2) develop a novel micro-bonding technique to extend the length of current polysilicon micro-electrodes to reach and monitor deep brain structures 3) design & develop high throughput packaging mechanism for constructing a dense array of movable microelectrodes. Using a combination of unique micro-bonding technique which involves conductive thermosetting epoxy’s with hermetically sealed support structures and a highly optimized, semi-automated, 90-minute flip-chip packaging process, I have now extended the repertoire of previously reported movable microelectrode arrays to bond conventional stainless steel and Pt/Ir microelectrode arrays of desired lengths to steerable polysilicon shafts. I tested scalable prototypes in rigorous bench top tests including Impedance measurements, accelerated aging and non-destructive testing to assess electrical and mechanical stability of micro-bonds under long-term implantation. I propose a 3D printed packaging method allows a wide variety of electrode configurations to be realized such as a rectangular or circular array configuration or other arbitrary geometries optimal for specific regions of the brain with inter-electrode distance as low as 25 um with an unprecedented capability of seeking and recording/stimulating targeted single neurons in deep brain structures up to 10 mm deep (with 6 μm displacement resolution). The advantage of this computer controlled moveable deep brain electrodes facilitates potential capabilities of moving past glial sheath surrounding microelectrodes to restore neural connection, counter the variabilities in signal amplitudes, and enable simultaneous recording/stimulation at precisely targeted layers of brain.
ContributorsPalaniswamy, Sivakumar (Author) / Muthuswamy, Jitendran (Thesis advisor) / Buneo, Christopher (Committee member) / Abbas, James (Committee member) / Arizona State University (Publisher)
Created2016
Description
Toward the ambitious long-term goal of a fleet of cooperating Flexible Autonomous Machines operating in an uncertain Environment (FAME), this thesis addresses several
critical modeling, design and control objectives for ground vehicles. One central objective was to show how off-the-shelf (low-cost) remote-control (RC) “toy” vehicles can be converted into intelligent multi-capability robotic-platforms for conducting FAME research. This is shown for two vehicle classes: (1) six differential-drive (DD) RC vehicles called Thunder Tumbler (DDTT) and (2) one rear-wheel drive (RWD) RC car called Ford F-150 (1:14 scale). Each DDTT-vehicle was augmented to provide a substantive suite of capabilities as summarized below (It should be noted, however, that only one DDTT-vehicle was augmented with an inertial measurement unit (IMU) and 2.4 GHz RC capability): (1) magnetic wheel-encoders/IMU for(dead-reckoning-based) inner-loop speed-control and outer-loop position-directional-control, (2) Arduino Uno microcontroller-board for encoder-based inner-loop speed-control and encoder-IMU-ultrasound-based outer-loop cruise-position-directional-separation-control, (3) Arduino motor-shield for inner-loop motor-speed-control, (4)Raspberry Pi II computer-board for demanding outer-loop vision-based cruise- position-directional-control, (5) Raspberry Pi 5MP camera for outer-loop cruise-position-directional-control (exploiting WiFi to send video back to laptop), (6) forward-pointing ultrasonic distance/rangefinder sensor for outer-loop separation-control, and (7) 2.4 GHz spread-spectrum RC capability to replace original 27/49 MHz RC. Each “enhanced”/ augmented DDTT-vehicle costs less than 175 but offers the capability of commercially available vehicles costing over 500. Both the Arduino and Raspberry are low-cost, well-supported (software wise) and easy-to-use. For the vehicle classes considered (i.e. DD, RWD), both kinematic and dynamical (planar xy) models are examined. Suitable nonlinear/linear-models are used to develop inner/outer-loopcontrol laws.
All demonstrations presented involve enhanced DDTT-vehicles; one the F-150; one a quadrotor. The following summarizes key hardware demonstrations: (1) cruise-control along line, (2) position-control along line (3) position-control along curve (4) planar (xy) Cartesian stabilization, (5) cruise-control along jagged line/curve, (6) vehicle-target spacing-control, (7) multi-robot spacing-control along line/curve, (8) tracking slowly-moving remote-controlled quadrotor, (9) avoiding obstacle while moving toward target, (10) RC F-150 followed by DDTT-vehicle. Hardware data/video is compared with, and corroborated by, model-based simulations. In short, many capabilities that are critical for reaching the longer-term FAME goal are demonstrated.
critical modeling, design and control objectives for ground vehicles. One central objective was to show how off-the-shelf (low-cost) remote-control (RC) “toy” vehicles can be converted into intelligent multi-capability robotic-platforms for conducting FAME research. This is shown for two vehicle classes: (1) six differential-drive (DD) RC vehicles called Thunder Tumbler (DDTT) and (2) one rear-wheel drive (RWD) RC car called Ford F-150 (1:14 scale). Each DDTT-vehicle was augmented to provide a substantive suite of capabilities as summarized below (It should be noted, however, that only one DDTT-vehicle was augmented with an inertial measurement unit (IMU) and 2.4 GHz RC capability): (1) magnetic wheel-encoders/IMU for(dead-reckoning-based) inner-loop speed-control and outer-loop position-directional-control, (2) Arduino Uno microcontroller-board for encoder-based inner-loop speed-control and encoder-IMU-ultrasound-based outer-loop cruise-position-directional-separation-control, (3) Arduino motor-shield for inner-loop motor-speed-control, (4)Raspberry Pi II computer-board for demanding outer-loop vision-based cruise- position-directional-control, (5) Raspberry Pi 5MP camera for outer-loop cruise-position-directional-control (exploiting WiFi to send video back to laptop), (6) forward-pointing ultrasonic distance/rangefinder sensor for outer-loop separation-control, and (7) 2.4 GHz spread-spectrum RC capability to replace original 27/49 MHz RC. Each “enhanced”/ augmented DDTT-vehicle costs less than 175 but offers the capability of commercially available vehicles costing over 500. Both the Arduino and Raspberry are low-cost, well-supported (software wise) and easy-to-use. For the vehicle classes considered (i.e. DD, RWD), both kinematic and dynamical (planar xy) models are examined. Suitable nonlinear/linear-models are used to develop inner/outer-loopcontrol laws.
All demonstrations presented involve enhanced DDTT-vehicles; one the F-150; one a quadrotor. The following summarizes key hardware demonstrations: (1) cruise-control along line, (2) position-control along line (3) position-control along curve (4) planar (xy) Cartesian stabilization, (5) cruise-control along jagged line/curve, (6) vehicle-target spacing-control, (7) multi-robot spacing-control along line/curve, (8) tracking slowly-moving remote-controlled quadrotor, (9) avoiding obstacle while moving toward target, (10) RC F-150 followed by DDTT-vehicle. Hardware data/video is compared with, and corroborated by, model-based simulations. In short, many capabilities that are critical for reaching the longer-term FAME goal are demonstrated.
ContributorsLin, Zhenyu (Author) / Rodriguez, Armando Antonio (Committee member) / Si, Jennie (Committee member) / Berman, Spring Melody (Committee member) / Arizona State University (Publisher)
Created2015
Description
Brain-machine interfaces (BMIs) were first imagined as a technology that would allow subjects to have direct communication with prosthetics and external devices (e.g. control over a computer cursor or robotic arm movement). Operation of these devices was not automatic, and subjects needed calibration and training in order to master this control. In short, learning became a key component in controlling these systems. As a result, BMIs have become ideal tools to probe and explore brain activity, since they allow the isolation of neural inputs and systematic altering of the relationships between the neural signals and output. I have used BMIs to explore the process of brain adaptability in a motor-like task. To this end, I trained non-human primates to control a 3D cursor and adapt to two different perturbations: a visuomotor rotation, uniform across the neural ensemble, and a decorrelation task, which non-uniformly altered the relationship between the activity of particular neurons in an ensemble and movement output. I measured individual and population level changes in the neural ensemble as subjects honed their skills over the span of several days. I found some similarities in the adaptation process elicited by these two tasks. On one hand, individual neurons displayed tuning changes across the entire ensemble after task adaptation: most neurons displayed transient changes in their preferred directions, and most neuron pairs showed changes in their cross-correlations during the learning process. On the other hand, I also measured population level adaptation in the neural ensemble: the underlying neural manifolds that control these neural signals also had dynamic changes during adaptation. I have found that the neural circuits seem to apply an exploratory strategy when adapting to new tasks. Our results suggest that information and trajectories in the neural space increase after initially introducing the perturbations, and before the subject settles into workable solutions. These results provide new insights into both the underlying population level processes in motor learning, and the changes in neural coding which are necessary for subjects to learn to control neuroprosthetics. Understanding of these mechanisms can help us create better control algorithms, and design training paradigms that will take advantage of these processes.
ContributorsArmenta Salas, Michelle (Author) / Helms Tillery, Stephen I (Thesis advisor) / Si, Jennie (Committee member) / Buneo, Christopher (Committee member) / Santello, Marco (Committee member) / Kleim, Jeffrey (Committee member) / Arizona State University (Publisher)
Created2015