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This thesis, entitled "A Community Perspective on Alcohol Education," was conducted over a ten month period during the Spring 2014 and Fall 2014 semesters, composed by Christopher Stuller and Nicholas Schmitzer. The research involved interviewing twelve professionals from Arizona State University and the City of Tempe to gather a holistic

This thesis, entitled "A Community Perspective on Alcohol Education," was conducted over a ten month period during the Spring 2014 and Fall 2014 semesters, composed by Christopher Stuller and Nicholas Schmitzer. The research involved interviewing twelve professionals from Arizona State University and the City of Tempe to gather a holistic view on alcohol education and alcohol safety as it involves the students at ASU. Upon completion of the interviews, recommendations were made regarding areas of improvement for alcohol education and alcohol safety at Arizona State University. These recommendations range from creating a mandatory alcohol education class to passing a Guardian Angel Law to creating a national network of alcohol education best practices. Through this thesis, the authors hope to prevent future alcohol related injuries, deaths, and tragedies. For the final display of this thesis a website was created. For the ease of reading, all information has been presented in text format.
ContributorsSchmitzer, Nicholas (Co-author) / Stuller, Christopher (Co-author) / Koretz, Lora (Thesis director) / Scott Lynch, Jacquelyn (Committee member) / Barrett, The Honors College (Contributor) / Department of Information Systems (Contributor) / School of Accountancy (Contributor) / Department of Supply Chain Management (Contributor)
Created2014-12
Description
Research was conducted on the topic of Arizona's Department of Emergency Management. Specifically, the research and creative project was centered on the Search and Rescue Branch of the department. The creative project covered the key aspects and elements of Search and Rescue organization, legal considerations, preparation, training, teams, and safety.

Research was conducted on the topic of Arizona's Department of Emergency Management. Specifically, the research and creative project was centered on the Search and Rescue Branch of the department. The creative project covered the key aspects and elements of Search and Rescue organization, legal considerations, preparation, training, teams, and safety. These different elements heavily impact the Search and Rescue teams of Arizona. The researched information was compiled into a paper and the overall themes were used as inspiration for a series of paintings. The paintings highlight the components that were researched and presented in the written paper.
ContributorsSavala, Renae Alejandrina (Author) / Yoshioka, Carlton (Thesis director) / Kozakiewicz, Scott (Committee member) / Barrett, The Honors College (Contributor) / W. P. Carey School of Business (Contributor) / Department of Supply Chain Management (Contributor)
Created2015-05
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The purpose of this thesis was to design a market entrance strategy for Company X to enter the microcontroller (MCU) market within the Internet of Things (IoT). The five IoT segments are automotive; medical; retail; industrial; and military, aerospace, and government. To reach a final decision, we will research the

The purpose of this thesis was to design a market entrance strategy for Company X to enter the microcontroller (MCU) market within the Internet of Things (IoT). The five IoT segments are automotive; medical; retail; industrial; and military, aerospace, and government. To reach a final decision, we will research the markets, analyze make versus buy scenarios, and deliver a financial analysis on the chosen strategy. Based on the potential financial benefits and compatibility with Company X's current business model, we recommend that Company X enter the automotive segment through mergers & acquisitions (M&A). After analyzing the supply chain structure of the automotive IoT, we advise Company X to acquire Freescale Semiconductor for $46.98 per share.
ContributorsBradley, Rachel (Co-author) / Fankhauser, Elisa (Co-author) / McCoach, Robert (Co-author) / Zheng, Weilin (Co-author) / Simonson, Mark (Thesis director) / Hertzel, Mike (Committee member) / Barrett, The Honors College (Contributor) / Department of Finance (Contributor) / Department of Supply Chain Management (Contributor) / School of Accountancy (Contributor) / School of International Letters and Cultures (Contributor) / WPC Graduate Programs (Contributor)
Created2015-05
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Upon investigating the current state of the high scrap problem at Niagara Bottling's Phoenix manufacturing facility, it was found that 49% of the scrap was being generated at the bottling lines in the form of plastic bottles, and 39% of scrap took the form of preforms accumulated at either the

Upon investigating the current state of the high scrap problem at Niagara Bottling's Phoenix manufacturing facility, it was found that 49% of the scrap was being generated at the bottling lines in the form of plastic bottles, and 39% of scrap took the form of preforms accumulated at either the bottling lines or the injection molding machines. The scope of this project includes all forms of polyethylene terephthalate (PET), but the large accumulation of scrap in these areas suggests a primary focus on the bottling lines and the injection molding machines. Further analysis of the bottling lines found that the filler at each line as well as the blower on line X1 were the biggest contributors to the scrap accumulation problem. Each of these machines was seeing over 0.4% of bottles rejected at the visual inspection units. Due to the underlying status and quality issues of the injection molding machines that were beyond the scope of this project, this process was only investigated for solutions involving the overall processes and people. Based on the data and process flow analysis there were several solutions proposed including a root-cause analysis of the highest faulting machines, the repair of the injection molding overhead conveyor systems, the creation of a low waste environment, and the implementation a scrap tracking and analysis process. Based on the current high variability in the scrap experience across all machines, it is recommended that Niagara Phoenix pursue the scrap tracking and analysis alternative. After the implementing the scrap tracking and analysis process, the initial results were encouraging and could potentially warrant the investment in a software platform that could automate the collection of data necessary for this process. Based on the initial results of the manual collection and analysis process, each individual line show signs of potential reduction in the scrap rate of over 50%. According to this improvement, purchasing the software platform would see a payoff period of only 36 days.
ContributorsSanchez, Thomas Camden (Author) / Kellso, James (Thesis director) / Lupe, Munoz (Committee member) / Barrett, The Honors College (Contributor) / School of International Letters and Cultures (Contributor) / Department of Supply Chain Management (Contributor)
Created2015-05
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Description
Bexarotene is a commercially produced drug commonly known as Targetin presecribed to treat cutaneous T-cell lymphoma (CTCL). Bex mimics the actions of natural 9-cis retinoic acid in the body, which are derived from Vitamin A in the diet and boost the immune system. Bex has been shown to be effective

Bexarotene is a commercially produced drug commonly known as Targetin presecribed to treat cutaneous T-cell lymphoma (CTCL). Bex mimics the actions of natural 9-cis retinoic acid in the body, which are derived from Vitamin A in the diet and boost the immune system. Bex has been shown to be effective in the treatment of multiple types of cancer, including lung cancer. However, the disadvantages of using Bex include increased instances of hypothyroidism and excessive concentrations of blood triglycerides. If an analog of Bex can be developed which retains high affinity RXR binding similar to the 9-cis retinoic acid while exhibiting less interference for heterodimerization pathways, it would be of great clinical significance in improving the quality of life for patients with CTCL. This thesis will detail the biological profiling of additional novel (Generation Two) analogs, which are currently in submission for publication, as well as that of Generation Three analogs. The results from these studies reveal that specific alterations in the core structure of the Bex "parent" compound structure can have dramatic effects in modifying the biological activity of RXR agonists.
ContributorsYang, Joanna (Author) / Jurutka, Peter (Thesis director) / Wagner, Carl (Committee member) / Hibler, Elizabeth (Committee member) / Barrett, The Honors College (Contributor)
Created2012-05
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Description
This thesis aims to explain how a child can deal with loss through a children's book that I have written and illustrated. The goal is to have a child, as young as the age of seven, be able to pick up the book and come away with an initial understanding

This thesis aims to explain how a child can deal with loss through a children's book that I have written and illustrated. The goal is to have a child, as young as the age of seven, be able to pick up the book and come away with an initial understanding of how grief affects people. There are references to other works of literature similarly dealing with the above topic. The different stages of grief are examined, as well as the ways in which grief can be handled. Facial expressions and body language are crucial to understanding others' pain and grief, so this thesis delves into how to translate different expressions and actions, and how artwork and illustrations can portray these same ideas. The story from the book is interwoven throughout the thesis, so as to show my reasoning for each section of the text. Finally, there is a full analysis of the text as well as the illustrations that explains why the text is fitting for each section of the story.
ContributorsFauste, Cristina Maria (Author) / Lewis, Stephen (Thesis director) / Gruber, Diane (Committee member) / Barrett, The Honors College (Contributor) / School of Social and Behavioral Sciences (Contributor) / School of Humanities, Arts, and Cultural Studies (Contributor)
Created2015-05
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Description
Bexarotene (Targretin®) is an FDA approved drug used to treat cutaneous T-cell lymphoma (CTCL), as well as off-label treatments for various cancers and neurodegenerative diseases. Previous research has indicated that bexarotene has a specific affinity for retinoid X receptors (RXR), which allows bexarotene to act as a ligand-activated-transcription factor

Bexarotene (Targretin®) is an FDA approved drug used to treat cutaneous T-cell lymphoma (CTCL), as well as off-label treatments for various cancers and neurodegenerative diseases. Previous research has indicated that bexarotene has a specific affinity for retinoid X receptors (RXR), which allows bexarotene to act as a ligand-activated-transcription factor and in return control cell differentiation and proliferation. Bexarotene targets RXR homodimerization to drive transcription of tumor suppressing genes; however, adverse reactions occur simultaneously when bound to other nuclear receptors. In this study, we used novel bexarotene analogs throughout 5 iterations synthesized in the laboratory of Dr. Wagner to test for their potency and ability to bind RXR. The aim of our study is to quantitatively measure RXR homodimerization driven by bexarotene analogs using a yeast two-hybrid system. Our results suggests there to be several compounds with higher protein activity than bexarotene, particularly in generations 3.0 and 5.0. This higher affinity for RXR homodimers may help scientists identify a compound that will minimize adverse effects and toxicity of bexarotene and serve as a better cancer treatment alternative.
ContributorsSeto, David Hua (Author) / Marshall, Pamela (Thesis director) / Wagner, Carl (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Natural Sciences (Contributor) / School of Social and Behavioral Sciences (Contributor)
Created2015-05
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Description
Chicago, the third largest city in the United States, is frequently in the national media's spotlight for negative news such as violence or failed gun laws. The city is hardly ever talked about in a positive light. This study aims to inform and educate outsiders of what the city is

Chicago, the third largest city in the United States, is frequently in the national media's spotlight for negative news such as violence or failed gun laws. The city is hardly ever talked about in a positive light. This study aims to inform and educate outsiders of what the city is like through the perspective lens of Chicago residents. To grasp a general understanding of Chicago, this creative project was completed through a narrative and interview-driven podcast series and split up into different topic categories. These categories were Chicago food, Chicago neighborhoods, Chicago's Southside, and Chicago sports. These topic areas are some of the things Chicago is most known for and give an adequate representation of what the city is like. Researching and putting this creative project into a podcast form proved how podcasts can be an alternative to in-depth and long-form journalism projects. The Chicago food episode called "Harold's v. Uncle Remus" explains the delicious food culture and showed two of the popular black restaurant chains that cater to the city. These two chicken spots are always a hot topic in heated debates of what place has the best chicken. The neighborhoods episode called "Won't You Be My Neighbor" highlights some of Chicago's interesting neighborhoods that tourists may not have on their attractions lists. This episode talks about the Pill Hill, Printers Row, and Little Italy neighborhoods, which all have unique histories. "Southside With You" explores the infamous region of Chicago, tells its history, and gives a theory as to why it continues to be the area it is known for in the media. Lastly, the sports episode "Sports: A History Lesson" is a full interview with a Chicago resident who has been a Chicago sports fan since the mid-60s and who has experienced the effects of racial divisions in sports. The episodes give only a peak of what the large city is like, but they demonstrate that Chicago is not this scary place, but a place with a complicatedly fascinating history.
ContributorsCarter, Jade (Author) / Thornton, Leslie-Jean (Thesis director) / Gatewood, Kira (Committee member) / School of Social and Behavioral Sciences (Contributor) / Walter Cronkite School of Journalism & Mass Comm (Contributor) / Barrett, The Honors College (Contributor)
Created2018-12
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Zoraida Ladrón de Guevarra was born in 1936 in Coyula, Mexico, a small village in the state of Oaxaca. Her father’s passing required Zoraida to find a job at age fourteen to support her family. Her story, a 200-page memoir entitled “After Papa Died,” follows Zoraida’s time as a servant

Zoraida Ladrón de Guevarra was born in 1936 in Coyula, Mexico, a small village in the state of Oaxaca. Her father’s passing required Zoraida to find a job at age fourteen to support her family. Her story, a 200-page memoir entitled “After Papa Died,” follows Zoraida’s time as a servant and eventual nanny in Veracruz. Flashing back to memories of her hometown and the people living in it, the story ends before she enters America first as a visitor in 1954, and later on a working Visa in 1957—the first woman in her village to leave to the United States. Hers is a story relevant today, evident with the paradoxes explored between poverty and riches, patriarchy and matriarchy, freedom and captivity. Assimilation impacts the reading of this memoir, as Zoraida began writing the memoir in her 80s (around fifty years after gaining American citizenship). This detailed family history is about the nature of memory, community, and in particular, the experience of being an immigrant. This thesis project centers on this text and includes three components: an edited memoir, informational interviews, and an introduction. Beginning as a diary steeped in the tradition of oral history, the memoir required a “translation” into a written form; chapters and chronological continuity helped with organization. Topics of interest from the story, such as identity, domestic violence, and religion, are further explored in a series of interviews with Zoraida. The inclusion of an introduction to the text contextualizes the stories documented in the memoir with supplemental information. The contents of the project are housed on a website: alongwaybabyproject.net.
ContributorsVan Slyke, Shea Elizabeth (Author) / Meloy, Elizabeth (Thesis director) / O'Flaherty, Katherine (Committee member) / Department of Supply Chain Management (Contributor) / Department of English (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
Spending time outdoors can have a positive impact on the physical and mental health of individuals. These physiological and psychological benefits were comprehensively reviewed, accompanied by a brief history of these views in American society and how modern programs are promoting outdoor activity. Some of the populations targeted in this

Spending time outdoors can have a positive impact on the physical and mental health of individuals. These physiological and psychological benefits were comprehensively reviewed, accompanied by a brief history of these views in American society and how modern programs are promoting outdoor activity. Some of the populations targeted in this research include children, veterans, the elderly, and the clinically ill. A guidebook for Arizona outdoor adventures \u2014 containing original landscape photography \u2014 was created to encourage ASU students to explore local hikes, campsites, and other outdoor opportunities near the city of Phoenix. Each entry contained a brief description of the area or trail, along with the distance from the ASU Tempe campus and information on the length and difficulty of the hike, if applicable. A section at the end of the book was aimed at education readers on basic outdoor survival protocol, as many people venture into the wild with very little understanding of the dangers associated with their activities. A website was made that mirrors the guidebook, but was intended to be a more accessible method of sharing our information. The final component of the project involved maintaining a social media account over the course of the year, allowing us to expand our reach to people beyond ASU and this community. Over the course of the project, the account gained a large following, and several posted photos went on to be featured on prominent regional accounts. By combining the four components described previously, several resources were created for people, particularly students attending ASU, to gain a better understanding of the outdoor adventures available to them, and the benefits that spending time surrounded by nature can have.
ContributorsSwitzer, Hannah (Co-author) / Weinstein, Casey (Co-author) / Smith, Andrew (Thesis director) / Lefler, Scott (Committee member) / Kozakiewicz, Scott (Committee member) / Harrington Bioengineering Program (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05