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The goal of this research project is to create a Mathcad template file capable of statistically modelling the effects of mean and standard deviation on a microparticle batch characterized by the log normal distribution model. Such a file can be applied during manufacturing to explore tolerances and increase cost and

The goal of this research project is to create a Mathcad template file capable of statistically modelling the effects of mean and standard deviation on a microparticle batch characterized by the log normal distribution model. Such a file can be applied during manufacturing to explore tolerances and increase cost and time effectiveness. Theoretical data for the time to 60% drug release and the slope and intercept of the log-log plot were collected and subjected to statistical analysis in JMP. Since the scope of this project focuses on microparticle surface degradation drug release with no drug diffusion, the characteristic variables relating to the slope (n = diffusional release exponent) and the intercept (k = kinetic constant) do not directly apply to the distribution model within the scope of the research. However, these variables are useful for analysis when the Mathcad template is applied to other types of drug release models.

ContributorsHan, Priscilla (Author) / Vernon, Brent (Thesis director) / Nickle, Jacob (Committee member) / Harrington Bioengineering Program (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description
The primary objective of this research project is to develop dual layered polymeric microparticles with a tunable delayed release profile. Poly(L-lactic acid) (PLA) and poly(lactic-co-glycolic acid) (PLGA) phase separate in a double emulsion process due to differences in hydrophobicity, which allows for the synthesis of double-walled microparticles with a PLA

The primary objective of this research project is to develop dual layered polymeric microparticles with a tunable delayed release profile. Poly(L-lactic acid) (PLA) and poly(lactic-co-glycolic acid) (PLGA) phase separate in a double emulsion process due to differences in hydrophobicity, which allows for the synthesis of double-walled microparticles with a PLA shell surrounding the PLGA core. The microparticles were loaded with bovine serum albumin (BSA) and different volumes of ethanol were added to the PLA shell phase to alter the porosity and release characteristics of the BSA. Different amounts of ethanol varied the total loading percentage of the BSA, the release profile, surface morphology, size distribution, and the localization of the protein within the particles. Scanning electron microscopy images detailed the surface morphology of the different particles. Loading the particles with fluorescently tagged insulin and imaging the particles through confocal microscopy supported the localization of the protein inside the particle. The study suggest that ethanol alters the release characteristics of the loaded BSA encapsulated in the microparticles supporting the use of a polar, protic solvent as a tool for tuning the delayed release profile of biological proteins.
ContributorsFauer, Chase Alexander (Author) / Stabenfeldt, Sarah (Thesis director) / Ankeny, Casey (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor)
Created2015-05
Description

There is a wide intersection where animal and human lives interact or mimic each other behaviorally or biologically. A lot of the products that are part of our day-to-day were first validated by animals, and eventually found their way to us. From food to beauty products to scientific developments, animals

There is a wide intersection where animal and human lives interact or mimic each other behaviorally or biologically. A lot of the products that are part of our day-to-day were first validated by animals, and eventually found their way to us. From food to beauty products to scientific developments, animals deal with a lot behind the scenes. Some humans are cognizant of what is happening backstage, while others only see the final presentation. Either way, all of us have our opinions in support or against animal treatment. The project is heavily inspired from my experience in a neurorehabilitation lab, so the foundation is similar to the structure and function of neurons. Through this project, I am focusing on one aspect of this debate, which is animal testing in the scietific setting. The goal of the project is not to force the viewer to choose one side, but to understand the big picture and the reasoning of the opposing side.

ContributorsSharma, Bhavya (Author) / Beiner, Susan (Thesis director) / Roberson, Robert (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

Polymer drug delivery system offers a key to a glaring issue in modern administration routes of drugs and biologics. Poly(lactic-co-glycolic acid) (PLGA) can be used to encapsulate drugs and biologics and deliver them into the patient, which allows high local concentration (compared to current treatment methods), protection of the cargo

Polymer drug delivery system offers a key to a glaring issue in modern administration routes of drugs and biologics. Poly(lactic-co-glycolic acid) (PLGA) can be used to encapsulate drugs and biologics and deliver them into the patient, which allows high local concentration (compared to current treatment methods), protection of the cargo from the bodily environment, and reduction in systemic side effects. This experiment used a single emulsion technique to encapsulate L-tyrosine in PLGA microparticles and UV spectrophotometry to analyze the drug release over a period of one week. The release assay found that for the tested samples, the released amount is distinct initially, but is about the same after 4 days, and they generally follow the same normalized percent released pattern. The experiment could continue with testing more samples, test the same samples for a longer duration, and look into higher w/w concentrations such as 20% or 50%.

ContributorsSeo, Jinpyo (Author) / Vernon, Brent (Thesis director) / Pal, Amrita (Committee member) / Dean, W.P. Carey School of Business (Contributor) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

Whispers from Above is a creative project that aims to normalize the conversation and validate the emotional experience of grief, through the use of art therapies. Art therapy can be expressive in which someone creates their own work, such as visual art, poetry, performance, music, movement, etc. Art therapy can

Whispers from Above is a creative project that aims to normalize the conversation and validate the emotional experience of grief, through the use of art therapies. Art therapy can be expressive in which someone creates their own work, such as visual art, poetry, performance, music, movement, etc. Art therapy can also be receptive in which someone analyzes and understands someone else's artwork. This project was released on SoundCloud in order to make grief resources more accessible to all and to build an online community.<br/><br/>Whispers from Above worked with twelve poets, fifteen artists, six different interviewees, and multiple musicians to create a month of grief support. The finale piece of Whispers from Above was devised from the twenty-nine poems used within this month-long healing journey. All the individual poems were woven into a single devised poem to be presented as the final piece symbolizing that no one is alone in grief.<br/><br/>Whispers from Above is creative community exploration of grief, loss, and death in which we hope contributors, and listeners find solace and support. This series will exist on SoundCloud after March 27th, 2021 with a monthly release of a poem or interview accompanied by art, and music.

ContributorsWendlandt, Morgan Marie (Author) / Bowditch, Rachel (Thesis director) / Lynch, John M. (Committee member) / Sandoval, Mathew (Committee member) / School of Art (Contributor) / Department of Management and Entrepreneurship (Contributor) / School of Music, Dance and Theatre (Contributor) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description
The goal of this project was to create a card game that would quickly and easily allow medical professionals to learn important information. This project seeks to advance ways in which medical staff gain information about disease outbreaks through the creation of a card game which teaches players the proper

The goal of this project was to create a card game that would quickly and easily allow medical professionals to learn important information. This project seeks to advance ways in which medical staff gain information about disease outbreaks through the creation of a card game which teaches players the proper steps and procedure to triage and treat patients who are suspected to have Ebola Hemorrhagic Fever, which was not done properly during the recent outbreak. To create this game, research was conducted on the information given by the Center for Disease Control and Prevention (CDC) on the various steps to triaging those who were suspected of having Ebola. Various prototypes of the game were made and tested to optimize the win-lose ratio while still being an enjoyable game to play. This card game is fast-paced, small, and can be played either individually or with more than one person. It is loosely based off of Solitaire. This game has gone through three prototypes of the cards as well as a few brief testing periods. Through the methods and procedure used in this game's creation, it has been concluded that this method is a great way to easily teach players a proper procedure, and that this method of game can be applied to other disease breakouts and even to other fields where information must be learned quickly. Future steps for this game include improving the graphic art used in the cards, and continuing on to create a smartphone application.
ContributorsHenriksen, Carissa (Co-author) / Pratt, Breanna (Co-author) / LaBelle, Jeffrey (Thesis director) / Coursen, Jerry (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2015-12
Description
Descent is a modern television adaptation of Dante's Inferno, in which the main characters must navigate the levels of the Dark Web instead of Hell. This Creative Project includes the script for the first episode of this series, as well as episode summaries for each of the 10 episodes in

Descent is a modern television adaptation of Dante's Inferno, in which the main characters must navigate the levels of the Dark Web instead of Hell. This Creative Project includes the script for the first episode of this series, as well as episode summaries for each of the 10 episodes in the first season.
ContributorsSchroeder, Elizabeth Marie (Author) / Bradley, Christopher (Thesis director) / Himberg, Julia (Committee member) / Winters, Justin (Committee member) / Department of English (Contributor) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2020-12
Description
Abstract
Exploring the Veil of Blackness is a creative project in the form of a podcast titled UKME America”. UKME America stands for Uwem mi Kederimbot America, which means “my life in the world in America”. It aims to explore the differences that divide individuals within the black community from a

Abstract
Exploring the Veil of Blackness is a creative project in the form of a podcast titled UKME America”. UKME America stands for Uwem mi Kederimbot America, which means “my life in the world in America”. It aims to explore the differences that divide individuals within the black community from a perspective of a First-Generation African American. It also illustrates how diverse the black community is. Drawing from my own experiences and research, this led me to a common theme centered around the following four questions: (a) what is it like to lose one’s identity; (b) where does this insecurity stem from; (c) how does society impact the way we view ourselves; and (d) how can we uplift ourselves. In my podcast, I interviewed individuals who identified as African Americans, First Generation African Americans, and Africans.
Everyone I interviewed told me their stories using historical, social, and cultural narratives. Overall, I want individuals to understand that there is fluidity behind the meaning of “black”, and the more individuals learn to embrace their differences, the more we can break down the barriers, put a united front, fight societal discrimination. I would like to thank my thesis director Dr. Neveser Köker and Second Committee Chair, Matthew Voorhees. I want to thank them for their guidance, motivation, patience, and for pushing and challenging me to reach new heights. I also would like thank my mom and Dr. Cynthia Patiño, for their constant encouragement and support. This would not have been possible without them.
ContributorsEdoh, Enyonam A (Author) / Koker, Neveser (Thesis director) / Voorhees, Matthew (Committee member) / Dean, W.P. Carey School of Business (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
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Description
The Honors Creative Project evolved drastically from start to finish, despite its origin remaining the same. My core goal in this project was to connect two seemingly mutually exclusive aspects of my life, engineering and dance. After conducting an IRB study and using data from my own personal experiences, I

The Honors Creative Project evolved drastically from start to finish, despite its origin remaining the same. My core goal in this project was to connect two seemingly mutually exclusive aspects of my life, engineering and dance. After conducting an IRB study and using data from my own personal experiences, I was able to see how dance had in fact made me a better engineer. There were skills that I gained and learned in dance that were directly applicable to engineering, and I believe will be critical to my success as an engineer. As the focal point of the project angled towards myself, I had to look deeply into who I am and how I reached this point. I conducted self-reflections on various aspects of my current life and also on the struggles and hardships I overcame during my years at ASU. From these reflections, I learned a lot about myself and how my personal identity has evolved. This identity evolution became the backbone behind my thesis defense. I took my research and self-reflections and designed a series of artwork that I personally designed and painted myself. I my engineering side to conduct the research and collect the data, and then used my artistic side to present my findings to the public in a way that attracted and audience and caused others to reflect upon their own identities.
ContributorsArizmendi, Romann Fuentes (Author) / Olarte, David (Thesis director) / Welz, Matt (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
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Description
“Why We Vote” explores attitudes and rationales among college students regarding civic and voter engagement. The major tangible outcome of this project is a photo series displaying portraits of students paired with a short vignette about their voting or civic engagement story. To diversify the series, we have engaged participants

“Why We Vote” explores attitudes and rationales among college students regarding civic and voter engagement. The major tangible outcome of this project is a photo series displaying portraits of students paired with a short vignette about their voting or civic engagement story. To diversify the series, we have engaged participants from a broad range of personal identities and civic engagement levels. We want to give visibility to the experiences of those who are commonly cast aside, especially in regard to civic and voting initiatives. Our project utilizes personal storytelling to spark dialogue about civic engagement,
particularly among the 18-24 age demographic. We chose to use storytelling as the primary medium for our project because it is a vehicle for empathy, a lacking component of modern civic life in the United States. It provokes students to think critically about how and why they engage in civic life and connect campus communities of students with common experiences. We are interested to see how our presence on campuses impacts the level and nature of their civic dialogue and how our findings are situated within our quantitative research.
ContributorsKwan, Alexis (Co-author) / Leveque, Trey (Co-author) / Salem, Hanna (Co-author) / Taliaferro, Karen (Thesis director) / Schugurensky, Daniel, 1958- (Committee member) / Watts College of Public Service & Community Solut (Contributor) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05