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- All Subjects: Creative Project
Description
This project examined the relationship of science teachers' knowledge about the laws relating to the teaching of creationism/evolution in public schools using multiple demographic factors. Overall, teachers correctly identified only 7 out of 10 "yes" or "no" answers about the laws, this score is only slightly better than the expected 5 out of 10 that would be obtained from guessing. Statistically significant results in differences in the overall score on the survey were found for three major variables. Teachers who say creationism should be taught in the classroom have a lower score than those who say it should not be taught in the classroom, with a large effect size. Teachers who teach biology or a life science had significantly higher scores than those who do not, with a small/medium effect size. Older teachers had significantly higher scores than younger teachers, with a small effect size. Identifying the demographic variables that effect teacher knowledge about the laws is the first step to determining how to educate teachers on the legality teaching of creationism/evolution in public school classrooms to avoid violations of the First Amendment.
ContributorsSorge, Aidan Bennet (Author) / Parker, John (Thesis director) / Lynch, John (Committee member) / School for the Future of Innovation in Society (Contributor) / Department of English (Contributor) / College of Integrative Sciences and Arts (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
Civic education in America should be focused on empowering future generations to take full advantage of their rights as citizens and realize their potential to incite change. Even at a young age, it is important that we educate children on what it means to be a United States citizen so that they can begin cultivating their personal political experience. As soon as the child is at the age where they can begin to understand basic political and governmental concepts, they should be encouraged to start thinking about their roles as citizens in a Democratic government. More often than not, young adults express that they wish they had been exposed to the political climate earlier on in life. When a lot of these adolescents reach voting age, they are woefully under-educated and apathetic towards their participation in the civic sphere. This activity booklet was designed to not only educate but also empower and inspire kids, and to really get them excited for their futures in the civic sphere.
ContributorsNelson, Madelyn (Author) / Lennon, Tara (Thesis director) / Black, Anna (Committee member) / College of Integrative Sciences and Arts (Contributor) / School of Politics and Global Studies (Contributor) / School of International Letters and Cultures (Contributor) / Department of English (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
This project, (im)permanence, aims to analyze the impact of temporary and permanent public art in downtown Phoenix through the voices of various artists, curators, city officials and art managers. Downtown Phoenix has seen rapid change and an influx of growth and development in recent years, yet its vibrant arts scene still characterizes and helps define much of the area. This project consists of five profile stories about public works of art downtown, organized on a scale of permanent to temporary. The stories feature the artists discussing the impact of their work in the public realm, the benefits and drawbacks of both temporary and permanent work, and the role public art plays amid downtown's many changes. The pieces and programs included in (im)permanence are the sculpture Her Secret is Patience at Civic Space Park, the forthcoming Wallace and Ladmo statue and Civic Space Park, the Three Birds in Flight Mural on Roosevelt Row, the public art incorporated into Valley Metro's light rail stops, and the temporary art projects of Scottsdale Public Art's IN FLUX program. These pieces, as determined by Leslie-Jean Thornton and myself, represent a microcosm of the temporary and permanent public art in the area, and showcase a range of stories emblematic of the character of downtown Phoenix. The design of the website features animations indicative of the temporary nature of the pieces -- elements fade in incrementally based on their degree of "permanence." This website was made using wix.com, and it incorporates multimedia elements such as photos, photo galleries, an infographic, and a photo slider. Website URL https://sundevilsgirl.wixsite.com/impermanence
ContributorsJarvis, Sarah Ashley (Author) / Thornton, Leslie (Thesis director) / Fahlman, Betsy (Committee member) / College of Integrative Sciences and Arts (Contributor) / School of Politics and Global Studies (Contributor) / Walter Cronkite School of Journalism and Mass Communication (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
This project uses ecocriticism to analyze prevalent issues in sustainability and resource management, as depicted in Science Fiction Literature. Through the essays in which I used the Keywords for Environmental Studies textbook by Joni Adamson et al., I analyzed how current Science Fiction novels deal with environmental issues. I then applied my findings to writing my own Science Fiction narrative, written in a Young Adult style to introduce the youth to the environmental problems we face in a creative and engaging manner.
In the story, Awaken, humans contest over territory with the avians — a sentient bid species. Years ago, the humans moved to underground dwellings in order to protect themselves from aerial assaults and developed sophisticated technology to keep the avians away from their crops. Over time, the avains became a legend humans tell their children to get them to behave, but a segment of the government remembers the real threat avians pose and are determined to vanquish their avian enemies. Kial Damian Johnson was created by his mother and father, who are involved in that segment of the government, with avian and human DNA. He finds himself drawn into the continuous battle between avians and humans. He learns that Yellowstone is going to erupt soon and neither avians nor humans can survive without sharing their resources, and he attempts to bring about peace between the two sides.
The narrative deals with issues prevalent in Animal Studies through giving the bird population a voice and a visible culture, and also reflects on current world issues as we strive to work together globally in the Anthropocene. Through researching and conducting interviews, I crafted this story to contribute to the environmental discourse. I wrote this story in a Young Adult style in order to invite the youth to engage in the conversation about issues of cross-cultural environmental sustainability.
In the story, Awaken, humans contest over territory with the avians — a sentient bid species. Years ago, the humans moved to underground dwellings in order to protect themselves from aerial assaults and developed sophisticated technology to keep the avians away from their crops. Over time, the avains became a legend humans tell their children to get them to behave, but a segment of the government remembers the real threat avians pose and are determined to vanquish their avian enemies. Kial Damian Johnson was created by his mother and father, who are involved in that segment of the government, with avian and human DNA. He finds himself drawn into the continuous battle between avians and humans. He learns that Yellowstone is going to erupt soon and neither avians nor humans can survive without sharing their resources, and he attempts to bring about peace between the two sides.
The narrative deals with issues prevalent in Animal Studies through giving the bird population a voice and a visible culture, and also reflects on current world issues as we strive to work together globally in the Anthropocene. Through researching and conducting interviews, I crafted this story to contribute to the environmental discourse. I wrote this story in a Young Adult style in order to invite the youth to engage in the conversation about issues of cross-cultural environmental sustainability.
ContributorsChristy, Krystin Cassidy (Author) / Adamson, Joni (Thesis director) / Eschrich, Joey (Committee member) / College of Integrative Sciences and Arts (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)
Created2018-12
Description
The following collection of YA prose poems have been designed to inspire and promote literacy among adolescents via its layers of depth and context while offering a productive and positive outlet for maturing emotions. By harnessing these emotional and psychological forces, we can inspire adolescents to use reading and writing to find meaning in their lives. These poems provide young adults with themes that reflect the growing pains and types of coming-of-age experiences that they can relate to and that helps them to make sense of their world. As educators, we want our students to fall in love with reading and writing. We must recognize that literacy is another significant developmental need of young adults and that YA poetry helps to bridge the gap between children's stories and adult classics thereby allowing for a smoother transition. This collection of poetry means to challenge our students to self-reflect and develop their own unique connections with the text. Adolescents need to be made to laugh and cry about issues concerning them, issues treated seriously and respectfully. Teenagers are on a journey of self-discovery and they are still trying to figure out who they are. Their need for peer acceptance must be balanced by their need for individuality. The following collection of poems makes use of a YA voice that transcends time and addresses issues concerning young adults of any multicultural generation.
ContributorsLepage, Michael Jean-Pierre-Kaina (Author) / Blasingame, James (Thesis director) / Ball, Sally (Committee member) / College of Integrative Sciences and Arts (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
Lactase persistence is the ability of adults to digest lactose in milk (Segurel & Bon, 2017). Mammals are generally distinguished by their mammary glands which gives females the ability to produce milk and feed their newborn children. The new born therefore requires the ability to breakdown the lactose in the milk to ensure its proper digestion (Segurel & Bon, 2017). Generally, humans lose the expression of lactase after weaning, which prevents them being able to breakdown lactose from dairy (Flatz, 1987).
My research is focused on the people of Turkana, a human pastoral population inhabiting Northwest Kenya. The people of Turkana are Nilotic people that are native to the Turkana district. There are currently no conclusive studies done on evidence for genetic lactase persistence in Turkana. Therefore, my research will be on the evolution of lactase persistence in the people of Turkana. The goal of this project is to investigate the evolutionary history of two genes with known involvement in lactase persistence, LCT and MCM6, in the Turkana. Variants in these genes have previously been identified to result in the ability to digest lactose post-weaning age. Furthermore, an additional study found that a closely related population to the Turkana, the Massai, showed stronger signals of recent selection for lactase persistence than Europeans in these genes. My goal is to characterize known variants associated with lactase persistence by calculating their allele frequencies in the Turkana and conduct selection scans to determine if LCT/MCM6 show signatures of positive selection. In doing this, we conducted a pilot study consisting of 10 female Turkana individuals and 10 females from four different populations from the 1000 genomes project namely: the Yoruba in Ibadan, Nigeria (YRI); Luhya in Webuye, Kenya; Utah Residents with Northern and Western European Ancestry (CEU); and the Southern Han Chinese. The allele frequency calculation suggested that the CEU (Utah Residents with Northern and Western European Ancestry) population had a higher lactase persistence associated allele frequency than all the other populations analyzed here, including the Turkana population. Our Tajima’s D calculations and analysis suggested that both the Turkana population and the four haplotype map populations shows signatures of positive selection in the same region. The iHS selection scans we conducted to detect signatures of positive selection on all five populations showed that the Southern Han Chinese (CHS), the LWK (Luhya in Webuye, Kenya) and the YRI (Yoruba in Ibadan, Nigeria) populations had stronger signatures of positive selection than the Turkana population. The LWK (Luhya in Webuye, Kenya) and the YRI (Yoruba in Ibadan, Nigeria) populations showed the strongest signatures of positive selection in this region. This project serves as a first step in the investigation of lactase persistence in the Turkana population and its evolution over time.
My research is focused on the people of Turkana, a human pastoral population inhabiting Northwest Kenya. The people of Turkana are Nilotic people that are native to the Turkana district. There are currently no conclusive studies done on evidence for genetic lactase persistence in Turkana. Therefore, my research will be on the evolution of lactase persistence in the people of Turkana. The goal of this project is to investigate the evolutionary history of two genes with known involvement in lactase persistence, LCT and MCM6, in the Turkana. Variants in these genes have previously been identified to result in the ability to digest lactose post-weaning age. Furthermore, an additional study found that a closely related population to the Turkana, the Massai, showed stronger signals of recent selection for lactase persistence than Europeans in these genes. My goal is to characterize known variants associated with lactase persistence by calculating their allele frequencies in the Turkana and conduct selection scans to determine if LCT/MCM6 show signatures of positive selection. In doing this, we conducted a pilot study consisting of 10 female Turkana individuals and 10 females from four different populations from the 1000 genomes project namely: the Yoruba in Ibadan, Nigeria (YRI); Luhya in Webuye, Kenya; Utah Residents with Northern and Western European Ancestry (CEU); and the Southern Han Chinese. The allele frequency calculation suggested that the CEU (Utah Residents with Northern and Western European Ancestry) population had a higher lactase persistence associated allele frequency than all the other populations analyzed here, including the Turkana population. Our Tajima’s D calculations and analysis suggested that both the Turkana population and the four haplotype map populations shows signatures of positive selection in the same region. The iHS selection scans we conducted to detect signatures of positive selection on all five populations showed that the Southern Han Chinese (CHS), the LWK (Luhya in Webuye, Kenya) and the YRI (Yoruba in Ibadan, Nigeria) populations had stronger signatures of positive selection than the Turkana population. The LWK (Luhya in Webuye, Kenya) and the YRI (Yoruba in Ibadan, Nigeria) populations showed the strongest signatures of positive selection in this region. This project serves as a first step in the investigation of lactase persistence in the Turkana population and its evolution over time.
ContributorsJobe, Ndey Bassin (Author) / Wilson Sayres, Melissa (Thesis director) / Paaijmans, Krijn (Committee member) / Taravella, Angela (Committee member) / School of Earth and Space Exploration (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
While specific resistance mechanisms to targeted inhibitors in BRAF-mutant cutaneous melanoma have been identified, surprisingly little is known about the rate at which resistance develops under different treatment options. There is increasing evidence that resistance arises from pre-existing clones rather than from de novo mutations, but there remains the need for a better understanding of how different drugs affect the fitness of clones within a tumor population and promote or delay the emergence of resistance. To this end, we have developed an assay that defines the in vitro rate of adaptation by analyzing the progressive change in sensitivity of a melanoma cell line to different treatments. We performed a proof-of-theory experiment based on the hypothesis that drugs that cause cell death (cytotoxic) impose a higher selection pressure for drug-resistant clones than drugs that cause cell-cycle arrest (cytostatic drugs), thereby resulting in a faster rate of adaptation. We tested this hypothesis by continuously treating the BRAFV600E melanoma cell line A375 with the cytotoxic MEK inhibitor E6201 and the cytostatic MEK inhibitor trametinib, both of which are known to be effective in the setting of constitutive oncogenic signaling driven by the BRAF mutation. While the identification of confounding factors prevented the direct comparison between E6201-treated and trametinib-treated cells, we observed that E6201-treated cells demonstrate decreased drug sensitivity compared to vehicle-treated cells as early as 18 days after treatment begins. We were able to quantify this rate of divergence at 2.6% per passage by measuring the increase over time in average viability difference between drug-treated and vehicle-treated cells within a DDR analysis. We argue that this value correlates to the rate of adaptation. Furthermore, this study includes efforts to establish a barcoded cell line to allow for individual clonal tracking and efforts to identify synergistic and antagonist drug combinations for use in future experiments. Ultimately, we describe here a novel system capable of quantifying adaptation rate in cancer cells undergoing treatment, and we anticipate that this assay will prove helpful in identifying treatment options that circumvent or delay resistance through future hypothesis-driven experiments.
ContributorsDe Luca, Valerie Jean (Author) / Wilson Sayres, Melissa (Thesis director) / Trent, Jeff (Committee member) / Hendricks, William (Committee member) / School of Molecular Sciences (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
Unlike the autosomes, recombination on the sex chromosomes is limited to the pseudoautosomal regions (PARs) at each end of the chromosome. PAR1 spans approximately 2.7 Mb from the tip of the proximal arm of each sex chromosome, and a pseudoautosomal boundary between the PAR1 and non-PAR region is thought to have evolved from a Y-specific inversion that suppressed recombination across the boundary. In addition to the two PARs, there is also a human-specific X-transposed region (XTR) that was duplicated from the X to the Y chromosome. Genetic diversity is expected to be higher in recombining than nonrecombining regions, particularly because recombination reduces the effects of linked selection, allowing neutral variation to accumulate. We previously showed that diversity decreases linearly across the previously defined pseudoautosomal boundary (rather than drop suddenly at the boundary), suggesting that the pseudoautosomal boundary may not be as strict as previously thought. In this study, we analyzed data from 1271 genetic females to explore the extent to which the pseudoautosomal boundary varies among human populations (broadly, African, European, South Asian, East Asian, and the Americas). We found that, in all populations, genetic diversity was significantly higher in the PAR1 and XTR than in the non-PAR regions, and that diversity decreased linearly from the PAR1 to finally reach a non-PAR value well past the pseudoautosomal boundary in all populations. However, we also found that the location at which diversity changes from reflecting the higher PAR1 diversity to the lower nonPAR diversity varied by as much as 500 kb among populations. The lack of genetic evidence for a strict pseudoautosomal boundary and the variability in patterns of diversity across the pseudoautosomal boundary are consistent with two potential explanations: (1) the boundary itself may vary across populations, or (2) that population-specific demographic histories have shaped diversity across the pseudoautosomal boundary.
ContributorsCotter, Daniel Juetten (Author) / Wilson Sayres, Melissa (Thesis director) / Stone, Anne (Committee member) / Webster, Timothy (Committee member) / School of Life Sciences (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
Tremendous phenotypic variation exists across people with Turner syndrome (45,X). This variation likely stems from differential dosage of genes on the X chromosome. X-inactivation is the process whereby all X chromosomes in excess of one are silenced. However, about 15% of the genes on the silenced X chromosome escape this inactivation and are candidates for affecting phenotype in people with Turner syndrome. In this study we take an evolutionary approach to rank candidate genes that may contribute to phenotypic variation among people with Turner Syndrome. We incorporate analysis of patterns of DNA methylation from 46,XX and 45,X individuals, and estimates of variable X-inactivation status across 46,XX individuals, with patterns of gene expression conservation on the X chromosomes across five tissues and ten species. We find that genes that escape XCI are possible candidate genes for Turner syndrome phenotype, indicated by the constant levels of expression in escape genes and inactivated genes. Variation in these genes is expected to affect phenotype when dosage is altered from typical levels.
ContributorsSchaffer, Kara Nina (Author) / Wilson Sayres, Melissa (Thesis director) / Crook, Sharon (Committee member) / Narang, Pooja (Committee member) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2015-12
Description
Uniforms and logos are an essential part of sports teams and are created with the intention of representing the city and state of their respective teams. More than a uniform: How culture influences the creation of Arizona sports logos and jerseys presents a look at the conversations and processes undergone before teams are able to unveil their new threads. Four local professional teams are involved with this project: Phoenix Suns, Arizona Diamondbacks, Arizona Coyotes and Arizona Cardinals. Members from each of the organizations were interviewed, in addition to Greg Fisher of Fisher Design. Information was gathered from each of those interviews in addition to research done on the history of each of the team’s uniforms. The information was then created into a documentary that consists of visual and verbal components. The film highlights how each team attempts to represent Arizona and its culture when it comes to what they are wearing on the field, court or ice. The interviews capture the mindset of creative teams as they explore growing new ideas and looks, in addition to a historical delve into two of the team’s debuts in the 1990s. Many of Arizona’s sports teams have much more behind their logos and jerseys than meets the eye. The project taught me how adapt broadcast skills into documentary style storytelling and how important visuals are for longer features. The interviews showed that so many things are taken into consideration when designing a sports logo or uniform and the process can take either months or years to finally reach fruition.
ContributorsNoel, Adam Jude (Author) / Dieffenbach, Paola (Thesis director) / Easley, Isaac (Committee member) / College of Integrative Sciences and Arts (Contributor) / Walter Cronkite School of Journalism and Mass Comm (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05