Matching Items (11)
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- Creators: Department of Supply Chain Management
- Status: Published
Description
This project aims to address the current protocol regarding the diagnosis and treatment of traumatic brain injury (TBI) in medical industries around the world. Although there are various methods used to qualitatively determine if TBI has occurred to a patient, this study attempts to aid in the creation of a system for quantitative measurement of TBI and its relative magnitude. Through a method of artificial evolution/selection called phage display, an antibody that binds highly specifically to a post-TBI upregulated brain chondroitin sulfate proteoglycan called neurocan has been identified. As TG1 Escheria Coli bacteria were infected with KM13 helper phage and M13 filamentous phage in conjunction, monovalent display of antibody fragments (ScFv) was performed. The ScFv bind directly to the neurocan and from screening, phage that produced ScFv's with higher affinity and specificity to neurocan were separated and purified. Future research aims to improve the ScFv characteristics through increased screening toward neurocan. The identification of a highly specific antibody could lead to improved targeting of neurocan post-TBI in-vivo, aiding researchers in quantitatively defining TBI by visualizing its magnitude.
ContributorsSeelig, Timothy Scott (Author) / Stabenfeldt, Sarah (Thesis director) / Ankeny, Casey (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor)
Created2015-05
Description
A chimeric, humanized monoclonal antibody that recognizes a highly conserved fusion loop found on flaviviruses was constructed with a geminiviral replicon and transiently expressed in Nicotiana benthamiana plants through Agrobacterium tumefaciens infiltration. Characterization and expression studies were then conducted to confirm correct assembly of the antibody. Once the antibody was purified, an ELISA was conducted to validate that the antibody was able to bind to the flavivirus fusion loop.
ContributorsPardhe, Mary (Author) / Mason, Hugh (Thesis director) / Chen, Qiang (Committee member) / Mor, Tsafrir (Committee member) / School of Life Sciences (Contributor) / Department of Information Systems (Contributor) / W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
This paper is rooted in the field of business, with an emphasis on entrepreneurship in the fashion industry. The questions we tried to answer were the following: What are factors of success for current fashion brands? What is important to our target market when shopping? How can we deliver these attributes to our target market? How can we use our findings to create a fashion brand? First, we conducted in-depth external analysis about existing retailers including, Forever 21, Zara and Brandy Melville. After doing so, we created brand molecules and learned about other people's perceptions in relation to these existing brands. Next, using our own qualitative and quantitative research, we sought to understand the many gaps in the overall shopping experience for college students and young working professionals. Our research revealed many common themes and trends that we will integrate into our proposed business plan in efforts to fill the gaps. Through our data analysis, common trends included how our demographic learns about new fashion trends, statement pieces versus mix-and-match basics, online shopping versus in-store shopping, price sensitivity of our target market, and lastly, the quality of customer service and the store's return policy. After our extensive research and data analysis, we began to construct our brand. We propose a new business model that targets our fashion-forward consumer with a memorable shopping experience that delivers high-quality and trendiness to their wardrobe. Using the elements and trends we identified, combined with our own vision, we combined them into one brand, The Capsule Collection. ur brand will feature high-quality, reasonably priced basics ranging from everyday casual to business casual. We will have store locations in cities where there are many young working professionals, and target them through social media advertising. Our store will feature an open layout with clean and minimalistic displays, keeping everything in neutral tones and accented with plants. The goal of The Capsule Collection is to make shopping as easy and exciting as possible, and focus entirely on the customer's experience.
ContributorsMeyyappan, Rathna (Co-author) / Aggarwal, Payal (Co-author) / Gray, Nancy (Thesis director) / Samper, Adriana (Committee member) / Department of Marketing (Contributor) / Department of Information Systems (Contributor) / Department of Supply Chain Management (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
The purpose of this creative project was to investigate the process a start-up or small business must complete to have a sell-able apparel product manufactured. The initial goal of the project was to experience the manufacturing process from start to finish and complete a full production run from a professional manufacturer. The conclusion found was that start-ups and small businesses will have to begin production within the United States.
ContributorsBour, Melissa (Author) / Sewell, Dennita (Thesis director) / Rogers, Dale (Committee member) / Ellis, Naomi (Committee member) / Dean, Herberger Institute for Design and the Arts (Contributor) / Department of Supply Chain Management (Contributor) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
Streetwear is a category of fashion that has evolved from being a niche style of dress influenced by American counter cultures, into a formidable industry. Over time, Streetwear has become a culture in itself whose members are critical of inauthentic brands and commercialization. Streetwear brands have the need to be perceived as authentic, exclusive, and being connected to celebrity to survive in the industry long-term. Additionally, as the industry grows larger, the marketplace has become increasingly saturated. This can be attributed to how easy it is to create a fledgling streetwear brand due to advances in garment production technology and streetwear's roots in low-cost clothing. Streetwear brands need to differentiate themselves in an effective manner to stand out to consumers in the saturated streetwear market. Primary research conducted via a survey administered to streetwear consumers was done to learn more about the effectiveness of popular tactics and marketplace events streetwear brands use to differentiate themselves. Secondary research was done in literature on the topics of creativity and energized differentiation. Research by Gerzema and Lebar presented in their book The Brand Bubble on the topic of energized differentiation is reviewed and applied to streetwear brands. This thesis will discuss the key elements brands need to have to be successful in the streetwear industry. Along with this, it will also look at the effectiveness of specific tactics bands can execute to effectively differentiate themselves in the saturated industry and the important role creativity plays in their success.
ContributorsGriblin, Austin W. (Author) / Ostrom, Amy (Thesis director) / Samper, Adriana (Committee member) / Department of Marketing (Contributor) / Herberger Institute for Design and the Arts (Contributor) / W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
Over the past two decades, the fashion industry has evolved to both create and respond to the consumer's demand for fast fashion, the industry of inexpensive clothing produced at high rates to respond to changing consumer trends. As fast fashion grew in popularity, the new standard of the industry was to create and manufacture every other week, producing continual new trends for a market designed for continual consumption. As the garments being produced were made for short life-spans, textile waste began to grow and the fashion industry was named the second largest pollutant in the world next to oil. Coming out of a market saturated with clothing, a new trend focused around sustainability and reuse has emerged: the resale market. With increased awareness for sustainability, circular fashion business models have emerged from a more linear and disposable supply chain. By focusing on environmental, social, and financial aspects of a supply chain, otherwise known as the triple bottom line, we discuss how second-hand shopping should be managed to satisfy customer shopping expectations.
The creative project of this thesis showcases various wardrobes that have solely been purchased second-hand. The purpose of the creative presentation is to show that no matter one’s style preference, occupation, or age, second hand shopping can appeal to every type of customer. Second hand shopping is not only for “thrifty” millennials, it it for everyone, and can encompass anyone’s clothing needs.
The creative project of this thesis showcases various wardrobes that have solely been purchased second-hand. The purpose of the creative presentation is to show that no matter one’s style preference, occupation, or age, second hand shopping can appeal to every type of customer. Second hand shopping is not only for “thrifty” millennials, it it for everyone, and can encompass anyone’s clothing needs.
ContributorsToomb, Sophia Mikaela (Author) / Sewell, Dennita (Thesis director) / Wiedmer, Robert (Committee member) / Department of Supply Chain Management (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
Monoclonal antibody therapy focuses on engineering immune cells to target specific peptide sequences indicative of disease. An impediment in the continued advancement of this market is the lack of an efficient, inexpensive means of characterization that can be broadly applied to any antibody while still providing high-density data. Many characterization methods address an antibody's affinity for its cognate sequence but overlook other important aspects of binding behavior such as off-target binding interactions. The purpose of this study is to demonstrate how the binding intensity between an antibody and a library of random-sequence peptides, otherwise known as an immunosignature, can be evaluated to determine antibody specificity and polyreactivity. A total of 24 commercially available monoclonal antibodies were assayed on 125K and 330K peptide microarrays and analyzed using a motif clustering program to predict candidate epitopes within each antigen sequence. The results support the further development of immunosignaturing as an antibody characterization tool that is relevant to both therapeutic and non-therapeutic antibodies.
ContributorsDai, Jennifer T. (Author) / Stafford, Phillip (Thesis director) / Diehnelt, Chris (Committee member) / School of Life Sciences (Contributor) / W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
The following report addresses sustainable supply chain management (SSCM) and its application in the fashion industry. The purpose is to draw conclusions on why companies implement sustainability into their processes, and how these sustainable monitoring practices contribute to operational, competitive and financial advantages. This report contains various methods of analysis. Research derived from numerous scholarly articles on measurement methods, theories and governance structures will be discussed to develop a background on the current status of SSCM in the fashion industry, including the notable strengths and weaknesses. To understand the depth of practices involved in managing a sustainable supply chain, four leading companies within the industry will be analyzed using their annual sustainability reports. Based on this analysis, it can be concluded that sustainable practices are abundantly present in today's leading fashion companies, each having different mindsets motivating their sustainable actions. With this conclusion, it's also important to acknowledge that there's far more progress to be made in terms of sustainable development on a company and industry level, in order to make a lasting impact.
ContributorsRezzonico, Jordan Nicole (Author) / Dooley, Kevin (Thesis director) / Wiedmer, Robert (Committee member) / W.P. Carey School of Business (Contributor) / Department of Supply Chain Management (Contributor) / Department of Management and Entrepreneurship (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
In looking at the world of fashion, it is hard to miss the many rental platforms that have become staples in the industry. While the business model makes sense for many consumers, it also feeds on many consumer trends and developing ideals. The driving purpose of this thesis is to better understand the success of rental platforms, to see what components of the industry are most important to the success of a rental company, and ultimately determine if rental will have a future in the next generation of fashion. The following research explores the fashion industry, rental’s place in that industry, and whether this new business model is here for the long haul. This research will prove vital in understanding the success of this new industry and the most important components that make up a successful rental business. Through this research it was found that the pillars of marketing, especially a deep understanding of consumers, and supply chain, have proven to be the most interesting aspects of the rental industry’s success. Specifically, the components of inventory management, transparency, consumer research, and pricing were found to be the most vital to any rental platform’s success.
ContributorsGeorge, Jessica Marie (Author) / Ostrom, Amy (Thesis director) / Davila, Eddie (Committee member) / Dean, W.P. Carey School of Business (Contributor) / Department of Supply Chain Management (Contributor) / Department of Finance (Contributor) / Barrett, The Honors College (Contributor)
Created2020-12
Description
This report addresses the value that companies can create along their supply chains by producing sustainably and locally, and proposes a business plan for a sleepwear and loungewear brand based on these findings. The purpose is to investigate whether or not there are opportunities for firms to make or save money by acting sustainably or producing locally, outside of the public relations value that could come from such efforts. By using research derived from scholarly articles and insight from experts, a background on the industry’s general trends and beliefs regarding sustainable and local production are addressed. Based on this research, it can be concluded that producing sustainably and locally is feasible and can provide supply chain related benefits for brands in certain situations. With this conclusion, a business plan was generated which aligned with the research presented in the analysis. It is important to acknowledge that there are certain actions related to sustainability and local production which could generally be beneficial for all apparel brands, but many suggestions are only applicable to smaller companies that sell at a higher price point.
ContributorsSierka, Macey (Author) / Keane, Katy (Thesis director) / Blackmer, Cindie (Committee member) / Barrett, The Honors College (Contributor) / Department of Supply Chain Management (Contributor) / School of Art (Contributor)
Created2022-05