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- All Subjects: Research
- Creators: Zaffar, Ehsan
- Status: Published
Differences between basic and applied research were explored through a wet-lab case study. Vaccinia virus (VACV) infections are a prime model of the competition between a virus and its host. VACV contains a gene that is highly evasive of the host immune system, gene E3L. The protein encoded by E3L is E3, which contains two highly conserved regions, a C-terminus, and a N-terminus. While the C-terminus is well-understood, the mechanism by which the N-terminus grants IFN resistance was previously unknown. This project demonstrated that the N-terminus prevents the initiation of programmed necrosis through host-encoded cellular proteins RIP3 and DAI. These findings provide insight into the function of the N-terminus of E3, as well as the unique functions of induced programmed necrosis.
This project was an example of “basic” research. However, it highlights the interconnectivity of basic and applied research and the danger in isolating both projects and perspectives. It points to the difficult decisions that must be made in science, and the need for a better research classification system that considers what makes science “good” outside of antiquated social class ideologies that have shaped science since ancient Greece. While there are no easy answers to determine what makes research “good,” thinking critically about the types of research projects that will be pursued, and the effects that research has on both science and society, will raise awareness, initiate new conversations, and encourage more dialogue about science in the 21st century.
The Difference Engine at Arizona State University developed the Women’s Power and Influence Index (WPI) in order to combat the systemic inequality faced by women in the workplace. It aims to analyze data, such as Equal Employment Opportunity data, from various Fortune 500 companies to provide a measure of workplace inequality as well as encourage these institutions to adopt more equitable policies. By rating companies based on what truly matters to women, ASU’s Difference Engine hopes to help both women in existing career paths as well as women seeking a new career or position in companies. However, in order for the WPI to become a relevant scoring metric of gender equality within the workplace, we must raise awareness about the issue of gender equality and of the index itself. By raising awareness about gender inequality as well as inspiring companies to further equality within their workplaces, the WPI will serve to have an integral role in increasing gender equality in the workplace. Our approach for raising awareness utilizes two different strategies: (1) establishing a new version of the WPI website that is both informative and aesthetically pleasing and (2) generating social media content on TikTok that appeal to a variety of audiences and introduce them to the WPI and our mission.
The Difference Engine at Arizona State University developed the Women’s Power and Influence Index (WPI) in order to combat the systemic inequality faced by women in the workplace. It aims to analyze data, such as Equal Employment Opportunity data, from various Fortune 500 companies to provide a measure of workplace inequality as well as encourage these institutions to adopt more equitable policies. By rating companies based on what truly matters to women, ASU’s Difference Engine hopes to help both women in existing career paths as well as women seeking a new career or position in companies. However, in order for the WPI to become a relevant scoring metric of gender equality within the workplace, we must raise awareness about the issue of gender equality and of the index itself. By raising awareness about gender inequality as well as inspiring companies to further equality within their workplaces, the WPI will serve to have an integral role in increasing gender equality in the workplace. Our approach for raising awareness utilizes two different strategies: (1) establishing a new version of the WPI website that is both informative and aesthetically pleasing and (2) generating social media content on TikTok that appeal to a variety of audiences and introduce them to the WPI and our mission.
The Difference Engine at Arizona State University developed the Women’s Power and Influence Index (WPI) in order to combat the systemic inequality faced by women in the workplace. It aims to analyze data, such as Equal Employment Opportunity data, from various Fortune 500 companies to provide a measure of workplace inequality as well as encourage these institutions to adopt more equitable policies. By rating companies based on what truly matters to women, ASU’s Difference Engine hopes to help both women in existing career paths as well as women seeking a new career or position in companies. However, in order for the WPI to become a relevant scoring metric of gender equality within the workplace, we must raise awareness about the issue of gender equality and of the index itself. By raising awareness about gender inequality as well as inspiring companies to further equality within their workplaces, the WPI will serve to have an integral role in increasing gender equality in the workplace. Our approach for raising awareness utilizes two different strategies: (1) establishing a new version of the WPI website that is both informative and aesthetically pleasing and (2) generating social media content on TikTok that appeal to a variety of audiences and introduce them to the WPI and our mission.
The Difference Engine at Arizona State University developed the Women’s Power and Influence Index (WPI) in order to combat the systemic inequality faced by women in the workplace. It aims to analyze data, such as Equal Employment Opportunity data, from various Fortune 500 companies to provide a measure of workplace inequality as well as encourage these institutions to adopt more equitable policies. By rating companies based on what truly matters to women, ASU’s Difference Engine hopes to help both women in existing career paths as well as women seeking a new career or position in companies. However, in order for the WPI to become a relevant scoring metric of gender equality within the workplace, we must raise awareness about the issue of gender equality and of the index itself. By raising awareness about gender inequality as well as inspiring companies to further equality within their workplaces, the WPI will serve to have an integral role in increasing gender equality in the workplace. Our approach for raising awareness utilizes two different strategies: (1) establishing a new version of the WPI website that is both informative and aesthetically pleasing and (2) generating social media content on TikTok that appeal to a variety of audiences and introduce them to the WPI and our mission.
The Difference Engine at Arizona State University developed the Women’s Power and Influence Index (WPI) in order to combat the systemic inequality faced by women in the workplace. It aims to analyze data, such as Equal Employment Opportunity data, from various Fortune 500 companies to provide a measure of workplace inequality as well as encourage these institutions to adopt more equitable policies. By rating companies based on what truly matters to women, ASU’s Difference Engine hopes to help both women in existing career paths as well as women seeking a new career or position in companies. However, in order for the WPI to become a relevant scoring metric of gender equality within the workplace, we must raise awareness about the issue of gender equality and of the index itself. By raising awareness about gender inequality as well as inspiring companies to further equality within their workplaces, the WPI will serve to have an integral role in increasing gender equality in the workplace. Our approach for raising awareness utilizes two different strategies: (1) establishing a new version of the WPI website that is both informative and aesthetically pleasing and (2) generating social media content on TikTok that appeal to a variety of audiences and introduce them to the WPI and our mission.
The Difference Engine at Arizona State University developed the Women’s Power and Influence Index (WPI) in order to combat the systemic inequality faced by women in the workplace. It aims to analyze data, such as Equal Employment Opportunity data, from various Fortune 500 companies to provide a measure of workplace inequality as well as encourage these institutions to adopt more equitable policies. By rating companies based on what truly matters to women, ASU’s Difference Engine hopes to help both women in existing career paths as well as women seeking a new career or position in companies. However, in order for the WPI to become a relevant scoring metric of gender equality within the workplace, we must raise awareness about the issue of gender equality and of the index itself. By raising awareness about gender inequality as well as inspiring companies to further equality within their workplaces, the WPI will serve to have an integral role in increasing gender equality in the workplace. Our approach for raising awareness utilizes two different strategies: (1) establishing a new version of the WPI website that is both informative and aesthetically pleasing and (2) generating social media content on TikTok that appeal to a variety of audiences and introduce them to the WPI and our mission.