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Description
Learning by trial-and-error requires retrospective information that whether a past action resulted in a rewarded outcome. Previous outcome in turn may provide information to guide future behavioral adjustment. But the specific contribution of this information to learning a task and the neural representations during the trial-and-error learning process is not

Learning by trial-and-error requires retrospective information that whether a past action resulted in a rewarded outcome. Previous outcome in turn may provide information to guide future behavioral adjustment. But the specific contribution of this information to learning a task and the neural representations during the trial-and-error learning process is not well understood. In this dissertation, such learning is analyzed by means of single unit neural recordings in the rats' motor agranular medial (AGm) and agranular lateral (AGl) while the rats learned to perform a directional choice task. Multichannel chronic recordings using implanted microelectrodes in the rat's brain were essential to this study. Also for fundamental scientific investigations in general and for some applications such as brain machine interface, the recorded neural waveforms need to be analyzed first to identify neural action potentials as basic computing units. Prior to analyzing and modeling the recorded neural signals, this dissertation proposes an advanced spike sorting system, the M-Sorter, to extract the action potentials from raw neural waveforms. The M-Sorter shows better or comparable performance compared with two other popular spike sorters under automatic mode. With the sorted action potentials in place, neuronal activity in the AGm and AGl areas in rats during learning of a directional choice task is examined. Systematic analyses suggest that rat's neural activity in AGm and AGl was modulated by previous trial outcomes during learning. Single unit based neural dynamics during task learning are described in detail in the dissertation. Furthermore, the differences in neural modulation between fast and slow learning rats were compared. The results show that the level of neural modulation of previous trial outcome is different in fast and slow learning rats which may in turn suggest an important role of previous trial outcome encoding in learning.
ContributorsYuan, Yu'an (Author) / Si, Jennie (Thesis advisor) / Buneo, Christopher (Committee member) / Santello, Marco (Committee member) / Chae, Junseok (Committee member) / Arizona State University (Publisher)
Created2014
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Description
Animals learn to choose a proper action among alternatives according to the circumstance. Through trial-and-error, animals improve their odds by making correct association between their behavioral choices and external stimuli. While there has been an extensive literature on the theory of learning, it is still unclear how individual neurons and

Animals learn to choose a proper action among alternatives according to the circumstance. Through trial-and-error, animals improve their odds by making correct association between their behavioral choices and external stimuli. While there has been an extensive literature on the theory of learning, it is still unclear how individual neurons and a neural network adapt as learning progresses. In this dissertation, single units in the medial and lateral agranular (AGm and AGl) cortices were recorded as rats learned a directional choice task. The task required the rat to make a left/right side lever press if a light cue appeared on the left/right side of the interface panel. Behavior analysis showed that rat's movement parameters during performance of directional choices became stereotyped very quickly (2-3 days) while learning to solve the directional choice problem took weeks to occur. The entire learning process was further broken down to 3 stages, each having similar number of recording sessions (days). Single unit based firing rate analysis revealed that 1) directional rate modulation was observed in both cortices; 2) the averaged mean rate between left and right trials in the neural ensemble each day did not change significantly among the three learning stages; 3) the rate difference between left and right trials of the ensemble did not change significantly either. Besides, for either left or right trials, the trial-to-trial firing variability of single neurons did not change significantly over the three stages. To explore the spatiotemporal neural pattern of the recorded ensemble, support vector machines (SVMs) were constructed each day to decode the direction of choice in single trials. Improved classification accuracy indicated enhanced discriminability between neural patterns of left and right choices as learning progressed. When using a restricted Boltzmann machine (RBM) model to extract features from neural activity patterns, results further supported the idea that neural firing patterns adapted during the three learning stages to facilitate the neural codes of directional choices. Put together, these findings suggest a spatiotemporal neural coding scheme in a rat AGl and AGm neural ensemble that may be responsible for and contributing to learning the directional choice task.
ContributorsMao, Hongwei (Author) / Si, Jennie (Thesis advisor) / Buneo, Christopher (Committee member) / Cao, Yu (Committee member) / Santello, Marco (Committee member) / Arizona State University (Publisher)
Created2014
Description
Peripheral Vascular Disease (PVD) is a debilitating chronic disease of the lower extremities particularly affecting older adults and diabetics. It results in reduction of the blood flow to peripheral tissue and sometimes causing tissue damage such that PVD patients suffer from pain in the lower legs, thigh and buttocks after

Peripheral Vascular Disease (PVD) is a debilitating chronic disease of the lower extremities particularly affecting older adults and diabetics. It results in reduction of the blood flow to peripheral tissue and sometimes causing tissue damage such that PVD patients suffer from pain in the lower legs, thigh and buttocks after activities. Electrical neurostimulation based on the "Gate Theory of Pain" is a known to way to reduce pain but current devices to do this are bulky and not well suited to implantation in peripheral tissues. There is also an increased risk associated with surgery which limits the use of these devices. This research has designed and constructed wireless ultrasound powered microstimulators that are much smaller and injectable and so involve less implantation trauma. These devices are small enough to fit through an 18 gauge syringe needle increasing their potential for clinical use. These piezoelectric microdevices convert mechanical energy into electrical energy that then is used to block pain. The design and performance of these miniaturized devices was modeled by computer while constructed devices were evaluated in animal experiments. The devices are capable of producing 500ms pulses with an intensity of 2 mA into a 2 kilo-ohms load. Using the rat as an animal model, a series of experiments were conducted to evaluate the in-vivo performance of the devices.
ContributorsZong, Xi (Author) / Towe, Bruce (Thesis advisor) / Kleim, Jeffrey (Committee member) / Santello, Marco (Committee member) / Arizona State University (Publisher)
Created2014
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Description
Non-line-of-sight (NLOS) imaging of objects not visible to either the camera or illumina-

tion source is a challenging task with vital applications including surveillance and robotics.

Recent NLOS reconstruction advances have been achieved using time-resolved measure-

ments. Acquiring these time-resolved measurements requires expensive and specialized

detectors and laser sources. In work proposes a data-driven

Non-line-of-sight (NLOS) imaging of objects not visible to either the camera or illumina-

tion source is a challenging task with vital applications including surveillance and robotics.

Recent NLOS reconstruction advances have been achieved using time-resolved measure-

ments. Acquiring these time-resolved measurements requires expensive and specialized

detectors and laser sources. In work proposes a data-driven approach for NLOS 3D local-

ization requiring only a conventional camera and projector. The localisation is performed

using a voxelisation and a regression problem. Accuracy of greater than 90% is achieved

in localizing a NLOS object to a 5cm × 5cm × 5cm volume in real data. By adopting

the regression approach an object of width 10cm to localised to approximately 1.5cm. To

generalize to line-of-sight (LOS) scenes with non-planar surfaces, an adaptive lighting al-

gorithm is adopted. This algorithm, based on radiosity, identifies and illuminates scene

patches in the LOS which most contribute to the NLOS light paths, and can factor in sys-

tem power constraints. Improvements ranging from 6%-15% in accuracy with a non-planar

LOS wall using adaptive lighting is reported, demonstrating the advantage of combining

the physics of light transport with active illumination for data-driven NLOS imaging.
ContributorsChandran, Sreenithy (Author) / Jayasuriya, Suren (Thesis advisor) / Turaga, Pavan (Committee member) / Dasarathy, Gautam (Committee member) / Arizona State University (Publisher)
Created2019
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Description
Computed tomography (CT) and synthetic aperture sonar (SAS) are tomographic imaging techniques that are fundamental for applications within medical and remote sensing. Despite their successes, a number of factors constrain their image quality. For example, a time-varying scene during measurement acquisition yields image artifacts. Additionally, factors such as bandlimited or

Computed tomography (CT) and synthetic aperture sonar (SAS) are tomographic imaging techniques that are fundamental for applications within medical and remote sensing. Despite their successes, a number of factors constrain their image quality. For example, a time-varying scene during measurement acquisition yields image artifacts. Additionally, factors such as bandlimited or sparse measurements limit image resolution. This thesis presents novel algorithms and techniques to account for these factors during image formation and outperform traditional reconstruction methods. In particular, this thesis formulates analysis-by-synthesis optimizations that leverage neural fields to predict the scene and differentiable physics models that incorporate prior knowledge about image formation. The specific contributions include: (1) a method for reconstructing CT measurements from time-varying (non-stationary) scenes; (2) a method for deconvolving SAS images, which benefits image quality; (3) a method that couples neural fields and a differentiable acoustic model for 3D SAS reconstructions.
ContributorsReed, Albert William (Author) / Jayasuriya, Suren (Thesis advisor) / Brown, Daniel C (Committee member) / Dasarathy, Gautam (Committee member) / Papandreou-Suppappola, Antonia (Committee member) / Arizona State University (Publisher)
Created2023
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Description
Quantum computing is becoming more accessible through modern noisy intermediate scale quantum (NISQ) devices. These devices require substantial error correction and scaling before they become capable of fulfilling many of the promises that quantum computing algorithms make. This work investigates the current state of NISQ devices by implementing multiple classical

Quantum computing is becoming more accessible through modern noisy intermediate scale quantum (NISQ) devices. These devices require substantial error correction and scaling before they become capable of fulfilling many of the promises that quantum computing algorithms make. This work investigates the current state of NISQ devices by implementing multiple classical computing scenarios with a quantum analog to observe how current quantum technology can be leveraged to achieve different tasks. First, quantum homomorphic encryption (QHE) is applied to the quantum teleportation protocol to show that this form of algorithm security is possible to implement with modern quantum computing simulators. QHE is capable of completely obscuring a teleported state with a liner increase in the number of qubit gates O(n). Additionally, the circuit depth increases minimally by only a constant factor O(c) when using only stabilizer circuits. Quantum machine learning (QML) is another potential application of NISQ technology that can be used to modify classical AI. QML is investigated using quantum hybrid neural networks for the classification of spoken commands on live audio data. Additionally, an edge computing scenario is examined to profile the interactions between a quantum simulator acting as a cloud server and an embedded processor board at the network edge. It is not practical to embed NISQ processors at a network edge, so this paradigm is important to study for practical quantum computing systems. The quantum hybrid neural network (QNN) learned to classify audio with equivalent accuracy (~94%) to a classical recurrent neural network. Introducing quantum simulation slows the systems responsiveness because it takes significantly longer to process quantum simulations than a classical neural network. This work shows that it is viable to implement classical computing techniques with quantum algorithms, but that current NISQ processing is sub-optimal when compared to classical methods.
ContributorsYarter, Maxwell (Author) / Spanias, Andreas (Thesis advisor) / Arenz, Christian (Committee member) / Dasarathy, Gautam (Committee member) / Arizona State University (Publisher)
Created2023
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Description
In the era of big data, more and more decisions and recommendations are being made by machine learning (ML) systems and algorithms. Despite their many successes, there have been notable deficiencies in the robustness, rigor, and reliability of these ML systems, which have had detrimental societal impacts. In the next

In the era of big data, more and more decisions and recommendations are being made by machine learning (ML) systems and algorithms. Despite their many successes, there have been notable deficiencies in the robustness, rigor, and reliability of these ML systems, which have had detrimental societal impacts. In the next generation of ML, these significant challenges must be addressed through careful algorithmic design, and it is crucial that practitioners and meta-algorithms have the necessary tools to construct ML models that align with human values and interests. In an effort to help address these problems, this dissertation studies a tunable loss function called α-loss for the ML setting of classification. The alpha-loss is a hyperparameterized loss function originating from information theory that continuously interpolates between the exponential (alpha = 1/2), log (alpha = 1), and 0-1 (alpha = infinity) losses, hence providing a holistic perspective of several classical loss functions in ML. Furthermore, the alpha-loss exhibits unique operating characteristics depending on the value (and different regimes) of alpha; notably, for alpha > 1, alpha-loss robustly trains models when noisy training data is present. Thus, the alpha-loss can provide robustness to ML systems for classification tasks, and this has bearing in many applications, e.g., social media, finance, academia, and medicine; indeed, results are presented where alpha-loss produces more robust logistic regression models for COVID-19 survey data with gains over state of the art algorithmic approaches.
ContributorsSypherd, Tyler (Author) / Sankar, Lalitha (Thesis advisor) / Berisha, Visar (Committee member) / Dasarathy, Gautam (Committee member) / Kosut, Oliver (Committee member) / Arizona State University (Publisher)
Created2022
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Description
According to the Center for Disease Control and Prevention report around 29,668 United States residents aged greater than 65 years had died as a result of a fall in 2016. Other injuries like wrist fractures, hip fractures, and head injuries occur as a result of a fall. Certain groups of

According to the Center for Disease Control and Prevention report around 29,668 United States residents aged greater than 65 years had died as a result of a fall in 2016. Other injuries like wrist fractures, hip fractures, and head injuries occur as a result of a fall. Certain groups of people are more prone to experience falls than others, one of which being individuals with stroke. The two most common issues with individuals with strokes are ankle weakness and foot drop, both of which contribute to falls. To mitigate this issue, the most popular clinical remedy given to these users is thermoplastic Ankle Foot Orthosis. These AFO's help improving gait velocity, stride length, and cadence. However, studies have shown that a continuous restraint on the ankle harms the compensatory stepping response and forward propulsion. It has been shown in previous studies that compensatory stepping and forward propulsion are crucial for the user's ability to recover from postural perturbations. Hence, there is a need for active devices that can supply a plantarflexion during the push-off and dorsiflexion during the swing phase of gait. Although advancements in the orthotic research have shown major improvements in supporting the ankle joint for rehabilitation, there is a lack of available active devices that can help impaired users in daily activities. In this study, our primary focus is to build an unobtrusive, cost-effective, and easy to wear active device for gait rehabilitation and fall prevention in individuals who are at risk. The device will be using a double-acting cylinder that can be easily incorporated into the user's footwear using a novel custom-designed powered ankle brace. The device will use Inertial Measurement Units to measure kinematic parameters of the lower body and a custom control algorithm to actuate the device based on the measurements. The study can be used to advance the field of gait assistance, rehabilitation, and potentially fall prevention of individuals with lower-limb impairments through the use of Active Ankle Foot Orthosis.
ContributorsRay, Sambarta (Author) / Honeycutt, Claire (Thesis advisor) / Dasarathy, Gautam (Thesis advisor) / Redkar, Sangram (Committee member) / Jayasuriya, Suren (Committee member) / Arizona State University (Publisher)
Created2020
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Description
Modern physical systems are experiencing tremendous evolutions with growing size, more and more complex structures, and the incorporation of new devices. This calls for better planning, monitoring, and control. However, achieving these goals is challenging since the system knowledge (e.g., system structures and edge parameters) may be unavailable for a

Modern physical systems are experiencing tremendous evolutions with growing size, more and more complex structures, and the incorporation of new devices. This calls for better planning, monitoring, and control. However, achieving these goals is challenging since the system knowledge (e.g., system structures and edge parameters) may be unavailable for a normal system, let alone some dynamic changes like maintenance, reconfigurations, and events, etc. Therefore, extracting system knowledge becomes a central topic. Luckily, advanced metering techniques bring numerous data, leading to the emergence of Machine Learning (ML) methods with efficient learning and fast inference. This work tries to propose a systematic framework of ML-based methods to learn system knowledge under three what-if scenarios: (i) What if the system is normally operated? (ii) What if the system suffers dynamic interventions? (iii) What if the system is new with limited data? For each case, this thesis proposes principled solutions with extensive experiments. Chapter 2 tackles scenario (i) and the golden rule is to learn an ML model that maintains physical consistency, bringing high extrapolation capacity for changing operational conditions. The key finding is that physical consistency can be linked to convexity, a central concept in optimization. Therefore, convexified ML designs are proposed and the global optimality implies faithfulness to the underlying physics. Chapter 3 handles scenario (ii) and the goal is to identify the event time, type, and locations. The problem is formalized as multi-class classification with special attention to accuracy and speed. Subsequently, Chapter 3 builds an ensemble learning framework to aggregate different ML models for better prediction. Next, to tackle high-volume data quickly, a tensor as the multi-dimensional array is used to store and process data, yielding compact and informative vectors for fast inference. Finally, if no labels exist, Chapter 3 uses physical properties to generate labels for learning. Chapter 4 deals with scenario (iii) and a doable process is to transfer knowledge from similar systems, under the framework of Transfer Learning (TL). Chapter 4 proposes cutting-edge system-level TL by considering the network structure, complex spatial-temporal correlations, and different physical information.
ContributorsLi, Haoran (Author) / Weng, Yang (Thesis advisor) / Tong, Hanghang (Committee member) / Dasarathy, Gautam (Committee member) / Sankar, Lalitha (Committee member) / Arizona State University (Publisher)
Created2022
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Description
A remarkable phenomenon in contemporary physics is quantum scarring in classically chaoticsystems, where the wave functions tend to concentrate on classical periodic orbits. Quantum scarring has been studied for more than four decades, but the problem of efficiently detecting quantum scars has remained to be challenging, relying mostly on human visualization of wave

A remarkable phenomenon in contemporary physics is quantum scarring in classically chaoticsystems, where the wave functions tend to concentrate on classical periodic orbits. Quantum scarring has been studied for more than four decades, but the problem of efficiently detecting quantum scars has remained to be challenging, relying mostly on human visualization of wave function patterns. This paper develops a machine learning approach to detecting quantum scars in an automated and highly efficient manner. In particular, this paper exploits Meta learning. The first step is to construct a few-shot classification algorithm, under the requirement that the one-shot classification accuracy be larger than 90%. Then propose a scheme based on a combination of neural networks to improve the accuracy. This paper shows that the machine learning scheme can find the correct quantum scars from thousands images of wave functions, without any human intervention, regardless of the symmetry of the underlying classical system. This will be the first application of Meta learning to quantum systems. Interacting spin networks are fundamental to quantum computing. Data-based tomography oftime-independent spin networks has been achieved, but an open challenge is to ascertain the structures of time-dependent spin networks using time series measurements taken locally from a small subset of the spins. Physically, the dynamical evolution of a spin network under time-dependent driving or perturbation is described by the Heisenberg equation of motion. Motivated by this basic fact, this paper articulates a physics-enhanced machine learning framework whose core is Heisenberg neural networks. This paper demonstrates that, from local measurements, not only the local Hamiltonian can be recovered but the Hamiltonian reflecting the interacting structure of the whole system can also be faithfully reconstructed. Using Heisenberg neural machine on spin networks of a variety of structures. In the extreme case where measurements are taken from only one spin, the achieved tomography fidelity values can reach about 90%. The developed machine learning framework is applicable to any time-dependent systems whose quantum dynamical evolution is governed by the Heisenberg equation of motion.
ContributorsHan, Chendi (Author) / Lai, Ying-Cheng (Thesis advisor) / Yu, Hongbin (Committee member) / Dasarathy, Gautam (Committee member) / Seo, Jae-Sun (Committee member) / Arizona State University (Publisher)
Created2022