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Description
Glioblastoma multiforme (GBM) is a malignant, aggressive and infiltrative cancer of the central nervous system with a median survival of 14.6 months with standard care. Diagnosis of GBM is made using medical imaging such as magnetic resonance imaging (MRI) or computed tomography (CT). Treatment is informed by medical images and includes chemotherapy, radiation therapy, and surgical removal if the tumor is surgically accessible. Treatment seldom results in a significant increase in longevity, partly due to the lack of precise information regarding tumor size and location. This lack of information arises from the physical limitations of MR and CT imaging coupled with the diffusive nature of glioblastoma tumors. GBM tumor cells can migrate far beyond the visible boundaries of the tumor and will result in a recurring tumor if not killed or removed. Since medical images are the only readily available information about the tumor, we aim to improve mathematical models of tumor growth to better estimate the missing information. Particularly, we investigate the effect of random variation in tumor cell behavior (anisotropy) using stochastic parameterizations of an established proliferation-diffusion model of tumor growth. To evaluate the performance of our mathematical model, we use MR images from an animal model consisting of Murine GL261 tumors implanted in immunocompetent mice, which provides consistency in tumor initiation and location, immune response, genetic variation, and treatment. Compared to non-stochastic simulations, stochastic simulations showed improved volume accuracy when proliferation variability was high, but diffusion variability was found to only marginally affect tumor volume estimates. Neither proliferation nor diffusion variability significantly affected the spatial distribution accuracy of the simulations. While certain cases of stochastic parameterizations improved volume accuracy, they failed to significantly improve simulation accuracy overall. Both the non-stochastic and stochastic simulations failed to achieve over 75% spatial distribution accuracy, suggesting that the underlying structure of the model fails to capture one or more biological processes that affect tumor growth. Two biological features that are candidates for further investigation are angiogenesis and anisotropy resulting from differences between white and gray matter. Time-dependent proliferation and diffusion terms could be introduced to model angiogenesis, and diffusion weighed imaging (DTI) could be used to differentiate between white and gray matter, which might allow for improved estimates brain anisotropy.
ContributorsAnderies, Barrett James (Author) / Kostelich, Eric (Thesis director) / Kuang, Yang (Committee member) / Stepien, Tracy (Committee member) / Harrington Bioengineering Program (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Glioblastoma Multiforme (GBM) is an aggressive and deadly form of brain cancer with a median survival time of about a year with treatment. Due to the aggressive nature of these tumors and the tendency of gliomas to follow white matter tracks in the brain, each tumor mass has a unique growth pattern. Consequently it is difficult for neurosurgeons to anticipate where the tumor will spread in the brain, making treatment planning difficult. Archival patient data including MRI scans depicting the progress of tumors have been helpful in developing a model to predict Glioblastoma proliferation, but limited scans per patient make the tumor growth rate difficult to determine. Furthermore, patient treatment between scan points can significantly compound the challenge of accurately predicting the tumor growth. A partnership with Barrow Neurological Institute has allowed murine studies to be conducted in order to closely observe tumor growth and potentially improve the current model to more closely resemble intermittent stages of GBM growth without treatment effects.
ContributorsSnyder, Lena Haley (Author) / Kostelich, Eric (Thesis director) / Frakes, David (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / Harrington Bioengineering Program (Contributor)
Created2014-05
Description
Mortality of 1918 influenza virus was high, partly due to bacteria coinfections. We characterize pandemic mortality in Arizona, which had high prevalence of tuberculosis. We applied regressions to over 35,000 data points to estimate the basic reproduction number and excess mortality. Age-specific mortality curves show elevated mortality for all age groups, especially the young, and senior sparing effects. The low value for reproduction number indicates that transmissibility was moderately low.
ContributorsJenner, Melinda Eva (Author) / Chowell-Puente, Gerardo (Thesis director) / Kostelich, Eric (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / School of Life Sciences (Contributor)
Created2015-05
Description
A distributed sensor network (DSN) is a set of spatially scattered intelligent sensors designed to obtain data across an environment. DSNs are becoming a standard architecture for collecting data over a large area. We need registration of nodal data across the network in order to properly exploit having multiple sensors. One major problem worth investigating is ensuring the integrity of the data received, such as time synchronization. Consider a group of match filter sensors. Each sensor is collecting the same data, and comparing the data collected to a known signal. In an ideal world, each sensor would be able to collect the data without offsets or noise in the system. Two models can be followed from this. First, each sensor could make a decision on its own, and then the decisions could be collected at a ``fusion center'' which could then decide if the signal is present or not. The fusion center can then decide if the signal is present or not based on the number true-or-false decisions that each sensor has made. Alternatively, each sensor could relay the data that it collects to the fusion center, and it could then make a decision based on all of the data that it then receives. Since the fusion center would have more information to base its decision on in the latter case--as opposed to the former case where it only receives a true or false from each sensor--one would expect the latter model to perform better. In fact, this would be the gold standard for detection across a DSN. However, there is random noise in the world that causes corruption of data collection, especially among sensors in a DSN. Each sensor does not collect the data in the exact same way or with the same precision. We classify these imperfections in data collections as offsets, specifically the offset present in the data collected by one sensor with respect to the rest of the sensors in the network. Therefore, reconsider the two models for a DSN described above. We can naively implement either of these models for data collection. Alternatively, we can attempt to estimate the offsets between the sensors and compensate. One could see how it would be expected that estimating the offsets within the DSN would provide better overall results than not finding estimators. This thesis will be structured as follows. First, there will be an extensive investigation into detection theory and the impact that different types of offsets have on sensor networks. Following the theory, an algorithm for estimating the data offsets will be proposed correct for the offsets. Next, we will look at Monte Carlo simulation results to see the impact on sensor performance of data offsets in comparison to a sensor network without offsets present. The algorithm is then implemented, and further experiments will demonstrate sensor performance with offset detection.
ContributorsMonardo, Vincent James (Author) / Cochran, Douglas (Thesis director) / Kierstead, Hal (Committee member) / Electrical Engineering Program (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
This thesis details the design process of a variable gain amplifier (VGA) based circuit which maintains a consistent output power over a wide range of input power signals. This effect is achieved by using power detection circuitry to adjust the gain of the VGA based on the current input power so that it is amplifier to a set power level. The paper details the theory behind this solutions as well as the design process which includes both simulations and physical testing of the actual circuit. It also analyses results of these tests and gives suggestions as to what could be done to further improve the design. The VGA based constant output power solution was designed as a section of a larger circuit which was developed as part of a senior capstone project, which is also briefly described in the paper.
ContributorsMeyer, Sheldon (Author) / Aberle, James (Thesis director) / Chakraborty, Partha (Committee member) / Electrical Engineering Program (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description
In this project we focus on COVID-19 in a university setting. Arizona State University has a very large population on the Tempe Campus. With the emergence of diseases such as COVID-19, it is very important to track how such a disease spreads within that type of community. This is vital for containment measures and the safety of everyone involved. We found in the literature several epidemiology models that utilize differential equations for tracking a spread of a disease. However, our goal is to provide a granular look at how disease may spread through contact in a classroom. This thesis models a single ASU classroom and tracks the spread of a disease. It is important to note that our variables and declarations are not aligned with COVID-19 or any other specific disease but are chosen to exemplify the impact of some key parameters on the epidemic size. We found that a smaller transmissibility alongside a more spread-out classroom of agents resulted in fewer infections overall. There are many extensions to this model that are needed in order to take what we have demonstrated and align those ideas with COVID-19 and it’s spread at ASU. However, this model successfully demonstrates a spread of disease through single-classroom interaction, which is the key component for any university campus disease transmission model.
ContributorsJoseph, Mariam (Author) / Bartko, Ezri (Co-author) / Sabuwala, Sana (Co-author) / Milner, Fabio (Thesis director) / O'Keefe, Kelly (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / Division of Teacher Preparation (Contributor)
Created2022-12
Description
The purpose of this thesis is to accurately simulate the surface brightness in various spectral emission lines of the HH 901 jets in the Mystic Mountain Formation of the Carina Nebula. To accomplish this goal, we gathered relevant spectral emission line data for [Fe II] 12660 Å, Hα 6563 Å, and [S II] 6720 Å to compare with Hubble Space Telescope observations of the HH 901 jets presented in Reiter et al. (2016). We derived the emissivities for these lines from the spectral synthesis code Cloudy by Ferland et al. (2017). In addition, we used WENO simulations of density, temperature, and radiative cooling to model the jet. We found that the computed surface brightness values agreed with most of the observational surface brightness values. Thus, the 3D cylindrically symmetric simulations of surface brightness using the WENO code and Cloudy spectral emission models are accurate for jets like HH 901. After detailing these agreements, we discuss the next steps for the project, like adding an external ambient wind and performing the simulations in full 3D.
ContributorsMohan, Arun (Author) / Gardner, Carl (Thesis director) / Jones, Jeremiah (Committee member) / Computer Science and Engineering Program (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
The objective of this paper is to find and describe trends in the fast Fourier transformed accelerometer data that can be used to predict the mechanical failure of large vacuum pumps used in industrial settings, such as providing drinking water. Using three-dimensional plots of the data, this paper suggests how a model can be developed to predict the mechanical failure of vacuum pumps.
ContributorsHalver, Grant (Author) / Taylor, Tom (Thesis director) / Konstantinos, Tsakalis (Committee member) / Fricks, John (Committee member) / School of Mathematical and Statistical Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
This Creative Project was carried out in coordination with the capstone project, Around the Corner Imaging with Terahertz Waves. This capstone project deals with a system designed to implement Around the Corner, or Non Line-of-Sight (NLoS) Imaging. This document discusses the creation of a GUI using MATLAB to control the Terahertz Imaging system. The GUI was developed in response to a need for synchronization, ease of operation, easy parameter modification, and data management. Along the way, many design decisions were made ranging from choosing a software platform to determining how variables should be passed. These decisions and considerations are discussed in this document. The resulting GUI has measured up to the design criteria and will be able to be used by anyone wishing to use the Terahertz Imaging System for further research in the field of Around the Corner or NLoS Imaging.
ContributorsWood, Jacob Cannon (Author) / Trichopoulos, Georgios (Thesis director) / Aberle, James (Committee member) / Electrical Engineering Program (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
Game theory, the mathematical study of mathematical models and simulations that often play out like a game, is applicable to a plethora of disciplines, one of which is infrastructure security. This is a rather new and niche subject area, and our aim is to perform a bibliographic analysis to analyze the thematic makeup of a selected body of publications in this area, as well as analyze trends in paper publication, journal contributions, country contributions, and trends in the authorship of the publications.
ContributorsChandra, Varun (Author) / Jevtic, Petar (Thesis director) / Gall, Melanie (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Statistical Sciences (Contributor)
Created2022-05