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Electrical neural activity detection and tracking have many applications in medical research and brain computer interface technologies. In this thesis, we focus on the development of advanced signal processing algorithms to track neural activity and on the mapping of these algorithms onto hardware to enable real-time tracking. At the heart

Electrical neural activity detection and tracking have many applications in medical research and brain computer interface technologies. In this thesis, we focus on the development of advanced signal processing algorithms to track neural activity and on the mapping of these algorithms onto hardware to enable real-time tracking. At the heart of these algorithms is particle filtering (PF), a sequential Monte Carlo technique used to estimate the unknown parameters of dynamic systems. First, we analyze the bottlenecks in existing PF algorithms, and we propose a new parallel PF (PPF) algorithm based on the independent Metropolis-Hastings (IMH) algorithm. We show that the proposed PPF-IMH algorithm improves the root mean-squared error (RMSE) estimation performance, and we demonstrate that a parallel implementation of the algorithm results in significant reduction in inter-processor communication. We apply our implementation on a Xilinx Virtex-5 field programmable gate array (FPGA) platform to demonstrate that, for a one-dimensional problem, the PPF-IMH architecture with four processing elements and 1,000 particles can process input samples at 170 kHz by using less than 5% FPGA resources. We also apply the proposed PPF-IMH to waveform-agile sensing to achieve real-time tracking of dynamic targets with high RMSE tracking performance. We next integrate the PPF-IMH algorithm to track the dynamic parameters in neural sensing when the number of neural dipole sources is known. We analyze the computational complexity of a PF based method and propose the use of multiple particle filtering (MPF) to reduce the complexity. We demonstrate the improved performance of MPF using numerical simulations with both synthetic and real data. We also propose an FPGA implementation of the MPF algorithm and show that the implementation supports real-time tracking. For the more realistic scenario of automatically estimating an unknown number of time-varying neural dipole sources, we propose a new approach based on the probability hypothesis density filtering (PHDF) algorithm. The PHDF is implemented using particle filtering (PF-PHDF), and it is applied in a closed-loop to first estimate the number of dipole sources and then their corresponding amplitude, location and orientation parameters. We demonstrate the improved tracking performance of the proposed PF-PHDF algorithm and map it onto a Xilinx Virtex-5 FPGA platform to show its real-time implementation potential. Finally, we propose the use of sensor scheduling and compressive sensing techniques to reduce the number of active sensors, and thus overall power consumption, of electroencephalography (EEG) systems. We propose an efficient sensor scheduling algorithm which adaptively configures EEG sensors at each measurement time interval to reduce the number of sensors needed for accurate tracking. We combine the sensor scheduling method with PF-PHDF and implement the system on an FPGA platform to achieve real-time tracking. We also investigate the sparsity of EEG signals and integrate compressive sensing with PF to estimate neural activity. Simulation results show that both sensor scheduling and compressive sensing based methods achieve comparable tracking performance with significantly reduced number of sensors.
ContributorsMiao, Lifeng (Author) / Chakrabarti, Chaitali (Thesis advisor) / Papandreou-Suppappola, Antonia (Thesis advisor) / Zhang, Junshan (Committee member) / Bliss, Daniel (Committee member) / Kovvali, Narayan (Committee member) / Arizona State University (Publisher)
Created2013
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Description
Immunosignaturing is a medical test for assessing the health status of a patient by applying microarrays of random sequence peptides to determine the patient's immune fingerprint by associating antibodies from a biological sample to immune responses. The immunosignature measurements can potentially provide pre-symptomatic diagnosis for infectious diseases or detection of

Immunosignaturing is a medical test for assessing the health status of a patient by applying microarrays of random sequence peptides to determine the patient's immune fingerprint by associating antibodies from a biological sample to immune responses. The immunosignature measurements can potentially provide pre-symptomatic diagnosis for infectious diseases or detection of biological threats. Currently, traditional bioinformatics tools, such as data mining classification algorithms, are used to process the large amount of peptide microarray data. However, these methods generally require training data and do not adapt to changing immune conditions or additional patient information. This work proposes advanced processing techniques to improve the classification and identification of single and multiple underlying immune response states embedded in immunosignatures, making it possible to detect both known and previously unknown diseases or biothreat agents. Novel adaptive learning methodologies for un- supervised and semi-supervised clustering integrated with immunosignature feature extraction approaches are proposed. The techniques are based on extracting novel stochastic features from microarray binding intensities and use Dirichlet process Gaussian mixture models to adaptively cluster the immunosignatures in the feature space. This learning-while-clustering approach allows continuous discovery of antibody activity by adaptively detecting new disease states, with limited a priori disease or patient information. A beta process factor analysis model to determine underlying patient immune responses is also proposed to further improve the adaptive clustering performance by formatting new relationships between patients and antibody activity. In order to extend the clustering methods for diagnosing multiple states in a patient, the adaptive hierarchical Dirichlet process is integrated with modified beta process factor analysis latent feature modeling to identify relationships between patients and infectious agents. The use of Bayesian nonparametric adaptive learning techniques allows for further clustering if additional patient data is received. Significant improvements in feature identification and immune response clustering are demonstrated using samples from patients with different diseases.
ContributorsMalin, Anna (Author) / Papandreou-Suppappola, Antonia (Thesis advisor) / Bliss, Daniel (Committee member) / Chakrabarti, Chaitali (Committee member) / Kovvali, Narayan (Committee member) / Lacroix, Zoé (Committee member) / Arizona State University (Publisher)
Created2013
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Description
This dissertation introduces stochastic ordering of instantaneous channel powers of fading channels as a general method to compare the performance of a communication system over two different channels, even when a closed-form expression for the metric may not be available. Such a comparison is with respect to a variety of

This dissertation introduces stochastic ordering of instantaneous channel powers of fading channels as a general method to compare the performance of a communication system over two different channels, even when a closed-form expression for the metric may not be available. Such a comparison is with respect to a variety of performance metrics such as error rates, outage probability and ergodic capacity, which share common mathematical properties such as monotonicity, convexity or complete monotonicity. Complete monotonicity of a metric, such as the symbol error rate, in conjunction with the stochastic Laplace transform order between two fading channels implies the ordering of the two channels with respect to the metric. While it has been established previously that certain modulation schemes have convex symbol error rates, there is no study of the complete monotonicity of the same, which helps in establishing stronger channel ordering results. Toward this goal, the current research proves for the first time, that all 1-dimensional and 2-dimensional modulations have completely monotone symbol error rates. Furthermore, it is shown that the frequently used parametric fading distributions for modeling line of sight exhibit a monotonicity in the line of sight parameter with respect to the Laplace transform order. While the Laplace transform order can also be used to order fading distributions based on the ergodic capacity, there exist several distributions which are not Laplace transform ordered, although they have ordered ergodic capacities. To address this gap, a new stochastic order called the ergodic capacity order has been proposed herein, which can be used to compare channels based on the ergodic capacity. Using stochastic orders, average performance of systems involving multiple random variables are compared over two different channels. These systems include diversity combining schemes, relay networks, and signal detection over fading channels with non-Gaussian additive noise. This research also addresses the problem of unifying fading distributions. This unification is based on infinite divisibility, which subsumes almost all known fading distributions, and provides simplified expressions for performance metrics, in addition to enabling stochastic ordering.
ContributorsRajan, Adithya (Author) / Tepedelenlioğlu, Cihan (Thesis advisor) / Papandreou-Suppappola, Antonia (Committee member) / Bliss, Daniel (Committee member) / Kosut, Oliver (Committee member) / Arizona State University (Publisher)
Created2014
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Description
Peptide microarrays have been used in molecular biology to profile immune responses and develop diagnostic tools. When the microarrays are printed with random peptide sequences, they can be used to identify antigen antibody binding patterns or immunosignatures. In this thesis, an advanced signal processing method is proposed to estimate

Peptide microarrays have been used in molecular biology to profile immune responses and develop diagnostic tools. When the microarrays are printed with random peptide sequences, they can be used to identify antigen antibody binding patterns or immunosignatures. In this thesis, an advanced signal processing method is proposed to estimate epitope antigen subsequences as well as identify mimotope antigen subsequences that mimic the structure of epitopes from random-sequence peptide microarrays. The method first maps peptide sequences to linear expansions of highly-localized one-dimensional (1-D) time-varying signals and uses a time-frequency processing technique to detect recurring patterns in subsequences. This technique is matched to the aforementioned mapping scheme, and it allows for an inherent analysis on how substitutions in the subsequences can affect antibody binding strength. The performance of the proposed method is demonstrated by estimating epitopes and identifying potential mimotopes for eight monoclonal antibody samples.

The proposed mapping is generalized to express information on a protein's sequence location, structure and function onto a highly localized three-dimensional (3-D) Gaussian waveform. In particular, as analysis of protein homology has shown that incorporating different kinds of information into an alignment process can yield more robust alignment results, a pairwise protein structure alignment method is proposed based on a joint similarity measure of multiple mapped protein attributes. The 3-D mapping allocates protein properties into distinct regions in the time-frequency plane in order to simplify the alignment process by including all relevant information into a single, highly customizable waveform. Simulations demonstrate the improved performance of the joint alignment approach to infer relationships between proteins, and they provide information on mutations that cause changes to both the sequence and structure of a protein.

In addition to the biology-based signal processing methods, a statistical method is considered that uses a physics-based model to improve processing performance. In particular, an externally developed physics-based model for sea clutter is examined when detecting a low radar cross-section target in heavy sea clutter. This novel model includes a process that generates random dynamic sea clutter based on the governing physics of water gravity and capillary waves and a finite-difference time-domain electromagnetics simulation process based on Maxwell's equations propagating the radar signal. A subspace clutter suppression detector is applied to remove dominant clutter eigenmodes, and its improved performance over matched filtering is demonstrated using simulations.
ContributorsO'Donnell, Brian (Author) / Papandreou-Suppappola, Antonia (Thesis advisor) / Bliss, Daniel (Committee member) / Johnston, Stephen A. (Committee member) / Kovvali, Narayan (Committee member) / Tepedelenlioğlu, Cihan (Committee member) / Arizona State University (Publisher)
Created2014
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Description
Thousands of high-resolution images are generated each day. Detecting and analyzing variations in these images are key steps in image understanding. This work focuses on spatial and multitemporal

visual change detection and its applications in multi-temporal synthetic aperture radar (SAR) images.

The Canny edge detector is one of the most widely-used edge

Thousands of high-resolution images are generated each day. Detecting and analyzing variations in these images are key steps in image understanding. This work focuses on spatial and multitemporal

visual change detection and its applications in multi-temporal synthetic aperture radar (SAR) images.

The Canny edge detector is one of the most widely-used edge detection algorithms due to its superior performance in terms of SNR and edge localization and only one response to a single edge. In this work, we propose a mechanism to implement the Canny algorithm at the block level without any loss in edge detection performance as compared to the original frame-level Canny algorithm. The resulting block-based algorithm has significantly reduced memory requirements and can achieve a significantly reduced latency. Furthermore, the proposed algorithm can be easily integrated with other block-based image processing systems. In addition, quantitative evaluations and subjective tests show that the edge detection performance of the proposed algorithm is better than the original frame-based algorithm, especially when noise is present in the images.

In the context of multi-temporal SAR images for earth monitoring applications, one critical issue is the detection of changes occurring after a natural or anthropic disaster. In this work, we propose a novel similarity measure for automatic change detection using a pair of SAR images

acquired at different times and apply it in both the spatial and wavelet domains. This measure is based on the evolution of the local statistics of the image between two dates. The local statistics are modeled as a Gaussian Mixture Model (GMM), which is more suitable and flexible to approximate the local distribution of the SAR image with distinct land-cover typologies. Tests on real datasets show that the proposed detectors outperform existing methods in terms of the quality of the similarity maps, which are assessed using the receiver operating characteristic (ROC) curves, and in terms of the total error rates of the final change detection maps. Furthermore, we proposed a new

similarity measure for automatic change detection based on a divisive normalization transform in order to reduce the computation complexity. Tests show that our proposed DNT-based change detector

exhibits competitive detection performance while achieving lower computational complexity as compared to previously suggested methods.
ContributorsXu, Qian (Author) / Karam, Lina J (Thesis advisor) / Chakrabarti, Chaitali (Committee member) / Bliss, Daniel (Committee member) / Tepedelenlioğlu, Cihan (Committee member) / Arizona State University (Publisher)
Created2014
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Description
The demand for the higher data rate in the wireless telecommunication is increasing rapidly. Providing higher data rate in cellular telecommunication systems is limited because of the limited physical resources such as telecommunication frequency channels. Besides, interference with the other users and self-interference signal in the receiver are the other

The demand for the higher data rate in the wireless telecommunication is increasing rapidly. Providing higher data rate in cellular telecommunication systems is limited because of the limited physical resources such as telecommunication frequency channels. Besides, interference with the other users and self-interference signal in the receiver are the other challenges in increasing the bandwidth of the wireless telecommunication system.

Full duplex wireless communication transmits and receives at the same time and the same frequency which was assumed impossible in the conventional wireless communication systems. Full duplex wireless communication, compared to the conventional wireless communication, doubles the channel efficiency and bandwidth. In addition, full duplex wireless communication system simplifies the reusing of the radio resources in small cells to eliminate the backhaul problem and simplifies the management of the spectrum. Finally, the full duplex telecommunication system reduces the costs of future wireless communication systems.

The main challenge in the full duplex wireless is the self-interference signal at the receiver which is very large compared to the receiver noise floor and it degrades the receiver performance significantly. In this dissertation, different techniques for the antenna interface and self-interference cancellation are proposed for the wireless full duplex transceiver. These techniques are designed and implemented on CMOS technology. The measurement results show that the full duplex wireless is possible for the short range and cellular wireless communication systems.
ContributorsAyati, Seyyed Amir (Author) / Kiaei, Sayfe (Thesis advisor) / Bakkaloglu, Bertan (Committee member) / Bliss, Daniel (Committee member) / Kitchen, Jennifer (Committee member) / Arizona State University (Publisher)
Created2017
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Description
This thesis investigates three different resource allocation problems, aiming to achieve two common goals: i) adaptivity to a fast-changing environment, ii) distribution of the computation tasks to achieve a favorable solution. The motivation for this work relies on the modern-era proliferation of sensors and devices, in the Data Acquisition Systems

This thesis investigates three different resource allocation problems, aiming to achieve two common goals: i) adaptivity to a fast-changing environment, ii) distribution of the computation tasks to achieve a favorable solution. The motivation for this work relies on the modern-era proliferation of sensors and devices, in the Data Acquisition Systems (DAS) layer of the Internet of Things (IoT) architecture. To avoid congestion and enable low-latency services, limits have to be imposed on the amount of decisions that can be centralized (i.e. solved in the ``cloud") and/or amount of control information that devices can exchange. This has been the motivation to develop i) a lightweight PHY Layer protocol for time synchronization and scheduling in Wireless Sensor Networks (WSNs), ii) an adaptive receiver that enables Sub-Nyquist sampling, for efficient spectrum sensing at high frequencies, and iii) an SDN-scheme for resource-sharing across different technologies and operators, to harmoniously and holistically respond to fluctuations in demands at the eNodeB' s layer.

The proposed solution for time synchronization and scheduling is a new protocol, called PulseSS, which is completely event-driven and is inspired by biological networks. The results on convergence and accuracy for locally connected networks, presented in this thesis, constitute the theoretical foundation for the protocol in terms of performance guarantee. The derived limits provided guidelines for ad-hoc solutions in the actual implementation of the protocol.

The proposed receiver for Compressive Spectrum Sensing (CSS) aims at tackling the noise folding phenomenon, e.g., the accumulation of noise from different sub-bands that are folded, prior to sampling and baseband processing, when an analog front-end aliasing mixer is utilized.

The sensing phase design has been conducted via a utility maximization approach, thus the scheme derived has been called Cognitive Utility Maximization Multiple Access (CUMMA).

The framework described in the last part of the thesis is inspired by stochastic network optimization tools and dynamics.

While convergence of the proposed approach remains an open problem, the numerical results here presented suggest the capability of the algorithm to handle traffic fluctuations across operators, while respecting different time and economic constraints.

The scheme has been named Decomposition of Infrastructure-based Dynamic Resource Allocation (DIDRA).
ContributorsFerrari, Lorenzo (Author) / Scaglione, Anna (Thesis advisor) / Bliss, Daniel (Committee member) / Ying, Lei (Committee member) / Reisslein, Martin (Committee member) / Arizona State University (Publisher)
Created2017
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Description
Fundamental limits of fixed-to-variable (F-V) and variable-to-fixed (V-F) length universal source coding at short blocklengths is characterized. For F-V length coding, the Type Size (TS) code has previously been shown to be optimal up to the third-order rate for universal compression of all memoryless sources over finite alphabets. The TS

Fundamental limits of fixed-to-variable (F-V) and variable-to-fixed (V-F) length universal source coding at short blocklengths is characterized. For F-V length coding, the Type Size (TS) code has previously been shown to be optimal up to the third-order rate for universal compression of all memoryless sources over finite alphabets. The TS code assigns sequences ordered based on their type class sizes to binary strings ordered lexicographically.

Universal F-V coding problem for the class of first-order stationary, irreducible and aperiodic Markov sources is first considered. Third-order coding rate of the TS code for the Markov class is derived. A converse on the third-order coding rate for the general class of F-V codes is presented which shows the optimality of the TS code for such Markov sources.

This type class approach is then generalized for compression of the parametric sources. A natural scheme is to define two sequences to be in the same type class if and only if they are equiprobable under any model in the parametric class. This natural approach, however, is shown to be suboptimal. A variation of the Type Size code is introduced, where type classes are defined based on neighborhoods of minimal sufficient statistics. Asymptotics of the overflow rate of this variation is derived and a converse result establishes its optimality up to the third-order term. These results are derived for parametric families of i.i.d. sources as well as Markov sources.

Finally, universal V-F length coding of the class of parametric sources is considered in the short blocklengths regime. The proposed dictionary which is used to parse the source output stream, consists of sequences in the boundaries of transition from low to high quantized type complexity, hence the name Type Complexity (TC) code. For large enough dictionary, the $\epsilon$-coding rate of the TC code is derived and a converse result is derived showing its optimality up to the third-order term.
ContributorsIri, Nematollah (Author) / Kosut, Oliver (Thesis advisor) / Bliss, Daniel (Committee member) / Sankar, Lalitha (Committee member) / Zhang, Junshan (Committee member) / Arizona State University (Publisher)
Created2018
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Description
Cognitive radio (CR) and device-to-device (D2D) systems are two promising dynamic spectrum access schemes in wireless communication systems to provide improved quality-of-service, and efficient spectrum utilization. This dissertation shows that both CR and D2D systems benefit from properly designed cooperation scheme.

In underlay CR systems, where secondary users (SUs)

Cognitive radio (CR) and device-to-device (D2D) systems are two promising dynamic spectrum access schemes in wireless communication systems to provide improved quality-of-service, and efficient spectrum utilization. This dissertation shows that both CR and D2D systems benefit from properly designed cooperation scheme.

In underlay CR systems, where secondary users (SUs) transmit simultaneously with primary users (PUs), reliable communication is by all means guaranteed for PUs, which likely deteriorates SUs’ performance. To overcome this issue, cooperation exclusively among SUs is achieved through multi-user diversity (MUD), where each SU is subject to an instantaneous interference constraint at the primary receiver. Therefore, the active number of SUs satisfying this constraint is random. Under different user distributions with the same mean number of SUs, the stochastic ordering of SU performance metrics including bit error rate (BER), outage probability, and ergodic capacity are made possible even without observing closed form expressions. Furthermore, a cooperation is assumed between primary and secondary networks, where those SUs exceeding the interference constraint facilitate PU’s transmission by relaying its signal. A fundamental performance trade-off between primary and secondary networks is observed, and it is illustrated that the proposed scheme outperforms non-cooperative underlay CR systems in the sense of system overall BER and sum achievable rate.

Similar to conventional cellular networks, CR systems suffer from an overloaded receiver having to manage signals from a large number of users. To address this issue, D2D communications has been proposed, where direct transmission links are established between users in close proximity to offload the system traffic. Several new cooperative spectrum access policies are proposed allowing coexistence of multiple D2D pairs in order to improve the spectral efficiency. Despite the additional interference, it is shown that both the cellular user’s (CU) and the individual D2D user's achievable rates can be improved simultaneously when the number of D2D pairs is below a certain threshold, resulting in a significant multiplexing gain in the sense of D2D sum rate. This threshold is quantified for different policies using second order approximations for the average achievable rates for both the CU and the individual D2D user.
ContributorsZeng, Ruochen (Author) / Tepedelenlioğlu, Cihan (Thesis advisor) / Papandreou-Suppappola, Antonia (Committee member) / Bliss, Daniel (Committee member) / Kosut, Oliver (Committee member) / Arizona State University (Publisher)
Created2017
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Description
In recent years, there has been an increased interest in sharing available bandwidth to avoid spectrum congestion. With an ever-increasing number wireless users, it is critical to develop signal processing based spectrum sharing algorithms to achieve cooperative use of the allocated spectrum among multiple systems in order to reduce

In recent years, there has been an increased interest in sharing available bandwidth to avoid spectrum congestion. With an ever-increasing number wireless users, it is critical to develop signal processing based spectrum sharing algorithms to achieve cooperative use of the allocated spectrum among multiple systems in order to reduce interference between systems. This work studies the radar and communications systems coexistence problem using two main approaches. The first approach develops methodologies to increase radar target tracking performance under low signal-to-interference-plus-noise ratio (SINR) conditions due to the coexistence of strong communications interference. The second approach jointly optimizes the performance of both systems by co-designing a common transmit waveform.

When concentrating on improving radar tracking performance, a pulsed radar that is tracking a single target coexisting with high powered communications interference is considered. Although the Cramer-Rao lower bound (CRLB) on the covariance of an unbiased estimator of deterministic parameters provides a bound on the estimation mean squared error (MSE), there exists an SINR threshold at which estimator covariance rapidly deviates from the CRLB. After demonstrating that different radar waveforms experience different estimation SINR thresholds using the Barankin bound (BB), a new radar waveform design method is proposed based on predicting the waveform-dependent BB SINR threshold under low SINR operating conditions.

A novel method of predicting the SINR threshold value for maximum likelihood estimation (MLE) is proposed. A relationship is shown to exist between the formulation of the BB kernel and the probability of selecting sidelobes for the MLE. This relationship is demonstrated as an accurate means of threshold prediction for the radar target parameter estimation of frequency, time-delay and angle-of-arrival.



For the co-design radar and communications system problem, the use of a common transmit waveform for a pulse-Doppler radar and a multiuser communications system is proposed. The signaling scheme for each system is selected from a class of waveforms with nonlinear phase function by optimizing the waveform parameters to minimize interference between the two systems and interference among communications users. Using multi-objective optimization, a trade-off in system performance is demonstrated when selecting waveforms that minimize both system interference and tracking MSE.
ContributorsKota, John S (Author) / Papandreou-Suppappola, Antonia (Thesis advisor) / Berisha, Visar (Committee member) / Bliss, Daniel (Committee member) / Kovvali, Narayan (Committee member) / Arizona State University (Publisher)
Created2016